EDUCATION

Medical School

  • University of Texas Southwestern Medical School , 1996 , Dallas , TX

Internship

  • Boston Combined Residency Program (BCRP) , 1998 , Boston , MA

Residency

  • Boston Combined Residency Program (BCRP) , 1998 , Boston , MA

Fellowship

  • Dana-Farber/Boston Children's Cancer and Blood Disorders Center , 2001 , Boston , MA

PROFESSIONAL HISTORY

Scott A. Armstrong, MD, PhD, became the President of Dana-Farber/Boston Children’s Cancer and Blood Disorders Center in 2019 and has been Chairman of the Department of Pediatric Oncology at Dana-Farber Cancer Institute since 2016. He also serves as Associate Chief of the Division of Hematology/Oncology at Boston Children’s Hospital. He was previously the Director of the Center for Epigenetics Research at Memorial Sloan Kettering Cancer Center and Professor of Pediatrics at the Weill Cornell Medical College. Dr. Armstrong earned his medical degree and his PhD from University of Texas Southwestern Medical School in 1996. After internship and residency training with the Boston Combined Residency Program (BCRP) at Boston Medical Center and Boston Children’s Hospital, he completed a hematology/oncology fellowship at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center.

The major focus of his career has been on delineating the biology of childhood cancers and the development of new therapeutic approaches for children with cancer. His research program has focused on the mechanisms of leukemia development and the relationship between leukemia and normal hematopoietic stem cells. He continues to direct a vigorous research program that focuses on development of new therapeutics that target chromatin based mechanisms, and he is actively involved in the development and translation of a number of new small molecule approaches that likely will be tested in clinical trials in the near future.

PUBLICATIONS

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  1. The Menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML. Blood. 2021 Sep 28. View abstract
  2. YBX1 mediates translation of oncogenic transcripts to control cell competition in AML. Leukemia. 2021 Aug 31. View abstract
  3. Taspase1 orchestrates fetal liver hematopoietic stem cell and vertebrae fates by cleaving TFIIA. JCI Insight. 2021 Aug 09; 6(15). View abstract
  4. Evaluation of the Efficacy of Doxycycline, Ciprofloxacin, Levofloxacin, and Co-trimoxazole Using In Vitro and In Vivo Models of Q Fever. Antimicrob Agents Chemother. 2021 10 18; 65(11):e0067321. View abstract
  5. High-resolution characterization of gene function using single-cell CRISPR tiling screen. Nat Commun. 2021 07 01; 12(1):4063. View abstract
  6. A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AML. Blood. 2021 06 17; 137(24):3403-3415. View abstract
  7. Histone PTM Crosstalk Stimulates Dot1 Methyltransferase Activity. Trends Biochem Sci. 2021 07; 46(7):522-524. View abstract
  8. HAND1 and BARX1 Act as Transcriptional and Anatomic Determinants of Malignancy in Gastrointestinal Stromal Tumor. Clin Cancer Res. 2021 03 15; 27(6):1706-1719. View abstract
  9. Targeting Chromatin Complexes in Myeloid Malignancies and Beyond: From Basic Mechanisms to Clinical Innovation. Cells. 2020 12 21; 9(12). View abstract
  10. Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition. Blood. 2020 11 19; 136(21):2442-2456. View abstract
  11. Author Correction: PGBD5 promotes site-specific oncogenic mutations in human tumors. Nat Genet. 2020 Nov; 52(11):1265. View abstract
  12. Novel inhibitors of the histone methyltransferase DOT1L show potent antileukemic activity in patient-derived xenografts. Blood. 2020 10 22; 136(17):1983-1988. View abstract
  13. Paediatric Strategy Forum for medicinal product development of epigenetic modifiers for children: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration. Eur J Cancer. 2020 11; 139:135-148. View abstract
  14. Leukemia Cell of Origin Influences Apoptotic Priming and Sensitivity to LSD1 Inhibition. Cancer Discov. 2020 10; 10(10):1500-1513. View abstract
  15. It's Not What You Say But How You Say It: Targeting RNA Methylation in AML. Mol Cell. 2020 06 18; 78(6):996-998. View abstract
  16. Chromatin Complexes Maintain Self-Renewal of Myeloid Progenitors in AML: Opportunities for Therapeutic Intervention. Stem Cell Reports. 2020 07 14; 15(1):6-12. View abstract
  17. Oncogenic Gene-Expression Programs in Leiomyosarcoma and Characterization of Conventional, Inflammatory, and Uterogenic Subtypes. Mol Cancer Res. 2020 09; 18(9):1302-1314. View abstract
  18. Higher-Order Linearization and Regularity in Nonlinear Homogenization. Arch Ration Mech Anal. 2020; 237(2):631-741. View abstract
  19. Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development. iScience. 2020 Mar 27; 23(3):100941. View abstract
  20. Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia. Science. 2020 01 31; 367(6477):586-590. View abstract
  21. A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia. Cancer Cell. 2019 12 09; 36(6):660-673.e11. View abstract
  22. Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia. Cancer Discov. 2020 02; 10(2):214-231. View abstract
  23. A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies. Science. 2019 08 09; 365(6453):599-604. View abstract
  24. Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia. Genes Dev. 2019 09 01; 33(17-18):1265-1279. View abstract
  25. Acute myeloid leukemia driven by the CALM-AF10 fusion gene is dependent on BMI1. Exp Hematol. 2019 06; 74:42-51.e3. View abstract
  26. Targeting chromatin complexes in fusion protein-driven malignancies. Nat Rev Cancer. 2019 05; 19(5):255-269. View abstract
  27. Enhancer Domains in Gastrointestinal Stromal Tumor Regulate KIT Expression and Are Targetable by BET Bromodomain Inhibition. Cancer Res. 2019 03 01; 79(5):994-1009. View abstract
  28. IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation. Cell Stem Cell. 2019 01 03; 24(1):153-165.e7. View abstract
  29. Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma. Elife. 2018 11 15; 7. View abstract
  30. Inhibition of MEK and ATR is effective in a B-cell acute lymphoblastic leukemia model driven by Mll-Af4 and activated Ras. Blood Adv. 2018 10 09; 2(19):2478-2490. View abstract
  31. Improved potency and reduced toxicity of the antifungal peptoid AEC5 through submonomer modification. Bioorg Med Chem Lett. 2018 12 01; 28(22):3514-3519. View abstract
  32. HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis. Cancer Cell. 2018 10 08; 34(4):643-658.e5. View abstract
  33. Location, Location, Location: Mutant NPM1c Cytoplasmic Localization Is Required to Maintain Stem Cell Genes in AML. Cancer Cell. 2018 09 10; 34(3):355-357. View abstract
  34. Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome. Proc Natl Acad Sci U S A. 2018 06 19; 115(25):E5746-E5755. View abstract
  35. The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia. Blood. 2018 06 14; 131(24):2661-2669. View abstract
  36. A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response. Cell. 2018 02 22; 172(5):1007-1021.e17. View abstract
  37. LSD1 inhibition exerts its antileukemic effect by recommissioning PU.1- and C/EBPa-dependent enhancers in AML. Blood. 2018 04 12; 131(15):1730-1742. View abstract
  38. MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia. Cancer Discov. 2018 04; 8(4):478-497. View abstract
  39. Peptidomimetic blockade of MYB in acute myeloid leukemia. Nat Commun. 2018 01 09; 9(1):110. View abstract
  40. Mixed-Lineage Leukemia Fusions and Chromatin in Leukemia. Cold Spring Harb Perspect Med. 2017 Nov 01; 7(11). View abstract
  41. SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia. Blood. 2017 12 14; 130(24):2631-2641. View abstract
  42. Erratum: PGBD5 promotes site-specific oncogenic mutations in human tumors. Nat Genet. 2017 09 27; 49(10):1558. View abstract
  43. miR-99 regulates normal and malignant hematopoietic stem cell self-renewal. J Exp Med. 2017 Aug 07; 214(8):2453-2470. View abstract
  44. A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription. Mol Cell. 2017 Jul 20; 67(2):308-321.e6. View abstract
  45. PGBD5 promotes site-specific oncogenic mutations in human tumors. Nat Genet. 2017 Jul; 49(7):1005-1014. View abstract
  46. Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells. Nat Genet. 2017 Jun; 49(6):866-875. View abstract
  47. Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands. Angew Chem Int Ed Engl. 2017 05 15; 56(21):5738-5743. View abstract
  48. Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations. EMBO Mol Med. 2017 04; 9(4):498-507. View abstract
  49. Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis. Nature. 2017 04 06; 544(7648):53-58. View abstract
  50. PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D. Science. 2017 03 24; 355(6331):1324-1330. View abstract
  51. ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia. Nature. 2017 03 09; 543(7644):265-269. View abstract
  52. Histone Acetyltransferase Activity of MOF Is Required for MLL-AF9 Leukemogenesis. Cancer Res. 2017 04 01; 77(7):1753-1762. View abstract
  53. NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis. Cancer Cell. 2016 Dec 12; 30(6):863-878. View abstract
  54. DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling. Nat Med. 2016 12; 22(12):1488-1495. View abstract
  55. Histone acetyltransferase activity of MOF is required for adult but not early fetal hematopoiesis in mice. Blood. 2017 01 05; 129(1):48-59. View abstract
  56. Controlled stem cell amplification by HOXB4 depends on its unique proline-rich region near the N terminus. Blood. 2017 01 19; 129(3):319-323. View abstract
  57. Discovery and Characterization of a Peptoid with Antifungal Activity against Cryptococcus neoformans. ACS Med Chem Lett. 2016 Dec 08; 7(12):1139-1144. View abstract
  58. AACR Cancer Progress Report 2016. Clin Cancer Res. 2016 10 01; 22 Suppl 19:S1-S137. View abstract
  59. Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML. Sci Signal. 2016 09 13; 9(445):ra91. View abstract
  60. Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia. Cancer Discov. 2016 10; 6(10):1166-1181. View abstract
  61. Forward genetic screen of human transposase genomic rearrangements. BMC Genomics. 2016 Aug 04; 17:548. View abstract
  62. The UK Neovascular AMD Database Report 3: inter-centre variation in visual acuity outcomes and establishing real-world measures of care. Eye (Lond). 2016 Nov; 30(11):1462-1468. View abstract
  63. Patient-derived xenotransplants can recapitulate the genetic driver landscape of acute leukemias. Leukemia. 2017 01; 31(1):151-158. View abstract
  64. Erratum: Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins. Nat Med. 2016 06 07; 22(6):692. View abstract
  65. Reply to "Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status". Nat Med. 2016 06 07; 22(6):578-9. View abstract
  66. The role of DOT1L in the maintenance of leukemia gene expression. Curr Opin Genet Dev. 2016 02; 36:68-72. View abstract
  67. Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins. Nat Med. 2016 06; 22(6):672-8. View abstract
  68. Exploiting the Epigenome to Control Cancer-Promoting Gene-Expression Programs. Cancer Cell. 2016 Apr 11; 29(4):464-476. View abstract
  69. Integrated genomic DNA/RNA profiling of hematologic malignancies in the clinical setting. Blood. 2016 06 16; 127(24):3004-14. View abstract
  70. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia. J Clin Invest. 2016 Apr 01; 126(4):1438-50. View abstract
  71. Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia. Cell Rep. 2016 Mar 01; 14(8):1953-65. View abstract
  72. MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C. J Clin Invest. 2016 Mar 01; 126(3):997-1011. View abstract
  73. Editorial overview: Differentiation and disease. Curr Opin Cell Biol. 2015 Dec; 37:v-vi. View abstract
  74. Drugging Chromatin in Cancer: Recent Advances and Novel Approaches. Mol Cell. 2015 Nov 19; 60(4):561-70. View abstract
  75. A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence. Genes Dev. 2015 Nov 01; 29(21):2231-43. View abstract
  76. Impact of FLT3-ITD location on sensitivity to TKI-therapy in vitro and in vivo. Leukemia. 2016 05; 30(5):1220-1225. View abstract
  77. JMJD1C is required for the survival of acute myeloid leukemia by functioning as a coactivator for key transcription factors. Genes Dev. 2015 Oct 15; 29(20):2123-39. View abstract
  78. Tumor-specific HSP90 inhibition as a therapeutic approach in JAK-mutant acute lymphoblastic leukemias. Blood. 2015 Nov 26; 126(22):2479-83. View abstract
  79. Loss of BAP1 function leads to EZH2-dependent transformation. Nat Med. 2015 Nov; 21(11):1344-9. View abstract
  80. The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79. Mol Cell. 2015 Oct 15; 60(2):319-27. View abstract
  81. Mediator kinase inhibition further activates super-enhancer-associated genes in AML. Nature. 2015 Oct 08; 526(7572):273-276. View abstract
  82. Hematopoietic Differentiation Is Required for Initiation of Acute Myeloid Leukemia. Cell Stem Cell. 2015 Nov 05; 17(5):611-23. View abstract
  83. Inactivation of Eed impedes MLL-AF9-mediated leukemogenesis through Cdkn2a-dependent and Cdkn2a-independent mechanisms in a murine model. Exp Hematol. 2015 Nov; 43(11):930-935.e6. View abstract
  84. Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond. Exp Hematol. 2015 Aug; 43(8):673-84. View abstract
  85. Designed to kill: novel menin-MLL inhibitors target MLL-rearranged leukemia. Cancer Cell. 2015 Apr 13; 27(4):431-3. View abstract
  86. DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia. Nat Med. 2015 Apr; 21(4):335-43. View abstract
  87. Selective Inhibition of HDAC1 and HDAC2 as a Potential Therapeutic Option for B-ALL. Clin Cancer Res. 2015 May 15; 21(10):2348-58. View abstract
  88. MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition. Haematologica. 2015 May; 100(5):e190-3. View abstract
  89. Structure-guided DOT1L probe optimization by label-free ligand displacement. ACS Chem Biol. 2015 Mar 20; 10(3):667-74. View abstract
  90. Evolutionarily conserved signaling pathways: acting in the shadows of acute myelogenous leukemia's genetic diversity. Clin Cancer Res. 2015 Jan 15; 21(2):240-8. View abstract
  91. Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy. Cell Stem Cell. 2014 Dec 04; 15(6):775-90. View abstract
  92. Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms. Proc Natl Acad Sci U S A. 2014 Dec 16; 111(50):E5401-10. View abstract
  93. AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes. Cancer Cell. 2014 Dec 08; 26(6):896-908. View abstract
  94. Erratum: Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies. Sci Data. 2014; 1:140044. View abstract
  95. Far infrared laser polarimetry and far forward scattering diagnostics for the C-2 field reversed configuration plasmas. Rev Sci Instrum. 2014 Nov; 85(11):11D401. View abstract
  96. Langmuir probe diagnostic suite in the C-2 field-reversed configuration. Rev Sci Instrum. 2014 Nov; 85(11):11D824. View abstract
  97. Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies. Sci Data. 2014; 1:140035. View abstract
  98. Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors. Stem Cell Reports. 2014 Nov 11; 3(5):832-40. View abstract
  99. CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma. Genes Dev. 2014 Aug 15; 28(16):1800-14. View abstract
  100. DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier. Nature. 2014 Oct 02; 514(7520):107-11. View abstract
  101. Acute myelogenous leukemia-induced sympathetic neuropathy promotes malignancy in an altered hematopoietic stem cell niche. Cell Stem Cell. 2014 Sep 04; 15(3):365-375. View abstract
  102. Sleep disruption in tetraplegia: a randomised, double-blind, placebo-controlled crossover trial of 3?mg melatonin. Spinal Cord. 2014 Aug; 52(8):629-34. View abstract
  103. Requirement for CDK6 in MLL-rearranged acute myeloid leukemia. Blood. 2014 Jul 03; 124(1):13-23. View abstract
  104. Genomic dark matter sheds light on EVI1-driven leukemia. Cancer Cell. 2014 Apr 14; 25(4):407-8. View abstract
  105. Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia. Nat Commun. 2014 Mar 24; 5:3469. View abstract
  106. Targeting epigenetic regulators for cancer therapy. Ann N Y Acad Sci. 2014 Feb; 1309:30-6. View abstract
  107. Stem cells: Dual response to Ras mutation. Nature. 2013 Dec 05; 504(7478):91-2. View abstract
  108. KRas(G12D)-evoked leukemogenesis does not require ß-catenin. Leukemia. 2014 Mar; 28(3):698-702. View abstract
  109. Pathprinting: An integrative approach to understand the functional basis of disease. Genome Med. 2013; 5(7):68. View abstract
  110. In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling. Cancer Cell. 2013 Jul 08; 24(1):45-58. View abstract
  111. Recent progress toward epigenetic therapies: the example of mixed lineage leukemia. Blood. 2013 Jun 13; 121(24):4847-53. View abstract
  112. Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-a in a murine model of polycythemia vera. Blood. 2013 May 02; 121(18):3692-702. View abstract
  113. DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions. Mol Cell Biol. 2013 May; 33(9):1735-45. View abstract
  114. Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l. Blood. 2013 Mar 28; 121(13):2533-41. View abstract
  115. Notch pathway activation targets AML-initiating cell homeostasis and differentiation. J Exp Med. 2013 Feb 11; 210(2):301-19. View abstract
  116. The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML. J Exp Med. 2013 Jan 14; 210(1):15-22. View abstract
  117. Cell of origin determines clinically relevant subtypes of MLL-rearranged AML. Leukemia. 2013 Apr; 27(4):852-60. View abstract
  118. Cancer. Can one cell influence cancer heterogeneity? Science. 2012 Nov 23; 338(6110):1035-6. View abstract
  119. Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l. Leukemia. 2013 Apr; 27(4):813-22. View abstract
  120. mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. Cell Stem Cell. 2012 Sep 07; 11(3):429-39. View abstract
  121. Chromatin modifications as therapeutic targets in MLL-rearranged leukemia. Trends Immunol. 2012 Nov; 33(11):563-70. View abstract
  122. A systemic approach to containing health care spending. N Engl J Med. 2012 Sep 06; 367(10):949-54. View abstract
  123. EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs. Blood. 2012 Jun 14; 119(24):5838-49. View abstract
  124. Genetic and pharmacologic inhibition of ß-catenin targets imatinib-resistant leukemia stem cells in CML. Cell Stem Cell. 2012 Apr 06; 10(4):412-24. View abstract
  125. Polycomb repressive complex 2 is required for MLL-AF9 leukemia. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):5028-33. View abstract
  126. Chromatin-modifying enzymes as modulators of reprogramming. Nature. 2012 Mar 04; 483(7391):598-602. View abstract
  127. Sequencing histone-modifying enzymes identifies UTX mutations in acute lymphoblastic leukemia. Leukemia. 2012 Aug; 26(8):1881-3. View abstract
  128. iCanPlot: visual exploration of high-throughput omics data using interactive Canvas plotting. PLoS One. 2012; 7(2):e31690. View abstract
  129. Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. Genes Dev. 2012 Feb 15; 26(4):344-9. View abstract
  130. A role for DOT1L in MLL-rearranged leukemias. Epigenomics. 2011 Dec; 3(6):667-70. View abstract
  131. The Stem Cell Discovery Engine: an integrated repository and analysis system for cancer stem cell comparisons. Nucleic Acids Res. 2012 Jan; 40(Database issue):D984-91. View abstract
  132. eXframe: reusable framework for storage, analysis and visualization of genomics experiments. BMC Bioinformatics. 2011 Nov 21; 12:452. View abstract
  133. AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias. Cell. 2011 Sep 02; 146(5):697-708. View abstract
  134. Self-renewal related signaling in myeloid leukemia stem cells. Int J Hematol. 2011 Aug; 94(2):109-117. View abstract
  135. Differential niche and Wnt requirements during acute myeloid leukemia progression. Blood. 2011 Sep 08; 118(10):2849-56. View abstract
  136. MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. Cancer Cell. 2011 Jul 12; 20(1):66-78. View abstract
  137. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell. 2011 Jul 12; 20(1):53-65. View abstract
  138. The clathrin-binding domain of CALM and the OM-LZ domain of AF10 are sufficient to induce acute myeloid leukemia in mice. Leukemia. 2011 Nov; 25(11):1718-27. View abstract
  139. Cancer: The flipside of Notch. Nature. 2011 May 12; 473(7346):159-60. View abstract
  140. Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis. Blood. 2011 Jul 07; 118(1):69-79. View abstract
  141. Common and overlapping oncogenic pathways contribute to the evolution of acute myeloid leukemias. Cancer Res. 2011 Jun 15; 71(12):4117-29. View abstract
  142. Targeting epigenetic programs in MLL-rearranged leukemias. Hematology Am Soc Hematol Educ Program. 2011; 2011:354-60. View abstract
  143. Genetics, epigenetics, and leukemia. N Engl J Med. 2010 Dec 16; 363(25):2460-1. View abstract
  144. DNA methylation profiling in acute myeloid leukemia: from recent technological advances to biological and clinical insights. Future Oncol. 2010 Sep; 6(9):1415-31. View abstract
  145. The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science. 2010 Mar 26; 327(5973):1650-3. View abstract
  146. MLL-rearranged B lymphoblastic leukemias selectively express the immunoregulatory carbohydrate-binding protein galectin-1. Clin Cancer Res. 2010 Apr 01; 16(7):2122-30. View abstract
  147. A novel mutation in the miR-128b gene reduces miRNA processing and leads to glucocorticoid resistance of MLL-AF4 acute lymphocytic leukemia cells. . 2010 Mar 15; 9(6):1037-42. View abstract
  148. NCI first International Workshop on the biology, prevention, and treatment of relapse after allogeneic hematopoietic stem cell transplantation: report from the committee on the biological considerations of hematological relapse following allogeneic stem cell transplantation unrelated to graft-versus-tumor effects: state of the science. Biol Blood Marrow Transplant. 2010 Jun; 16(6):709-28. View abstract
  149. HELP for AML: methylation profiling opens new avenues. Cancer Cell. 2010 Jan 19; 17(1):1-3. View abstract
  150. Association of high-level MCL-1 expression with in vitro and in vivo prednisone resistance in MLL-rearranged infant acute lymphoblastic leukemia. Blood. 2010 Feb 04; 115(5):1018-25. View abstract
  151. miR-128b is a potent glucocorticoid sensitizer in MLL-AF4 acute lymphocytic leukemia cells and exerts cooperative effects with miR-221. Blood. 2009 Nov 05; 114(19):4169-78. View abstract
  152. Transformation from committed progenitor to leukemia stem cells. Ann N Y Acad Sci. 2009 Sep; 1176:144-9. View abstract
  153. Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis. Cell Stem Cell. 2009 Jun 05; 4(6):559-67. View abstract
  154. Chromatin maps, histone modifications and leukemia. Leukemia. 2009 Jul; 23(7):1243-51. View abstract
  155. Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis. Blood. 2009 Apr 09; 113(15):3461-71. View abstract
  156. Leukemia stem cells and human acute lymphoblastic leukemia. Semin Hematol. 2009 Jan; 46(1):33-8. View abstract
  157. Gene expression profiling of leukemia stem cells. Methods Mol Biol. 2009; 538:231-46. View abstract
  158. HOXA9 is required for survival in human MLL-rearranged acute leukemias. Blood. 2009 Mar 12; 113(11):2375-85. View abstract
  159. H3K79 methylation profiles define murine and human MLL-AF4 leukemias. Cancer Cell. 2008 Nov 04; 14(5):355-68. View abstract
  160. Linking miRNA regulation to BCR-ABL expression: the next dimension. Cancer Cell. 2008 Jun; 13(6):467-9. View abstract
  161. Cancer: inappropriate expression of stem cell programs? Cell Stem Cell. 2008 Apr 10; 2(4):297-9. View abstract
  162. Cancer stem cells in hematopoietic malignancies. Biol Blood Marrow Transplant. 2008 Jan; 14(1 Suppl 1):12-6. View abstract
  163. Cancer Stem Cells in Hematopoietic Malignancies. Biol Blood Marrow Transplant. 2008 Jan; 14(Supplement 1):12-16. View abstract
  164. BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia. Blood. 2008 Feb 15; 111(4):2300-9. View abstract
  165. MLL translocations, histone modifications and leukaemia stem-cell development. Nat Rev Cancer. 2007 Nov; 7(11):823-33. View abstract
  166. Defining leukemia stem cells in MLL-translocated leukemias: implications for novel therapeutic strategies. Klin Padiatr. 2007 Nov-Dec; 219(6):306-11. View abstract
  167. Mixed lineage leukemia translocations and a leukemia stem cell program. Cancer Res. 2007 Sep 15; 67(18):8425-8. View abstract
  168. MLL-AF9 and FLT3 cooperation in acute myelogenous leukemia: development of a model for rapid therapeutic assessment. Leukemia. 2008 Jan; 22(1):66-77. View abstract
  169. Therapeutic implications of leukemia stem cell development. Clin Cancer Res. 2007 Jun 15; 13(12):3439-42. View abstract
  170. FLT3 as a therapeutic target in childhood acute leukemia. Curr Drug Targets. 2007 Jun; 8(6):703-14. View abstract
  171. Genome-wide SNP analysis in cancer: leukemia shows the way. Cancer Cell. 2007 Apr; 11(4):308-9. View abstract
  172. High-throughput oncogene mutation profiling in human cancer. Nat Genet. 2007 Mar; 39(3):347-51. View abstract
  173. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell. 2007 Jan 26; 128(2):325-39. View abstract
  174. Genomewide identification of prednisolone-responsive genes in acute lymphoblastic leukemia cells. Blood. 2007 May 01; 109(9):3929-35. View abstract
  175. Microarrays to identify new therapeutic strategies for cancer. Adv Cancer Res. 2007; 96:51-74. View abstract
  176. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science. 2006 Sep 29; 313(5795):1929-35. View abstract
  177. Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance. Cancer Cell. 2006 Oct; 10(4):331-42. View abstract
  178. Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature. 2006 Aug 17; 442(7104):818-22. View abstract
  179. Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell. 2006 May; 9(5):351-65. View abstract
  180. Silencing of the tumor suppressor gene FHIT is highly characteristic for MLL gene rearranged infant acute lymphoblastic leukemia. Leukemia. 2006 Feb; 20(2):264-71. View abstract
  181. Gene expression profiling identifies BAX-delta as a novel tumor antigen in acute lymphoblastic leukemia. Cancer Res. 2005 Nov 01; 65(21):10050-8. View abstract
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