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Research & Innovation | Overview

The Boston Children's Hospital Home Parenteral Nutrition Program is dedicated to several quality improvement initiatives:

  • improving discharge outcomes
  • reducing community acquired central line associated blood stream infections
  • decreasing pharmacy compounding discrepancies

The program has been at the forefront of numerous advances in the field. Below is a selection of published journal articles by the Home Parenteral Nutrition Program team:

Khan FA, Fisher JG, Sparks EA, Potemkin A, Duggan C, Raphael BP, Modi BP, Jaksic T. Preservation of biochemical liver function with low-dose soy-based lipids in children with intestinal failure-associated liver disease. J Pediatr Gastroenterol Nutr. 2015 Mar;60(3):375-7. doi: 10.1097/MPG.0000000000000609.

Forchielli ML, Richardson D, Folkman J, Gura K, Lo CW.  Better living through chemistry, constant monitoring, and prompt interventions: 26 years on home parenteral nutrition without major complications. Nutrition. 2008 Jan;24(1):103-7. Epub 2007 Nov 8.

Gura KM, Lee S, Valim C, Zhou J, Kim S, Modi BP, Arsenault DA, Strijbosch RA, Lopes S, Duggan C, Puder M. Safety and efficacy of a fish-oil-based fat emulsion in the treatment of parenteral nutrition-associated liver disease. Pediatrics. 2008 Mar;121(3):e678-86. doi: 10.1542/peds.2007-2248.

Jones BA, Hull MA, Richardson DS, Zurakowski D, Gura K, Fitzgibbons SC, Duro D, Lo CW, Duggan C, Jaksic T. Efficacy of ethanol locks in reducing central venous catheter infections in pediatric patients with intestinal failure. J Pediatr Surg. 2010 Jun;45(6):1287-93. doi: 10.1016/j.jpedsurg.2010.02.099.

Miller J, Dalton MK, Duggan C, Lam S, Iglesias J, Jaksic T, Gura KM. Going with the flow or swimming against the tide: should children with central venous catheters swim? Nutr Clin Pract. 2014 Feb;29(1):97-109. doi: 10.1177/0884533613515931. Epub 2013 Dec 17.

Raphael BP, Duggan C. Prevention and treatment of intestinal failure-associated liver disease in children. Semin Liver Dis. 2012 Nov;32(4):341-7. doi: 10.1055/s-0032-1329903. Epub 2013 Feb 8.

Raphael BP, Mitchell PD, Finkton D, Jiang H, Jaksic T, Duggan C. Necrotizing Enterocolitis and Central Line Associated Blood Stream Infection Are Predictors of Growth Outcomes in Infants with Short Bowel Syndrome. J Pediatr. 2015 Jul;167(1):35-40.e1. doi: 10.1016/j.jpeds.2015.02.053. Epub 2015 Apr 1.

Discrepancies Between Prescribed and Actual Pediatric Home Parenteral Nutrition Solutions.