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Research & Innovation | Overview

Our current research projects with promise for treating moyamoya and pediatric stroke include:

  • Neurosurgeon’s pioneering technique helps thousands of children: Using 20 years of data, Boston Children’s R. Michael Scott, MD and Edward Smith, MD, track the long-term outcomes of pial synangiosis, the surgical treatment for moyamoya pioneered by Scott in the 1980s, in 59 of their patients.
  • Higher volume hospitals have better outcomes: Dr. Smith and his colleagues published an analysis of 2,454 admissions of pediatric moyamoya patients across the U.S. in the largest study of its kind. The results show that higher volume centers provide improved care and reduced mortality.
  • Evaluating possible growth factors in blood, cerebrospinal fluid, and urine: Dr. Smith and his colleagues are studying molecular compounds and growth factors in blood and in cerebrospinal fluid. They believe that these growth factors may yield crucial insights into the causes and progression of moyamoya, and may lead to therapies not only for that disorder, but also for cancer and other conditions involving the proliferation of blood vessels.
  • Considering possible nonsurgical treatments for moyamoya: Dr. Smith is also working to determine whether new drug therapies may provide a reasonable alternative to surgery for children with moyamoya.
  • Identifying biological warning signs for moyamoya: Our researchers are working to identify telltale proteins in blood and urine that could serve as early warning signals for the presence of disease by developing a urinary biomarker panel.
  • Understanding the role of certain proteins in moyamoya and other disorders: Dr. Smith is investigating whether specific molecules may be culpable in the onset of several diseases of the central nervous system, including moyamoya, brain tumors, and vascular malformations of the brain.

Selected papers

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