Current Environment:

Note: List of publications from researchers at Boston Children’s Hospital who used the core facility.

2019

Barnett KC, Coronas-Serna JM, Zhou W, Ernandes MJ, Cao A, Kranzusch PJ,Kagan JC. Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA. Cell. 2019;176(6):1432-46 e11. Epub 2019/03/05. doi: 10.1016/j.cell.2019.01.049. PubMed PMID: 30827685; PMCID: PMC6697112.

Royal JM, Oh YJ, Grey MJ, Lencer WI, Ronquillo N, Galandiuk S, Matoba N. A modified cholera toxin B subunit containing an ER retention motif enhances colon epithelial repair via an unfolded protein response. FASEB J. 2019:fj201901255R. Epub 2019/09/29. doi: 10.1096/fj.201901255R. PubMed PMID: 31560862.

Bazarbashi AN, McCarty TR, Al-Obaid LN, Skinner MJ, Thompson CC. Efficacy and Safety of Novel, Disposable Endoscopic Scissors in Patients with Roux-en-Y Gastric Bypass: a Single-Center Feasibility Study. Obes Surg. 2019 Aug 19;. doi: 10.1007/s11695-019-04125-7. PubMed PMID: 31428973; NIHMSID:NIHMS1537814. [Epub ahead of print]

Chen M, He X. APC Deficiency Leads to beta-Catenin Stabilization and Signaling Independent of LRP5/6. Dev Cell. 2019;49(6):825-6. Epub 2019/06/19. doi: 10.1016/j.devcel.2019.05.013. PubMed PMID: 31211990.

de Oliveira Mann CC, Orzalli MH, King DS, Kagan JC, Lee ASY, Kranzusch PJ. Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-kappaB Signaling Adaptation. Cell Rep. 2019;27(4):1165-75 e5. Epub 2019/04/25. doi: 10.1016/j.celrep.2019.03.098. PubMed PMID: 31018131.

Duan T, Cil O, Thiagarajah JR, Verkman AS. Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea. JCI insight. 2019 Jan 22. doi: 10.1172/jci.insight.126444. PubMed PMID: 30668547; PMCID: PMC6478423.

Di Gioia M, Spreafico R, Springstead JR, Mendelson MM, Joehanes R, Levy D,Zanoni I. Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation. Nature Immunology. In press

Elliott M, Favre-Guilmard C, Liu SM, Maignel J, Masuyer G, Beard M, Boone C, Carre D, Kalinichev M, Lezmi S, Mir I, Nicoleau C, Palan S, Perier C, Raban E, Zhang S, Dong M**, Stenmark P**, Krupp J** (2019). Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models. Science Advances. 2019, 5:eaau7196, PMC6357751.

Graham WV, He W, Marchiando AM, Zha J, Singh G, Li H, Biswas A, Ong MLDM, Jiang Z-H, Choi W, Zuccola H, Wang Y, Griffith J, Wu J, Rosenberg H, Wang Y, Snapper SB, Ostrov D, Meredith SC, Miller LW, Turner JR. IntracellularMLCK1 diversion reverses barrier loss to restore mucosal homeostasis. Nat Med. 2019 Apr;25(4):690-700. Epub 2019 Apr. 1. doi: 10.1038/s41591-019-0393-7. PubMed PMID: 30936544; PMCID: PMC6461392.

Goettel JA, Kotlarz D, Emani R, Canavan JB, Konnikova L, Illig D, Frei SM, Field M, Kowalik M, Peng K, Gringauz J, Mitsialis V, Wall SM, Tsou A, GriffithAE, Huang Y, Friedman JR, Towne JE, Plevy SE, O'Hara Hall A, Snapper SB. Low-Dose Interleukin-2 Ameliorates Colitis in a Preclinical Humanized Mouse Model. Cell Mol Gastroenterol Hepatol. 2019 May 9;8(2):193-195. doi: 10.1016/j.jcmgh.2019.05.001. [Epub ahead of print] PubMed PMID: 31078723; PubMed Central PMCID: PMC6661391.

Hsu BB, Gibson TE, Yeliseyev V, Liu Q, LyonL, Bry L, Silver PA. Dynamic Modulation of the Gut Microbiota and Metabolome by Bacteriophages in a Mouse Model. Cell Host & Microbe. 2019, June , Vol. 25, page814, PMCID: PMC3965317

Jalili-Firoozinezhad S, Gazzaniga FS, Calamari EL, Camacho DM, Fadel CW, Bein A, Swenor B, Nestor B, Cronce MJ, Tovaglieri A, Levy O, Gregory KE,Breault DT, Cabral JMS, Kasper DL, Novak R, Ingber DE. A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip. Nat Biomed Eng. 2019. Epub 2019/05/16. doi: 10.1038/s41551-019-0397-0. PubMed PMID: 31086325; PMCID: PMC6658209. 

Kang YH, Biswas A, Field M, Snapper SB. STAT1 signaling shields T cells from NK cell-mediated cytotoxicity. Nat Commun. 2019 Feb 22;10(1):912. doi: 10.1038/s41467-019-08743-8. PubMed PMID: 30796216; PubMed Central PMCID: PMC6385318.

Mansfield MJ, Wentz TG, Zhang S, Lee EJ, Dong M, Sharma SK, Doxey AC. Bioinformatic discovery of a toxin family in Chryseobacterium piperi with sequence similarity to botulinum neurotoxins. Sci Rep. 2019;9(1):1634. Epub 2019/02/09. doi: 10.1038/s41598-018-37647-8. PubMed PMID: 30733520; PMCID: PMC6367388

Monino-Romero S, Lexmond WS, Singer J, Bannert C, Amoah AS, Yazdanbakhsh M, Boakye DA, Jensen-Jarolim E, Fiebiger E, Szepfalusi Z. Soluble FcvarepsilonRI: A biomarker for IgE-mediated diseases. Allergy. 2019. Epub 2019/02/07. doi: 10.1111/all.13734. PubMed PMID: 30725474.

Pan L, Fu TM, Zhao W, Zhao L, Chen W, Qiu C, Liu W, Liu Z, Piai A, Fu Q, Chen S, Wu H, Chou JJ. Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling. Cell. 2019 Mar 7;176(6):1477-1489.e14. Epub 2019 Feb 28. doi:10.1016/j.cell.2019.02.001. PubMed PMID: 30827683; PMCID: PMC6529188.

Shen C, Lu A, Xie WJ, Ruan J, Negro R, Egelman EH, Fu T, Wu H (2019). Molecular mechanism for NLRP6 inflammasome assembly and activation. Proc Natl Acad Sci U S A. 2019. Feb 5;116(6):2052-2057 Epub 2019 Jan 23. doi: 10.1073/pnas.1817221116. PubMed PMID: 30674671; PMCID: PMC6369754.
2019

Tan Y, Kagan JC. Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility. Cell. 2019;177(2):384-98 e11. Epub 2019/03/7. doi: 10.1016/j.cell.2019.01.039. PubMed PMID: 30853218; PMCID: PMC6710629.

Tao L, Tian S, Zhang J, Liu Z, Robinson-McCarthy L, Miyashita SI, Breault DT, Gerhard R, Oottamasathien S, Whelan SPJ, Dong M. Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells. Nat Microbiol. 2019. Epub 2019/06/05. doi: 10.1038/s41564-019-0464-z. PubMed PMID: 31160825.

Tovaglieri A, Sontheimer-Phelps A, Geirnaert A, Prantil-Baun R, Camacho DM, Chou DB, Jalili-Firoozinezhad S, de Wouters T, Kasendra M, Super M, Cartwright MJ, Richmond CA, Breault DT, Lacroix C, Ingber DE. Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites. Microbiome. 2019;7(1):43. Epub 2019/03/21. doi: 10.1186/s40168-019-0650-5. PubMed PMID: 30890187; PMCID: PMC6425591.

2018

Biswas A, Shouval DS, Griffith A, Goettel JA, Field M, Kang YH, Konnikova L, Janssen E, Redhu NS, Thrasher AJ, Chatila T, Kuchroo VK, Geha RS, Notarangelo LD, Pai SY, Horwitz BH, Snapper SB. WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis. Nat Commun. 2018 May 3;9(1):1779. doi: 10.1038/s41467-018-03670-6. PubMed PMID: 29725003; PubMed Central PMCID: PMC5934380.

Chen P, Tao L, Wang T, Zhang J, He A, Lam KH, Liu Z, He X, Perry K, Dong M, Jin R. Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B. Science. 2018;360(6389):664-9. Epub 2018/05/12. doi: 10.1126/science.aar1999. PubMed PMID: 29748286; PMCID: PMC6231499.
2018

Edington CD, Chen WLK, Geishecker E, Kassis T, Soenksen LR, Bhushan BM, Freake D, Kirschner J, Maass C, Tsamandouras N, Valdez J, Cook CD, Parent T, Snyder S, Yu J, Suter E, Shockley M, Velazquez J, Velazquez JJ, Stockdale L, Papps JP, Lee I, Vann N, Gamboa M, LaBarge ME, Zhong Z, Wang X, Boyer LA, Lauffenburger DA, Carrier RL, Communal C, Tannenbaum SR, Stokes CL, Hughes DJ, Rohatgi G, Trumper DL, Cirit M, Griffith LG. Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies. Sci Rep. 2018;8(1):4530. Epub 2018/03/16. doi: 10.1038/s41598-018-22749-0. PubMed PMID: 29540740; PMCID: PMC5852083.

Evavold CL, Ruan J, Tan Y, Xia S, Wu H, Kagan JC. The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages.Immunity. 2018;48(1):35-44 e6. Epub 2017/12/03. doi: 10.1016/j.immuni.2017.11.013. PubMed PMID: 29195811; PMCID: PMC5773350.

Frank SR, Kollmann CP, Luong P, Galli GG, Zou L, Bernards A, Getz G, Calogero RA, Frodin M, Hansen SH. Correction: p190 RhoGAP promotes contact inhibition in epithelial cells by repressing YAP activity. J Cell Biol. 2018. Epub 2018/06/24. doi: 10.1083/jcb.201710058. PubMed PMID: 20045860; PMCID: PMC6122999.

Franz KM, Neidermyer WJ, Tan YJ, Whelan SPJ, Kagan JC. STING-dependent translation inhibition restricts RNA virus replication. Proc Natl Acad Sci U S A. 2018;115(9):E2058-E67. Epub 2018/02/15. doi: 10.1073/pnas.1716937115. PubMed PMID: 29440426; PMCID: PMC5834695.

Fu TM, Shen C, Li Q, Zhang P, Wu H (2018). Mechanism of ubiquitin transfer promoted by TRAF6. Proc Natl Acad Sci U S A. 115(8):1783-1788.Epub 2018/02/05. PubMed PMID: 29432170; PMCID: PMC5828637.

Garber JJ, Mallick EM, Scanlon KM, Turner JR, Donnenberg MS, Leong JM, Snapper SB. Attaching-and-Effacing Pathogens Exploit Junction Regulatory Activities of N-WASP and SNX9 to Disrupt the Intestinal Barrier. Cell Mol Gastroenterol Hepatol. 2017 Dec 15;5(3):273-288. doi: 10.1016/j.jcmgh.2017.11.015. eCollection 2018 Mar. PubMed PMID: 29675452; PMCID: PMC5904039.

Garcia-Castillo MD, Lencer WI, Chinnapen DJ. Transcytosis Assay for Transport of Glycosphingolipids across MDCK-II Cells. Bio Protoc. 2018;8(20). Epub 2018/12/07. doi: 10.21769/BioProtoc.3049. PubMed PMID: 30505885; PMCID: PMC6261372.

Garcia-Castillo MD, Chinnapen DJ, Te Welscher YM, Gonzalez RJ, Softic S, Pacheco M, Mrsny RJ, Kahn CR, von Andrian UH, Lau J, Pentelute BL, Lencer WI. Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids. elife. 2018;7. Epub 2018/06/01. doi: 10.7554/eLife.34469. PubMed PMID: 29851380; PMCID: PMC5980230.

Hosomi S, Grootjans J, Huang YH, Kaser A, Blumberg RS. New Insights Into the Regulation of Natural-Killer Group 2 Member D (NKG2D) and NKG2D-Ligands: Endoplasmic Reticulum Stress and CEA-Related Cell Adhesion Molecule 1. Front Immunol. 2018;9:1324. Epub 2018/07/06. doi: 10.3389/fimmu.2018.01324. PubMed PMID: 29973929; PMCID: PMC6020765.

Kamareddine L, Robins WP, Berkey CD, Mekalanos JJ, and Watnick PI. The Drosophila immune deficiency pathway modulates enteroendocrine function and host metabolism. Cell Metab. 2018 Jun 15. pii: S1550-4131(18)30379-6. doi: 10.1016/j.cmet.2018.05.026. PubMed PMID: 29937377; PubMed Central PMCID: PMC6125180.

Kasendra M, Tovaglieri A, Sontheimer-Phelps A, Jalili-Firoozinezhad S, Bein A, Chalkiadaki A, Scholl W, Zhang C, Rickner H, Richmond CA, Li H, Breault DT, Ingber DE. Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids. Sci Rep. 2018;8(1):2871. Epub 2018/02/15. doi: 10.1038/s41598-018-21201-7. PubMed PMID: 29440725; PMCID: PMC5811607.

Konnikova L, Boschetti G, Rahman A, Mitsialis V, Lord J, Richmond C, Tomov VT, Gordon W, Jelinsky S, Canavan J, Liss A, Wall S, Field M, Zhou F, Goldsmith JD, Bewtra M, Breault DT, Merad M, Snapper SB. High-dimensional immune phenotyping and transcriptional analyses reveal robust recovery of viable human immune and epithelial cells from frozen gastrointestinal tissue. Mucosal Immunol. 2018;11(6):1684-93. Epub 2018/08/17. doi: 10.1038/s41385-018-0047-y. PubMed PMID: 30111863; PMCID: PMC6512331. 

Liao J, Gibson JA, Pickering BS, Watnick PI. Sublingual Adjuvant Delivery by a Live Attenuated Vibrio cholerae-Based Antigen Presentation Platform. mSphere.2018;3(3). Epub 2018/06/08. doi: 10.1128/mSphere.00245-18. PubMed PMID: 29875145; PMCID: PMC5990885.

Liao J, Smith DR, Brynjarsdottir J, Watnick PI. A Self-Assembling Whole-Cell Vaccine Antigen Presentation Platform. J Bacteriol. 2018;200(15). Epub 2018/02/28. doi: 10.1128/JB.00752-17. PubMed PMID: 29483163; PMCID: PMC6040178.

Liao J, Xu G, Mevers EE, Clardy J, Watnick PI. A high-throughput, whole cell assay to identify compounds active against carbapenem-resistant Klebsiella pneumoniae. PLoS One. 2018;13(12):e0209389. Epub 2018/12/24. doi: 10.1371/journal.pone.0209389. PubMed PMID: 30576339; PMCID: PMC6303040. 2018

Liu NN, Uppuluri P, Broggi A, Besold A, Ryman K, Kambara H, Solis N, Lorenz V, Qi W, Acosta-Zaldivar M, Emami SN, Bao B, An D, Bonilla FA, Sola-Visner M, Filler SG, Luo HR, Engstrom Y, Ljungdahl PO, Culotta VC, Zanoni I, Lopez-Ribot JL, Kohler JR. Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence. PLoS Pathog. 2018;14(7):e1007076. Epub 2018/07/31. doi: 10.1371/journal.ppat.1007076. PubMed PMID: 30059535; PMCID: PMC6085062. 

Li Y, Fu TM, Lu A, Witt K, Ruan J, Shen C, Wu H (2018). Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1. Proc Natl Acad Sci U S A. 115(43):10845-10852. Epub 2018/10/02. doi: 10.1073/pnas.1810524115. PubMed PMID: 30279182; PMCID: PMC6205419.
2018

Luong PH, Hedl M, Yan J, Zuo T, Fu TM, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C, Lencer WI. INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. elife. 2018;7. Epub 2018/10/26. doi: 10.7554/eLife.38539. PubMed PMID: 30355448; PMCID: PMC6226287.

Lyons J, Ghazi PC, Starchenko A, Tovaglieri A, Baldwin KR, Poulin EJ, Gierut JJ, Genetti C, Yajnik V, Breault DT, Lauffenburger DA, Haigis KM. The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile. PLoS Biol. 2018;16(3):e2002417. Epub 2018/03/30. doi: 10.1371/journal.pbio.2002417. PubMed PMID: 29596476; PMCID: PMC5892915.

Malhotra N, Leyva-Castillo JM, Jadhav U, Barreiro O, Kam C, O’Neill NK, Meylan F, O’Leary D, Chambon P, von Andrian UH, Siegel RM, Wang EC, Shivdasani RA, Geha RS (Inter-Member collaboration). RORa-expressing T regulatory cells restrain allergic skin inflammation. Sci Immunol 2018; Mar 2;3(21). pii: eaao6923. doi: 10.1126/sciimmunol.aao6923. PubMed PMID: 29500225; PMCID: PMC5912895.

Monino-Romero S, Erkert L, Schmidthaler K, Diesner SC, Sallis BF, Pennington L, Jardetzky T, Oettgen HC, Bohle B, Fiebiger E, Szepfalusi Z. The soluble isoform of human FcvarepsilonRI is an endogenous inhibitor of IgE-mediated mast cell responses. Allergy. 2018. Epub 2018/07/22. doi: 10.1111/all.13567. PubMed PMID: 30030936.

O'Connell AE, Zhou F, Shah MS, Murphy Q, Rickner H, Kelsen J, Boyle J, Doyle JJ, Gangwani B, Thiagarajah JR, Kamin DS, Goldsmith JD, Richmond C, Breault DT, Agrawal PB. Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations. Am J Hum Genet. 2018;103(1):131-7. Epub 2018/06/19. doi: 10.1016/j.ajhg.2018.05.007. PubMed PMID: 29909964; PMCID: PMC6035368.

Ohsaki A, Venturelli N, Buccigrosso TM, Osganian SK, Lee J, Blumberg RS, Oyoshi MK. Maternal IgG immune complexes induce food allergen-specific tolerance in offspring. J Exp Med. 2018;215(1):91-113. Epub 2017/11/22. doi: 10.1084/jem.20171163. PubMed PMID: 29158374; PMCID: PMC5748859.

Orzalli MH, Smith A, Jurado KA, Iwasaki A, Garlick JA, Kagan JC. An Antiviral Branch of the IL-1 Signaling Pathway Restricts Immune-Evasive Virus Replication. Mol Cell. 2018;71(5):825-40 e6. Epub 2018/08/14. doi: 10.1016/j.molcel.2018.07.009. PubMed PMID: 30100266; PMCID: PMC6411291.

Pacheco AR, Lazarus JE, Sit B, Schmieder S, Lencer WI, Blondel CJ, Doench JG, Davis BM, Waldor MK. CRISPR Screen Reveals that EHEC's T3SS and Shiga Toxin Rely on Shared Host Factors for Infection. MBio. 2018;9(3). Epub 2018/06/21. doi: 10.1128/mBio.01003-18. PubMed PMID: 29921669; PMCID: PMC6016243.

Richardson GD, Sage A, Bennaceur K, Al Zhrany N, Coelho-Lima J, Dookun E, Draganova L, Saretzki G, Breault DT, Mallat Z, Spyridopoulos I. Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T- Cells. Arterioscler Thromb Vasc Biol. 2018 Jun;38(6):1283-1296. doi: 10.1161/ATVBAHA.117.309940. Epub 2018 Mar 29. PubMed PMID: 29599138; PubMed Central PMCID: PMC5965929.

Richmond CA, Rickner H, Shah MS, Ediger T, Deary L, Zhou F, Tovaglieri A, Carlone DL, Breault DT. JAK/STAT-1 Signaling Is Required for Reserve Intestinal Stem Cell Activation during Intestinal Regeneration Following Acute Inflammation. Stem Cell Reports. 2018;10(1):17-26. Epub 2017/12/26. doi: 10.1016/j.stemcr.2017.11.015. PubMed PMID: 29276155; PMCID: PMC5768934.

Rodriguez-Fraticelli AE, Wolock SL, Weinreb CS, Panero R, Patel SH, Jankovic M, Sun J, Calogero RA, Klein AM, Camargo FD. Clonal analysis of lineage fate in native haematopoiesis. Nature. 2018 Jan 11;553(7687):212-216. doi: 10.1038/nature25168. Epub 2018 Jan 3. PubMed PMID: 29323290; PubMed Central PMCID: PMC5884107.

Ryzhakov G, West NR, Franchini F, Clare S, Ilott NE, Sansom SN, Bullers SJ,Pearson C, Costain A, Vaughan-Jackson A, Goettel JA, Ermann J, Horwitz BH, Buti L, Lu X, Mukhopadhyay S, Snapper SB, Powrie F. Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis. Nat Commun. 2018 Sep 18;9(1):3797. doi: 10.1038. PMID: 30228258; PMCID: PMC6143560.

Sabatos-Peyton CA, Nevin J, Brock A, Venable JD, Tan DJ, Kassam N, Xu F, Taraszka J, Wesemann L, Pertel T, Acharya N, Klapholz M, Etminan Y, Jiang X, Huang YH, Blumberg RS, Kuchroo VK, Anderson AC. Blockade of Tim-3 binding to phosphatidylserine and CEACAM1 is a shared feature of anti-Tim-3 antibodies that have functional efficacy. Oncoimmunology. 2018;7(2):e1385690. Epub 2018/01/09. doi: 10.1080/2162402X.2017.1385690. PubMed PMID: 29308307; PMCID: PMC5749620.

Sallis BF, Acar U, Hawthorne K, Babcock SJ, Kanagaratham C, Goldsmith JD,Rosen R, Vanderhoof JA, Nurko S, Fiebiger E. A Distinct Esophageal mRNA Pattern Identifies Eosinophilic Esophagitis Patients With Food Impactions. Front Immunol. 2018;9:2059. Epub 2018/11/21. doi: 10.3389/fimmu.2018.02059. PubMed PMID: 30455683; PMCID: PMC6230678.

Santus W, Mingozzi F, Vai M, Granucci F, Zanoni I. Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses. J Vis Exp. 2018. Jun 13;(136). doi: 10.3791/57574. PubMed PMID: 29985352; PMCID: PMC6101704.

Tan Y, Kagan JC. Biochemical Isolation of the Myddosome from Murine Macrophages. Methods Mol Biol. 2018;1714:79-95. Epub 2017/11/28. doi: 10.1007/978-1-4939-7519-8_6. PubMed PMID: 29177857; PMCID: PMC6698367.

Tian S, Muneeruddin K, Choi MY, Tao L, Bhuiyan RH, Ohmi Y, Furukawa K, Furukawa K, Boland S, Shaffer SA, Adam RM, Dong M. Genome-wide CRISPR screens for Shiga toxins and Ricin reveal Golgi proteins critical for glycosylation. PloS Biology,2018 16(11):e2006951. eCollection 2018 Nov. doi: 10.1371/journal.pbio.2006951. PubMed PMID: 30481169; PMCID: PMC6258472.

Wang L, Fu TM, Zhou Y, Xia S, Greka A, Wu H (2018). Structures and gating mechanism of human TRPM2. Science.362(6421). pii: eaav4809. Epub 2018/11/22. doi: 10.1126/science.aav4809. PubMed PMID: 30467180; PMCID: PMC6459600.

Wen, L., Javed, T.A., Yimlamai, D., Mukherjee, A., Xiao, X., Husain, S.Z. Transient High Pressure in Pancreatic Ducts Promotes Inflammation and Alters Tight Junctions via Calcineurin Signaling in Mice. Gastroenterology. 2018. S0016-5085(18)34658-4. Epub 2018/06/19. doi: 10.1053/j.gastro.2018.06.036. PubMed PMID: 29928898; PMCID: PMC6174093.

Zaytouni, T., Tsai, P-Y., Hitchcock, D.S., DuBois, C.D., Freinkman, E., Lin, L., Morales-Oyarvide, V., Lenehan, P.J., Wolpin, B.M., Mino-Kenudson, M., Torres, E.M., Stylopoulos, N., Clish, C.B., and Kalaany, N.Y. Critical role for arginase 2 and the urea cycle in obesity-associated pancreatic cancer, Nat Commun, 2017, August, 8: 242, PMCID: PMC5556090

Zhao M, Xiong X, Ren K, Xu B, Cheng M, Sahu C, Wu K, Nie Y, Huang Z, Blumberg RS, Han X, Ruan HB. Deficiency in intestinal epithelial O-GlcNAcylation predisposes to gut inflammation. EMBO Mol Med. 2018 Aug;10(8). PMID:29941542 PMCID: PMC6079539