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Summary

In this research study we want to learn more about the characteristics of neutrophils that are present in the blood and secretions from a breathing tube of patients with sepsis. Sepsis is a severe type of infection, affecting various parts of the body. Neutrophils are a type of white blood cell that are part of the body's immune system. Even though neutrophils are important in getting rid of germs, they also may be harmful to parts of the body by causing injury in the lungs in patients with sepsis. Neutrophils can change their character in sepsis. Because of this, it is important for doctors to know what kind of neutrophils are in the blood and secretions from the breathing tube of patients with sepsis so that they can work to develop therapies to prevent these cells from being harmful.

Conditions

Sepsis

Recruitment Status

Recruiting

Eligibility Criteria

Case Inclusion Criteria:

sepsis patient in the ICU with a breathing tube

Control Inclusion Criteria:

scheduled for an elective surgical procedure and need preoperative blood draw or will have an intravenous catheter placed for the purpose of their surgical procedure
Plan to have endotracheal tube for planned procedures.

Exclusion Criteria:

On chronic immunosuppressive drugs such as chronic corticosteroid use, or preexisting immunodeficiency diseases (oncology patients, patients with transplantation)

Intervention

Intervention Type

Intervention Name

Other

Sepsis

Gender

All

Min Age

2 Years

Max Age

50 Years

Download Date

August 9, 2022

Principal Investigator

Koichi Yuki

Primary Contact Information

Koichi Yuki, MD

617-355-6225

koichi.yuki@childrens.harvard.edu

For more information on this trial, visit clinicaltrials.gov.

Contact

For more information and to contact the study team: