Alex Cuenca | Medical Services
Specialties
- Biliary Atresia
- Choledochal Cysts
- Chronic Lung Disease of Prematurity
- Circumcision
- Cirrhosis
- Fatty Liver
- Gastroschisis
- Germ Cell Tumors
- Hepatoblastoma
- Hepatocellular Carcinoma
- Hydrocele
- Intestinal Atresia and Stenosis
- Intraventricular Hemorrhage
- Intussusception
- Lung Resection
- Minimally Invasive Surgery
- Necrotizing Enterocolitis
- Omphalocele
- Polycystic Kidney Disease
- Pyloric Stenosis
Programs & Services
- Kidney Tumor Program
- Liver Tumor Center
- Midaortic Syndrome and Renovascular Hypertension Center
- Pancreatic Disorders Program
- Pediatric Transplant Center
- Surgery
Languages
- English
- Spanish
Alex Cuenca | Education
Undergraduate School
New College
1997, Sarasota, FL
Medical School
University of Florida
2006, Gainesville, FL
Internship
Shands Teaching Hospital/ University of Florida
2007, Gainesville, FL
Graduate School
University of Florida
2012, Gainesville, FL
Residency
Shands Teaching Hospital/ University of Florida
2015, Gainesville, FL
Fellowship
Boston Children's Hospital
2017, Boston, MA
Fellowship
Massachusetts General Hospital
2019, Boston, MA
Alex Cuenca | Certifications
- American Board of Surgery (General)
- American Board of Surgery (Pediatric Surgery)
Alex Cuenca | Professional History
Dr. Cuenca completed his medical school, graduate school, and residency at the University of Florida in Gainesville, Fl. During his research hiatus in residency, he obtained a PhD examining the role of innate immunity and toll-like receptor signaling in neonatal sepsis. He then went on to complete a fellowship in Pediatric Surgery at Boston Children’s Hospital. Due to his interest in pediatric hepatobiliary disease and transplant medicine, he went on to complete a fellowship in Transplant Surgery at Massachusetts General Hospital. He is clinically interested in pediatric hepatobiliary and pancreatic disease, solid organ transplantation, mid-aortic vascular disease, and other general surgical conditions of children. His research efforts are focused on examining the role of innate immunity in allograft tolerance, as well as novel efforts to expand the utility of normothermic machine perfusion for use in solid organ transplantation.
Alex Cuenca | Publications
Early Graft Loss With Suspected Seventh-Day Syndrome Following Pediatric Liver Transplantation. Pediatr Transplant. 2024 Aug; 28(5):e14818. View Early Graft Loss With Suspected Seventh-Day Syndrome Following Pediatric Liver Transplantation. Abstract
Surgical management of liver tumors. Pediatr Blood Cancer. 2025 Apr; 72 Suppl 2:e31155. View Surgical management of liver tumors. Abstract
Effect of citizenship status on access to pediatric liver and kidney transplantation. Am J Transplant. 2024 Oct; 24(10):1868-1880. View Effect of citizenship status on access to pediatric liver and kidney transplantation. Abstract
Metastatic pulmonary calcifications after pediatric liver transplantation. Pediatr Transplant. 2024 Feb; 28(1):e14693. View Metastatic pulmonary calcifications after pediatric liver transplantation. Abstract
Immediate extubation after pediatric liver transplantation: Update on a single-center experience. Pediatr Transplant. 2024 Feb; 28(1):e14669. View Immediate extubation after pediatric liver transplantation: Update on a single-center experience. Abstract
Critical elements of pediatric liver cancer surgery. Semin Pediatr Surg. 2023 Oct; 32(5):151340. View Critical elements of pediatric liver cancer surgery. Abstract
Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter. bioRxiv. 2023 Nov 21. View Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter. Abstract
Pediatric Organ Donation and Transplantation: Across the Care Continuum. Pediatrics. 2023 Aug 01; 152(2). View Pediatric Organ Donation and Transplantation: Across the Care Continuum. Abstract
Intragraft B cell differentiation during the development of tolerance to kidney allografts is associated with a regulatory B cell signature revealed by single cell transcriptomics. Am J Transplant. 2023 09; 23(9):1319-1330. View Intragraft B cell differentiation during the development of tolerance to kidney allografts is associated with a regulatory B cell signature revealed by single cell transcriptomics. Abstract
Adjuvant conditioning induces an immunosuppressive milieu that delays alloislet rejection through the expansion of myeloid-derived suppressor cells. Am J Transplant. 2023 07; 23(7):935-945. View Adjuvant conditioning induces an immunosuppressive milieu that delays alloislet rejection through the expansion of myeloid-derived suppressor cells. Abstract
Innate immune cellular therapeutics in transplantation. Front Transplant. 2023; 2. View Innate immune cellular therapeutics in transplantation. Abstract
Outcomes of internal biliary diversion using cholecystocolostomy for patients with severe Alagille syndrome. J Surg Case Rep. 2022 Jul; 2022(7):rjac307. View Outcomes of internal biliary diversion using cholecystocolostomy for patients with severe Alagille syndrome. Abstract
Organ allocation in pediatric abdominal transplant. Semin Pediatr Surg. 2022 Jun; 31(3):151180. View Organ allocation in pediatric abdominal transplant. Abstract
Functional side-to-side splenorenal shunts to treat extrahepatic portal vein thrombosis in children. Am J Surg. 2022 07; 224(1 Pt B):530-534. View Functional side-to-side splenorenal shunts to treat extrahepatic portal vein thrombosis in children. Abstract
Triple gallbladder with heterotopic gastric mucosa: a case report. BMC Pediatr. 2022 01 20; 22(1):52. View Triple gallbladder with heterotopic gastric mucosa: a case report. Abstract
Prenatal diagnosis of rapidly enlarging choledochal cyst with gastric outlet obstruction. J Surg Case Rep. 2021 Dec; 2021(12):rjab547. View Prenatal diagnosis of rapidly enlarging choledochal cyst with gastric outlet obstruction. Abstract
Midaortic syndrome and renovascular hypertension. Semin Pediatr Surg. 2021 Dec; 30(6):151124. View Midaortic syndrome and renovascular hypertension. Abstract
Short Bowel Syndrome and Kidney Transplantation: Challenges, Outcomes, and the Use of Teduglutide. Case Rep Transplant. 2020; 2020:8819345. View Short Bowel Syndrome and Kidney Transplantation: Challenges, Outcomes, and the Use of Teduglutide. Abstract
Resolution of a High Grade and Metastatic BK Polyomavirus-Associated Urothelial Cell Carcinoma Following Radical Allograft Nephroureterectomy and Immune Checkpoint Treatment: A Case Report. Transplant Proc. 2020 Nov; 52(9):2720-2725. View Resolution of a High Grade and Metastatic BK Polyomavirus-Associated Urothelial Cell Carcinoma Following Radical Allograft Nephroureterectomy and Immune Checkpoint Treatment: A Case Report. Abstract
Immediate administration of antiviral therapy after transplantation of hepatitis C-infected livers into uninfected recipients: Implications for therapeutic planning. Am J Transplant. 2020 06; 20(6):1619-1628. View Immediate administration of antiviral therapy after transplantation of hepatitis C-infected livers into uninfected recipients: Implications for therapeutic planning. Abstract
Pediatric liver transplant following near catastrophic head bleed: Lessons learned. Pediatr Transplant. 2020 03; 24(2):e13646. View Pediatric liver transplant following near catastrophic head bleed: Lessons learned. Abstract
Giant Gastroschisis with Complete Liver Herniation: A Case Report of Two Patients. Case Rep Surg. 2019; 2019:4136214. View Giant Gastroschisis with Complete Liver Herniation: A Case Report of Two Patients. Abstract
Pediatric liver transplantation. Semin Pediatr Surg. 2017 Aug; 26(4):217-223. View Pediatric liver transplantation. Abstract
Clostridium difficile Infections after Blunt Trauma: A Different Patient Population? Surg Infect (Larchmt). 2015 Aug; 16(4):421-7. View Clostridium difficile Infections after Blunt Trauma: A Different Patient Population? Abstract
Improved emergency myelopoiesis and survival in neonatal sepsis by caspase-1/11 ablation. Immunology. 2015 Jun; 145(2):300-11. View Improved emergency myelopoiesis and survival in neonatal sepsis by caspase-1/11 ablation. Abstract
Successful implementation of a packed red blood cell and fresh frozen plasma transfusion protocol in the surgical intensive care unit. PLoS One. 2015; 10(5):e0126895. View Successful implementation of a packed red blood cell and fresh frozen plasma transfusion protocol in the surgical intensive care unit. Abstract
TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis. J Immunol. 2015 Feb 01; 194(3):1169-77. View TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis. Abstract
Delayed emergency myelopoiesis following polymicrobial sepsis in neonates. Innate Immun. 2015 May; 21(4):386-91. View Delayed emergency myelopoiesis following polymicrobial sepsis in neonates. Abstract
Omental flaps for coverage of sacral or gluteal defects: a useful and potentially underused tool. Am Surg. 2014 Jul; 80(7):e202-4. View Omental flaps for coverage of sacral or gluteal defects: a useful and potentially underused tool. Abstract
A better understanding of why murine models of trauma do not recapitulate the human syndrome. Crit Care Med. 2014 Jun; 42(6):1406-13. View A better understanding of why murine models of trauma do not recapitulate the human syndrome. Abstract
Novel role for tumor-induced expansion of myeloid-derived cells in cancer cachexia. J Immunol. 2014 Jun 15; 192(12):6111-9. View Novel role for tumor-induced expansion of myeloid-derived cells in cancer cachexia. Abstract
Host responses to sepsis vary in different low-lethality murine models. PLoS One. 2014; 9(5):e94404. View Host responses to sepsis vary in different low-lethality murine models. Abstract
Protective immunity and defects in the neonatal and elderly immune response to sepsis. J Immunol. 2014 Apr 01; 192(7):3156-65. View Protective immunity and defects in the neonatal and elderly immune response to sepsis. Abstract
Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma. J Trauma Acute Care Surg. 2014 Jan; 76(1):21-9; discussion 29-30. View Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma. Abstract
Aged mice are unable to mount an effective myeloid response to sepsis. J Immunol. 2014 Jan 15; 192(2):612-22. View Aged mice are unable to mount an effective myeloid response to sepsis. Abstract
Is there value in plasma cytokine measurements in patients with severe trauma and sepsis? Methods. 2013 May 15; 61(1):3-9. View Is there value in plasma cytokine measurements in patients with severe trauma and sepsis? Abstract
Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients. Crit Care Med. 2013 May; 41(5):1175-85. View Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients. Abstract
Acute kidney injury is associated with early cytokine changes after trauma. J Trauma Acute Care Surg. 2013 Apr; 74(4):1005-13. View Acute kidney injury is associated with early cytokine changes after trauma. Abstract
Identification and description of a novel murine model for polytrauma and shock. Crit Care Med. 2013 Apr; 41(4):1075-85. View Identification and description of a novel murine model for polytrauma and shock. Abstract
Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3507-12. View Genomic responses in mouse models poorly mimic human inflammatory diseases. Abstract
Role of innate immunity in neonatal infection. Am J Perinatol. 2013 Feb; 30(2):105-12. View Role of innate immunity in neonatal infection. Abstract
A genomic analysis of Clostridium difficile infections in blunt trauma patients. J Trauma Acute Care Surg. 2013 Jan; 74(1):334-8. View A genomic analysis of Clostridium difficile infections in blunt trauma patients. Abstract
Soybean oil: a potentially new intravascular perfusate. Perfusion. 2013 Mar; 28(2):160-6. View Soybean oil: a potentially new intravascular perfusate. Abstract
The acute immunological response to blood transfusion is influenced by polymicrobial sepsis. Shock. 2012 Dec; 38(6):598-606. View The acute immunological response to blood transfusion is influenced by polymicrobial sepsis. Abstract
Pediatric pancreatic trauma: trending toward nonoperative management? Am Surg. 2012 Nov; 78(11):1204-10. View Pediatric pancreatic trauma: trending toward nonoperative management? Abstract
Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care. J Trauma Acute Care Surg. 2012 Jun; 72(6):1491-501. View Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care. Abstract
Myeloid-derived suppressor cells in sepsis: friend or foe? Intensive Care Med. 2012 Jun; 38(6):928-30. View Myeloid-derived suppressor cells in sepsis: friend or foe? Abstract
Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures. Ann Surg. 2012 May; 255(5):993-9. View Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures. Abstract
"Pulling the plug"--management of meconium plug syndrome in neonates. J Surg Res. 2012 Jun 15; 175(2):e43-6. View "Pulling the plug"--management of meconium plug syndrome in neonates. Abstract
Obese patients show a depressed cytokine profile following severe blunt injury. Shock. 2012 Mar; 37(3):253-6. View Obese patients show a depressed cytokine profile following severe blunt injury. Abstract
A genomic storm in critically injured humans. J Exp Med. 2011 Dec 19; 208(13):2581-90. View A genomic storm in critically injured humans. Abstract
Microfluidics-based capture of human neutrophils for expression analysis in blood and bronchoalveolar lavage. Lab Invest. 2011 Dec; 91(12):1787-95. View Microfluidics-based capture of human neutrophils for expression analysis in blood and bronchoalveolar lavage. Abstract
The Glue Grant experience: characterizing the post injury genomic response. Eur J Trauma Emerg Surg. 2011 Dec; 37(6):549-58. View The Glue Grant experience: characterizing the post injury genomic response. Abstract
B cells enhance early innate immune responses during bacterial sepsis. J Exp Med. 2011 Aug 01; 208(8):1673-82. View B cells enhance early innate immune responses during bacterial sepsis. Abstract
Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling. J Immunol. 2011 Jul 15; 187(2):911-8. View Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling. Abstract
Critical role for CXC ligand 10/CXC receptor 3 signaling in the murine neonatal response to sepsis. Infect Immun. 2011 Jul; 79(7):2746-54. View Critical role for CXC ligand 10/CXC receptor 3 signaling in the murine neonatal response to sepsis. Abstract
The usefulness of the upper gastrointestinal series in the pediatric patient before anti-reflux procedure or gastrostomy tube placement. J Surg Res. 2011 Oct; 170(2):247-52. View The usefulness of the upper gastrointestinal series in the pediatric patient before anti-reflux procedure or gastrostomy tube placement. Abstract
Sepsis induces early alterations in innate immunity that impact mortality to secondary infection. J Immunol. 2011 Jan 01; 186(1):195-202. View Sepsis induces early alterations in innate immunity that impact mortality to secondary infection. Abstract
A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma. Mol Med. 2011 Mar-Apr; 17(3-4):281-92. View A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma. Abstract
Cecal ligation and puncture. Curr Protoc Immunol. 2010 Nov; Chapter 19:Unit 19.13. View Cecal ligation and puncture. Abstract
Do Tregs link sepsis to tumor growth? Blood. 2010 Jun 03; 115(22):4324-5. View Do Tregs link sepsis to tumor growth? Abstract
Cutting edge: bacterial infection induces hematopoietic stem and progenitor cell expansion in the absence of TLR signaling. J Immunol. 2010 Mar 01; 184(5):2247-51. View Cutting edge: bacterial infection induces hematopoietic stem and progenitor cell expansion in the absence of TLR signaling. Abstract
Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10. J Exp Med. 2010 Feb 15; 207(2):319-26. View Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10. Abstract
Diminishing role of contrast enema in simple meconium ileus. J Pediatr Surg. 2009 Nov; 44(11):2130-2. View Diminishing role of contrast enema in simple meconium ileus. Abstract
Equestrian injuries in children. J Pediatr Surg. 2009 Jan; 44(1):148-50. View Equestrian injuries in children. Abstract
Pulmonary surgery in cystic fibrosis. Semin Pediatr Surg. 2008 Feb; 17(1):60-5. View Pulmonary surgery in cystic fibrosis. Abstract
Emerging implications of nanotechnology on cancer diagnostics and therapeutics. Cancer. 2006 Aug 01; 107(3):459-66. View Emerging implications of nanotechnology on cancer diagnostics and therapeutics. Abstract
In vivo disruption of tolerogenic cross-presentation mechanisms uncovers an effective T-cell activation by B-cell lymphomas leading to antitumor immunity. Blood. 2006 Apr 01; 107(7):2871-8. View In vivo disruption of tolerogenic cross-presentation mechanisms uncovers an effective T-cell activation by B-cell lymphomas leading to antitumor immunity. Abstract
Imatinib mesylate (STI-571) enhances antigen-presenting cell function and overcomes tumor-induced CD4+ T-cell tolerance. Blood. 2005 Feb 01; 105(3):1135-43. View Imatinib mesylate (STI-571) enhances antigen-presenting cell function and overcomes tumor-induced CD4+ T-cell tolerance. Abstract
Extra-lymphatic solid tumor growth is not immunologically ignored and results in early induction of antigen-specific T-cell anergy: dominant role of cross-tolerance to tumor antigens. Cancer Res. 2003 Dec 15; 63(24):9007-15. View Extra-lymphatic solid tumor growth is not immunologically ignored and results in early induction of antigen-specific T-cell anergy: dominant role of cross-tolerance to tumor antigens. Abstract
A critical role for Stat3 signaling in immune tolerance. Immunity. 2003 Sep; 19(3):425-36. View A critical role for Stat3 signaling in immune tolerance. Abstract
Cross-presentation of tumor antigens by bone marrow-derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression. Blood. 2001 Aug 15; 98(4):1070-7. View Cross-presentation of tumor antigens by bone marrow-derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression. Abstract
Pancreas transplant graft evaluation using the MIBI scan--a useful tool. Transplant Proc. 1998 Mar; 30(2):257-60. View Pancreas transplant graft evaluation using the MIBI scan--a useful tool. Abstract
Pancreaticojejunostomy versus controlled pancreaticocutaneous fistula in pancreaticoduodenectomy for periampullary carcinoma. Am J Surg. 1995 Jun; 169(6):585-8. View Pancreaticojejunostomy versus controlled pancreaticocutaneous fistula in pancreaticoduodenectomy for periampullary carcinoma. Abstract