Sampson Lab

The overall goal of the Sampson Lab is to help improve the health of children with nephrotic syndrome through applied genomics, with a focus on samples and data collected from patients with this condition. We use computational genomics and bioinformatics to discover new, and map known, nephrotic syndrome-associated variants. We use systems genomics to integrate this genetic data with other genome-scale molecular datasets to try to understand the mechanisms linking these genetic changes with disease. And we use epidemiology to discover the clinical consequences for patients carrying disease-associated genetic variants.

Our lab is equally committed to ethically and responsibly sharing genomic data in a manner that is of maximal usefulness for our colleagues. We firmly believe that widespread sharing in this way will allow parallelization of genomic discovery efforts — accelerating progress toward treatments and cures for nephrotic syndrome.

Finally, we are committed to helping to increase the genomic literacy of both pediatric and adult nephrologists. We do this by offering research opportunities in our lab for colleagues at all levels of training and by participating in local, national, and international efforts related to clinical “nephrogenetics.”