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Juvenile Arthritis | Overview


Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis

Authors: Henderson LA, Hoyt KJ, Lee PY, Rao DA, Jonsson AH, Nguyen JP, Rutherford K, Julé AM, Charbonnier LM, Case S, Chang MH, Cohen EM, Dedeoglu F, Fuhlbrigge RC, Halyabar O, Hazen MM, Janssen E, Kim S, Lo J, Lo MS, Meidan E, Son MBF, Sundel RP, Stoll ML, Nusbaum C, Lederer JA, Chatila TA, Nigrovic PA

Summary: In this article the authors studied T cells from patients with systemic juvenile idiopathic arthritis to evaluate their role in the clinical manifestations of this disease. The authors found certain T cell subsets are polarized to an inflammatory, Th17 phenotype based on the stage of disease. These results highlight new immune pathways involved in systemic juvenile idiopathic arthritis that may be novel targets for disease treatment. 
Publication Information: JCI Insight, March 2020

Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans for Juvenile Idiopathic Arthritis-Associated and Idiopathic Chronic Anterior Uveitis

Authors: Angeles-Han ST, Lo MS, Henderson LA, Lerman MA, Abramson L, Cooper AM, Parsa MF, Zemel LS, Ronis T, Beukelman T, Cox E, Sen HN, Holland GN, Brunner HI, Lasky A, Rabinovich CE; Juvenile Idiopathic Arthritis Disease-Specific and Uveitis Subcommittee of the Childhood Arthritis Rheumatology and Research Alliance

Summary: Drs. Lo and Henderson worked with other pediatric rheumatologists and ophthalmologists in CARRA to develop 2 consensus treatment plans for patients with chronic anterior uveitis. The goal is to study treatments for patients with uveitis in a pragmatic setting and determine which medication work best for children with this disease.
Publication Information: Arthritis Care & Research, April 2019

Antibody-dependent and -independent mechanisms of inflammatory arthritis

Authors: Chang MH, Nigrovic PA

Summary: Dr. Chang and Dr. Nigrovic review the various immune mechanisms that can trigger arthritis and highlight potential opportunities for intervention. 

Publication Information: JCI Insight, March 2019

Impact of biologics on disease course in systemic onset juvenile idiopathic arthritis

Authors: Baris HE, Anderson E, Sozeri B, Dedeoglu F

Summary: In this paper, the authors retrospectively analyzed clinical data from 76 patients who were diagnosed with systemic onset juvenile idiopathic arthritis (SoJIA). The goal was to determine the impact of biologic disease-modifying antirheumatic drugs (BDMARDs) on disease course. The analysis found that in recent years patients are diagnosed earlier and BDMARDs are used sooner. The study also showed that duration of steroid use decreased significantly and more patients are in remission in recent years.

Publication Information: Clinical Rheumatology, December 2018

High-throughput identification of noncoding functional SNPs via type IIS enzyme restriction

Authors: Li G, Martínez-Bonet M, Wu D, Yang Y, Cui J, Nguyen HN, Cunin P, Levescot A, Bai M, Westra HJ, Okada Y, Brenner MB, Raychaudhuri S, Hendrickson EA, Maas RL, Nigrovic PA.

Summary: Dr. Nigrovic and his collaborators developed a new technique called SNP-seq to better understand genetic changes in children with juvenile idiopathic arthritis. By using this technique, the Nigrovic Lab identified new genes and regulatory proteins that may play a role in the pathogenesis of juvenile arthritis.

Publication Information: Nature Genetics, July 2018

Bayesian comparative effectiveness study of four consensus treatment plans for initial management of systemic juvenile idiopathic arthritis: FiRst-Line Options for Systemic juvenile idiopathic arthritis Treatment (FROST)

Authors: Nigrovic PA, Beukelman T, Tomlinson G, Feldman BM, Schanberg LE, Kimura Y; Childhood Arthritis and Rheumatology Research Alliance Systemic Juvenile Idiopathic Arthritis Consensus Treatment Plan Workgroup.

Summary: Dr. Nigrovic and several other CARRA investigators report on the development of consensus treatment guidelines for systemic juvenile idiopathic arthritis in this manuscript.

Publication Information: Clinical Trials, June 2018

Review: Genetics and the Classification of Arthritis in Adults and Children

Authors: Nigrovic PA, Raychaudhuri S, Thompson SD.

Summary: Drs. Nigrovic, Raychaudhuri, and Thompson report on the known genetic changes associated with juvenile idiopathic arthritis in this review. The authors argue the juvenile idiopathic arthritis has many similarities to adult inflammatory arthritis.

Publication Information: Arthritis and Rheumatology, January 2018

Next-Generation Sequencing Reveals Restriction and Clonotypic Expansion of Treg Cells in Juvenile Idiopathic Arthritis

Authors: Henderson LA, Volpi S, Frugoni F, Janssen E, Kim S, Sundel RP, Dedeoglu F, Lo MS, Hazen MM, Beth Son M, Mathieu R, Zurakowski D, Yu N, Lebedeva T, Fuhlbrigge RC, Walter JE, Nee Lee Y, Nigrovic PA, Notarangelo LD.

Summary: Dr. Henderson and colleagues collected blood and synovial fluid samples from children with juvenile idiopathic arthritis who were seen at Boston Children’s Hospital. Next generation sequencing technology was used to study the receptors on T cells, immune cells that may drive arthritis. T cells found in the blood and joints of children with arthritis had an abnormal array of T cell receptors. This study helps us better understand the characteristics of T cells in the joints of children with arthritis and supports the hypothesis that T cells are important in driving disease.

Publication Information: Arthritis and Rheumatology, July 2016

Frequency and Morbidity of Temporomandibular Joint Involvement in Adult Patients with a History of Juvenile Idiopathic Arthritis

Authors: Resnick CM, Dang R, Henderson LA, Zander DA, Daniels KM, Nigrovic PA, Kaban LB

Summary: Dr. Resnick, an oral surgeon at Boston Children’s Hospital, worked with a team of radiologists and pediatric rheumatologists to study the frequency of jaw joint involvement in juvenile idiopathic arthritis. Adults who were once patients with juvenile arthritis and cared for at Boston Children’s Hospital were studied. These patients were found to have high rates of jaw joint involvement even though many study subjects did not have jaw pain or symptoms as a child. This study highlights the importance of screening and monitoring children with arthritis for jaw involvement.

Publication Information: Journal of Oral and Maxillofacial Surgery, December 2016

Quantifying Temporomandibular Joint Synovitis in Children with Juvenile Idiopathic Arthritis

Authors: Resnick CM, Vakilian PM, Breen M, Zurakowski D, Caruso P, Henderson L, Nigrovic PA, Kaban LB, Peacock ZS.

Summary: Dr. Resnick, an oral surgeon at Boston Children’s Hospital, worked with a team of radiologists and pediatric rheumatologists to study a new MRI technique that can be used to quantify jaw joint arthritis. The authors found the technique to be a promising radiographic method to study the jaw.

Publication Information: Arthritis Care and Research, December 2016