Through a single sterile needle, some of your blood is removed and passed through a platelet pheresis machine. The platelet pheresis machine separates the platelet/plasma from your blood then returns your blood back to you through the same needle. Donating platelets takes 60 to 120 minutes depending on your size and platelet count, and you may be able to donate up to 24 times a year. During your donation you can read, listen to music, watch TV or a DVD, or just sit back and relax.