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The Center for Childhood Liver Disease specializes in helping infants, children, adolescents, and young adults who have a wide variety of liver, gallbladder, and bile-duct disorders, as well as liver tumors and masses. Children with liver disease come to us from all over the world because of our extensive experience, dedication, and commitment to finding solutions.

Our expertise in treating liver disease

As an advanced training center for pediatric liver disorders and transplants, we have access to state-of-the-art equipment and services, as well as investigational drug therapies currently in clinical trials. We are one of very few pediatric hospitals in the country to participate in research to find better treatment options for our patients. We offer comprehensive care plans focused on long-term outcomes.

Diagnostic services at the center include blood and biopsy testing, imaging (ultrasound, CT, MRI and MR cholangiography), elastography, and endoscopic examinations, including non-invasive capsule endoscopy and ECRP.

Comprehensive liver care

Depending on the need of each child, care plans may include medications, surgery, and specialized endoscopic procedures, such as ERCP. We try to care for children without using surgery for as long as possible, and partner closely with families, primary care physicians, and other GI specialists to ensure that every child's care is seamless.

Should your child need extensive treatment, we work with teams of pediatric physicians at Boston Children’s to create integrated care plans with a focus on long-term outcomes. We work with other groups at Boston Children’s, including the Metabolism Program, Cystic Fibrosis Center, Obesity Prevention Center, Inflammatory Bowel Disease Center, and Liver Transplant Program.

Boy sits on blanket

Meet our liver center patients

Read some of the stories of our remarkable patients with childhood liver disease.

Leading the way in the use of FibroScan®

Boston Children’s was the first pediatric hospital in the U.S. to study FibroScan® (Vibration-Controlled Transient Elastography). This noninvasive test measures your child’s liver stiffness and fat, which allows us to predict their degree of scarring and fatty liver disease. We recently acquired the latest version of the FibroScan machine, which measures both liver and spleen stiffness.

The team in the Center for Childhood Liver Disease is the first pediatric institution in the nation to study the feasibility and accuracy of the latest FibroScan machine, which is specifically calibrated to measure both liver and spleen stiffness. “By non-invasively measuring liver and spleen stiffness on this innovative new machine, we will be able to study the progression of portal hypertension in children with chronic liver disease. The goal is to develop non-invasive measures which help identify those children who need further endoscopic surveillance for esophageal varices and portal gastropathy,” says Dr. Christine Lee, MD, hepatologist and study primary investigator.

Childhood Liver Disease Program research

The Liver Center's physicians, nurses and researchers are dedicated to participating in clinical trials and research to find better therapeutic options for childhood liver diseases. We are one of very few pediatric hospitals in the country to do so.

Our physicians are often asked to contribute to write pediatric guidelines to help other doctors and nurses to diagnose and treat chronic conditions, such as hepatitis B and hepatitis C in children.

Clinical trials include:

  • hepatitis B and hepatitis c treatment trials
  • treatment trials for cystic fibrosis liver disease
  • evaluation of ultrasound-based imaging technology (FibroScan) as a way to assess a child's liver scarring noninvasively.
  • treatment trials for fatty liver disorders