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Research at Boston Children's Hospital

The research enterprise at Boston Children’s Hospital, comprising more than 3,000 researchers, is the world’s largest at a pediatric center. Our work is fueled by a deep understanding of disease biology coupled with world-class discovery platforms, including genetics and genomics, gene editing, bioinformatics, proteomics, bioengineering, image analysis, biobanks, disease-specific stem cell lines, and a range of animal models. We have special expertise in rare disease discovery, a robust Translational Research Program and large, diverse patient populations for clinical research and trials.

More than 3,000 researchers and scientific staff

1 million square feet of research space — and growing

3,400 articles/year in peer reviewed journals — the most of any pediatric hospital

Lasker Foundation Announces 2022 Lasker Award Winners

Congratulations to Timothy A. Springer for winning the 2022 Lasker Award for discoveries concerning integrins – key mediators of cell-matrix and cell-cell interactions in physiology and diseases.

Learn more about the Lasker Award

A new view of heart health: Mutations accumulate in the heart starting in childhood

Why does the risk of heart disease go up as we age? Risk factors don’t completely explain it. This first-of-its-kind study now shows that the cells that make up our heart muscle accumulate new DNA mutations over time — while losing the ability to repair them.

LEARN MORE about heart mutations

Making ready-made CAR T cells for cancer immunotherapy

CAR T-cell immunotherapy is a powerful weapon against certain cancers. But creating CAR T cells for individual patients is expensive and time-consuming. A method developed in the Daley Lab enables the production of generic, “ready made” CAR T cells from stem cells at scale.

LEARN MORE about car-t cells

A new vaccine formulation could finally protect babies against RSV

After 50+ years, vaccine to protect infants from respiratory syncytial virus could finally be on the horizon, with the addition of adjuvants tailored to elicit immune responses in newborns. In early tests, the formulation strongly activated Th1 responses.

LEARN MORE about a new vaccine to protect babies from RSV

An image worth 1,000 words?

The 2021 Science Media Exhibition solicited more than 40 science image submissions from research laboratories and programs throughout Boston Children’s Hospital. The images here were presented live during a virtual event held in June in conjunction with Dr. M. Judah Folkman Research Day.