Research

Research at Boston Children's Hospital

The research enterprise at Boston Children’s Hospital, comprising more than 3,000 researchers, is the world’s largest at a pediatric center. Our work is fueled by a deep understanding of disease biology coupled with world-class discovery platforms, including genetics and genomics, gene editing, bioinformatics, proteomics, bioengineering, image analysis, biobanks, disease-specific stem cell lines, and a range of animal models. We have special expertise in rare disease discovery, a robust Translational Research Program and large, diverse patient populations for clinical research and trials.
researchers

More than 3,000 researchers and scientific staff

research space

1 million square feet of research space — and growing

Boston Children's research funding

$423 million in research funding in FY2020 — #1 in NIH funding for pediatric research

Boston Children's Journal articles

3,400 articles/year in peer reviewed journals — the most of any pediatric hospital

Boston Children's inventions

149 new inventions in FY2020 alone

iPSC derived airway infected with SARS-CoV-2. Image: Ruobing Wang, Boston Children’s Hospital

COVID-19 Research

As of March 2021, Boston Children’s Hospital had produced 1,127 COVID-19-related research publications, according to Erudera. These range from molecular investigations of SARS-CoV-2 and the immune response to large-scale clinical studies of the effects of COVID-19 in children.

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Research Highlights

GlycoRNA graphic

Glycosylated RNAs upend cell biology as we know it

Ryan Flynn, MD, PhD, a new investigator in our Stem Cell program, has discovered a new category of sugar-coated molecules that ride on our cells. His groundbreaking work should open multiple research avenues in immunology and beyond.

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Preterm infant microbiome illustration

Piecing together the preterm infant microbiome

Understanding how the microbiome forms in preterm infants is essential to knowing how to intervene to protect their future health, says Seth Rakoff-Nahoum, MD, PhD. He tracks how microbes plant their flags in this nearly pristine environment.
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Neural stem cells illustration

Recommendations for reproducibility in stem cell research

Lab research on intellectual and developmental disabilities often uses induced pluripotent stem cells differentiated into neural cells. But lab to lab variation makes results hard to reproduce. Mustafa Sahin, MD, PhD, et al. aim to provide consistency, speeding research progress.
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An image worth 1,000 words?

The 2021 Science Media Exhibition solicited more than 40 science image submissions from research laboratories and programs throughout Boston Children’s Hospital. The images here were presented live during a virtual event held in June in conjunction with Dr. M. Judah Folkman Research Day.

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BCH Innovation News @BCH_Innovation 10/7/2021 6:06:57 PM
RT @nansonaham: As of June 30, more than 140K children had lost a parent or grandparent caregiver to #COVID. The number is likely higher no…
BCH Innovation News @BCH_Innovation 10/6/2021 9:00:00 PM
The lab of Yi Zhang describes novel methods for identifying imprinted regions of the #germline. They reveal abundan… https://t.co/neR1snZdoW
BCH Innovation News @BCH_Innovation 10/5/2021 8:30:05 PM
Congratulations to Mariella Filbin, MD, Ph.D. (@FilbinMariella) of @DFBC_PedCare, who received a 2021 @NIH Director… https://t.co/X3NasYJA2j
BCH Innovation News @BCH_Innovation 10/5/2021 5:33:07 PM
How do unrelated cell lineages in developing organisms end up producing much the same kinds of cells? New work from… https://t.co/Mym8He5QSq
BCH Innovation News @BCH_Innovation 10/4/2021 8:30:01 PM
Many lineages, but similar cells: @k_mizeracka and @maxwellheiman show what worms have to tell us about cell differ… https://t.co/oWvooVMfv6
BCH Innovation News @BCH_Innovation 10/1/2021 5:30:00 PM
Overturning #diet dogma? A study in @AJCNutrition, led by @davidludwigmd and Cara Ebbeling, suggests that #low-carb… https://t.co/6BZu3hFRJy
The commitment and compassion with which we care for all children and families is matched only by the pioneering spirit of discovery and innovation that drives us to think differently, to find answers, and to build a better tomorrow for children everywhere.

Kevin B. Churchwell, President and CEO