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Indoor Air Quality and Respiratory Morbidity in School-Aged Children With BPD

ClinicalTrials.gov ID: NCT04107701

Summary

Investigators want to learn the role of indoor environmental exposures on respiratory symptoms, and, separately, on lung function deficits in school-aged children with bronchopulmonary dysplasia (BPD).

Conditions

Bronchopulmonary Dysplasia

Chronic Lung Disease of Newborn

Environmental Exposure

Recruitment Status

Recruiting

Details

Detailed Description

Bronchopulmonary dysplasia (BPD) is the most common respiratory disease affecting children born prematurely and leads to long-term respiratory symptoms and lung function impairment throughout childhood. This study will, evaluate the contribution of indoor sources of respiratory irritants to respiratory health impairment in school-aged children with BPD. State-of-the-art measures of indoor air quality constituents will assess the relationship of nitrogen dioxide (NO2), particulate matter (PM2.5), as well as, concentrations of allergens (mold, mouse, cockroach, pet), endotoxin, air temperature and humidity with concurrently measured respiratory symptoms and lung function in a well-characterized cohort of children with BPD. This research will identify specific harmful components of the indoor environment associated with respiratory morbidity and poor lung function in children with BPD. Investigators will ask the participants to come in for a one time clinic visit for undergoing procedures as well as answering questions regarding health and home environment. During the 1 year of participation there will also be 2 home assessment visits where investigators will take a sample of the home environment as well record home characteristics.

Eligibility Criteria


Inclusion Criteria:

- children 6-12 yrs old

- born <32 wks gestational age

- diagnosis of BPD or > 28 days of oxygen or respiratory support

Exclusion Criteria:

- major airway or chest surgery

- physical or mental impairment that will prevent from doing spirometry

- plans to move out of state within the next 9 months

Gender

All

Minimum Age

6 Years

Maximum Age

12 Years

Download Date

October 02, 2019

Principal Investigator

Jonathan Gaffin

Primary Contact Information

Jonathan Gaffin, MD. MMSc.
857-218-5336
jonathan.gaffin@childrens.harvard.edu


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For more information on this trial, visit clinicaltrials.gov.

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