Current Environment: Production

Alex Cuenca | Education

Undergraduate School

New College

1997, Sarasota, FL

Medical School

University of Florida

2006, Gainesville, FL

Internship

Shands Teaching Hospital/ University of Florida

2007, Gainesville, FL

Graduate School

University of Florida

2012, Gainesville, FL

Residency

Shands Teaching Hospital/ University of Florida

2015, Gainesville, FL

Fellowship

Boston Children's Hospital

2017, Boston, MA

Fellowship

Massachusetts General Hospital

2019, Boston, MA

Alex Cuenca | Certifications

  • American Board of Surgery (General)
  • American Board of Surgery (Pediatric Surgery)

Alex Cuenca | Professional History

Dr. Cuenca completed his medical school, graduate school, and residency at the University of Florida in Gainesville, Fl. During his research hiatus in residency, he obtained a PhD examining the role of innate immunity and toll-like receptor signaling in neonatal sepsis. He then went on to complete a fellowship in Pediatric Surgery at Boston Children’s Hospital. Due to his interest in pediatric hepatobiliary disease and transplant medicine, he went on to complete a fellowship in Transplant Surgery at Massachusetts General Hospital. He is clinically interested in pediatric hepatobiliary and pancreatic disease, solid organ transplantation, mid-aortic vascular disease, and other general surgical conditions of children. His research efforts are focused on examining the role of innate immunity in allograft tolerance, as well as novel efforts to expand the utility of normothermic machine perfusion for use in solid organ transplantation.

Alex Cuenca | Publications

  1. Early Graft Loss With Suspected Seventh-Day Syndrome Following Pediatric Liver Transplantation. Pediatr Transplant. 2024 Aug; 28(5):e14818. View Early Graft Loss With Suspected Seventh-Day Syndrome Following Pediatric Liver Transplantation. Abstract

  2. Surgical management of liver tumors. Pediatr Blood Cancer. 2025 Apr; 72 Suppl 2:e31155. View Surgical management of liver tumors. Abstract

  3. Effect of citizenship status on access to pediatric liver and kidney transplantation. Am J Transplant. 2024 Oct; 24(10):1868-1880. View Effect of citizenship status on access to pediatric liver and kidney transplantation. Abstract

  4. Metastatic pulmonary calcifications after pediatric liver transplantation. Pediatr Transplant. 2024 Feb; 28(1):e14693. View Metastatic pulmonary calcifications after pediatric liver transplantation. Abstract

  5. Immediate extubation after pediatric liver transplantation: Update on a single-center experience. Pediatr Transplant. 2024 Feb; 28(1):e14669. View Immediate extubation after pediatric liver transplantation: Update on a single-center experience. Abstract

  6. Critical elements of pediatric liver cancer surgery. Semin Pediatr Surg. 2023 Oct; 32(5):151340. View Critical elements of pediatric liver cancer surgery. Abstract

  7. Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter. bioRxiv. 2023 Nov 21. View Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter. Abstract

  8. Pediatric Organ Donation and Transplantation: Across the Care Continuum. Pediatrics. 2023 Aug 01; 152(2). View Pediatric Organ Donation and Transplantation: Across the Care Continuum. Abstract

  9. Intragraft B cell differentiation during the development of tolerance to kidney allografts is associated with a regulatory B cell signature revealed by single cell transcriptomics. Am J Transplant. 2023 09; 23(9):1319-1330. View Intragraft B cell differentiation during the development of tolerance to kidney allografts is associated with a regulatory B cell signature revealed by single cell transcriptomics. Abstract

  10. Adjuvant conditioning induces an immunosuppressive milieu that delays alloislet rejection through the expansion of myeloid-derived suppressor cells. Am J Transplant. 2023 07; 23(7):935-945. View Adjuvant conditioning induces an immunosuppressive milieu that delays alloislet rejection through the expansion of myeloid-derived suppressor cells. Abstract

  11. Innate immune cellular therapeutics in transplantation. Front Transplant. 2023; 2. View Innate immune cellular therapeutics in transplantation. Abstract

  12. Outcomes of internal biliary diversion using cholecystocolostomy for patients with severe Alagille syndrome. J Surg Case Rep. 2022 Jul; 2022(7):rjac307. View Outcomes of internal biliary diversion using cholecystocolostomy for patients with severe Alagille syndrome. Abstract

  13. Organ allocation in pediatric abdominal transplant. Semin Pediatr Surg. 2022 Jun; 31(3):151180. View Organ allocation in pediatric abdominal transplant. Abstract

  14. Functional side-to-side splenorenal shunts to treat extrahepatic portal vein thrombosis in children. Am J Surg. 2022 07; 224(1 Pt B):530-534. View Functional side-to-side splenorenal shunts to treat extrahepatic portal vein thrombosis in children. Abstract

  15. Triple gallbladder with heterotopic gastric mucosa: a case report. BMC Pediatr. 2022 01 20; 22(1):52. View Triple gallbladder with heterotopic gastric mucosa: a case report. Abstract

  16. Prenatal diagnosis of rapidly enlarging choledochal cyst with gastric outlet obstruction. J Surg Case Rep. 2021 Dec; 2021(12):rjab547. View Prenatal diagnosis of rapidly enlarging choledochal cyst with gastric outlet obstruction. Abstract

  17. Midaortic syndrome and renovascular hypertension. Semin Pediatr Surg. 2021 Dec; 30(6):151124. View Midaortic syndrome and renovascular hypertension. Abstract

  18. Short Bowel Syndrome and Kidney Transplantation: Challenges, Outcomes, and the Use of Teduglutide. Case Rep Transplant. 2020; 2020:8819345. View Short Bowel Syndrome and Kidney Transplantation: Challenges, Outcomes, and the Use of Teduglutide. Abstract

  19. Resolution of a High Grade and Metastatic BK Polyomavirus-Associated Urothelial Cell Carcinoma Following Radical Allograft Nephroureterectomy and Immune Checkpoint Treatment: A Case Report. Transplant Proc. 2020 Nov; 52(9):2720-2725. View Resolution of a High Grade and Metastatic BK Polyomavirus-Associated Urothelial Cell Carcinoma Following Radical Allograft Nephroureterectomy and Immune Checkpoint Treatment: A Case Report. Abstract

  20. Immediate administration of antiviral therapy after transplantation of hepatitis C-infected livers into uninfected recipients: Implications for therapeutic planning. Am J Transplant. 2020 06; 20(6):1619-1628. View Immediate administration of antiviral therapy after transplantation of hepatitis C-infected livers into uninfected recipients: Implications for therapeutic planning. Abstract

  21. Pediatric liver transplant following near catastrophic head bleed: Lessons learned. Pediatr Transplant. 2020 03; 24(2):e13646. View Pediatric liver transplant following near catastrophic head bleed: Lessons learned. Abstract

  22. Giant Gastroschisis with Complete Liver Herniation: A Case Report of Two Patients. Case Rep Surg. 2019; 2019:4136214. View Giant Gastroschisis with Complete Liver Herniation: A Case Report of Two Patients. Abstract

  23. Pediatric liver transplantation. Semin Pediatr Surg. 2017 Aug; 26(4):217-223. View Pediatric liver transplantation. Abstract

  24. Clostridium difficile Infections after Blunt Trauma: A Different Patient Population? Surg Infect (Larchmt). 2015 Aug; 16(4):421-7. View Clostridium difficile Infections after Blunt Trauma: A Different Patient Population? Abstract

  25. Improved emergency myelopoiesis and survival in neonatal sepsis by caspase-1/11 ablation. Immunology. 2015 Jun; 145(2):300-11. View Improved emergency myelopoiesis and survival in neonatal sepsis by caspase-1/11 ablation. Abstract

  26. Successful implementation of a packed red blood cell and fresh frozen plasma transfusion protocol in the surgical intensive care unit. PLoS One. 2015; 10(5):e0126895. View Successful implementation of a packed red blood cell and fresh frozen plasma transfusion protocol in the surgical intensive care unit. Abstract

  27. TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis. J Immunol. 2015 Feb 01; 194(3):1169-77. View TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis. Abstract

  28. Delayed emergency myelopoiesis following polymicrobial sepsis in neonates. Innate Immun. 2015 May; 21(4):386-91. View Delayed emergency myelopoiesis following polymicrobial sepsis in neonates. Abstract

  29. Omental flaps for coverage of sacral or gluteal defects: a useful and potentially underused tool. Am Surg. 2014 Jul; 80(7):e202-4. View Omental flaps for coverage of sacral or gluteal defects: a useful and potentially underused tool. Abstract

  30. A better understanding of why murine models of trauma do not recapitulate the human syndrome. Crit Care Med. 2014 Jun; 42(6):1406-13. View A better understanding of why murine models of trauma do not recapitulate the human syndrome. Abstract

  31. Novel role for tumor-induced expansion of myeloid-derived cells in cancer cachexia. J Immunol. 2014 Jun 15; 192(12):6111-9. View Novel role for tumor-induced expansion of myeloid-derived cells in cancer cachexia. Abstract

  32. Host responses to sepsis vary in different low-lethality murine models. PLoS One. 2014; 9(5):e94404. View Host responses to sepsis vary in different low-lethality murine models. Abstract

  33. Protective immunity and defects in the neonatal and elderly immune response to sepsis. J Immunol. 2014 Apr 01; 192(7):3156-65. View Protective immunity and defects in the neonatal and elderly immune response to sepsis. Abstract

  34. Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma. J Trauma Acute Care Surg. 2014 Jan; 76(1):21-9; discussion 29-30. View Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma. Abstract

  35. Aged mice are unable to mount an effective myeloid response to sepsis. J Immunol. 2014 Jan 15; 192(2):612-22. View Aged mice are unable to mount an effective myeloid response to sepsis. Abstract

  36. Is there value in plasma cytokine measurements in patients with severe trauma and sepsis? Methods. 2013 May 15; 61(1):3-9. View Is there value in plasma cytokine measurements in patients with severe trauma and sepsis? Abstract

  37. Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients. Crit Care Med. 2013 May; 41(5):1175-85. View Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients. Abstract

  38. Acute kidney injury is associated with early cytokine changes after trauma. J Trauma Acute Care Surg. 2013 Apr; 74(4):1005-13. View Acute kidney injury is associated with early cytokine changes after trauma. Abstract

  39. Identification and description of a novel murine model for polytrauma and shock. Crit Care Med. 2013 Apr; 41(4):1075-85. View Identification and description of a novel murine model for polytrauma and shock. Abstract

  40. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3507-12. View Genomic responses in mouse models poorly mimic human inflammatory diseases. Abstract

  41. Role of innate immunity in neonatal infection. Am J Perinatol. 2013 Feb; 30(2):105-12. View Role of innate immunity in neonatal infection. Abstract

  42. A genomic analysis of Clostridium difficile infections in blunt trauma patients. J Trauma Acute Care Surg. 2013 Jan; 74(1):334-8. View A genomic analysis of Clostridium difficile infections in blunt trauma patients. Abstract

  43. Soybean oil: a potentially new intravascular perfusate. Perfusion. 2013 Mar; 28(2):160-6. View Soybean oil: a potentially new intravascular perfusate. Abstract

  44. The acute immunological response to blood transfusion is influenced by polymicrobial sepsis. Shock. 2012 Dec; 38(6):598-606. View The acute immunological response to blood transfusion is influenced by polymicrobial sepsis. Abstract

  45. Pediatric pancreatic trauma: trending toward nonoperative management? Am Surg. 2012 Nov; 78(11):1204-10. View Pediatric pancreatic trauma: trending toward nonoperative management? Abstract

  46. Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care. J Trauma Acute Care Surg. 2012 Jun; 72(6):1491-501. View Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care. Abstract

  47. Myeloid-derived suppressor cells in sepsis: friend or foe? Intensive Care Med. 2012 Jun; 38(6):928-30. View Myeloid-derived suppressor cells in sepsis: friend or foe? Abstract

  48. Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures. Ann Surg. 2012 May; 255(5):993-9. View Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures. Abstract

  49. "Pulling the plug"--management of meconium plug syndrome in neonates. J Surg Res. 2012 Jun 15; 175(2):e43-6. View "Pulling the plug"--management of meconium plug syndrome in neonates. Abstract

  50. Obese patients show a depressed cytokine profile following severe blunt injury. Shock. 2012 Mar; 37(3):253-6. View Obese patients show a depressed cytokine profile following severe blunt injury. Abstract

  51. A genomic storm in critically injured humans. J Exp Med. 2011 Dec 19; 208(13):2581-90. View A genomic storm in critically injured humans. Abstract

  52. Microfluidics-based capture of human neutrophils for expression analysis in blood and bronchoalveolar lavage. Lab Invest. 2011 Dec; 91(12):1787-95. View Microfluidics-based capture of human neutrophils for expression analysis in blood and bronchoalveolar lavage. Abstract

  53. The Glue Grant experience: characterizing the post injury genomic response. Eur J Trauma Emerg Surg. 2011 Dec; 37(6):549-58. View The Glue Grant experience: characterizing the post injury genomic response. Abstract

  54. B cells enhance early innate immune responses during bacterial sepsis. J Exp Med. 2011 Aug 01; 208(8):1673-82. View B cells enhance early innate immune responses during bacterial sepsis. Abstract

  55. Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling. J Immunol. 2011 Jul 15; 187(2):911-8. View Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling. Abstract

  56. Critical role for CXC ligand 10/CXC receptor 3 signaling in the murine neonatal response to sepsis. Infect Immun. 2011 Jul; 79(7):2746-54. View Critical role for CXC ligand 10/CXC receptor 3 signaling in the murine neonatal response to sepsis. Abstract

  57. The usefulness of the upper gastrointestinal series in the pediatric patient before anti-reflux procedure or gastrostomy tube placement. J Surg Res. 2011 Oct; 170(2):247-52. View The usefulness of the upper gastrointestinal series in the pediatric patient before anti-reflux procedure or gastrostomy tube placement. Abstract

  58. Sepsis induces early alterations in innate immunity that impact mortality to secondary infection. J Immunol. 2011 Jan 01; 186(1):195-202. View Sepsis induces early alterations in innate immunity that impact mortality to secondary infection. Abstract

  59. A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma. Mol Med. 2011 Mar-Apr; 17(3-4):281-92. View A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma. Abstract

  60. Cecal ligation and puncture. Curr Protoc Immunol. 2010 Nov; Chapter 19:Unit 19.13. View Cecal ligation and puncture. Abstract

  61. Do Tregs link sepsis to tumor growth? Blood. 2010 Jun 03; 115(22):4324-5. View Do Tregs link sepsis to tumor growth? Abstract

  62. Cutting edge: bacterial infection induces hematopoietic stem and progenitor cell expansion in the absence of TLR signaling. J Immunol. 2010 Mar 01; 184(5):2247-51. View Cutting edge: bacterial infection induces hematopoietic stem and progenitor cell expansion in the absence of TLR signaling. Abstract

  63. Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10. J Exp Med. 2010 Feb 15; 207(2):319-26. View Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10. Abstract

  64. Diminishing role of contrast enema in simple meconium ileus. J Pediatr Surg. 2009 Nov; 44(11):2130-2. View Diminishing role of contrast enema in simple meconium ileus. Abstract

  65. Equestrian injuries in children. J Pediatr Surg. 2009 Jan; 44(1):148-50. View Equestrian injuries in children. Abstract

  66. Pulmonary surgery in cystic fibrosis. Semin Pediatr Surg. 2008 Feb; 17(1):60-5. View Pulmonary surgery in cystic fibrosis. Abstract

  67. Emerging implications of nanotechnology on cancer diagnostics and therapeutics. Cancer. 2006 Aug 01; 107(3):459-66. View Emerging implications of nanotechnology on cancer diagnostics and therapeutics. Abstract

  68. In vivo disruption of tolerogenic cross-presentation mechanisms uncovers an effective T-cell activation by B-cell lymphomas leading to antitumor immunity. Blood. 2006 Apr 01; 107(7):2871-8. View In vivo disruption of tolerogenic cross-presentation mechanisms uncovers an effective T-cell activation by B-cell lymphomas leading to antitumor immunity. Abstract

  69. Imatinib mesylate (STI-571) enhances antigen-presenting cell function and overcomes tumor-induced CD4+ T-cell tolerance. Blood. 2005 Feb 01; 105(3):1135-43. View Imatinib mesylate (STI-571) enhances antigen-presenting cell function and overcomes tumor-induced CD4+ T-cell tolerance. Abstract

  70. Extra-lymphatic solid tumor growth is not immunologically ignored and results in early induction of antigen-specific T-cell anergy: dominant role of cross-tolerance to tumor antigens. Cancer Res. 2003 Dec 15; 63(24):9007-15. View Extra-lymphatic solid tumor growth is not immunologically ignored and results in early induction of antigen-specific T-cell anergy: dominant role of cross-tolerance to tumor antigens. Abstract

  71. A critical role for Stat3 signaling in immune tolerance. Immunity. 2003 Sep; 19(3):425-36. View A critical role for Stat3 signaling in immune tolerance. Abstract

  72. Cross-presentation of tumor antigens by bone marrow-derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression. Blood. 2001 Aug 15; 98(4):1070-7. View Cross-presentation of tumor antigens by bone marrow-derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression. Abstract

  73. Pancreas transplant graft evaluation using the MIBI scan--a useful tool. Transplant Proc. 1998 Mar; 30(2):257-60. View Pancreas transplant graft evaluation using the MIBI scan--a useful tool. Abstract

  74. Pancreaticojejunostomy versus controlled pancreaticocutaneous fistula in pancreaticoduodenectomy for periampullary carcinoma. Am J Surg. 1995 Jun; 169(6):585-8. View Pancreaticojejunostomy versus controlled pancreaticocutaneous fistula in pancreaticoduodenectomy for periampullary carcinoma. Abstract

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