Summary
Acute kidney injury (AKI) is common in children after cardiac surgery with a reported incidence of 20-40%. Pediatric AKI has been found to be associated with important short and long-term adverse outcomes. A major challenge to management of AKI after cardiac surgery and cardiopulmonary bypass is the lack of early diagnostic markers. Current diagnostic criteria for AKI in children relies exclusively on elevation of serum creatinine concentration and oliguria. Both of these markers lack sensitivity and specificity, and result in delayed detection of kidney injury. This study aims to determine if UDP-glucose can be used as a urinary biomarker to detect subclinical acute kidney injury following pediatric cardiac surgery with cardiopulmonary bypass.
Conditions
Acute Kidney Injury
Recruitment Status
Recruiting
Eligibility Criteria
Inclusion Criteria:
less than or equal to 8 years of age
scheduled for cardiac surgery
Exclusion Criteria:
severe pre-existing renal insufficiency
Intervention
Intervention Type
Intervention Name
Other
Discarded urine sample
Gender
All
Min Age
N/A
Max Age
8 Years
Download Date
February 17, 2023
Principal Investigator
Douglas Atkinson
Primary Contact Information
For more information on this trial, visit clinicaltrials.gov.
Contact
For more information and to contact the study team: