Transposition of the Great Arteries (TGA) | Symptoms & Causes

What are the symptoms of transposition of the great arteries?

The symptoms of transposition of the great arteries may include:

  • Cyanosis (blue coloration of the skin)
  • Shortness of breath
  • Lack of appetite
  • Poor weight gain

What causes transposition of the great arteries?

Transposition of the great arteries (TGA) is a congenital heart defect, which means children are born with it.

The heart forms during the first eight weeks of fetal development. The problems associated with TGA occur in the middle of these weeks, when the aorta and the pulmonary artery each attach to the incorrect heart chamber. It isn’t clear what causes congenital heart malformations, including TGA, although in most cases it appears that some combination of genetics and environment is involved.

Very few risk factors have been identified, but it appears that the risk of TGA is increased in mothers with type 1 diabetes mellitus (formerly known as "insulin-dependent" or "juvenile") and possibly with the ingestion of certain drugs, such as benzodiazepines.

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