Barbara O'Brien | Medical Services
Programs & Services
Languages
- English
Barbara O'Brien | Education
Medical School
New York Medical College
Valhalla, NY
Internship
Obstetrics and Gynecology
Tufts Medical Center
Boston, MA
Residency
Obstetrics and Gynecology
Tufts Medical Center
Boston, MA
Fellowship
Maternal-Fetal Medicine/Medical Genomics
Tufts Medical Center
Boston, MA
Barbara O'Brien | Professional History
Dr. O’Brien is a maternal-fetal medicine specialist at Beth Israel Deaconess Medical Center (BIDMC). She is triple-board certified in Obstetrics and Gynecology, Maternal-Fetal Medicine, as well as Medical Genetics and Genomics, and is an Associate Professor at Harvard Medical School. She completed her residency and fellowship trainings at Tufts Medical Center. Her clinical interests include medical complications of pregnancy, non-invasive prenatal genetic testing and prenatal diagnosis. She also serves as the Program Director of the Maternal-Fetal Medicine Fellowship and the newly combined Maternal-Fetal Medicine/Genetics and Genomics Fellowship at BIDMC and Boston Children’s Hospital. In addition to her faculty position at BIDMC, she works in collaboration with the Fetal Care and Surgery Center at Boston Children's Hospital to provide consultations to patients with complex fetal conditions.
Barbara O'Brien | Publications
Caudal regression in fetus with de novo SMARCA2 pathogenic variant. Prenat Diagn. 2024 08; 44(9):1111-1114. View Caudal regression in fetus with de novo SMARCA2 pathogenic variant. Abstract
Prenatal Screening and Diagnosis: Time for a Paradigm Shift. Am J Perinatol. 2025 Mar; 42(4):538-545. View Prenatal Screening and Diagnosis: Time for a Paradigm Shift. Abstract
RASopathies are the most common set of monogenic syndromes identified by exome sequencing for nonimmune hydrops fetalis: A systematic review and meta-analysis. Am J Med Genet A. 2024 05; 194(5):e63494. View RASopathies are the most common set of monogenic syndromes identified by exome sequencing for nonimmune hydrops fetalis: A systematic review and meta-analysis. Abstract
Cochrane update: news and reviews from the Cochrane US Network. Am J Obstet Gynecol MFM. 2024 02; 6(2):101255. View Cochrane update: news and reviews from the Cochrane US Network. Abstract
Clinician communication after discovery of a soft marker of aneuploidy during pregnancy: A mixed methods assessment of a communication workshop. J Gynecol Obstet Hum Reprod. 2023 Nov; 52(9):102652. View Clinician communication after discovery of a soft marker of aneuploidy during pregnancy: A mixed methods assessment of a communication workshop. Abstract
Low fetal fraction of cell-free DNA predicts placental dysfunction and hypertensive disease in pregnancy. Pregnancy Hypertens. 2019 Apr; 16:148-153. View Low fetal fraction of cell-free DNA predicts placental dysfunction and hypertensive disease in pregnancy. Abstract
Risk of ischemic placental disease in fresh and frozen embryo transfer cycles. Fertil Steril. 2019 04; 111(4):714-721. View Risk of ischemic placental disease in fresh and frozen embryo transfer cycles. Abstract
What education, background, and credentials are required to provide genetic counseling? Semin Perinatol. 2018 08; 42(5):290-295. View What education, background, and credentials are required to provide genetic counseling? Abstract
Peripartum management of HLA alloimmune platelet refractoriness. Transfusion. 2018 07; 58(7):1583-1587. View Peripartum management of HLA alloimmune platelet refractoriness. Abstract
Cell-Free DNA: Screening for Single-Gene Disorders and Determination of Fetal Rhesus D Genotype. Obstet Gynecol Clin North Am. 2018 Mar; 45(1):27-39. View Cell-Free DNA: Screening for Single-Gene Disorders and Determination of Fetal Rhesus D Genotype. Abstract
Relaxin-2 connecting peptide (pro-RLX2) levels in second trimester serum samples to predict preeclampsia. Pregnancy Hypertens. 2018 Jan; 11:124-128. View Relaxin-2 connecting peptide (pro-RLX2) levels in second trimester serum samples to predict preeclampsia. Abstract
Separate transcriptionally regulated pathways specify distinct classes of sister dendrites in a nociceptive neuron. Dev Biol. 2017 12 15; 432(2):248-257. View Separate transcriptionally regulated pathways specify distinct classes of sister dendrites in a nociceptive neuron. Abstract
How Should Clinicians Counsel a Woman with a Strong Family History of Early-Onset Alzheimer's Disease about Her Pregnancy? AMA J Ethics. 2017 Jul 01; 19(7):663-674. View How Should Clinicians Counsel a Woman with a Strong Family History of Early-Onset Alzheimer's Disease about Her Pregnancy? Abstract
Nuchal translucency measurement in the era of prenatal screening for aneuploidy using cell free (cf)DNA. Prenat Diagn. 2017 03; 37(3):303-305. View Nuchal translucency measurement in the era of prenatal screening for aneuploidy using cell free (cf)DNA. Abstract
The clinical utility of DNA-based screening for fetal aneuploidy by primary obstetrical care providers in the general pregnancy population. Genet Med. 2017 07; 19(7):778-786. View The clinical utility of DNA-based screening for fetal aneuploidy by primary obstetrical care providers in the general pregnancy population. Abstract
Neurodevelopment: Three's a Crowd, Four Is a Receptor Complex. Curr Biol. 2016 09 12; 26(17):R799-801. View Neurodevelopment: Three's a Crowd, Four Is a Receptor Complex. Abstract
The North American Fetal Therapy Network Consensus Statement: prenatal management of uncomplicated monochorionic gestations. Obstet Gynecol. 2015 May; 125(5):1236-1243. View The North American Fetal Therapy Network Consensus Statement: prenatal management of uncomplicated monochorionic gestations. Abstract
Managing Multi-Center Recruitment in the PLCO Cancer Screening Trial. Rev Recent Clin Trials. 2015; 10(3):187-93. View Managing Multi-Center Recruitment in the PLCO Cancer Screening Trial. Abstract
Comprehensive Quality Management (CQM) in the PLCO Trial. Rev Recent Clin Trials. 2015; 10(3):223-32. View Comprehensive Quality Management (CQM) in the PLCO Trial. Abstract
The North American Fetal Therapy Network consensus statement: prenatal surveillance of uncomplicated monochorionic gestations. Obstet Gynecol. 2015 Jan; 125(1):118-123. View The North American Fetal Therapy Network consensus statement: prenatal surveillance of uncomplicated monochorionic gestations. Abstract
Iatrogenic Preterm Premature Rupture of Membranes after Fetoscopic Laser Ablative Surgery. Fetal Diagn Ther. 2015; 38(1):29-34. View Iatrogenic Preterm Premature Rupture of Membranes after Fetoscopic Laser Ablative Surgery. Abstract
Evaluation of patient education materials: the example of circulating cell free DNA testing for aneuploidy. J Genet Couns. 2015 Apr; 24(2):259-66. View Evaluation of patient education materials: the example of circulating cell free DNA testing for aneuploidy. Abstract
Maternal plasma DNA testing: experience of women counseled at a prenatal diagnosis center. Genet Test Mol Biomarkers. 2014 Oct; 18(10):665-9. View Maternal plasma DNA testing: experience of women counseled at a prenatal diagnosis center. Abstract
In reply. Obstet Gynecol. 2014 Aug; 124(2 Pt 1):379-380. View In reply. Abstract
Fetal craniopharyngioma: management, postmortem diagnosis, and literature review of an intracranial tumor detected in utero. Pediatr Dev Pathol. 2014 Sep-Oct; 17(5):409-12. View Fetal craniopharyngioma: management, postmortem diagnosis, and literature review of an intracranial tumor detected in utero. Abstract
Maternal and fetal safety of fluid-restrictive general anesthesia for endoscopic fetal surgery in monochorionic twin gestations. J Clin Anesth. 2014 May; 26(3):184-90. View Maternal and fetal safety of fluid-restrictive general anesthesia for endoscopic fetal surgery in monochorionic twin gestations. Abstract
Noninvasive prenatal testing for microdeletion syndromes and expanded trisomies: proceed with caution. Obstet Gynecol. 2014 May; 123(5):1097-1099. View Noninvasive prenatal testing for microdeletion syndromes and expanded trisomies: proceed with caution. Abstract
Monochorionic twins discordant for mosaic trisomy 14. Am J Med Genet A. 2014 May; 164A(5):1227-33. View Monochorionic twins discordant for mosaic trisomy 14. Abstract
Maternal plasma DNA testing for aneuploidy in pregnancies achieved by assisted reproductive technologies. Genet Med. 2014 May; 16(5):419-22. View Maternal plasma DNA testing for aneuploidy in pregnancies achieved by assisted reproductive technologies. Abstract
Karyotype versus microarray testing for genetic abnormalities after stillbirth. N Engl J Med. 2012 Dec 06; 367(23):2185-93. View Karyotype versus microarray testing for genetic abnormalities after stillbirth. Abstract
Midwifery and obstetrics: twenty years of collaborative academic practice. Obstet Gynecol Clin North Am. 2012 Sep; 39(3):335-46. View Midwifery and obstetrics: twenty years of collaborative academic practice. Abstract
Colorectal-cancer incidence and mortality with screening flexible sigmoidoscopy. N Engl J Med. 2012 Jun 21; 366(25):2345-57. View Colorectal-cancer incidence and mortality with screening flexible sigmoidoscopy. Abstract
Long-term morbidity after fetal endoscopic surgery for severe twin-to-twin transfusion syndrome. J Pediatr Surg. 2012 Jan; 47(1):51-6. View Long-term morbidity after fetal endoscopic surgery for severe twin-to-twin transfusion syndrome. Abstract
Laser ablation of placental vessels in twin-to-twin transfusion syndrome: a paradigm for endoscopic fetal surgery. J Laparoendosc Adv Surg Tech A. 2011 Nov; 21(9):869-72. View Laser ablation of placental vessels in twin-to-twin transfusion syndrome: a paradigm for endoscopic fetal surgery. Abstract
Linking topography to tonotopy in the mouse auditory thalamocortical circuit. J Neurosci. 2011 Feb 23; 31(8):2983-95. View Linking topography to tonotopy in the mouse auditory thalamocortical circuit. Abstract
Bombay blood type and use of red cell apheresis during pregnancy. Obstet Gynecol. 2011 Feb; 117(2 Pt 2):463-465. View Bombay blood type and use of red cell apheresis during pregnancy. Abstract
Improving foodborne illness prevention among transplant recipients. Health Promot Pract. 2011 Mar; 12(2):235-43. View Improving foodborne illness prevention among transplant recipients. Abstract
Influence of experience, case load, and stage distribution on outcome of endoscopic laser surgery for TTTS--a review. Prenat Diagn. 2010 Apr; 30(4):314-9. View Influence of experience, case load, and stage distribution on outcome of endoscopic laser surgery for TTTS--a review. Abstract
Feto-fetal transfusion syndrome in monochorionic quadruplets. Obstet Gynecol. 2010 Feb; 115(2 Pt 2):470-472. View Feto-fetal transfusion syndrome in monochorionic quadruplets. Abstract
Reflectance spectrometry for real-time hemoglobin determination of placental vessels during endoscopic laser surgery for twin-to-twin transfusion syndrome. J Pediatr Surg. 2010 Jan; 45(1):59-64. View Reflectance spectrometry for real-time hemoglobin determination of placental vessels during endoscopic laser surgery for twin-to-twin transfusion syndrome. Abstract
The pediatric surgeons' contribution to in utero treatment of twin-to-twin transfusion syndrome. Ann Surg. 2009 Sep; 250(3):456-62. View The pediatric surgeons' contribution to in utero treatment of twin-to-twin transfusion syndrome. Abstract
Prenatal features of Costello syndrome: ultrasonographic findings and atrial tachycardia. Prenat Diagn. 2009 Jul; 29(7):682-90. View Prenatal features of Costello syndrome: ultrasonographic findings and atrial tachycardia. Abstract
MFM/geneticist view on prenatal management of twins. Am J Med Genet C Semin Med Genet. 2009 May 15; 151C(2):155-61. View MFM/geneticist view on prenatal management of twins. Abstract
Mortality results from a randomized prostate-cancer screening trial. N Engl J Med. 2009 Mar 26; 360(13):1310-9. View Mortality results from a randomized prostate-cancer screening trial. Abstract
Uses of misoprostol in obstetrics and gynecology. Rev Obstet Gynecol. 2009; 2(3):159-68. View Uses of misoprostol in obstetrics and gynecology. Abstract
Power and interpretation of a randomized study on the treatment of severe twin-to-twin transfusion syndrome. Am J Obstet Gynecol. 2008 May; 198(5):607; author reply 607-8. View Power and interpretation of a randomized study on the treatment of severe twin-to-twin transfusion syndrome. Abstract
Sampling the sample. Nurse Educ. 2008 Mar-Apr; 33(2):51-2. View Sampling the sample. Abstract
Cell-free fetal DNA in amniotic fluid: unique fragmentation signatures in euploid and aneuploid fetuses. Clin Chem. 2007 Mar; 53(3):405-11. View Cell-free fetal DNA in amniotic fluid: unique fragmentation signatures in euploid and aneuploid fetuses. Abstract
Postpartum haemorrhage: prevention. Clin Evid. 2006 Jun; (15):1932-50. View Postpartum haemorrhage: prevention. Abstract
Fetal therapy for single gene disorders. Clin Obstet Gynecol. 2005 Dec; 48(4):885-96. View Fetal therapy for single gene disorders. Abstract
Survival factors in replantation and revascularization of the amputated thumb--10 years experience. Scand J Plast Reconstr Surg. 1984; 18(2):163-73. View Survival factors in replantation and revascularization of the amputated thumb--10 years experience. Abstract
Replantation and revascularization of digits. Surg Gynecol Obstet. 1980 Oct; 151(4):508-12. View Replantation and revascularization of digits. Abstract
Results of the use of autotransplantation of the intraabdominal testis using microsurgical vascular anastomosis. J Pediatr Surg. 1980 Feb; 15(1):92-6. View Results of the use of autotransplantation of the intraabdominal testis using microsurgical vascular anastomosis. Abstract
An experimental study of microvascular patency using a continuous suture technique. Br J Plast Surg. 1979 Jul; 32(3):153-4. View An experimental study of microvascular patency using a continuous suture technique. Abstract
The cross toe flap. Br J Plast Surg. 1979 Jul; 32(3):213-6. View The cross toe flap. Abstract
Coexisting familial abnormalities of karyotype and phenotype. Chromosome 16 and an unusual form of cutis laxa with skin webs. Med J Aust. 1970 Aug 01; 2(5):235-8. View Coexisting familial abnormalities of karyotype and phenotype. Chromosome 16 and an unusual form of cutis laxa with skin webs. Abstract