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Research & Innovation | Overview

Our mission is to advance the complex science that underlies the treatment of children and adults with congenital and pediatric acquired heart disease so that we can continuously improve care and patient outcomes. To help meet this goal, the Benderson Family Heart Center maintains an active roster of clinical trials and ongoing research.

Since 1949, Boston Children's has pioneered cardiovascular innovations that have dramatically improved survival rates and the quality of life those born with heart defects. The Benderson Family Heart Center attracts major research support from funding agencies, including the National Institutes of Health and the American Heart Association. We have the nation's largest clinical and basic research program focused on pediatric heart disease, and we are an innovator in translational research — bringing laboratory discoveries to the bedside as quickly as possible.

Clinician looks at molecules in petri dish

Learn about the ongoing Cardiology clinical trials and research labs that are advancing the field forward.

Recent research and innovation stories

Innovation plays a critical role in our patients' health, so we are constantly creating new ways to treat heart diseases. Our scientists investigate every aspect of the heart and the conditions that affect it, so we can offer new and improved treatments to our patients. Our program's culture is one of innovation — of solving difficult problems that others haven't been able to solve, tackling the most complex cases, and figuring out ways to make the process easier on pediatric and adult patients.


May 2024
  1. Agarwal A, Duan R, Sobhani NC, Sabanayagam A, Marcus GM, Gurvitz M. Health Service Use and Costs During Pregnancy Among Privately Insured Individuals With Congenital Heart Disease. JAMA Netw Open. 2024;7(5):e2410763. Epub 20240501. doi: 10.1001/jamanetworkopen.2024.10763. PubMed PMID: 38739390; PubMed Central PMCID: PMCPMC11091763.
  2. Alhamdan F, Koutsogiannaki S, Yuki K. The landscape of immune dysregulation in pediatric sepsis at a single-cell resolution. Clin Immunol. 2024;262:110175. Epub 20240307. doi: 10.1016/j.clim.2024.110175. PubMed PMID: 38460893; PubMed Central PMCID: PMCPMC11009045.
  3. Barreto JA, Wenger J, Dewan M, Topjian A, Roberts J. Postcardiac Arrest Care Delivery in Pediatric Intensive Care Units: A Plan and Call to Action. Pediatr Qual Saf. 2024;9(3):e727. Epub 20240509. doi: 10.1097/pq9.0000000000000727. PubMed PMID: 38751898; PubMed Central PMCID: PMCPMC11093557.
  4. Bates JE, Rancati T, Keshavarz H, Gagliardi G, Aznar MC, Howell RM, Shrestha S, Moiseenko V, Yorke E, Armenian S, Kremer L, Chen MH, van der Pal HJ, Cutter DJ, Constine LS, Hodgson D. Cardiac Disease in Childhood Cancer Survivors Treated With Radiation Therapy: A PENTEC Comprehensive Review. Int J Radiat Oncol Biol Phys. 2024;119(2):522-32. Epub 20230414. doi: 10.1016/j.ijrobp.2023.03.045. PubMed PMID: 37061912.
  5. Bertrandt RA, Gist K, Hasson D, Zang H, Reichle G, Krawczeski C, Winlaw D, Bailly D, Goldstein S, Selewski D, Alten J, Neonatal, Pediatric H, Renal Outcomes Network Investigators (Brandewie, KL, Diddle, JW, Ghbeis M, Mah K, Neumayr, TM, Raymond, TT, Prodhan, P, Garcia, X, Ramer S. Alberton M, Cooper D, Rodriquez, Z, Lukacs M, Gaies M, Sammons A, Sachez de Toledo J, Domnina YA, Saenz L, Baust T, Kluck J, Koch JD, Sasaki, J, et al.) Cardiac Surgery-Associated Acute Kidney Injury in Neonates Undergoing the Norwood Operation: Retrospective Analysis of the Multicenter Neonatal and Pediatric Heart and Renal Outcomes Network Dataset, 2015-2018. Pediatr Crit Care Med. 2024;25(5):e246-e57. Epub 20240314. doi: 10.1097/PCC.0000000000003498. PubMed PMID: 38483198.
  6. Bodenstein DF, Siebiger G, Zhao Y, Clasky AJ, Mukkala AN, Beroncal EL, Banh L, Aslostovar L, Brijbassi S, Hogan SE, McCully JD, Mehrabian M, Petersen TH, Robinson LA, Walker M, Zachos C, Consortium MIi-MMT, Viswanathan S, Gu FX, Rotstein OD, Cypel M, Radisic M, Andreazza AC. Bridging the gap between in vitro and in vivo models: a way forward to clinical translation of mitochondrial transplantation in acute disease states. Stem Cell Res Ther. 2024;15(1):157. Epub 20240531. doi: 10.1186/s13287-024-03771-8. PubMed PMID: 38816774; PubMed Central PMCID: PMCPMC11140916.
  7. Brown ML, Nasr VG. The Minimum Requirements for a Pediatric Cardiac Surgical Site: What is Needed? J Cardiothorac Vasc Anesth. 2024;38(6):1302-4. Epub 20240307. doi: 10.1053/j.jvca.2024.03.002. PubMed PMID: 38503626.
  8. Chowdhury D, Bansal N, Ansong A, Baker Smith C, Bauser-Heaton H, Choueiter N, Co-Vu J, Elliott PB, Fuller S, Jain SS, Jone PN, Johnson JN, Karamlou T, Kipps AK, Laraja K, Lopez KN, Rasheed M, Ronai C, Sachdeva R, Saidi A, Snyder C, Sutton N, Stiver C, Taggart NW, Shaffer K, Williams R. Mind the Gap! Working Toward Gender Equity in Pediatric and Congenital Heart Disease: Present and Future. J Am Heart Assoc. 2024;13(9):e032837. Epub 20240419. doi: 10.1161/JAHA.123.032837. PubMed PMID: 38639355.
  9. Cimbak N, Zalieckas JM, Staffa SJ, Lemire L, Janeczek J, Sheils C, Visner G, Mullen M, Studley M, Becker R, Dickie BH, Demehri FR, Buchmiller TL. Disparities in Healthcare Utilization: An Analysis of Disease Specific and Patient Level Factors in a Congenital Diaphragmatic Hernia Clinic. J Pediatr Surg. 2024. Epub 20240507. doi: 10.1016/j.jpedsurg.2024.04.023. PubMed PMID: 38806317.
  10. Coacci S, Alston ELJ, Yamasaki T, Ronai C, Sanders SP, Carreon CK. The Connection Between Anatomical Substrate and Clinical Severity in Fetal Ebstein Anomaly. Pediatr Dev Pathol. 2024:10935266241250235. Epub 20240519. doi: 10.1177/10935266241250235. PubMed PMID: 38762771.
  11. Dagli-Hernandez C, Ferreira GM, Freitas RCC, Borges JB, Oliveira VF, Goncalves RM, Faludi AA, Marcal E, Bastos GM, Bortolin RH, Hirata MH, Hirata RDC. Predicted deleterious variants in ABCA1, LPL, LPA and KIF6 are associated with statin response and adverse events in patients with familial hypercholesterolemia and disturb protein structure and stability. Pharmacogenet Genomics. 2024;34(4):91-104. Epub 20240207. doi: 10.1097/FPC.0000000000000524. PubMed PMID: 38682317.
  12. Faraoni D, DiNardo JA. Bivalirudin: The misunderstood alternative to heparin. Paediatr Anaesth. 2024;34(5):394-5. Epub 20240305. doi: 10.1111/pan.14868. PubMed PMID: 38440919.
  13. Fernandez-Cisneros A, Feins E, Newburger J, Sekhavat S, Quinn B, Quinonez L. Repeat Repair After Translocation of an Anomalous Left Coronary Artery. Ann Thorac Surg. 2024. Epub 20240522. doi: 10.1016/j.athoracsur.2024.03.036. PubMed PMID: 38621655.
  14. Frelinger AL, 3rd, Haynes RL, Goldstein RD, Berny-Lang MA, Gerrits AJ, Riehs M, Haas EA, Paunovic B, Mena OJ, Campman SC, Milne GL, Sleeper LA, Kinney HC, Michelson AD. Dysregulation of platelet serotonin, 14-3-3, and GPIX in sudden infant death syndrome. Sci Rep. 2024;14(1):11092. Epub 20240515. doi: 10.1038/s41598-024-61949-9. PubMed PMID: 38750089; PubMed Central PMCID: PMCPMC11096399.
  15. Gabbay JM, Mayourian J, Bajaj BVM, Wu AC, Graham RJ, Perez JM. Child opportunity and outcomes in pediatric critical asthma: A multicenter analysis. J Allergy Clin Immunol Pract. 2024. Epub 20240503. doi: 10.1016/j.jaip.2024.04.051. PubMed PMID: 38703821.
  16. Gikandi A, Baird CW, Del Nido PJ, Emani SM. Right ventricular papillary muscle approximation to the septum as an adjunct technique during tricuspid valve repair in congenital heart surgery. J Thorac Cardiovasc Surg. 2024;167(5):1547-55 e1. Epub 20230916. doi: 10.1016/j.jtcvs.2023.09.026. PubMed PMID: 37722623.
  17. Gikandi A, Chiu P, Secor J, Nathan M, O'Leary E, Walsh E, Geva T, Beroukhim R, Del Nido P. Surgical Debulking of Large Ventricular Fibromas in Children. J Thorac Cardiovasc Surg. 2024. Epub 20240525. doi: 10.1016/j.jtcvs.2024.05.013. PubMed PMID: 38802044.
  18. Gross RS, Thaweethai T, Rosenzweig EB, Chan J, Chibnik LB, Cicek MS, Elliott AJ, Flaherman VJ, Foulkes AS, Gage Witvliet M, Gallagher R, Gennaro ML, Jernigan TL, Karlson EW, Katz SD, Kinser PA, Kleinman LC, Lamendola-Essel MF, Milner JD, Mohandas S, Mudumbi PC, Newburger JW, Rhee KE, Salisbury AL, Snowden JN, Stein CR, Stockwell MS, Tantisira KG, Thomason ME, Truong DT, Warburton D, Wood JC, Ahmed S, Akerlundh A, Alshawabkeh AN, Anderson BR, Aschner JL, Atz AM, Aupperle RL, Baker FC, Balaraman V, Banerjee D, Barch DM, Baskin-Sommers A, Bhuiyan S, Bind MC, Bogie AL, Bradford T, Buchbinder NC, Bueler E, Bukulmez H, Casey BJ, Chang L, Chrisant M, Clark DB, Clifton RG, Clouser KN, Cottrell L, Cowan K, D'Sa V, Dapretto M, Dasgupta S, Dehority W, Dionne A, Dummer KB, Elias MD, Esquenazi-Karonika S, Evans DN, Faustino EVS, Fiks AG, Forsha D, Foxe JJ, Friedman NP, Fry G, Gaur S, Gee DG, Gray KM, Handler S, Harahsheh AS, Hasbani K, Heath AC, Hebson C, Heitzeg MM, Hester CM, Hill S, Hobart-Porter L, Hong TKF, Horowitz CR, Hsia DS, Huentelman M, Hummel KD, Irby K, Jacobus J, Jacoby VL, Jone PN, Kaelber DC, Kasmarcak TJ, Kluko MJ, Kosut JS, Laird AR, Landeo-Gutierrez J, Lang SM, Larson CL, Lim PPC, Lisdahl KM, McCrindle BW, McCulloh RJ, McHugh K, Mendelsohn AL, Metz TD, Miller J, Mitchell EC, Morgan LM, Muller-Oehring EM, Nahin ER, Neale MC, Ness-Cochinwala M, Nolan SM, Oliveira CR, Osakwe O, Oster ME, Payne RM, Portman MA, Raissy H, Randall IG, Rao S, Reeder HT, Rosas JM, Russell MW, Sabati AA, Sanil Y, Sato AI, Schechter MS, Selvarangan R, Sexson Tejtel SK, Shakti D, Sharma K, Squeglia LM, Srivastava S, Stevenson MD, Szmuszkovicz J, Talavera-Barber MM, Teufel RJ, 2nd, Thacker D, Trachtenberg F, Udosen MM, Warner MR, Watson SE, Werzberger A, Weyer JC, Wood MJ, Yin HS, Zempsky WT, Zimmerman E, Dreyer BP, Consortium RE-P. Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design. PLoS One. 2024;19(5):e0285635. Epub 20240507. doi: 10.1371/journal.pone.0285635. PubMed PMID: 38713673; PubMed Central PMCID: PMCPMC11075869.
  19. Guseh S, Tworetzky W. Transforming congenital heart disease management: Advances in fetal cardiac interventions. Prenat Diagn. 2024. Epub 20240520. doi: 10.1002/pd.6592. PubMed PMID: 38768017.
  20. He X, Yang T, Lu YW, Wu G, Dai G, Ma Q, Zhang M, Zhou H, Long T, Yan Y, Liang Z, Liu C, Pu WT, Dong Y, Ou J, Chen H, Mably JD, He J, Wang DZ, Huang ZP. The long non-coding RNA CARDINAL attenuates cardiac hypertrophy by modulating protein translation. J Clin Invest. 2024. Epub 20240514. doi: 10.1172/JCI169112. PubMed PMID: 38743498.
  21. Hummel K, Michelson A, Zmora R, de Ferranti S, Jenkins K, Saleeb SF. Implementation of the International Consortium of Health Outcomes Measurement CHD standard set in patients undergoing pulmonary valve replacement. Cardiol Young. 2024:1-6. Epub 20240507. doi: 10.1017/S1047951124000866. PubMed PMID: 38711375.
  22. Kalfa D, Rajab TK, Cordoves E, Emani S, Bacha E, Jaggers J, Goldstone A, Eghtesady P, Turek J. Living allogenic heart valve transplantation: Relative advantages and unanswered questions. J Thorac Cardiovasc Surg. 2024;167(5):1543-6. Epub 20230922. doi: 10.1016/j.jtcvs.2023.09.036. PubMed PMID: 37743011.
  23. Kim ME, Baskar S, Janson CM, Chandler SF, Whitehill RD, Dionne A, Law MA, Domnina Y, Smith-Parrish MN, Bird GL, Banerjee M, Zhang W, Reichle G, Schumacher KR, Czosek RJ, Morales DLS, Alten JA. Epidemiology of Postoperative Junctional Ectopic Tachycardia in Infants Undergoing Cardiac Surgery. Ann Thorac Surg. 2024;117(6):1178-85. Epub 20240312. doi: 10.1016/j.athoracsur.2024.03.002. PubMed PMID: 38484909.
  24. Kneyber MCJ, Cheifetz IM, Asaro LA, Graves TL, Viele K, Natarajan A, Wypij D, Curley MAQ, Pediatric Acute Lung I, Sepsis Investigators N. Protocol for the Prone and Oscillation Pediatric Clinical Trial (PROSpect). Pediatr Crit Care Med. 2024. Epub 20240527. doi: 10.1097/PCC.0000000000003541. PubMed PMID: 38801306.
  25. Kumar SR, Gaynor JW, Heuerman H, Mayer JE, Jr., Nathan M, O'Brien JE, Jr., Pizarro C, Subacius H, Wacker L, Wellnitz C, Eghtesady P. The Society of Thoracic Surgeons Congenital Heart Surgery Database: 2023 Update on Outcomes and Research. Ann Thorac Surg. 2024;117(5):904-14. Epub 20240324. doi: 10.1016/j.athoracsur.2024.03.018. PubMed PMID: 38522772.
  26. Lin RZ, Im GB, Luo AC, Zhu Y, Hong X, Neumeyer J, Tang HW, Perrimon N, Melero-Martin JM. Mitochondrial transfer mediates endothelial cell engraftment through mitophagy. Nature. 2024;629(8012):660-8. Epub 20240501. doi: 10.1038/s41586-024-07340-0. PubMed PMID: 38693258.
  27. Mah DY. Wearable technology for heart rhythm monitoring in children. Heart Rhythm. 2024;21(5):590-1. Epub 20240206. doi: 10.1016/j.hrthm.2024.02.003. PubMed PMID: 38331305.
  28. McCormick AD, Puri K, Asaki SY, Amdani S, Chowdhury D, Glickstein JS, Tierney S, Ibeziako P, Cousino MK, Ronai C. Mental Health Care for Children with Heart Disease and Their Families: Practical Approaches and Considerations for the Pediatric and Pediatric Cardiology Clinician. Pediatr Cardiol. 2024. Epub 20240516. doi: 10.1007/s00246-024-03518-5. PubMed PMID: 38753034.
  29. McLellan MC, Irshad M, Penny KC, Rufo M, Atwood S, Dacey H, Ireland CM, de Ferranti S, Saia T, Fisk AC, Saleeb SF. Enhanced Safety and Efficiency of Ambulatory Cardiology Admissions: A Quality Improvement Initiative. Pediatr Qual Saf. 2024;9(3):e726. Epub 20240509. doi: 10.1097/pq9.0000000000000726. PubMed PMID: 38751893; PubMed Central PMCID: PMCPMC11093579.
  30. Milligan C, Williams RJ, Singh TP, Bastardi HJ, Esteso P, Almond CS, Gauvreau K, Daly KP. Impact of a positive crossmatch on pediatric heart transplant outcomes. J Heart Lung Transplant. 2024;43(6):963-72. Epub 20240227. doi: 10.1016/j.healun.2024.02.1457. PubMed PMID: 38423415; PubMed Central PMCID: PMCPMC11090719.
  31. Mohamed M, Frasketi M, Hoffman H, Elgendy M, Aly S, Aly H. Cerebral tissue oxygen desaturations and increased fractional oxygen extraction events vary by gestational age in preterm infants. Pediatr Neonatol. 2024. Epub 20240521. doi: 10.1016/j.pedneo.2023.12.008. PubMed PMID: 38821763.
  32. Nathan M, Gauvreau K, White O, Anderson BR, Bacha EA, Barron DJ, Cleveland J, Del Nido PJ, Eghtesady P, Galantowicz M, Kennedy A, Kohlsaat K, Ma M, Mattila C, Van Arsdell G, Gaynor JW. Comparing apples to apples: Exploring public reporting of congenital cardiac surgery outcomes based on common congenital heart operations. J Thorac Cardiovasc Surg. 2024;167(5):1570-80 e3. Epub 20230907. doi: 10.1016/j.jtcvs.2023.08.052. PubMed PMID: 37689234.
  33. O'Leary E, Valente AM, Tadros T. Tempering the Storm of Arrhythmias in Adults With Congenital Heart Disease. J Am Heart Assoc. 2024;13(9):e9566. Epub 20240417. doi: 10.1161/JAHA.124.034536. PubMed PMID: 38629434.
  34. Opotowsky AR, Khairy P, Diller G, Kasparian NA, Brophy J, Jenkins K, Lopez KN, McCoy A, Moons P, Ollberding NJ, Rathod RH, Rychik J, Thanassoulis G, Vasan RS, Marelli A. Clinical Risk Assessment and Prediction in Congenital Heart Disease Across the Lifespan: JACC Scientific Statement. J Am Coll Cardiol. 2024;83(21):2092-111. doi: 10.1016/j.jacc.2024.02.055. PubMed PMID: 38777512.
  35. Pontes Aires B, Wobma H, Samad A, Chandler MT, Chang MH, Dedeoglu F, Fishman MP, Klouda T, Levin J, Halyabar O, Saleeb SF, Tworetzky W, Son MBF, Newburger JW, Casey A, Henderson LA. Severe Features of Systemic Juvenile Idiopathic Arthritis in Patients with Congenital Heart Disease. J Rheumatol. 2024. Epub 20240601. doi: 10.3899/jrheum.2024-0180. PubMed PMID: 38825355.
  36. Recco DP, Kneier NE, Earley PD, Kizilski SB, Hammer PE, Hoganson DM. Fiberscope-Based Measurement of Coaptation Height for Intraoperative Assessment of Mitral Valve Repair. World J Pediatr Congenit Heart Surg. 2024;15(3):371-9. Epub 20240207. doi: 10.1177/21501351231221459. PubMed PMID: 38327093.
  37. Reijman MD, Kusters DM, Groothoff JW, Arbeiter K, Dann EJ, de Boer LM, de Ferranti SD, Gallo A, Greber-Platzer S, Hartz J, Hudgins LC, Ibarretxe D, Kayikcioglu M, Klingel R, Kolovou GD, Oh J, Planken RN, Stefanutti C, Taylan C, Wiegman A, Schmitt CP. Clinical practice recommendations on lipoprotein apheresis for children with homozygous familial hypercholesterolaemia: An expert consensus statement from ERKNet and ESPN. Atherosclerosis. 2024;392:117525. Epub 20240327. doi: 10.1016/j.atherosclerosis.2024.117525. PubMed PMID: 38598969.
  38. Sahni A, Marshall L, Cetatoiu MA, Davee J, Schulz N, Eickhoff ER, St Clair N, Ghelani S, Prakash A, Hammer PE, Hoganson DM, Del Nido PJ, Rathod RH, Govindarajan V. Biomechanical Analysis of Age-Dependent Changes in Fontan Power Loss. Ann Biomed Eng. 2024. Epub 20240516. doi: 10.1007/s10439-024-03534-9. PubMed PMID: 38753109.
  39. Smith TM, Basu S, Moynihan KM. A Nudge or a Shove: The Importance of Balancing Parameters and Training in Decision-Making Communication. Pediatr Crit Care Med. 2024;25(5):470-4. Epub 20240502. doi: 10.1097/PCC.0000000000003460. PubMed PMID: 38695697.
  40. VanderPluym CJ. The power of "it will be okay". Pediatr Transplant. 2024;28(3):e14710. doi: 10.1111/petr.14710. PubMed PMID: 38553813.
  41. Yamasaki T, Sanders SP, Hylind RJ, Milligan C, Fynn-Thompson F, Mayer JE, Jr., Blume ED, Daly KP, Carreon CK. Pathology of explanted pediatric hearts: An 11-year study. Population characteristics and implications for outcomes. Pediatr Transplant. 2024;28(4):e14742. doi: 10.1111/petr.14742. PubMed PMID: 38702926.
  42. Yamasaki T, Toba S, Sanders SP, Carreon CK. A modifiable valve-sparing pediatric cardiac dissection technique promotes specimen longevity and optimizes advanced image analysis postpathological examination. Pathol Int. 2024. Epub 20240507. doi: 10.1111/pin.13435. PubMed PMID: 38712791.
  43. Yang P, Lou Y, Geng Z, Guo Z, Wu S, Li Y, Song K, Shi T, Zhang S, Xiong J, Chen AF, Li D, Pu WT, Da L, Zhang Y, Sun K, Zhang B. Allele-Specific Suppression of Variant MHC With High-Precision RNA Nuclease CRISPR-Cas13d Prevents Hypertrophic Cardiomyopathy. Circulation. 2024. Epub 20240516. doi: 10.1161/CIRCULATIONAHA.123.067890. PubMed PMID: 38752340
April 2024
  • Alemany VS, Crawford A, Gauvreau K, Bucholz EM, Del Nido PJ, Schidlow DN, Nathan M. Early and long-term outcomes following cardiac surgery for patients with heterotaxy syndrome. JTCVS Open. 2024;18:167-79. Epub 20240227. doi: 10.1016/j.xjon.2024.02.011. PubMed PMID: 38690436; PubMed Central PMCID: PMCPMC11056491.
  • Arroum T, Hish GA, Burghardt KJ, McCully JD, Huttemann M, Malek MH. Mitochondrial Transplantation's Role in Rodent Skeletal Muscle Bioenergetics: Recharging the Engine of Aging. Biomolecules. 2024;14(4). Epub 20240418. doi: 10.3390/biom14040493. PubMed PMID: 38672509; PubMed Central PMCID: PMCPMC11048484.
  • Barbieri M, Hooijmans MT, Moulin K, Cork TE, Ennis DB, Gold GE, Kogan F, Mazzoli V. A deep learning approach for fast muscle water T2 mapping with subject specific fat T2 calibration from multi-spin-echo acquisitions. Sci Rep. 2024;14(1):8253. Epub 20240408. doi: 10.1038/s41598-024-58812-2. PubMed PMID: 38589478; PubMed Central PMCID: PMCPMC11002020.
  • Butler SC, Carroll K, Catalano K, Atkinson C, Chiujdea M, Kerr J, Severtson K, Drumm S, Gustafson K, Gingrasfield J. Sleeping Safe and Sound: A Multidisciplinary Hospital-wide Infant Safe Sleep Quality Improvement Initiative. J Pediatr Health Care. 2024. Epub 20240419. doi: 10.1016/j.pedhc.2024.02.007. PubMed PMID: 38647508.
  • Butler SC, Rofeberg V, Smith-Parrish M, LaRonde M, Vittner DJ, Goldberg S, Bailey V, Weeks MM, McCowan S, Severtson K, Glowick K, Rachwal CM. Caring for hearts and minds: a quality improvement approach to individualized developmental care in the cardiac intensive care unit. Front Pediatr. 2024;12:1384615. Epub 20240409. doi: 10.3389/fped.2024.1384615. PubMed PMID: 38655280; PubMed Central PMCID: PMCPMC11037267.
  • Castellanos DA, Jang J, Schidlow DN, Brassaw K, Agudelo S, Heuvelink-Marck A, Lipsitz SR, Powell AJ. The impact of audiovisual breathing guidance on respiratory-triggered cardiac magnetic resonance cine imaging. Magn Reson Imaging. 2024;111:15-20. Epub 20240403. doi: 10.1016/j.mri.2024.04.001. PubMed PMID: 38579974.
  • Chowdhury D, Bansal N, Ansong A, Baker Smith C, Bauser-Heaton H, Choueiter N, Co-Vu J, Elliott PB, Fuller S, Jain SS, Jone PN, Johnson JN, Karamlou T, Kipps AK, Laraja K, Lopez KN, Rasheed MM, Ronai CM, Sachdeva R, Saidi A, Snyder C, Sutton N, Stiver C, Taggart NW, Shaffer K, Williams R. Mind the Gap! Working Toward Gender Equity in Pediatric and Congenital Heart Disease: Present and Future. J Am Heart Assoc. 2024;13(9):e032837. Epub 20240419. doi: 10.1161/JAHA.123.032837. PubMed PMID: 38639355.
  • Duarte VE, Yamamura K, Economy KE, Graf JA, Lu M, Assenza GE, Karur GR, Marenco A, Ishikita A, Duncan ME, Geva T, Wald RM, Valente AM. The Effects of Pregnancy in Subjects with Repaired Tetralogy of Fallot. Am Heart J. 2024. Epub 20240425. doi: 10.1016/j.ahj.2024.04.015. PubMed PMID: 38677503.
  • Fernandez-Cisneros A, Feins E, Newburger J, Sekhavat S, Quinn B, Quinonez L. Re-Repair after Translocation of an Anomalous Left Coronary Artery. Ann Thorac Surg. 2024. Epub 20240413. doi: 10.1016/j.athoracsur.2024.03.036. PubMed PMID: 38621655.
  • Govindarajan V, Marshall L, Sahni A, Cetatoiu MA, Eickhoff EE, Davee J, St Clair N, Schulz NE, Hoganson DM, Hammer PE, Ghelani SJ, Prakash A, Del Nido PJ, Rathod RH. Impact of Age-Related Change in Caval Flow Ratio on Hepatic Flow Distribution in the Fontan Circulation. Circ Cardiovasc Imaging. 2024;17(4):e016104. Epub 20240403. doi: 10.1161/CIRCIMAGING.123.016104. PubMed PMID: 38567518; PubMed Central PMCID: PMCPMC11073583.
  • Kobayashi RL, Sperotto F, Alexander PMA. Targeting Hemodynamics of Cardiopulmonary Resuscitation to Cardiac Physiology-The Next Frontier for Resuscitation Science? Pediatr Crit Care Med. 2024;25(4):380-2. Epub 20240404. doi: 10.1097/PCC.0000000000003466. PubMed PMID: 38573041; PubMed Central PMCID: PMCPMC10997157.
  • Konstantinov IE, Chai P, Bacha E, Caldarone CA, Da Silva JP, Da Fonseca Da Silva L, Dearani J, Hornberger L, Knott-Craig C, Del Nido P, Qureshi M, Sarris G, Starnes V, Tsang V. The American Association for Thoracic Surgery (AATS) 2024 Expert Consensus Document: Management of neonates and infants with Ebstein anomaly. J Thorac Cardiovasc Surg. 2024. Epub 20240418. doi: 10.1016/j.jtcvs.2024.04.018. PubMed PMID: 38685467.
  • Landzberg MJ. Palliative Care in Adult Congenital Heart Disease-Associated Advanced Heart Disease. Heart Fail Clin. 2024;20(2):237-43. Epub20240103. doi: 10.1016/j.hfc.2023.12.005. PubMed PMID: 38462327.
  • Mejia-Bautista M, Romanowicz J, Hollowell M, Geva T, Carreon CK, Beroukhim RS. Rare Cardiac Inflammatory Pseudotumor in a Toddler: Complementary Roles of Cardiac Magnetic Resonance and Positron Emission Tomography. Cardiovasc Pathol. 2024:107639. Epub 20240401. doi: 10.1016/j.carpath.2024.107639. PubMed PMID: 38570104.
  • Moynihan KM, Sharma M, Mehta A, Lillie J, Ziegenfuss M, Festa M, Chan T, Thiagarajan R. Race-Conscious Research Using Extracorporeal Life Support Organization Registry Data: A Narrative Review. ASAIO J. 2024. Epub 20240416. doi: 10.1097/MAT.0000000000002206. PubMed PMID: 38648078.
  • O'Leary E, Valente AM, Tadros T. Tempering the Storm of Arrhythmias in Adults With Congenital Heart Disease. J Am Heart Assoc. 2024;13(9):e9566. Epub 20240417. doi: 10.1161/JAHA.124.034536. PubMed PMID: 38629434.
  • O'Leary ET, Sneider D, Przybylski R, Dionne A, Alexander ME, Mah DY, Triedman JK, DeWitt ES. Comparative utility of omnipolar and bipolar electroanatomic mapping methods to detect and localize dual nodal substrate in patients with atrioventricular nodal reentrant tachycardia. J Interv Card Electrophysiol. 2024. Epub 20240418. doi: 10.1007/s10840-024-01800-3. PubMed PMID: 38634991.
  • Perry T, Rosenthal DN, Lorts A, Zafar F, Zhang W, VanderPluym C, Dewitt AG, Reichle G, Banerjee M, Schumacher KR. Mechanical Ventilation and Outcomes of Children Who Undergo Ventricular Assist Device Placement: 2014-2020 Linked Analysis From the Advanced Cardiac Therapies Improving Outcomes Network and Pediatric Cardiac Critical Care Consortium Registries. Pediatr Crit Care Med. 2024. Epub 20240415. doi: 10.1097/PCC.0000000000003520. PubMed PMID: 38619330.
  • Roy N. Commentary: Who and when to leave behind: Difficult decisions around extracorporeal membrane oxygenation selection in coronavirus disease2019. J Thorac Cardiovasc Surg. 2024;167(4):1344-5. Epub 20221112. doi: 10.1016/j.jtcvs.2022.11.005. PubMed PMID: 36473748; PubMed Central PMCID: PMCPMC9652094.
  • Shafer KM, Valente AM. Home-based fitness training: chicken soup for the ACHD soul? Eur Heart J. 2024;45(16):1474-6. doi: 10.1093/eurheartj/ehae142. PubMed PMID: 38621021.
  • Shah N, Mathur S, Shanmugham P, Li X, Thiagarajan RR, Natarajan S, Raman L. Neurologic Statistical Prognostication and Risk Assessment for Kids on Extracorporeal Membrane Oxygenation-Neuro SPARK. ASAIO J. 2024;70(4):305-12. Epub 20231221. doi: 10.1097/MAT.0000000000002106. PubMed PMID: 38557687.
  • Sperotto F, France K, Gobbo M, Bindakhil M, Pimolbutr K, Holmes H, Monteiro L, Graham L, Hong CHL, Sollecito TP, Lodi G, Lockhart PB, Thornhill M, Diz Dios P, Turati F, Edefonti V. Antibiotic Prophylaxis and Infective Endocarditis Incidence Following Invasive Dental Procedures: A Systematic Review and Meta-Analysis. JAMA Cardiol. 2024. Epub 20240406. doi: 10.1001/jamacardio.2024.0873. PubMed PMID: 38581643; PubMed Central PMCID: PMCPMC10999003.
  • Yucel D, Pu WT. From vitality to vulnerability: the impact of oxygen on cardiac function and regeneration. J Cardiovasc Aging. 2024;4(2). Epub 20240221. doi: 10.20517/jca.2024.05. PubMed PMID: 38694792; PubMed Central PMCID: PMCPMC11062631.
March 2024
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  2. Chubb H, Mah DY, Shah M, Lin KY, Peng DM, Hale BW, May L, Etheridge S, Goodyer W, Ceresnak SR, Motonaga KS, Rosenthal DN, Almond CS, McElhinney DB, Dubin AM. Multicenter Study of Survival Benefit of Cardiac Resynchronization Therapy in Pediatric and Congenital Heart Disease. JACC Clin Electrophysiol. 2024;10(3):539-50. Epub 20240110. doi: 10.1016/j.jacep.2023.11.008. PubMed PMID: 38206260.
  3. Critser PJ, Buchmiller TL, Gauvreau K, Zalieckas JM, Sheils CA, Visner GA, Shafer KM, Chen MH, Mullen MP. Exercise-induced Pulmonary Hypertension in Long-term Survivors of Congenital Diaphragmatic Hernia. J Pediatr. 2024:114034. Epub 20240327. doi: 10.1016/j.jpeds.2024.114034. PubMed PMID: 38552948.
  4. DiLorenzo MP, Lee S, Rathod RH, Raimondi F, Farooqi KM, Jain SS, Samyn MM, Johnson TR, Olivieri LJ, Fogel MA, Lai WW, Renella P, Powell AJ, Buddhe S, Stafford C, Johnson JN, Helbing WA, Pushparajah K, Voges I, Muthurangu V, Miles KG, Greil G, McMahon CJ, Slesnick TC, Fonseca BM, Morris SA, Soslow JH, Grosse-Wortmann L, Beroukhim RS, Grotenhuis HB. Design and implementation of multicenter pediatric and congenital studies with cardiovascular magnetic resonance: Big data in smaller bodies. J Cardiovasc Magn Reson. 2024;26(1):101041. Epub 20240323. doi: 10.1016/j.jocmr.2024.101041. PubMed PMID: 38527706.
  5. Ferraro AM, Harrild DM, Powell AJ, Levy PT, Marx GR. Evolving Role of Three-Dimensional Echocardiography for Right Ventricle Volume Analysis in Pediatric Heart Disease: Literature Review and Clinical Applications. J Am Soc Echocardiogr. 2024. Epub 20240309. doi: 10.1016/j.echo.2024.03.001. PubMed PMID: 38467312.
  6. Kayoum AA, Rivera Flores E, Reyes M, Almasarweh SI, Ojito J, Burke RP, Sasaki J. Safety of bloodless open-heart surgery on cardiopulmonary bypass in selected children: A single center experience with minimal invasive extracorporeal circulation. Perfusion. 2024;39(2):391-8. Epub 20221208. doi: 10.1177/02676591221145623. PubMed PMID: 36482703.
  7. Kim ME, Baskar S, Janson CM, Chandler SF, Whitehill RD, Dionne A, Law MA, Domnina Y, Smith-Parrish MN, Bird GL, Banerjee M, Zhang W, Reichle G, Schumacher KR, Czosek RJ, Morales DLS, Alten JA. Epidemiology of Postoperative Junctional Ectopic Tachycardia in Infants Undergoing Cardiac Surgery. Ann Thorac Surg. 2024. Epub 20240312. doi: 10.1016/j.athoracsur.2024.03.002. PubMed PMID: 38484909.
  8. Klassen SL, Okello E, Ferrer JME, Alizadeh F, Barango P, Chillo P, Chimalizeni Y, Dagnaw WW, Eisele JL, Eberly L, Gomanju A, Gupta N, Koirala B, Kpodonu J, Kwan G, Mailosi BGD, Mbau L, Mutagaywa R, Pfaff C, Pinero D, Pinto F, Rusingiza E, Sanni UA, Sanyahumbi A, Shakya U, Sharma SK, Sherpa K, Sinabulya I, Wroe EB, Bukhman G, Mocumbi A. Decentralization and Integration of Advanced Cardiac Care for the World's Poorest Billion Through the PEN-Plus Strategy for Severe Chronic Non-Communicable Disease. Glob Heart. 2024;19(1):33. Epub 20240327. doi: 10.5334/gh.1313. PubMed PMID: 38549727; PubMed Central PMCID: PMCPMC10976983.
  9. Kumar SR, Gaynor JW, Heuerman H, Mayer JE, Jr., Nathan M, O'Brien JE, Jr., Pizarro C, Subacius H, Wacker L, Wellnitz C, Eghtesady P. The Society of Thoracic Surgeons Congenital Heart Surgery Database: 2023 Update on Outcomes and Research. Ann Thorac Surg. 2024. Epub 20240322. doi: 10.1016/j.athoracsur.2024.03.018. PubMed PMID: 38522772.
  10. McGeoghegan P, Lu M, Sleeper LA, Emani S, Baird C, Feins E, Gellis LA, Friedman KG. Cleft closure and other predictors of contemporary outcomes after atrioventricular canal repair in patients with parachute left atrioventricular valve. Interdiscip Cardiovasc Thorac Surg. 2024. Epub 20240327. doi: 10.1093/icvts/ivae048. PubMed PMID: 38539038.
  11. Niebler RA, Shezad M, Absi M, Aljohani OA, Amdani S, Auerbach S, Bearl DW, Boucek K, Buchholz H, Castleberry C, Dykes J, Engelhardt K, Friedland-Little J, Hope K, Iqbal M, Jeewa A, Joong A, Lorts A, May L, Mokshagundam D, Nandi D, O'Connor M, Parent JJ, Peng DM, Shwaish N, Shugh SB, VanderPluym C, Vaughn G, Zinn M. Impact of HeartWare ventricular assist device discontinuation on the pediatric population: An Advanced Cardiac Therapies Improving Outcomes Network (ACTION) registry analysis. JHLT Open. 2024;4:100064. doi: [2]
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February 2024
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  4. Foster SN, Best K, Tumin D, Li X, Desher K, Thiagarajan RR, Raman L. Survival and Neurobehavioral Outcomes Following Out-of-Hospital Cardiac Arrest in Pediatric Patients with Pre-Existing Morbidity: An Analysis of the THAPCA Out-of-Hospital Arrest Data. Resuscitation. 2024:110144. Epub 20240215. doi: 10.1016/j.resuscitation.2024.110144. PubMed PMID: 38367829.
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  6. Geanacopoulos AT, Zielonka B, Fox MT, Kerr S, Chambers KD, Przybylski R, Burns MM. Pediatric antiarrhythmics and toxicity: A clinical review. J Am Coll Emerg Physicians Open. 2024;5(1):e13090. Epub 20240215. doi: 10.1002/emp2.13090. PubMed PMID: 38371660; PubMed Central PMCID: PMCPMC10869663.
  7. Jacquemyn X, Singh TP, Gossett JG, Averin K, Kutty S, Zuhlke LJ, Abdullahi LH, Kulkarni A. Mortality and Heart Transplantation After Hybrid Palliation of Hypoplastic Left Heart Syndrome: A Systematic Review and Meta-Analysis. World J Pediatr Congenit Heart Surg. 2024:21501351231224323. Epub 20240225. doi: 10.1177/21501351231224323. PubMed PMID: 38404131.
  8. Knapp WP, O'Leary ET, Quinn B, Porras D, Mah DY. Safety and efficacy of combined dilation/stenting of venous abnormalities, including complete obstructions, during lead extractions in patients with congenital heart disease. J Cardiovasc Electrophysiol. 2024. Epub 20240208. doi: 10.1111/jce.16202. PubMed PMID: 38332493.
  9. Liddle D, Gearhart A, Sleeper LA, Lu M, Feins E, Schidlow DN, Ghelani S, Powell AJ, Emani S, Beroukhim RS. Mitral Valve Orifice Area Predicts Outcome after Biventricular Repair in Patients with Hypoplastic Left Ventricles. J Cardiovasc Magn Reson. 2024:101029. Epub 20240223. doi: 10.1016/j.jocmr.2024.101029. PubMed PMID: 38403073.
  10. Lopez L, Saurers DL, Barker PCA, Cohen MS, Colan SD, Dwyer J, Forsha D, Friedberg MK, Lai WW, Printz BF, Sachdeva R, Soni-Patel NR, Truong DT, Young LT, Altman CA. Guidelines for Performing a Comprehensive Pediatric Transthoracic Echocardiogram: Recommendations From the American Society of Echocardiography. J Am Soc Echocardiogr. 2024;37(2):119-70. doi: 10.1016/j.echo.2023.11.015. PubMed PMID: 38309834.
  11. Mah DY. Wearable technology for heart rhythm monitoring in children. Heart Rhythm. 2024. Epub 20240206. doi: 10.1016/j.hrthm.2024.02.003. PubMed PMID: 38331305.
  12. Mayourian J, La Cava WG, Vaid A, Nadkarni GN, Ghelani SJ, Mannix R, Geva T, Dionne A, Alexander ME, Duong SQ, Triedman JK. Pediatric ECG-Based Deep Learning to Predict Left Ventricular Dysfunction and Remodeling. Circulation. 2024. Epub 20240205. doi: 10.1161/CIRCULATIONAHA.123.067750. PubMed PMID: 38314583.
  13. Michelena HI, Della Corte A, Evangelista A, Maleszewski JJ, Edwards WD, Roman MJ, Devereux RB, Fernandez B, Asch FM, Barker AJ, Sierra LM, de Kerchove L, Fernandes SM, Fedak PWM, Girdauskas E, Delgado V, Abbara S, Lansac E, Prakash SK, Bissell MM, Popescu BA, Hope MD, Sitges M, Thourani VH, Pibarot P, Chandrasekaran K, Lancellotti P, Borger MA, Forrest JK, Webb J, Milewicz DM, Makkar R, Leon MB, Sanders SP, Markl M, Ferrari VA, Roberts WC, Song JK, Blanke P, White CS, Siu S, Svensson LG, Braverman AC, Bavaria J, Sundt TM, El Khoury G, de Paulis R, Enriquez-Sarano M, Bax JJ, Otto CM, Schafers HJ. [Summary: International consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional and research purposes]. Arch Cardiol Mex. 2024. Epub 20240207. doi: 10.24875/ACM.24000002. PubMed PMID: 38325117.
  14. Milligan C, Williams RJ, Singh TP, Bastardi HJ, Esteso P, Almond CSD, Gauvreau K, Daly KP. Impact of a Positive Crossmatch on Pediatric Heart Transplant Outcomes. J Heart Lung Transplant. 2024. Epub 20240227. doi: 10.1016/j.healun.2024.02.1457. PubMed PMID: 38423415.
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  17. Prondzynski M, Pioner JM, Sala L, Bellin M, Meraviglia V. Editorial: Advances in pluripotent stem cell-based in vitro models of the human heart for cardiac physiology, disease modeling and clinical applications. Front Physiol. 2024;15:1378495. Epub 20240219. doi: 10.3389/fphys.2024.1378495. PubMed PMID: 38440346; PubMed Central PMCID: PMCPMC10910021.
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  23. Wu S, Yang P, Geng Z, Li Y, Guo Z, Lou Y, Zhang S, Xiong J, Hu H, Guo X, Pu WT, Zhang Y, Zhu D, Zhang B. Base editing effectively prevents early-onset severe cardiomyopathy in Mybpc3 mutant mice. Cell Res. 2024. Epub 20240209. doi: 10.1038/s41422-024-00930-7. PubMed PMID: 38337022.
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  25. Zaidi AH, Saleeb SF, Gurvitz M, Bucholz E, Gauvreau K, Jenkins KJ, de Ferranti SD. Social Determinants of Health Including Child Opportunity Index Leading to Gaps in Care for Patients With Significant Congenital Heart Disease. J Am Heart Assoc. 2024;13(4):e028883. Epub 20240214. doi: 10.1161/JAHA.122.028883. PubMed PMID: 38353239.
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January 2024
  1. Armenian SH, Hudson MM, Lindenfeld L, Chen S, Chow EJ, Colan S, Collier W, Su X, Marcus E, Echevarria M, Iukuridze A, Robison LL, Wong FL, Chen MH, Bhatia S. Effect of carvedilol versus placebo on cardiac function in anthracycline-exposed survivors of childhood cancer (PREVENT-HF): a randomised, controlled, phase 2b trial. Lancet Oncol. 2024;25(2):235-45. Epub 20240109. doi: 10.1016/S1470-2045(23)00637-X. PubMed PMID: 38215764.
  2. Boscamp NS, Maschietto N, Porras D. Transcatheter pulmonary valve replacement in surgically-created double-barrel right ventricular outflow tracts: A single center case-series. Catheter Cardiovasc Interv. 2024. Epub 20240111. doi: 10.1002/ccd.30954. PubMed PMID: 38204358.
  3. Broman MT, Nadadur RD, Perez-Cervantes C, Burnicka-Turek O, Lazarevic S, Gams A, Laforest B, Steimle JD, Iddir S, Wang Z, Smith L, Mazurek SR, Olivey HE, Zhou P, Gadek M, Shen KM, Khan Z, Theisen JWM, Yang XH, Ikegami K, Efimov IR, Pu WT, Weber CR, McNally EM, Svensson EC, Moskowitz IP. A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network. Circulation. 2024. Epub 20240108. doi: 10.1161/CIRCULATIONAHA.123.066804. PubMed PMID: 38189150.
  4. Brown SR, Assy J, Anderson MP, Thiagarajan RR, Brogan TV. Outcomes After Respiratory Extracorporeal Life Support in Teens and Young Adults: An Extracorporeal Life Support Organization Registry Analysis. Crit Care Med. 2024;52(1):11-9. Epub 20230905. doi: 10.1097/CCM.0000000000006049. PubMed PMID: 38095517.
  5. Day-Lewis M, Berbert L, Baker A, Dionne A, Newburger JW, Son MBF. Updated Case Definition of MIS-C and Implications for Clinical Care. Pediatrics. 2024;153(2). doi: 10.1542/peds.2023-063259. PubMed PMID: 38204335.
  6. Doulamis IP, Tzani A. Can mitochondria brown the lower-limb adipocytes? Mol Ther Methods Clin Dev. 2024;32(1):101181. Epub 20240105. doi: 10.1016/j.omtm.2023.101181. PubMed PMID: 38282897; PubMed Central PMCID: PMCPMC10818182.
  7. Jurow K, Gauvreau K, Maschietto N, Prakash A. Growth of the right ventricular outflow tract in repaired tetralogy of Fallot: A longitudinal CMR study. J Cardiovasc Magn Reson. 2024;26(1):100002. Epub 20240110. doi: 10.1016/j.jocmr.2023.100002. PubMed PMID: 38211659.
  8. Mandell JG, Romanowicz J, Loke YH, Ikeda N, Pena E, Siddiqi U, Hibino N, Alexander ME, Powell AJ, Olivieri LJ. Aortic arch shape after arch repair predicts exercise capacity: a multicentre analysis. Eur Heart J Open. 2024;4(1):oead138. Epub 20231226. doi: 10.1093/ehjopen/oead138. PubMed PMID: 38223303; PubMed Central PMCID: PMCPMC10786438.
  9. Mills KI, Albert BD, Bechard LJ, Chu S, Duggan CP, Kaza A, Rakoff-Nahoum S, Sleeper LA, Newburger JW, Priebe GP, Mehta NM. Stress Ulcer Prophylaxis Versus Placebo-A Blinded Pilot Randomized Controlled Trial to Evaluate the Safety of Two Strategies in Critically Ill Infants With Congenital Heart Disease. Pediatr Crit Care Med. 2024;25(2):118-27. Epub 20240119. doi: 10.1097/PCC.0000000000003384. PubMed PMID: 38240536; PubMed Central PMCID: PMCPMC10829532.
  10. Moynihan KM, Taylor LS, Siegel B, Nassar N, Lelkes E, Morrison W. "Death as the One Great Certainty": ethical implications of children with irreversible cardiorespiratory failure and dependence on extracorporeal membrane oxygenation. Front Pediatr. 2023;11:1325207. Epub 20240111. doi: 10.3389/fped.2023.1325207. PubMed PMID: 38274466; PubMed Central PMCID: PMCPMC10808631.
  11. Olsen FJ, Biering-Sorensen T, Lunze F, Hegde SM, Colan SD, Ehrbar R, Massaro J, Ferraro AM, Harrild DM, Kleinman ME, Gordon LB, Prakash A. Abnormal Myocardial Deformation Despite Normal Ejection Fraction in Hutchinson-Gilford Progeria Syndrome. J Am Heart Assoc. 2024:e031470. Epub 20240131. doi: 10.1161/JAHA.123.031470. PubMed PMID: 38293952.
  12. Park C, Singh M, Saeed MY, Nguyen CT, Roche ET. Biorobotic hybrid heart as a benchtop cardiac mitral valve simulator. Device. 2024;2(1). Epub 20240110. doi: 10.1016/j.device.2023.100217. PubMed PMID: 38312504; PubMed Central PMCID: PMCPMC10836162.
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