Current Environment:

Summary

The study objective is to compare neurodevelopmental (ND) and behavioral outcomes between children with Down syndrome (DS) who had complete atrioventricular septal defect (CAVSD) repair and children from the same clinical sites with DS without major congenital heart disease (CHD) requiring previous or planned CHD surgery.

Conditions

Down Syndrome, Congenital Heart Disease

Recruitment Status

Recruiting

Detailed Description

We will conduct a multicenter cohort study, ancillary to the Pediatric Heart Network (PHN) Residual Lesion Score (RLS) study, to investigate determinants of ND and behavioral outcomes in children with DS, focusing on the role of CHD surgery. We will only include RLS Study children with DS who had CAVSD repair, as this group comprises 91% of all children with DS in the RLS Study, with similar underlying congenital cardiac defect and surgical repair complexity, allowing our children with DS and CHD to be a homogeneous group. Moreover, one in five individuals with DS is born with an AVSD, a 2000 times higher incidence than in those with normal chromosomes. In addition to recruiting RLS Study children with DS who had CAVSD repair, we will recruit similarly-aged children with DS who do not have documented major CHD (i.e., CHD requiring previous or planned CHD surgery) to come into the same PHN site for a single study visit consisting of detailed phenotyping by completion of a Health & Developmental History Intake form, ND and behavioral assessments, and optional collection and storage of saliva specimens in the PHN Biorepository. By building our sample from RLS Study participants and recruiting a comparison group from the same PHN sites, we will leverage rich prospective data in a group of DS children with CAVSD repair from a nationally representative sample, and the expertise of the PHN and Boston Children's Hospital (BCH).

Eligibility Criteria

Inclusion Criteria:

Down Syndrome CAVSD Repair Group:

Trisomy 21
Male or Female, age 5 years through 8 years
Pediatric Heart Network (PHN) Residual Lesion Score (RLS) study participant having CAVSD repair within the first year of life at a subset of recruitment sites
Parent or guardian and patient willing to comply with protocol, complete all study assessments, and provide written informed consent using the English language
Child and parent able to speak and understand English

Down Syndrome Comparison Group

Trisomy 21
Male or Female, age 5 years through 8 years
No major CHD, defined as CHD requiring previous or planned CHD surgery
Parent or guardian and patient willing to comply with protocol, complete all study assessments, and provide written informed consent using the English language
Child and parent able to speak and understand English

Exclusion Criteria:

Both Groups

- Mosaic DS

Down Syndrome CAVSD Repair Group only - Not a participant in the PHN RLS Study

Down Syndrome Comparison Group only

- Major CHD requiring previous or planned CHD surgery - i.e., CHD surgery occurring (a) in the period between birth and time of recruitment into the CHILD-DS Study, or (b) planned for a future date.

Intervention

Intervention Type

Intervention Name

Other

Stanford Binet Intelligence Scales, Fifth Edition

Other

Vineland Adaptive Behavior Scales Third Edition

Other

Peabody Picture Vocabulary Test, Fifth Edition

Other

Expressive Vocabulary Test, Third Edition

Other

Leiter International Performance Scale, Third Edition

Other

Social Communication Questionnaire, Current Form

Other

Aberrant Behavior Checklist

Other

Repetitive Behavior Scale, Revised

Gender

All

Min Age

60 Months

Max Age

108 Months

Download Date

August 5, 2022

Principal Investigator

Meena Nathan

This field has been modified from ClinicalTrials.gov to show a contact specific to Boston Children's.

Primary Contact Information

Lisa Jean Buckley
lisajean.buckley@cardio.chboston.org
617-355-5421

This field has been modified from ClinicalTrials.gov to show a contact specific to Boston Children's.

For more information on this trial, visit clinicaltrials.gov.

Contact

For more information and to contact the study team: