MEDICAL SERVICES

Departments

Languages

  • English

EDUCATION

Medical School

  • Yale University School of Medicine , 1991 , New Haven , CT

Internship

  • Boston Children's Hospital , 1992 , Boston , MA

Residency

  • Boston Children's Hospital , 1994 , Boston , MA

Fellowship

  • Boston Children's Hospital , 1996 , Boston , MA

CERTIFICATIONS

  • American Board of Pediatrics, Pediatric Emergency Medicine
  • American Board of Pediatrics, General Pediatrics

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Variants in STXBP3 are Associated with Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation. J Crohns Colitis. 2021 Nov 08; 15(11):1908-1919. View abstract
  2. Utilizing a reductionist model to study host-microbe interactions in intestinal inflammation. Microbiome. 2021 Nov 03; 9(1):215. View abstract
  3. Increased ACE2 Levels and Mortality Risk of Patients With COVID-19 on Proton Pump Inhibitor Therapy. Am J Gastroenterol. 2021 08 01; 116(8):1638-1645. View abstract
  4. Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19. Cell. 2021 09 02; 184(18):4713-4733.e22. View abstract
  5. Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19. bioRxiv. 2021 Feb 20. View abstract
  6. Characterizing T cell subsets in the nasal mucosa of children with acute respiratory symptoms. Pediatr Res. 2021 Nov; 90(5):1023-1030. View abstract
  7. Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn's Disease. Gastroenterology. 2020 08; 159(2):591-608.e10. View abstract
  8. Effects of Colonization of Gnotobiotic Swiss Webster Mice with Helicobacter bilis. Comp Med. 2020 06 01; 70(3):216-232. View abstract
  9. Generation of protective pneumococcal-specific nasal resident memory CD4+ T cells via parenteral immunization. Mucosal Immunol. 2020 01; 13(1):172-182. View abstract
  10. Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis. Nat Commun. 2018 09 18; 9(1):3797. View abstract
  11. WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis. Nat Commun. 2018 05 03; 9(1):1779. View abstract
  12. Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor. Elife. 2017 07 05; 6. View abstract
  13. Inhibition of Inflammatory Gene Transcription by IL-10 Is Associated with Rapid Suppression of Lipopolysaccharide-Induced Enhancer Activation. J Immunol. 2017 04 01; 198(7):2906-2915. View abstract
  14. Interleukin-22 drives nitric oxide-dependent DNA damage and dysplasia in a murine model of colitis-associated cancer. Mucosal Immunol. 2017 11; 10(6):1504-1517. View abstract
  15. Interleukin 1ß Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency. Gastroenterology. 2016 12; 151(6):1100-1104. View abstract
  16. O-005 YI Microbiota Drives Inflammation by Altering Intestinal Lamina Propria Macrophage Phenotype in a Novel IL10R-Deficient Model of Very Early Onset IBD. Inflamm Bowel Dis. 2016 Mar; 22 Suppl 1:S2-3. View abstract
  17. Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3. Blood. 2015 Jun 18; 125(25):3886-95. View abstract
  18. Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function. Immunity. 2014 May 15; 40(5):706-19. View abstract
  19. Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans. Adv Immunol. 2014; 122:177-210. View abstract
  20. Pathogenic intestinal bacteria enhance prostate cancer development via systemic activation of immune cells in mice. PLoS One. 2013; 8(8):e73933. View abstract
  21. Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-ß autocrine signaling to promote monocyte recruitment. Immunity. 2013 May 23; 38(5):1025-37. View abstract
  22. Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice. Gastroenterology. 2012 Sep; 143(3):719-729.e2. View abstract
  23. Nfkb1 inhibits LPS-induced IFN-ß and IL-12 p40 production in macrophages by distinct mechanisms. PLoS One. 2012; 7(3):e32811. View abstract
  24. NF-?B1 inhibits TLR-induced IFN-ß production in macrophages through TPL-2-dependent ERK activation. J Immunol. 2011 Feb 15; 186(4):1989-96. View abstract
  25. Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer. Mucosal Immunol. 2011 Jan; 4(1):22-30. View abstract
  26. Unifying roles for regulatory T cells and inflammation in cancer. Int J Cancer. 2010 Apr 01; 126(7):1651-65. View abstract
  27. Serum markers in acute appendicitis. J Surg Res. 2011 Jun 01; 168(1):70-5. View abstract
  28. Discovery and validation of urine markers of acute pediatric appendicitis using high-accuracy mass spectrometry. Ann Emerg Med. 2010 Jan; 55(1):62-70.e4. View abstract
  29. Cytotoxic-T-lymphocyte-associated antigen 4 blockade abrogates protection by regulatory T cells in a mouse model of microbially induced innate immune-driven colitis. Infect Immun. 2008 Dec; 76(12):5834-42. View abstract
  30. Acute appendicitis is characterized by a uniform and highly selective pattern of inflammatory gene expression. Mucosal Immunol. 2008 Jul; 1(4):297-308. View abstract
  31. c-Rel is essential for the development of innate and T cell-induced colitis. J Immunol. 2008 Jun 15; 180(12):8118-25. View abstract
  32. NF-kappaB p50 and p65 subunits control intestinal homeostasis. Eur J Immunol. 2007 Sep; 37(9):2509-17. View abstract
  33. Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma. Carcinogenesis. 2007 Dec; 28(12):2614-23. View abstract
  34. The straw that stirs the drink: insight into the pathogenesis of inflammatory bowel disease revealed through the study of microflora-induced inflammation in genetically modified mice. Inflamm Bowel Dis. 2007 Apr; 13(4):490-500. View abstract
  35. Inhibition of Helicobacter hepaticus-induced colitis by IL-10 requires the p50/p105 subunit of NF-kappa B. J Immunol. 2006 Nov 15; 177(10):7332-9. View abstract
  36. Innate immune inflammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in mice. Cancer Res. 2006 Aug 01; 66(15):7395-400. View abstract
  37. Defective activation of ERK in macrophages lacking the p50/p105 subunit of NF-kappaB is responsible for elevated expression of IL-12 p40 observed after challenge with Helicobacter hepaticus. J Immunol. 2006 Jan 15; 176(2):1244-51. View abstract
  38. Proinflammatory CD4+ CD45RB(hi) lymphocytes promote mammary and intestinal carcinogenesis in Apc(Min/+) mice. Cancer Res. 2006 Jan 01; 66(1):57-61. View abstract
  39. NF-kappa B, an inhibitor of microflora-induced colitis. J Pediatr Gastroenterol Nutr. 2005 Apr; 40 Suppl 1:S22-3. View abstract
  40. A role for NF-kappa B subunits p50 and p65 in the inhibition of lipopolysaccharide-induced shock. J Immunol. 2004 Nov 01; 173(9):5786-93. View abstract
  41. Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB. Int Immunol. 2004 Mar; 16(3):395-404. View abstract
  42. Gastroenteritis in NF-kappaB-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strains. Infect Immun. 2004 Feb; 72(2):1116-25. View abstract
  43. Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses. Eur J Immunol. 2003 Oct; 33(10):2706-16. View abstract
  44. CD4(+)CD25(+) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in mice. Cancer Res. 2003 Sep 15; 63(18):6042-50. View abstract
  45. NF-kappa B is required within the innate immune system to inhibit microflora-induced colitis and expression of IL-12 p40. J Immunol. 2003 Aug 01; 171(3):1484-92. View abstract
  46. CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice. Am J Pathol. 2003 Feb; 162(2):691-702. View abstract
  47. Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitment. J Immunol. 2001 Aug 01; 167(3):1592-600. View abstract
  48. Mechanisms of granulocytosis in the absence of CD18. Blood. 2001 Mar 15; 97(6):1578-83. View abstract
  49. Typhlocolitis in NF-kappa B-deficient mice. J Immunol. 2001 Feb 01; 166(3):1443-7. View abstract
  50. Nuclear factor kappa B is required for the development of marginal zone B lymphocytes. J Exp Med. 2000 Oct 16; 192(8):1175-82. View abstract
  51. Effects of CD18 deficiency on the emigration of murine neutrophils during pneumonia. J Immunol. 1999 Jul 15; 163(2):995-9. View abstract
  52. The p65 subunit of NF-kappa B is redundant with p50 during B cell proliferative responses, and is required for germline CH transcription and class switching to IgG3. J Immunol. 1999 Feb 15; 162(4):1941-6. View abstract
  53. Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cells. Immunity. 1997 Jun; 6(6):765-72. View abstract
  54. Inverse relationship of peripheral thyrotropin-stimulating hormone levels to brain activity in mood disorders. Am J Psychiatry. 1997 Feb; 154(2):224-30. View abstract
  55. Brain activity during transient sadness and happiness in healthy women. Am J Psychiatry. 1995 Mar; 152(3):341-51. View abstract
  56. Regional brain activity when selecting a response despite interference: An H2 (15) O PET study of the stroop and an emotional stroop. Hum Brain Mapp. 1994; 1(3):194-209. View abstract
  57. Bovine papillomavirus E2 gene regulates expression of the viral E5 transforming gene. J Virol. 1988 Oct; 62(10):3608-13. View abstract