Current Environment:

Publications

  • Haeberle B, Rangaswami A, Krailo M, Czauderna P, Hiyama E, Maibach R, Lopez-Terrada D, Aronson DC, Alaggio R, Ansari M, Malogolowkin MH, Perilongo G, O’Neill AF, Trobaugh-Lotrario AD, Watanabe K, Schmid I, von Schweinitz D, Ranganathan S, Yoshimura K, Hishiki T, Tanaka Y, Piao J, Feng Y, Rinaldi E, Saraceno D, Derosa M, Meyers RL. The importance of age as a prognostic factor for the outcome of patients with hepatoblastoma: Analysis from the Children’s Hepatic tumors International Collaboration (CHIC) database. PBC 2020. 67(8):e28350.
  • Abou-Alfa GK, Mayer R, Venook AP, O'Neill AF, Beg MS, LaQuaglia M, Kingham PT, Kobos R, Basturk O, Brennan C, Yopp A, Harding JJ, Leong S, Crown J, Hoti E, Leonard G, Ly M, Bradley M, Valentino E, Markowitz D, Zukiwski A, Ren K, Gordan JD. Phase II Multicenter, Open-Label Study of Oral ENMD-2076 for the Treatment of Patients with Advanced Fibrolamellar Carcinoma. Oncologist. Online ahead of print. 2020.
  • Dika IE, Mayer RJ, Venook AP, Capanu M, LaQuaglia MP, Kobos R, O’Neill AF, Chou JF, Ly M, Ang C, O’Reilly EM, Gordan JD, Abou-Alfa GK. A Multicenter Randomized Three-Arm Phase II Study of (1) Everolimus, (2) Estrogen Deprivation Therapy (EDT) with Leuprolide + Letrozole, and (3) Everolimus + EDT in Patients with Unresectable Fibrolamellar Carcinoma. Oncologist. Online ahead of print. 2020.
  • Pinches RS, Clinton CM, Ward A. Meyer SC, Al-Ibraheemi A, Forrest SJ, Strand GR, Detert H, Piche-Schulman A, Gill K, Restrepo T, Tavares Proulx R, Perez-Atayde A, Vargas SO, Shaikh R, Weldon C, Alexandrescu S, Hong AL, O’Neill AF, Hollowell M, Harris MH, Janeway KA, Crompton BD, Church AJ. Making the most of small samples: optimization of tissue allocation of pediatric solid tumors for clinical and research use. Pediatric Blood & Cancer. 2020 Jul 15; e28326. doi: 10.1002/pbc.28326.
  • Katzenstein HM, Langham MR, Malogolowkin MH, Krailo MD, Towbin AJ, McCarville EB, Finegold MJ, Ranganathan S, Dunn S, McGahren E, Tiao G, O’Neill AF, Qayed M, Furman WB, Xia C, Rodriguez-Galindo C, Meyers RL. Minimal Adjuvant Chemotherapy for Hepatoblastoma Resected at Diagnosis (AHEP0731): a Children’s Oncology Group non-randomized, multicenter, phase 3 trial. Lancet Oncology. 2019. 20(5): 719-727.
  • Ramos-Gonzalez R, LaQuaglia M, O’Neill AF, Elisofon S, Zurakowski D, Kim HB, Vakili K. Long-term Outcomes of Liver Transplantation for Hepatoblastoma: a Single-Center 14-year Experience. Pediatric Transplantation. 2018. 11:e13250.
  • LaQuaglia MJ, Kim HB, Fynn-Thompson F, Baird C, Vakili K. Resection of hepatic tumors with central venous and right atrial extension using cardiopulmonary bypass. Journal of Pediatric Surgery Case Reports. 2018;30:14-18.
  • Towbin AJ, Meyers RL, Woodley H, Miyazaki O, Weldon CB, Morland B, Hiyama E, Czauderna P, Roebuck DJ, Tiao GM. 2017 PRETEXT: radiologic staging system for primary hepatic malignancies of childhood revised for the Paediatric Hepatic International Tumour Trial (PHITT). Pediatr Radiol. 2018; 48(4):536-54.
  • O'Neill AF, Towbin AJ, Krailo MD, Xia C, Gao Y, McCarville MB, Meyers RL, McGahren ED, Tiao GM, Dunn SP, Langham MR Jr, Weldon CB, Finegold MJ, Ranganathan S, Furman WL, Malogolowkin M, Rodriguez-Galindo C, Katzenstein HM. Characterization of pulmonary metastases in children with hepatoblastoma treated on Children's Oncology Group Protocol AHEP0731 (The treatment of children with all stages of hepatoblastoma): A report from the Children's Oncology Group. Journal of Clinical Oncology, 2017. 20; 35(30): 3465-3473.
  • Lee E, Hodgkinson N, Fawaz R, Vakili K, Kim HB. Multivisceral transplantation for abdominal tumors in children: A single center experience and review of the literature. Pediatr Transplant. 2017 Aug; 21(5).
  • Trobaugh-Lotrario AD, Meyers RL, O’Neill AF, Feusner JH. Unresectable hepatoblastoma: current perspectives. Hepatic Medicine: Evidence and Research. 2017, volume 2017(9): 1-6.
  • Trobaugh-Lotrario AD, O’Neill AF, Li P, Towbin A, Weldon C, López-Terrada D, Malogolowkin MH. Advances in pediatric liver tumors. Current Hepatology Reports. 2017. p:1-13.
  • Pogoriler J, O’Neill, AF, Voss S, Shamberger RC, Perez-Atayde AR. Hepatocellular carcinoma in Fanconi-Bickel syndrome. Pediatric and Developmental Pathology. 2017, p: 1-7.
  • LaQuaglia ML, Grijalva JL, Mueller KA, Perez-Atayde AR, Kim HB, Sadri-Vakili G, Vakili K. YAP subcellular localization and hippo pathway transcriptome analysis in pediatric hepatocellular carcinoma. Scientific Reports. Sci Rep. 2016 Sep; 6:30238.
  • Cauley R, Potanos K, Fullington N, Grijalva J, Graham D, Kim HB, Vakili K. The effect of graft type on mortality in liver transplantation for hepatocellular carcinoma. Annals of Transplantation. 2015 Apr; 20:175-185.
  • Potanos KM, Hodgkinson N, Fullington NM, Narla A, Albritton K, Kozakewich H, Kim HB. Long term survival in pediatric hepatic angiosarcoma (PHAS): A case report and review of the literature. Journal of Pediatric Surgery Case Reports. 2015; 3:410-413.

Presentations

  • O’Neill AF. Checkpoint Inhibition in pediatric hepatocellular carcinoma. International Liver Tumor Symposium, Cincinnati Children’s Hospital. Cincinnati, OH 2020.
  • O’Neill AF. Relapsed hepatoblastoma: A historical perspective. International Liver Tumor Symposium, Cincinnati Children’s Hospital. Cincinnati, OH 2020.
  • O’Neill AF. Relapsed hepatoblastoma and hepatocellular carcinoma RELIVE Registry. International Liver Tumor Symposium, Cincinnati Children’s Hospital. Cincinnati, OH 2020.
  • Church A. Staying current with molecular diagnostics; emerging technologies and implications for responsible clinical implementation. ASCP National Meeting. Austin, TX 2020.
  • Church A. The evolving field of molecular pediatric pathology: Focus on extracranial solid tumors. University of North Carolina. Chapel Hill, NC 2020.
  • O’Neill AF. Relapsed disease and novel agents: Planning for a PHITT successor trial. Prague, Czechoslovakia. 2019.
  • O’Neill AF. Checkpoint inhibition in pediatric hepatocellular carcinoma. Prague, Czechoslovakia. 2019.
  • O’Neill AF. Creation of an intercontinental consortium to evaluate the prognostic value of alfa-feto protein (AFP) decline: A collaborative review of clinical trial data. Kyoto, Japan. 2018.
  • O’Neill AF. Checkpoint inhibition in pediatric hepatocellular carcinoma. Kyoto, Japan. 2018.
  • O’Neill AF. Pediatric Hepatic Malignancy International Therapeutic Trial. Liver Tumor Biology Symposium, Society for Pediatric Pathology. Vancouver, Canada. 2018.
  • Church A. Pediatric liver tumors: New advances in pathologic classification, molecular diagnostics and international cooperative trials. Vancouver, Canada. 2018.
  • O’Neill AF, Malogolowkin M, Krailo MD, Xia C, Trobaugh-Lotario A, Thompson P, Meyers RL, Katzenstein HM. AFP decline in upfront unresectable, non-metastatic hepatoblastoma. Accepted for oral presentation: Société Internationale d'Oncologie Pédiatrique (SIOP), Kyoto, Japan. 2018.
  • O’Neill AF. Pediatric Liver Tumors. The 3rd Annual China International Forum of Pediatric Development in Hematology/Oncology. Beijing, China. 2017.
  • O’Neill AF. Collaboration in the treatment of pediatric liver tumors. American Society of Pediatric Hematology Oncology (ASPHO). Montreal, Canada. 2017.
  • O’Neill AF. Results and lessons learned from COG AHEP0731. International Liver Tumor Symposium, Texas Children’s Hospital. Houston, TX. 2017.
  • O’Neill AF, Malogolowkin M, Krailo MD, Xia C, Qayed M, Langham Jr. MR, Meyers RL, and Katzenstein HM. AFP as a biologic marker and prognostic factor in newly diagnosed completely resected hepatoblastoma. Accepted for oral presentation: Société Internationale d'Oncologie Pédiatrique (SIOP). Washington DC. 2017.
  • O’Neill AF, Towbin AJ, Krailo MD, McCarville B, Meyers RL, McGahren ED, Tiao GM, Dunn SP, Langham MR Jr., Weldon CB, Finegold M, Ranganathan S, Furman WL, Malogolowkin M, Rodriguez-Galindo C, Katzenstein HM. Characterization of pulmonary metastases in children with hepatoblastoma. Accepted for oral presentation: Société Internationale d'Oncologie Pédiatrique (SIOP). Dublin, Ireland. 2016.
  • Michael J. LaQuaglia, Allison F. O’Neill, Scott Elisofon, Heung Bae Kim, Khashayar Vakili. Liver transplantation for hepatoblastoma: Single-center long-term outcomes. Accepted for oral presentation: Pacific Association of Pediatric Surgeons conference. Kauai, Hawaii. 2016.
  • O’Neill AF, Malogolowkin MH, Brugieres L, Casanova M, Geller JI, Schmid I, Venkatramani R, Thompson P, Feusner J, Rangaswami A. Gemcitabine and oxaliplatin for the treatment of pediatric patients with hepatocellular carcinoma. Accepted for electronic poster presentation: International Liver Cancer Association, 9th Annual Conference. Paris, France. 2015.
  • O’Neill AF. Pediatric liver tumors: Paths of progress and a model for collaboration. Memorial Sloan Kettering Cancer Center (MKSCC). New York, NY. 2015.
  • O’Neill AF, Malogolowkin MH, Brugieres L, Casanova M, Geller JI, Schmid I, Venkatramani R, Thompson P, Feusner J, Rangaswami A. Gemcitabine and oxaliplatin for the treatment of pediatric patients with hepatocellular carcinoma. Oral presentation: Société Internationale d'Oncologie Pédiatrique (SIOP). Toronto, Canada. 2014.

Consortia

  • RELIVE International Consortium for Relapsed/Refractory Liver Tumor Patients, North American co-chair and steering committee member (O’Neill, AF)

Podcast

  • Hepatocellular carcinoma in children: Does modified platinum and doxorubicin-based chemotherapy increase tumor resectability and change outcome? Lessons learned from SIOPEL 2 and 3 studies. Murawski et al. Journal of Clinical Oncology, 2016. O’Neill AF. Written in association with Dr. Howard Katzenstein.

Media

Editorials

  • O’Neill AF, Hanto DW, Katzenstein HM. Cause and Effect: The etiology of pediatric hepatocellular carcinoma and the role for liver transplantation. Pediatric Transplantation, invited editorial. 2016. 20(7): 878-879.

Chapters

  • Church AJ. “Next Generation Sequencing” in Genomic Medicine: A Practical Guide. Ed. Tafe LJ and Arcila ME. Elsevier. 2020
  • Update in Pediatrics. Chapter: Solid Tumors of Childhood. O’Neill AF. Shalea Piteau (Ed.). Springer-Verlag In press. 2018
  • Minneman J, Kim HB. “Hepatic Resection” In Mattei P (ed): Fundamentals of Pediatric Surgery, Second Edition. Springer 2017. Cancer in Adolescents and Young Adults. Chapter: Liver Tumors. Malogolowkin M, Rangaswami A, O’Neill AF, Plaschkes J, Zimmerman A. Springer-Verlag Berlin Heidelberg. In press. 2016