Current Environment: Production

Medical Services

Programs & Services

Languages

  • English

Education

Medical School

University of Pennsylvania School of Medicine

1985, Philadelphia, PA

Internship

St. Mary's Hospital and Medical Center

1986, San Francisco, CA

Residency

University of California Davis Medical Center

1989, Sacramento, CA

Fellowship

Boston Children's Hospital

1990, Boston, MA

Certifications

  • American Board of Anesthesiology (General)

Publications

  1. Dexmedetomidine and Clonidine Attenuate Sevoflurane-Induced Tau Phosphorylation and Cognitive Impairment in Young Mice via a-2 Adrenergic Receptor. Anesth Analg. 2021 03 01; 132(3):878-889. View Abstract

  2. Mechanistic consideration of the effect of perioperative volatile anesthetics on phagocytes. Clin Immunol. 2021 01; 222:108635. View Abstract

  3. The Unspoken Question! Anesth Analg. 2020 09; 131(3):720-722. View Abstract

  4. Is Anesthesia Bad for the Brain? Current Knowledge on the Impact of Anesthetics on the Developing Brain. Anesthesiol Clin. 2020 Sep; 38(3):477-492. View Abstract

  5. Does general anesthesia affect neurodevelopment in infants and children? BMJ. 2019 Dec 09; 367:l6459. View Abstract

  6. The volatile anesthetic sevoflurane reduces neutrophil apoptosis via Fas death domain-Fas-associated death domain interaction. FASEB J. 2019 11; 33(11):12668-12679. View Abstract

  7. Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial. Lancet. 2019 02 16; 393(10172):664-677. View Abstract

  8. A Summary of Preclinical Poster Presentations at the Sixth Biennial Pediatric Anesthesia Neurodevelopment Assessment (PANDA) Symposium. J Neurosurg Anesthesiol. 2019 Jan; 31(1):163-165. View Abstract

  9. Anesthesia and the developing brain: A way forward for laboratory and clinical research. Paediatr Anaesth. 2018 09; 28(9):758-763. View Abstract

  10. Sevoflurane Acts on Ubiquitination-Proteasome Pathway to Reduce Postsynaptic Density 95 Protein Levels in Young Mice. Anesthesiology. 2017 12; 127(6):961-975. View Abstract

  11. Differences in Blood Pressure in Infants After General Anesthesia Compared to Awake Regional Anesthesia (GAS Study-A Prospective Randomized Trial). Anesth Analg. 2017 09; 125(3):837-845. View Abstract

  12. Thinking, fast and slow: highlights from the 2016 BJA seminar on anaesthetic neurotoxicity and neuroplasticity. Br J Anaesth. 2017 09 01; 119(3):443-447. View Abstract

  13. Coenzyme Q10 reduces sevoflurane-induced cognitive deficiency in young mice. Br J Anaesth. 2017 Sep 01; 119(3):481-491. View Abstract

  14. From the Cover: Prolonged Exposure to Volatile Anesthetic Isoflurane Worsens the Outcome of Polymicrobial Abdominal Sepsis. Toxicol Sci. 2017 04 01; 156(2):402-411. View Abstract

  15. Anesthesia, brain changes, and behavior: Insights from neural systems biology. Prog Neurobiol. 2017 06; 153:121-160. View Abstract

  16. Dexmedetomidine-Induced Neuroapoptosis Is Dependent on Its Cumulative Dose. Anesth Analg. 2016 10; 123(4):1008-17. View Abstract

  17. Leukocyte function-associated antigen-1 deficiency impairs responses to polymicrobial sepsis. World J Clin Cases. 2015 Sep 16; 3(9):793-806. View Abstract

  18. Imaging the progression of anesthetic-induced neurotoxicity: a leap toward translational relevance. Anesthesiology. 2015 Sep; 123(3):497-8. View Abstract

  19. The role of macrophage 1 antigen in polymicrobial sepsis. Shock. 2014 Dec; 42(6):532-9. View Abstract

  20. Anesthesia for intracranial surgery in infants and children. Curr Opin Anaesthesiol. 2014 Oct; 27(5):465-9. View Abstract

  21. Progress in anesthesia and management of the newborn surgical patient. Semin Pediatr Surg. 2014 Oct; 23(5):244-8. View Abstract

  22. Not just neuroanesthesia, but Pediatric neuroanesthesia! Paediatr Anaesth. 2014 Jul; 24(7):645-6. View Abstract

  23. Anesthetic neurotoxicity. Anesthesiol Clin. 2014 Mar; 32(1):133-55. View Abstract

  24. Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar. Br J Anaesth. 2013 Aug; 111(2):143-51. View Abstract

  25. Population pharmacokinetics of tranexamic acid in paediatric patients undergoing craniosynostosis surgery. Clin Pharmacokinet. 2013 Apr; 52(4):267-76. View Abstract

  26. Role of glycogen synthase kinase-3ß in ketamine-induced developmental neuroapoptosis in rats. Br J Anaesth. 2013 Jun; 110 Suppl 1:i3-9. View Abstract

  27. Morphine-enhanced apoptosis in selective brain regions of neonatal rats. Int J Dev Neurosci. 2013 Jun; 31(4):258-66. View Abstract

  28. Selective anesthesia-induced neuroinflammation in developing mouse brain and cognitive impairment. Anesthesiology. 2013 Mar; 118(3):502-15. View Abstract

  29. Neuroanesthesiology fellowship training: curricular guidelines from the Society for Neuroscience in Anesthesiology and Critical Care. J Neurosurg Anesthesiol. 2013 Jan; 25(1):1-7. View Abstract

  30. Perioperative central nervous system injury in neonates. Br J Anaesth. 2012 Dec; 109 Suppl 1:i60-i67. View Abstract

  31. Neurotoxicity of ketamine: known unknowns. Crit Care Med. 2012 Aug; 40(8):2518-9. View Abstract

  32. Noxious stimulation attenuates ketamine-induced neuroapoptosis in the developing rat brain. Anesthesiology. 2012 Jul; 117(1):64-71. View Abstract

  33. General anesthetics in pediatric anesthesia: influences on the developing brain. Curr Drug Targets. 2012 Jun; 13(7):944-51. View Abstract

  34. Anesthetic concerns for pediatric patients in an intraoperative MRI suite. Curr Opin Anaesthesiol. 2011 Oct; 24(5):480-6. View Abstract

  35. Spinal anesthesia in infant rats: development of a model and assessment of neurologic outcomes. Anesthesiology. 2011 Jun; 114(6):1325-35. View Abstract

  36. Efficacy of tranexamic acid in pediatric craniosynostosis surgery: a double-blind, placebo-controlled trial. Anesthesiology. 2011 Apr; 114(4):862-71. View Abstract

  37. Sedative drug modulates T-cell and lymphocyte function-associated antigen-1 function. Anesth Analg. 2011 Apr; 112(4):830-8. View Abstract

  38. Endoscopic strip craniectomy in early infancy: the initial five years of anesthesia experience. Anesth Analg. 2011 Feb; 112(2):407-14. View Abstract

  39. Sevoflurane binds and allosterically blocks integrin lymphocyte function-associated antigen-1. Anesthesiology. 2010 Sep; 113(3):600-9. View Abstract

  40. Detection of intestinal inflammation by MicroPET imaging using a (64)Cu-labeled anti-beta(7) integrin antibody. Inflamm Bowel Dis. 2010 Sep; 16(9):1458-66. View Abstract

  41. Ketamine activates cell cycle signaling and apoptosis in the neonatal rat brain. Anesthesiology. 2010 May; 112(5):1155-63. View Abstract

  42. Thinking about the neurotoxic effects of sedatives on the developing brain. Pediatr Crit Care Med. 2010 Mar; 11(2):306-7. View Abstract

  43. Acute intraoperative neurogenic pulmonary edema during endoscopic ventriculoperitoneal shunt revision. Anesth Analg. 2010 Feb 01; 110(2):594-5. View Abstract

  44. Thinking about the neurotoxic effects of sedatives on the developing brain. Pediatric Critical Care Medicine. 2010; in press.

  45. Detection of intestinal inflammation by PET imaging using a 64Cu-labeled anti-ƒÒ7 integrin antibody. Inflammatory Bowel Disease. 2010; in press.

  46. Is anesthesia bad for the newborn brain? Anesthesiol Clin. 2009 Jun; 27(2):269-84. View Abstract

  47. Clinical research approaches to studying pediatric anesthetic neurotoxicity. Neurotoxicology. 2009 Sep; 30(5):766-71. View Abstract

  48. Prolonged exposure to ketamine increases brain derived neurotrophic factor levels in developing rat brains. Curr Drug Saf. 2009 Jan; 4(1):11-6. View Abstract

  49. Anesthesia for Pediatric Neurosurgery and Traumatic Brain Injury. Smith's Anesthesia for Infants and Children. 2009.

  50. Pediatric Neuroanesthesia, Winn R (ed). Youman's Neurological Surgery. 2008.

  51. The volatile anesthetic agent isoflurane perturbs the conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity. FASEB. 2008; 22(12):4109-16.

  52. SNACC: Basic and Clinical Neurosciences in Perfect Harmony. ASA Newsletter. 2008; 72(9):48-49.

  53. The volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity. FASEB J. 2008 Dec; 22(12):4109-16. View Abstract

  54. CON: The toxic effects of anesthetics in the developing brain: the clinical perspective. Anesth Analg. 2008 Jun; 106(6):1664-9. View Abstract

  55. An assessment of the effects of general anesthetics on developing brain structure and neurocognitive function. Anesth Analg. 2008 Jun; 106(6):1681-707. View Abstract

  56. Central nervous system inflammation. Eur J Anaesthesiol Suppl. 2008; 42:154-9. View Abstract

  57. Anesthetic considerations and postoperative ICU care. Pediatric Epilepsy Surgery: Preoperative Assessment and Surgical Treatment, Cataltepe O and Jallo G (eds.). 2008.

  58. The Central Nervous System: Pediatric Neuroanesthesia. A Practical Approach to Pediatric Anesthesia, Holzman RS, Mancuso T, Polaner D (eds.). 2008.

  59. Pediatric Neuroanesthesia. Anesthesia and Neurosurgery, Cottrell J and Young W eds. 2008.

  60. Pediatric Neuroanesthesia. Pediatric Anesthesia, Principles and Practice, Bissonnette, B. (ed.). 2008.

  61. Pediatric Neuroanesthesia. A Practice of Anesthesia for Infants and Children Cote CJ and Lerman J(eds.). 2008.

  62. Recognition and Alleviation of Pain in Laboratory Animals. 2008.

  63. Pediatric Neuroanesthesia. Anesthesia for Neurosurgery in Principles and Practice of Pediatric Neurosurgery Albright AL, Pollack IF, and Adelson D (eds.). 2008.

  64. Detection of unanticipated intracranial hemorrhage during intraoperative magnetic resonance image-guided neurosurgery. Report of two cases. J Neurosurg. 2007 May; 106(5 Suppl):398-400. View Abstract

  65. Pediatric neuroanesthesia. Neuroimaging Clin N Am. 2007 May; 17(2):259-67. View Abstract

  66. Lidocaine pretreatment for the prevention of propofol-induced transient motor disturbances in children during anesthesia induction: a randomized controlled trial in children undergoing invasive hematologic procedures. Paediatr Anaesth. 2006 Dec; 16(12):1232-7. View Abstract

  67. Anesthesia for epilepsy surgery in children. Childs Nerv Syst. 2006 Aug; 22(8):834-43. View Abstract

  68. Summary proceedings from the neonatal pain-control group. Pediatrics. 2006 Mar; 117(3 Pt 2):S9-S22. View Abstract

  69. Anesthetic management of pial synangiosis and intracranial hemorrhage with a Fontan circulation. Paediatr Anaesth. 2006 Jan; 16(1):72-6. View Abstract

  70. Let's not throw the baby out with the bath water: potential neurotoxicity of anesthetic drugs in infants and children. J Neurosurg Anesthesiol. 2005 Oct; 17(4):207-9. View Abstract

  71. Cerebrospinal fluid may mediate CNS ischemic injury. Cerebrospinal Fluid Res. 2005 Sep 20; 2:7. View Abstract

  72. Analgesia and anesthesia for neonates: study design and ethical issues. Clin Ther. 2005 Jun; 27(6):814-43. View Abstract

  73. Anesthesia and analgesia during and after surgery in neonates. Clin Ther. 2005 Jun; 27(6):900-21. View Abstract

  74. Anesthetics and brain toxicity. Curr Opin Anaesthesiol. 2005 Jun; 18(3):293-7. View Abstract

  75. Of mice and men: should we extrapolate rodent experimental data to the care of human neonates? Anesthesiology. 2005 Apr; 102(4):866-8; author reply 868-9. View Abstract

  76. Society of Neurosurgical Anesthesia and Critical Care (SNACC) Problem-based learning discussion: 3 month old boy with saggital craniosynostosis SNACC Website http://www.snacc.org/ed/casedisc/Craniosynostosis.pdf. 2005.

  77. Anesthetic agents and the immature brain: are these toxic or therapeutic? Anesthesiology. 2004 Aug; 101(2):527-30. View Abstract

  78. Perioperative management of diabetes insipidus in children. J Neurosurg Anesthesiol. 2004 Jul; 16(3):220-5. View Abstract

  79. Does anaesthesia harm the developing brain--evidence or speculation? Paediatr Anaesth. 2004 Mar; 14(3):199-200. View Abstract

  80. Long-term outcome in children with moyamoya syndrome after cranial revascularization by pial synangiosis. J Neurosurg. 2004 Feb; 100(2 Suppl Pediatrics):142-9. View Abstract

  81. Perioperative management of diabetes insipidus in children [corrected]. J Neurosurg Anesthesiol. 2004 Jan; 16(1):14-9. View Abstract

  82. Antiepileptic-induced resistance to neuromuscular blockers: mechanisms and clinical significance. Clin Pharmacokinet. 2004; 43(2):71-81. View Abstract

  83. Society for Neurosurgical Anesthesia and Critical Care (SNACC) Bibliography, SNACC website: http://www.snacc.org/ed/bib/StartBIB.html. 2004.

  84. Pediatric Neuroanesthesia. Youman's Neurological Surgery Winn HR (ed.). 2004; 3187-3197.

  85. Society of Neurosurgical Anesthesia and Critical Care (SNACC) newsletter: report of the 2002 annual meeting, Orlando, Florida. J Neurosurg Anesthesiol. 2003 Apr; 15(2):165-7. View Abstract

  86. Repeated administration of ketamine may lead to neuronal degeneration in the developing rat brain. Paediatr Anaesth. 2002 Nov; 12(9):770-4. View Abstract

  87. Anaesthetic management of children with tuberous sclerosis. Paediatr Anaesth. 2002 Oct; 12(8):700-4. View Abstract

  88. Pediatric neuroanesthesia. Anesthesiol Clin North Am. 2002 Jun; 20(2):389-404. View Abstract

  89. Mice deficient in fractalkine are less susceptible to cerebral ischemia-reperfusion injury. J Neuroimmunol. 2002 Apr; 125(1-2):59-65. View Abstract

  90. Levels of soluble adhesion molecules are elevated in the cerebrospinal fluid of children with moyamoya syndrome. Neurosurgery. 2002 Mar; 50(3):544-9. View Abstract

  91. Neuroanesthesia. Innovative techniques and monitoring. Anesthesiol Clin North Am. 2002 Mar; 20(1):137-51. View Abstract

  92. Hemostatic changes in pediatric neurosurgical patients as evaluated by thrombelastograph. Anesth Analg. 2001 Oct; 93(4):887-92. View Abstract

  93. Gentle dorsal root retraction and dissection can cause areflexia: implications for intraoperative monitoring during "selective" partial dorsal rhizotomy. Muscle Nerve. 2001 Oct; 24(10):1352-8. View Abstract

  94. Pharmacokinetics and pharmacodynamics of vecuronium in children receiving phenytoin or carbamazepine for chronic anticonvulsant therapy. Br J Anaesth. 2001 Feb; 86(2):223-9. View Abstract

  95. Pediatric Neuroanesthesia. A Practice of Anesthesia for Infants and Children Cote CJ (ed.). 2001; 493-521.

  96. The effect of propofol on intraoperative electrocorticography and cortical stimulation during awake craniotomies in children. Paediatr Anaesth. 2000; 10(1):29-34. View Abstract

  97. Onset and duration of action of rocuronium in children receiving chronic anticonvulsant therapy. Paediatr Anaesth. 2000; 10(2):133-6. View Abstract

  98. P- and E-selectin-deficient mice are susceptible to cerebral ischemia-reperfusion injury. Brain Res. 1999 Jul 24; 835(2):360-4. View Abstract

  99. Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury. Stroke. 1999 Jan; 30(1):134-9. View Abstract

  100. Anesthesia for Pediatric Neurosurgery. Pediatric Anesthesia Volume VII, Miller RD (series editor) Atlas of Anesthesia, Greeley WJ (volume ed.). 1999; 7:7-11.

  101. Rebound swelling of astroglial cells exposed to hypertonic mannitol. Anesthesiology. 1998 Jun; 88(6):1586-91. View Abstract

  102. Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice. Nat Med. 1998 Feb; 4(2):228-31. View Abstract

  103. ICAM-1 dependent pathway is not involved in the development of neuronal apoptosis after transient focal cerebral ischemia. Brain Res. 1998 Jan 12; 780(2):337-41. View Abstract

  104. Surgical airway, rigid bronchoscopy, and transtracheal jet ventilation in the pediatric patient. Anesthesiol Clin of North America. 1998; 16:827-838.

  105. Sevoflurane depresses myocardial contractility less than halothane during induction of anesthesia in children. Anesthesiology. 1996 Dec; 85(6):1260-7. View Abstract

  106. Effects of ondansetron on emesis in the first 24 hours after craniotomy in children. Anesth Analg. 1996 Aug; 83(2):325-8. View Abstract

  107. Cerebral blood flow velocity after mannitol infusion in children. Can J Anaesth. 1996 May; 43(5 Pt 1):461-6. View Abstract

  108. Intercellular adhesion molecule-1-deficient mice are less susceptible to cerebral ischemia-reperfusion injury. Ann Neurol. 1996 May; 39(5):618-24. View Abstract

  109. The critical importance of stimulus intensity in intraoperative monitoring for partial dorsal rhizotomy. Muscle Nerve. 1996 Apr; 19(4):415-22. View Abstract

  110. Resection of a massive sacrococcygeal teratoma using hypothermic hypoperfusion: a novel use of extracorporeal membrane oxygenation. J Pediatr Surg. 1995 Nov; 30(11):1557-9. View Abstract

  111. Neuroanesthesia. Neurosurg Clin N Am. 1995 Jul; 6(3):505-20. View Abstract

  112. Anesthesia for stereotactic radiosurgery in children. J Neurosurg Anesthesiol. 1995 Apr; 7(2):100-8. View Abstract

  113. Nitrous oxide depresses the H-reflex in children with cerebral palsy. Anesth Analg. 1995 Feb; 80(2):239-41. View Abstract

  114. Doppler sensor placement during neurosurgical procedures for children in the prone position. J Neurosurg Anesthesiol. 1994 Jul; 6(3):153-5. View Abstract

  115. H reflex studies in cerebral palsy patients undergoing partial dorsal rhizotomy. Muscle Nerve. 1994 May; 17(5):539-49. View Abstract

  116. Anesthetic management of children with moyamoya syndrome. Anesth Analg. 1993 Nov; 77(5):1066-70. View Abstract

  117. EEG power changes are more sensitive than spectral edge frequency variation for detection of cerebral ischemia during carotid artery surgery: a prospective assessment of processed EEG monitoring. J Cardiothorac Vasc Anesth. 1992 Jun; 6(3):292-4. View Abstract

  118. Neonatal surgical emergencies. Seminars in Anesthesia. 1992; 9:309-316.

  119. Posterior fossa craniotomy. Common problems in pediatric anesthesia Stehling L, (ed.). 1992; 307-315.

  120. A recommendation for reduced lidocaine dosage during intravenous regional bretylium treatment of reflex sympathetic dystrophy. Anesthesiology. 1989 Nov; 71(5):811-2. View Abstract

  121. Osteomalacia in a night nurse. Clinical Orthopedics. 1986; 205:216-221..
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