Current Environment: Production

Medical Services

Specialties

Programs & Services

Languages

  • English

Education

Undergraduate School

Johns Hopkins University

Baltimore, MD

Medical School

Harvard Medical School

Boston, MA

Residency

Pediatrics

Boston Combined Residency Program (BCRP)

Boston, MA

Fellowship

Harvard Program in Neonatal-Perinatal Medicine

Boston, MA

Certifications

  • American Board of Pediatrics (General)
  • American Board of Pediatrics (Neonatal-Perinatal Medicine)

Professional History

Dr. Brian Kalish is a neonatologist and neurobiologist with a special interest in neonatal neuroprotection and plasticity. Dr. Kalish studied Public Health at Johns Hopkins and completed medical school at Harvard. After residency in the Boston Combined Program in Pediatrics on the Accelerated Research Pathway, he completed fellowship in the Harvard Program in Neonatal-Perinatal Medicine. Dr. Kalish was a Staff Neonatologist, Director of Neonatology Research, and Scientist in the Program in Neuroscience and Mental Health at the Hospital for Sick Children before returning to Boston Children's Hospital in 2024. His clinical expertise is in neonatal neuroscience and his research focuses on understanding how intrauterine and early life experience shapes neurodevelopment.

Publications

  1. Postnatal management of preterm infants with congenital diaphragmatic hernia. Pediatr Surg Int. 2025 Jan 16; 41(1):67. View Abstract

  2. Neonatal Brain Injury Triggers Niche-Specific Changes to Cellular Biogeography. eNeuro. 2024 Dec; 11(12). View Abstract

  3. Automated Neuroprognostication Via Machine Learning in Neonates with Hypoxic-Ischemic Encephalopathy. Ann Neurol. 2025 Apr; 97(4):791-802. View Abstract

  4. Remote ischemic post-conditioning for neonatal encephalopathy: a safety and feasibility trial. Pediatr Res. 2024 Oct 12. View Abstract

  5. Prognostic Indicators of Reorientation of Care in Perinatal Hypoxic-Ischemic Encephalopathy Spectrum. J Pediatr. 2025 Jan; 276:114273. View Abstract

  6. Blood product transfusion practices in neonates with hypoxic-ischemic encephalopathy. J Perinatol. 2024 Oct; 44(10):1485-1490. View Abstract

  7. Fetal hypoplastic lungs have multilineage inflammation that is reversed by amniotic fluid stem cell extracellular vesicle treatment. Sci Adv. 2024 Jul 26; 10(30):eadn5405. View Abstract

  8. Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticity. Nat Commun. 2024 Jul 13; 15(1):5898. View Abstract

  9. Translating regenerative medicine therapies in neonatal necrotizing enterocolitis. Pediatr Res. 2024 Dec; 96(7):1609-1615. View Abstract

  10. Small but mighty: the rise of microprotein biology in neuroscience. Front Mol Neurosci. 2024; 17:1386219. View Abstract

  11. Proceedings of the 15th International Newborn Brain Conference: Neuroprotection strategies in the neonate. J Neonatal Perinatal Med. 2024; 17(3):S317-S344. View Abstract

  12. Neonatal Hypoxic-Ischemic Encephalopathy Spectrum: Severity-Stratified Analysis of Neuroimaging Modalities and Association with Neurodevelopmental Outcomes. J Pediatr. 2024 Mar; 266:113866. View Abstract

  13. Single-Nucleus Profiling Identifies Accelerated Oligodendrocyte Precursor Cell Senescence in a Mouse Model of Down Syndrome. eNeuro. 2023 08; 10(8). View Abstract

  14. ?-Protocadherins control synapse formation and peripheral branching of touch sensory neurons. Neuron. 2023 06 07; 111(11):1776-1794.e10. View Abstract

  15. Neurodevelopmental outcomes after neonatal surgery. Pediatr Surg Int. 2022 Nov 30; 39(1):22. View Abstract

  16. Developmental dynamics of RNA translation in the human brain. Nat Neurosci. 2022 10; 25(10):1353-1365. View Abstract

  17. The Genomic Architecture of Pregnancy-Associated Plasticity in the Maternal Mouse Hippocampus. eNeuro. 2022 Sep-Oct; 9(5). View Abstract

  18. ECI Biocommentary: Brian T. Kalish. Pediatr Res. 2022 Apr; 91(5):1017. View Abstract

  19. Repetitive Mild Closed Head Injury in Adolescent Mice Is Associated with Impaired Proteostasis, Neuroinflammation, and Tauopathy. J Neurosci. 2022 03 23; 42(12):2418-2432. View Abstract

  20. Subclinical Electrographic Seizures in the Newborn-Is More Treatment Better? JAMA Netw Open. 2021 12 01; 4(12):e2140677. View Abstract

  21. Single-cell immunophenotyping of the fetal immune response to maternal SARS-CoV-2 infection in late gestation. Pediatr Res. 2022 04; 91(5):1090-1098. View Abstract

  22. Neuronal SETD2 activity links microtubule methylation to an anxiety-like phenotype in mice. Brain. 2021 09 04; 144(8):2527-2540. View Abstract

  23. Acetazolamide Improves Right Ventricular Function and Metabolic Gene Dysregulation in Experimental Pulmonary Arterial Hypertension. Front Cardiovasc Med. 2021; 8:662870. View Abstract

  24. Single-cell immunophenotyping of the fetal immune response to maternal SARS-CoV-2 infection in late gestation. Res Sq. 2021 Mar 16. View Abstract

  25. Maternal immune activation in mice disrupts proteostasis in the fetal brain. Nat Neurosci. 2021 02; 24(2):204-213. View Abstract

  26. The impact of maternal obesity on childhood neurodevelopment. J Perinatol. 2021 05; 41(5):928-939. View Abstract

  27. Risk Factors for Mortality and Circulatory Outcome Among Neonates Prenatally Diagnosed With Ebstein Anomaly or Tricuspid Valve Dysplasia: A Multicenter Study. J Am Heart Assoc. 2020 11 03; 9(21):e016684. View Abstract

  28. Single-nucleus RNA sequencing of mouse auditory cortex reveals critical period triggers and brakes. Proc Natl Acad Sci U S A. 2020 05 26; 117(21):11744-11752. View Abstract

  29. Factors Associated With Mortality in Children Who Successfully Wean From Extracorporeal Membrane Oxygenation. Pediatr Crit Care Med. 2018 09; 19(9):875-883. View Abstract

  30. Visual Experience-Dependent Expression of Fn14 Is Required for Retinogeniculate Refinement. Neuron. 2018 08 08; 99(3):525-539.e10. View Abstract

  31. Discovery of proteins associated with a predefined genomic locus via dCas9-APEX-mediated proximity labeling. Nat Methods. 2018 06; 15(6):437-439. View Abstract

  32. Single-cell transcriptomics of the developing lateral geniculate nucleus reveals insights into circuit assembly and refinement. Proc Natl Acad Sci U S A. 2018 01 30; 115(5):E1051-E1060. View Abstract

  33. Sonographic Pulmonary Abnormalities in Fetuses With Hypoplastic Left Heart Syndrome and Intact Atrial Septum Undergoing Attempted Atrial Septostomy In Utero. Ultrasound Q. 2017 Mar; 33(1):82-85. View Abstract

  34. Management of Neonatal Hypotension. Neonatal Netw. 2017 Jan 01; 36(1):40-47. View Abstract

  35. Association of Extracorporeal Membrane Oxygenation Support Adequacy and Residual Lesions With Outcomes in Neonates Supported After Cardiac Surgery. Pediatr Crit Care Med. 2016 11; 17(11):1045-1054. View Abstract

  36. Assessment of Progressive Pathophysiology After Early Prenatal Diagnosis of the Ebstein Anomaly or Tricuspid Valve Dysplasia. Am J Cardiol. 2017 Jan 01; 119(1):106-111. View Abstract

  37. Weight Drop Models in Traumatic Brain Injury. Methods Mol Biol. 2016; 1462:193-209. View Abstract

  38. The Impact of Institutional Review Boards (IRBs) on Clinical Innovation: A Survey of Investigators and IRB Members. J Empir Res Hum Res Ethics. 2015 Dec; 10(5):481-7. View Abstract

  39. Clinically Relevant Mechanisms of Lipid Synthesis, Transport, and Storage. JPEN J Parenter Enteral Nutr. 2015 Sep; 39(1 Suppl):8S-17S. View Abstract

  40. Outcomes and Predictors of Perinatal Mortality in Fetuses With Ebstein Anomaly or Tricuspid Valve Dysplasia in the Current Era: A Multicenter Study. Circulation. 2015 Aug 11; 132(6):481-9. View Abstract

  41. Dietary ?-3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease. Haematologica. 2015 Jul; 100(7):870-80. View Abstract

  42. Associations of prenatal maternal blood mercury concentrations with early and mid-childhood blood pressure: a prospective study. Environ Res. 2014 Aug; 133:327-33. View Abstract

  43. Perinatal and infant outcomes of prenatal diagnosis of heterotaxy syndrome (asplenia and polysplenia). Am J Cardiol. 2014 Aug 15; 114(4):612-7. View Abstract

  44. In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight. Nat Nanotechnol. 2014 Aug; 9(8):648-655. View Abstract

  45. Takedown of cavopulmonary shunt at biventricular repair. J Thorac Cardiovasc Surg. 2014 Oct; 148(4):1506-11. View Abstract

  46. Technical challenges of atrial septal stent placement in fetuses with hypoplastic left heart syndrome and intact atrial septum. Catheter Cardiovasc Interv. 2014 Jul 01; 84(1):77-85. View Abstract

  47. Reply to letter: "Prehospital intravenous fluid administration is associated with higher mortality in trauma patients". Ann Surg. 2014 Feb; 259(2):e20-1. View Abstract

  48. Reply to letter: "Prehospital intravenous fluid administration is associated with higher mortality in trauma patients". Ann Surg. 2014 Feb; 259(2):e23. View Abstract

  49. Docosahexaenoic acid, G protein-coupled receptors, and melanoma: is G protein-coupled receptor 40 a potential therapeutic target? J Surg Res. 2014 May 15; 188(2):451-8. View Abstract

  50. Intravenous fish oil lipid emulsion promotes a shift toward anti-inflammatory proresolving lipid mediators. Am J Physiol Gastrointest Liver Physiol. 2013 Dec; 305(11):G818-28. View Abstract

  51. Biventricular conversion after single ventricle palliation in patients with small left heart structures: short-term outcomes. Ann Thorac Surg. 2013 Oct; 96(4):1406-1412. View Abstract

  52. Epoxyeicosanoids promote organ and tissue regeneration. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13528-33. View Abstract

  53. The growing role of eicosanoids in tissue regeneration, repair, and wound healing. Prostaglandins Other Lipid Mediat. 2013 Jul-Aug; 104-105:130-8. View Abstract

  54. A.S.P.E.N. clinical guidelines: nutrition support of neonatal patients at risk for metabolic bone disease. JPEN J Parenter Enteral Nutr. 2013 Sep; 37(5):570-98. View Abstract

  55. A metabolomic analysis of two intravenous lipid emulsions in a murine model. PLoS One. 2013; 8(4):e59653. View Abstract

  56. The role of the ?-3 fatty acid DHA in the human life cycle. JPEN J Parenter Enteral Nutr. 2013 Jan; 37(1):15-22. View Abstract

  57. The effect of varying ratios of docosahexaenoic acid and arachidonic acid in the prevention and reversal of biochemical essential fatty acid deficiency in a murine model. Metabolism. 2013 Apr; 62(4):499-508. View Abstract

  58. Quality assessment in pancreatic surgery: what might tomorrow require? J Gastrointest Surg. 2013 Jan; 17(1):86-93; discussion p.93. View Abstract

  59. Dietary fish oil aggravates paracetamol-induced liver injury in mice. JPEN J Parenter Enteral Nutr. 2013 Mar; 37(2):268-73. View Abstract

  60. A tutorial on fatty acid biology. JPEN J Parenter Enteral Nutr. 2012 Jul; 36(4):380-8. View Abstract

  61. HIV testing in emergency departments in the United States: a national survey. Ann Emerg Med. 2011 Jul; 58(1 Suppl 1):S10-6.e1-8. View Abstract

  62. Operational methods of HIV testing in emergency departments: a systematic review. Ann Emerg Med. 2011 Jul; 58(1 Suppl 1):S96-103. View Abstract

  63. Prehospital intravenous fluid administration is associated with higher mortality in trauma patients: a National Trauma Data Bank analysis. Ann Surg. 2011 Feb; 253(2):371-7. View Abstract

  64. Serial amnioinfusions prevent fetal pulmonary hypoplasia in a large animal model of oligohydramnios. J Pediatr Surg. 2011 Jan; 46(1):67-71. View Abstract

  65. Systematic review and meta-analysis of steatosis as a risk factor in major hepatic resection. Br J Surg. 2010 Sep; 97(9):1331-9. View Abstract

  66. Spine immobilization in penetrating trauma: more harm than good? J Trauma. 2010 Jan; 68(1):115-20; discussion 120-1. View Abstract

  67. National survey of Laboratory Response Network sentinel laboratory preparedness. Disaster Med Public Health Prep. 2009 Jun; 3(2 Suppl):S17-23. View Abstract

  68. Population immunity to measles virus and the effect of HIV-1 infection after a mass measles vaccination campaign in Lusaka, Zambia: a cross-sectional survey. Lancet. 2009 Mar 21; 373(9668):1025-32. View Abstract

  69. Update on emerging infections: news from the Centers for Disease Control and Prevention. False-positive oral fluid rapid HIV tests--New York City, 2005-2008. Ann Emerg Med. 2009 Jan; 53(1):151-4; discussion 154-6. View Abstract
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