Jay Thiagarajah

SPECTREPlex: an automated, fast, high-resolution enabled approach for multiplexed cyclic imaging and tissue spatial analysis. Commun Biol. 2025 Apr 19; 8(1):636. View SPECTREPlex: an automated, fast, high-resolution enabled approach for multiplexed cyclic imaging and tissue spatial analysis. Abstract

The Genetic Architecture of Congenital Diarrhea and Enteropathy. N Engl J Med. 2025 Apr 03; 392(13):1297-1309. View The Genetic Architecture of Congenital Diarrhea and Enteropathy. Abstract

Advancing precision care in pregnancy through a treatable fetal findings list. Am J Hum Genet. 2025 Apr 03. View Advancing precision care in pregnancy through a treatable fetal findings list. Abstract

Stretch and Flex: Mechanosensing and Stem Cells. Gastroenterology. 2025 Mar 05. View Stretch and Flex: Mechanosensing and Stem Cells. Abstract

Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution. Cell. 2025 Mar 20; 188(6):1623-1641.e26. View Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution. Abstract

Hospital-wide access to genomic data advanced pediatric rare disease research and clinical outcomes. NPJ Genom Med. 2024 Dec 02; 9(1):60. View Hospital-wide access to genomic data advanced pediatric rare disease research and clinical outcomes. Abstract

Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair. Cell. 2024 Dec 26; 187(26):7533-7550.e23. View Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair. Abstract

Overcoming problematic growth phenotypes in organoids from patients with monogenic GI disease. PLoS One. 2024; 19(11):e0309072. View Overcoming problematic growth phenotypes in organoids from patients with monogenic GI disease. Abstract

ViCE: An automated and quantitative program to assess intestinal tissue morphology. J Pathol Inform. 2024 Dec; 15:100397. View ViCE: An automated and quantitative program to assess intestinal tissue morphology. Abstract

A MERFISHing Expedition for Colitis. Gastroenterology. 2024 Nov; 167(6):1239-1240. View A MERFISHing Expedition for Colitis. Abstract

Diet management in congenital diarrheas and enteropathies - general concepts and disease-specific approach, a narrative review. Am J Clin Nutr. 2024 07; 120(1):17-33. View Diet management in congenital diarrheas and enteropathies - general concepts and disease-specific approach, a narrative review. Abstract

Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production. Cell Mol Gastroenterol Hepatol. 2024; 18(2):101350. View Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production. Abstract

WNT2B Deficiency Causes Enhanced Susceptibility to Colitis Due to Increased Inflammatory Cytokine Production. Cell Mol Gastroenterol Hepatol. 2024; 18(2):101349. View WNT2B Deficiency Causes Enhanced Susceptibility to Colitis Due to Increased Inflammatory Cytokine Production. Abstract

Modeling the cell biology of monogenetic intestinal epithelial disorders. J Cell Biol. 2024 07 01; 223(7). View Modeling the cell biology of monogenetic intestinal epithelial disorders. Abstract

Holding Back the Tide: Interferon-gamma to the Rescue. Gastroenterology. 2024 06; 166(6):1191-1192. View Holding Back the Tide: Interferon-gamma to the Rescue. Abstract

Patient-derived enteroids provide a platform for the development of therapeutic approaches in microvillus inclusion disease. J Clin Invest. 2023 10 16; 133(20). View Patient-derived enteroids provide a platform for the development of therapeutic approaches in microvillus inclusion disease. Abstract

Intermittent Feasting: Dampening Our Gut Immune Spirits. Gastroenterology. 2024 01; 166(1):212. View Intermittent Feasting: Dampening Our Gut Immune Spirits. Abstract

A Roadmap for the Human Gut Cell Atlas. Nat Rev Gastroenterol Hepatol. 2023 09; 20(9):597-614. View A Roadmap for the Human Gut Cell Atlas. Abstract

Perspectives of Rare Disease Experts on Newborn Genome Sequencing. JAMA Netw Open. 2023 05 01; 6(5):e2312231. View Perspectives of Rare Disease Experts on Newborn Genome Sequencing. Abstract

WNT2B Deficiency Causes Increased Susceptibility to Colitis in Mice and Impairs Intestinal Epithelial Development in Humans. bioRxiv. 2023 Apr 22. View WNT2B Deficiency Causes Increased Susceptibility to Colitis in Mice and Impairs Intestinal Epithelial Development in Humans. Abstract

Therapy Development for Microvillus Inclusion Disease using Patient-derived Enteroids. bioRxiv. 2023 Jan 29. View Therapy Development for Microvillus Inclusion Disease using Patient-derived Enteroids. Abstract

Gasdermin D pore-forming activity is redox-sensitive. Cell Rep. 2023 01 31; 42(1):112008. View Gasdermin D pore-forming activity is redox-sensitive. Abstract

The Immune Ghosts of Pandemics Past. Gastroenterology. 2023 04; 164(4):696. View The Immune Ghosts of Pandemics Past. Abstract

The genetics of monogenic intestinal epithelial disorders. Hum Genet. 2023 May; 142(5):613-654. View The genetics of monogenic intestinal epithelial disorders. Abstract

Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection. Cell. 2022 10 27; 185(22):4190-4205.e25. View Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection. Abstract

The epithelial-specific ER stress sensor ERN2/IRE1ß enables host-microbiota crosstalk to affect colon goblet cell development. J Clin Invest. 2022 09 01; 132(17). View The epithelial-specific ER stress sensor ERN2/IRE1ß enables host-microbiota crosstalk to affect colon goblet cell development. Abstract

Disrupting Polarized Trafficking in Intestinal Epithelial Cells: Insights From a Novel Congenital Enteropathy Gene. Gastroenterology. 2022 09; 163(3):777. View Disrupting Polarized Trafficking in Intestinal Epithelial Cells: Insights From a Novel Congenital Enteropathy Gene. Abstract

Membrane Lipids in Epithelial Polarity: Sorting out the PIPs. Front Cell Dev Biol. 2022; 10:893960. View Membrane Lipids in Epithelial Polarity: Sorting out the PIPs. Abstract

Pediatric Gastrointestinal Histopathology in Patients With Tetratricopeptide Repeat Domain 7A (TTC7A) Germline Mutations: A Rare Condition Leading to Multiple Intestinal Atresias, Severe Combined Immunodeficiency, and Congenital Enteropathy. Am J Surg Pathol. 2022 06 01; 46(6):846-853. View Pediatric Gastrointestinal Histopathology in Patients With Tetratricopeptide Repeat Domain 7A (TTC7A) Germline Mutations: A Rare Condition Leading to Multiple Intestinal Atresias, Severe Combined Immunodeficiency, and Congenital Enteropathy. Abstract

Minimally Invasive Image-Guided Gut Transport Function Measurement Probe. Front Phys. 2021 Sep; 9. View Minimally Invasive Image-Guided Gut Transport Function Measurement Probe. Abstract

Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway. Cell. 2021 08 19; 184(17):4495-4511.e19. View Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway. Abstract

Pycro-Manager: open-source software for customized and reproducible microscope control. Nat Methods. 2021 03; 18(3):226-228. View Pycro-Manager: open-source software for customized and reproducible microscope control. Abstract

Novel variants in the stem cell niche factor WNT2B define the disease phenotype as a congenital enteropathy with ocular dysgenesis. Eur J Hum Genet. 2021 06; 29(6):998-1007. View Novel variants in the stem cell niche factor WNT2B define the disease phenotype as a congenital enteropathy with ocular dysgenesis. Abstract

Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling. Proc Natl Acad Sci U S A. 2020 11 03; 117(44):27502-27508. View Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling. Abstract

NOX1 Regulates Collective and Planktonic Cell Migration: Insights From Patients With Pediatric-Onset IBD and NOX1 Deficiency. Inflamm Bowel Dis. 2020 07 17; 26(8):1166-1176. View NOX1 Regulates Collective and Planktonic Cell Migration: Insights From Patients With Pediatric-Onset IBD and NOX1 Deficiency. Abstract

IRE1ß negatively regulates IRE1a signaling in response to endoplasmic reticulum stress. J Cell Biol. 2020 Feb 03; 219(2). View IRE1ß negatively regulates IRE1a signaling in response to endoplasmic reticulum stress. Abstract

A quantitative single-cell assay for retrograde membrane traffic enables rapid detection of defects in cellular organization. Mol Biol Cell. 2020 03 19; 31(7):511-519. View A quantitative single-cell assay for retrograde membrane traffic enables rapid detection of defects in cellular organization. Abstract

Drug Screen Identifies Leflunomide for Treatment of Inflammatory Bowel Disease Caused by TTC7A Deficiency. Gastroenterology. 2020 03; 158(4):1000-1015. View Drug Screen Identifies Leflunomide for Treatment of Inflammatory Bowel Disease Caused by TTC7A Deficiency. Abstract

Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea. JCI Insight. 2019 02 21; 4(4). View Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea. Abstract

An Intravenous Fish Oil-Based Lipid Emulsion Successfully Treats Intractable Pruritus and Cholestasis in a Patient with Microvillous Inclusion Disease. Hepatology. 2019 03; 69(3):1353-1356. View An Intravenous Fish Oil-Based Lipid Emulsion Successfully Treats Intractable Pruritus and Cholestasis in a Patient with Microvillous Inclusion Disease. Abstract

INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. Elife. 2018 10 25; 7. View INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. Abstract

Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations. Am J Hum Genet. 2018 07 05; 103(1):131-137. View Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations. Abstract

Advances in Evaluation of Chronic Diarrhea in Infants. Gastroenterology. 2018 Jun; 154(8):2045-2059.e6. View Advances in Evaluation of Chronic Diarrhea in Infants. Abstract

Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia. Proc Natl Acad Sci U S A. 2017 01 17; 114(3):568-573. View Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia. Abstract

The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion. Oncogene. 2017 03 30; 36(13):1816-1828. View The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion. Abstract

Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion. Mol Biol Cell. 2016 Apr 01; 27(7):1120-30. View Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion. Abstract

CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation. Cell Mol Gastroenterol Hepatol. 2016 May; 2(3):317-327. View CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation. Abstract

Secretory diarrhoea: mechanisms and emerging therapies. Nat Rev Gastroenterol Hepatol. 2015 Aug; 12(8):446-57. View Secretory diarrhoea: mechanisms and emerging therapies. Abstract

Congenital chloride-losing diarrhea in a Mexican child with the novel homozygous SLC26A3 mutation G393W. Front Physiol. 2015; 6:179. View Congenital chloride-losing diarrhea in a Mexican child with the novel homozygous SLC26A3 mutation G393W. Abstract

Altered goblet cell differentiation and surface mucus properties in Hirschsprung disease. PLoS One. 2014; 9(6):e99944. View Altered goblet cell differentiation and surface mucus properties in Hirschsprung disease. Abstract

Discovery and development of antisecretory drugs for treating diarrheal diseases. Clin Gastroenterol Hepatol. 2014 Feb; 12(2):204-9. View Discovery and development of antisecretory drugs for treating diarrheal diseases. Abstract

Chloride channel inhibition by a red wine extract and a synthetic small molecule prevents rotaviral secretory diarrhoea in neonatal mice. Gut. 2014 Jul; 63(7):1120-9. View Chloride channel inhibition by a red wine extract and a synthetic small molecule prevents rotaviral secretory diarrhoea in neonatal mice. Abstract

Chloride channel-targeted therapy for secretory diarrheas. Curr Opin Pharmacol. 2013 Dec; 13(6):888-94. View Chloride channel-targeted therapy for secretory diarrheas. Abstract

Response to "Diffusion versus convection". J Gen Physiol. 2013 Aug; 142(2):173. View Response to "Diffusion versus convection". Abstract

Convective washout reduces the antidiarrheal efficacy of enterocyte surface-targeted antisecretory drugs. J Gen Physiol. 2013 Feb; 141(2):261-72. View Convective washout reduces the antidiarrheal efficacy of enterocyte surface-targeted antisecretory drugs. Abstract

CFTR inhibitors. Curr Pharm Des. 2013; 19(19):3529-41. View CFTR inhibitors. Abstract

CFTR inhibitors for treating diarrheal disease. Clin Pharmacol Ther. 2012 Sep; 92(3):287-90. View CFTR inhibitors for treating diarrheal disease. Abstract

Airway surface liquid depth imaged by surface laser reflectance microscopy. J Gen Physiol. 2010 Sep; 136(3):353-62. View Airway surface liquid depth imaged by surface laser reflectance microscopy. Abstract

Inhibition of Ca2+-activated Cl- channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea. FASEB J. 2010 Nov; 24(11):4178-86. View Inhibition of Ca2+-activated Cl- channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea. Abstract

Impaired enterocyte proliferation in aquaporin-3 deficiency in mouse models of colitis. Gut. 2007 Nov; 56(11):1529-35. View Impaired enterocyte proliferation in aquaporin-3 deficiency in mouse models of colitis. Abstract

Slowed diffusion in tumors revealed by microfiberoptic epifluorescence photobleaching. Nat Methods. 2006 Apr; 3(4):275-80. View Slowed diffusion in tumors revealed by microfiberoptic epifluorescence photobleaching. Abstract

Noninvasive early detection of brain edema in mice by near-infrared light scattering. J Neurosci Res. 2005 Apr 15; 80(2):293-9. View Noninvasive early detection of brain edema in mice by near-infrared light scattering. Abstract

New drug targets for cholera therapy. Trends Pharmacol Sci. 2005 Apr; 26(4):172-5. View New drug targets for cholera therapy. Abstract

Submucosal gland dysfunction as a primary defect in cystic fibrosis. FASEB J. 2005 Mar; 19(3):431-3. View Submucosal gland dysfunction as a primary defect in cystic fibrosis. Abstract

A small molecule CFTR inhibitor produces cystic fibrosis-like submucosal gland fluid secretions in normal airways. FASEB J. 2004 May; 18(7):875-7. View A small molecule CFTR inhibitor produces cystic fibrosis-like submucosal gland fluid secretions in normal airways. Abstract

Prevention of toxin-induced intestinal ion and fluid secretion by a small-molecule CFTR inhibitor. Gastroenterology. 2004 Feb; 126(2):511-9. View Prevention of toxin-induced intestinal ion and fluid secretion by a small-molecule CFTR inhibitor. Abstract

CFTR pharmacology and its role in intestinal fluid secretion. Curr Opin Pharmacol. 2003 Dec; 3(6):594-9. View CFTR pharmacology and its role in intestinal fluid secretion. Abstract

Sodium and chloride concentrations, pH, and depth of airway surface liquid in distal airways. J Gen Physiol. 2003 Nov; 122(5):511-9. View Sodium and chloride concentrations, pH, and depth of airway surface liquid in distal airways. Abstract

Role of airway surface liquid and submucosal glands in cystic fibrosis lung disease. Am J Physiol Cell Physiol. 2003 Jan; 284(1):C2-15. View Role of airway surface liquid and submucosal glands in cystic fibrosis lung disease. Abstract

Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest. 2002 Dec; 110(11):1651-8. View Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. Abstract

Progesterone stimulation of fluid absorption by the rat uterine gland. Reproduction. 2002 May; 123(5):633-8. View Progesterone stimulation of fluid absorption by the rat uterine gland. Abstract

Aquaporin deletion in mice reduces corneal water permeability and delays restoration of transparency after swelling. J Biol Chem. 2002 May 24; 277(21):19139-44. View Aquaporin deletion in mice reduces corneal water permeability and delays restoration of transparency after swelling. Abstract

Evidence for modulation of pericryptal sheath myofibroblasts in rat descending colon by transforming growth factor beta and angiotensin II. BMC Gastroenterol. 2002; 2:4. View Evidence for modulation of pericryptal sheath myofibroblasts in rat descending colon by transforming growth factor beta and angiotensin II. Abstract

Chloride concentration in endosomes measured using a ratioable fluorescent Cl- indicator: evidence for chloride accumulation during acidification. J Biol Chem. 2002 Feb 15; 277(7):5506-13. View Chloride concentration in endosomes measured using a ratioable fluorescent Cl- indicator: evidence for chloride accumulation during acidification. Abstract

In vivo fluorescence measurement of Na(+) concentration in the pericryptal space of mouse descending colon. Am J Physiol Cell Physiol. 2001 Dec; 281(6):C1898-903. View In vivo fluorescence measurement of Na(+) concentration in the pericryptal space of mouse descending colon. Abstract

Evidence of amiloride-sensitive fluid absorption in rat descending colonic crypts from fluorescence recovery of FITC-labelled dextran after photobleaching. J Physiol. 2001 Oct 15; 536(Pt 2):541-53. View Evidence of amiloride-sensitive fluid absorption in rat descending colonic crypts from fluorescence recovery of FITC-labelled dextran after photobleaching. Abstract

Radiation induced cytochrome c release causes loss of rat colonic fluid absorption by damage to crypts and pericryptal myofibroblasts. Gut. 2000 Nov; 47(5):675-84. View Radiation induced cytochrome c release causes loss of rat colonic fluid absorption by damage to crypts and pericryptal myofibroblasts. Abstract