Conduct a cross-sectional analysis of the nutritional status of individuals with PKU treated with pegvaliase for one or more years or who have followed an unrestricted diet for 6 or more months while on pegvaliase treatment. We will evaluate laboratory markers of nutritional status, including markers of protein and micronutrient nutriture. In addition, a three-day food record and food frequency questionnaire will be obtained to assess protein intake and overall diet quality.
Diagnosis of phenylketonuria
Aged 18-65 years
Currently treated with pegvaliase
Have either 1) received treatment with pegvaliase for one or more years or 2) followed an unrestricted diet for 6 or more months while on pegvaliase
Currently following an unrestricted diet that meets or exceeds the RDA for protein (0.8 g/kg/day)
Unable to consent to study
Under age 18 years or over age 65
Routine food intake provides less than the RDA for protein (0.8 g/kg/d)
Consuming any PKU medical foods
March 4, 2021
Primary Contact Information
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