Current Environment:

Summary

Acute kidney injury (AKI) is common in children after cardiac surgery with a reported incidence of 20-40%. Pediatric AKI has been found to be associated with important short and long-term adverse outcomes. A major challenge to management of AKI after cardiac surgery and cardiopulmonary bypass is the lack of early diagnostic markers. Current diagnostic criteria for AKI in children relies exclusively on elevation of serum creatinine concentration and oliguria. Both of these markers lack sensitivity and specificity, and result in delayed detection of kidney injury. This study aims to determine if UDP-glucose can be used as a urinary biomarker to detect subclinical acute kidney injury following pediatric cardiac surgery with cardiopulmonary bypass.

Conditions

Acute Kidney Injury

Recruitment Status

Recruiting

Eligibility Criteria

Inclusion Criteria:

less than or equal to 8 years of age
scheduled for cardiac surgery

Exclusion Criteria:

severe pre-existing renal insufficiency

Intervention

Intervention Type

Intervention Name

Other

Discarded urine sample

Gender

All

Minimum Age

N/A

Maximum Age

8 Years

Download Date

February 1, 2022

Principal Investigator

Douglas Atkinson

Primary Contact Information

Douglas Atkinson, MD

617-355-6225

Douglas.Atkinson@childrens.harvard.edu

Rachel Bernier, MPH

857-218-5348

Rachel.Bernier@childrens.harvard.edu

For more information on this trial, visit clinicaltrials.gov.

Contact

For more information and to contact the study team: