Current Environment:


Acute kidney injury (AKI) is common in children after cardiac surgery with a reported incidence of 20-40%. Pediatric AKI has been found to be associated with important short and long-term adverse outcomes. A major challenge to management of AKI after cardiac surgery and cardiopulmonary bypass is the lack of early diagnostic markers. Current diagnostic criteria for AKI in children relies exclusively on elevation of serum creatinine concentration and oliguria. Both of these markers lack sensitivity and specificity, and result in delayed detection of kidney injury. This study aims to determine if UDP-glucose can be used as a urinary biomarker to detect subclinical acute kidney injury following pediatric cardiac surgery with cardiopulmonary bypass.


Acute Kidney Injury

Recruitment Status


Eligibility Criteria

Inclusion Criteria:

less than or equal to 8 years of age
scheduled for cardiac surgery

Exclusion Criteria:

severe pre-existing renal insufficiency


Intervention Type

Intervention Name


Discarded urine sample



Min Age


Max Age

8 Years

Download Date

February 17, 2023

Principal Investigator

Douglas Atkinson

Primary Contact Information

Douglas Atkinson, MD


Rachel Bernier, MPH


For more information on this trial, visit


For more information and to contact the study team:

Evaluation of UDP-glucose as a Urinary Biomarker for Early Detection of Cardiac Surgery-associated Pediatric Acute Kidney Injury NCT03263325 Douglas Atkinson, MD 617-355-6225 Rachel Bernier, MPH 857-218-5348