Myeloproliferative Neoplasms (MPNs) | Diagnosis & Treatment

How are myeloproliferative neoplasms diagnosed?

To diagnosis a myeloproliferative neoplasm (MPN), your doctor will complete a physical examination and request a thorough health history.

A series of tests will be performed to confirm the diagnosis, including:

  • complete blood count looking at the total number and type of blood cells in the blood
  • blood smear to examine you or your child’s blood under a microscope
  • bone marrow aspiration and biopsy for a definitive diagnosis
  • cytogenetic analysis to see whether chromosomes are abnormal
  • sequencing analysis of blood or bone marrow for common mutations causing MPNs 

How are MPNs treated?

MPNs cannot be cured, but there are a number of different ways to manage the type of condition to safeguard short- and long-term health. Low-risk MPNs can be treated with low-dose aspirin along with a phlebotomy to reduce the risk of a blood clot. Higher-risk MPNs will require treatments to manage overactive blood cell production, such as chemotherapy, radiation therapy, stem cell transplant, splenectomy, or targeted therapies.

Clinical trials may offer additional treatment options and promising new treatments or procedures.