Ureterocele | Research & Clinical Trials

At Boston Children’s Hospital, we’re continually learning from our experiences with patients, evaluating the most current data and studying the causes of diseases and new treatments with the aim of developing innovative methods for caring for kids with congenital conditions like ureteroceles.

Proteomics and biomarkers

  • Proteomics, the study of an organism's complete complement of proteins, picks up where the Human Genome Project left off, asking what proteins each gene codes for and what they do in the body.

  • In urology, Richard Lee, MD, and colleagues are using proteomics tools to categorize the entire collection of urine proteins and understand how the "urine proteome" changes in congenital urologic conditions like ureteroceles. They are also using proteomics to detect changes in bladder tissue that may be associated with disease progression.

Managing pain after surgery

  • Children’s has been a pioneer in anesthesia for children, and our urologists and anesthesia doctors have worked together to develop highly effective pain-management techniques for children who have surgery.

  • Using these methods, most children recover quickly after surgery and their pain is kept to a minimum. Most children can go home within one or two days. In addition, we have been leaders in development of less invasive methods of correcting ureteroceles. Our pioneering surgeons have used laparoscopic and robotic-assisted laparoscopic surgery to successfully correct ureteroceles in many children.

  • Hiep T. Nguyen, MD, Co-Director, Robotic Surgery, Research and Training Program at Children’s has undertaken a series of studies to that suggest that giving children a pre-operative aerosol-based pain medication can lead to a reduction in post-operative pain. Dr. Nguyen studied a set of children undergoing robotically assisted procedures to remove urinary tract blockages.

Working together to treat ureteroceles

Launched hospital-wide in 2011, the SCAMPs (Standardized Clinical Assessment and Management Plans) initiative aims to streamline and standardize care for conditions like ureteroceles. Combining years of research on clinical outcomes, the accumulated body of knowledge allows physicians to customize care for each child while using a tried-and-tested framework that’s been effective in treating other children with the same condition.