Current Environment: Production

Medical Services

Programs & Services

Languages

  • English

Education

Undergraduate School

Yale University

1988, New Haven, CT

Medical School

Harvard Medical School

1993, Boston, MA

Internship

Boston Children's Hospital

1994, Boston, MA

Residency

Boston Children's Hospital

1996, Boston, MA

Fellowship

Boston Children's Hospital

1999, Boston, MA

Certifications

  • American Board of Pediatrics (Cardiology)

Professional History

I grew up in upstate New York. From college at Yale through medical school at Harvard and training in pediatrics and pediatric cardiology at Boston Children’s, my passion has been to bring advances in science to bear on the problems faced by patients.

Publications

  1. SCIG: Machine learning uncovers cell identity genes in single cells by genetic sequence codes. Nucleic Acids Res. 2025 May 22; 53(10). View Abstract

  2. Response by Bortolin and Pu to Letter Regarding Article, "Antisense Oligonucleotide Therapy for Calmodulinopathy". Circulation. 2025 May 06; 151(18):e970-e971. View Abstract

  3. A murine model of Barth syndrome recapitulates human cardiac and skeletal muscle phenotypes. Dis Model Mech. 2025 May 01; 18(5). View Abstract

  4. Translational insights into statin-induced myotoxicity: Differential impact of lipophilic and hydrophilic statins on iPSC-derived skeletal muscle cells from patients with familial hypercholesterolemia. Toxicology. 2025 Aug; 515:154159. View Abstract

  5. Dysregulation of N-terminal acetylation causes cardiac arrhythmia and cardiomyopathy. Nat Commun. 2025 Apr 16; 16(1):3604. View Abstract

  6. Somatic Genomic and Transcriptomic Changes in Single Ischemic Human Heart Cardiomyocytes. Res Sq. 2025 Jan 31. View Abstract

  7. Regulation of sarcomere formation and function in the healthy heart requires a titin intronic enhancer. J Clin Invest. 2024 Dec 17; 135(4). View Abstract

  8. CHD4 Interacts With TBX5 to Maintain the Gene Regulatory Network of Postnatal Atrial Cardiomyocytes. bioRxiv. 2024 Dec 05. View Abstract

  9. Genetic and Molecular Underpinnings of Atrial Fibrillation. NPJ Cardiovasc Health. 2024; 1. View Abstract

  10. Cardiac Applications of CRISPR/AAV-Mediated Precise Genome Editing. bioRxiv. 2024 Dec 04. View Abstract

  11. Virally delivered CMYA5 enhances the assembly of cardiac dyads. Nat Biomed Eng. 2025 May; 9(5):730-741. View Abstract

  12. Non-Cell-Autonomous Cardiomyocyte Regulation Complicates Gene Supplementation Therapy for Lmna-Associated Cardiac Defects in Mice. JACC Basic Transl Sci. 2024 Nov; 9(11):1308-1325. View Abstract

  13. Antisense Oligonucleotide Therapy for Calmodulinopathy. Circulation. 2024 Oct 08; 150(15):1199-1210. View Abstract

  14. Activation of VGLL4 Suppresses Cardiomyocyte Maturational Hypertrophic Growth. Cells. 2024 08 13; 13(16). View Abstract

  15. Vestigial like 4 regulates the adipogenesis of classical brown adipose tissue. bioRxiv. 2024 Jul 27. View Abstract

  16. In vivo proximity proteomics uncovers palmdelphin (PALMD) as a Z-disc-associated mitigator of isoproterenol-induced cardiac injury. Acta Pharmacol Sin. 2024 Dec; 45(12):2540-2552. View Abstract

  17. Dysregulation of N-terminal acetylation causes cardiac arrhythmia and cardiomyopathy. Res Sq. 2024 Jul 19. View Abstract

  18. Efficient and reproducible generation of human iPSC-derived cardiomyocytes and cardiac organoids in stirred suspension systems. Nat Commun. 2024 Jul 15; 15(1):5929. View Abstract

  19. Therapeutic Inhibition of LincRNA-p21 Protects Against Cardiac Hypertrophy. Circ Res. 2024 Jul 19; 135(3):434-449. View Abstract

  20. Remote assessment and management of patients with dizziness: development, validation, and feasibility of a gamified vestibular rehabilitation therapy platform. Front Neurol. 2024; 15:1367582. View Abstract

  21. Pioneer factor ETV2 safeguards endothelial cell specification by recruiting the repressor REST to restrict alternative lineage commitment. bioRxiv. 2024 May 30. View Abstract

  22. MicroRNA-122-Mediated Liver Detargeting Enhances the Tissue Specificity of Cardiac Genome Editing. Circulation. 2024 May 28; 149(22):1778-1781. View Abstract

  23. Allele-Specific Suppression of Variant MHC With High-Precision RNA Nuclease CRISPR-Cas13d Prevents Hypertrophic Cardiomyopathy. Circulation. 2024 Jul 23; 150(4):283-298. View Abstract

  24. The long noncoding RNA CARDINAL attenuates cardiac hypertrophy by modulating protein translation. J Clin Invest. 2024 May 14; 134(13). View Abstract

  25. Efficient and reproducible generation of human iPSC-derived cardiomyocytes using a stirred bioreactor. bioRxiv. 2024 Feb 28. View Abstract

  26. From vitality to vulnerability: the impact of oxygen on cardiac function and regeneration. J Cardiovasc Aging. 2024 Apr; 4(2). View Abstract

  27. Functional dissection of human cardiac enhancers and noncoding de novo variants in congenital heart disease. Nat Genet. 2024 Mar; 56(3):420-430. View Abstract

  28. Molecular and Spatial Signatures of Mouse Embryonic Endothelial Cells at Single-Cell Resolution. Circ Res. 2024 03; 134(5):529-546. View Abstract

  29. Base editing effectively prevents early-onset severe cardiomyopathy in Mybpc3 mutant mice. Cell Res. 2024 Apr; 34(4):327-330. View Abstract

  30. A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network. Circulation. 2024 Apr 09; 149(15):1205-1230. View Abstract

  31. In vivo proximity proteomics uncovers palmdelphin (PALMD) as a Z-line-associated mitigator of isoproterenol-induced cardiac injury. bioRxiv. 2023 Dec 07. View Abstract

  32. Author Correction: Tbx5 maintains atrial identity in postnatal cardiomyocytes by regulating an atrial-specific enhancer network. Nat Cardiovasc Res. 2023 Nov; 2(11):1095. View Abstract

  33. Reduced Mitochondrial Protein Translation Promotes Cardiomyocyte Proliferation and Heart Regeneration. Circulation. 2023 12 05; 148(23):1887-1906. View Abstract

  34. Tbx5 maintains atrial identity in post-natal cardiomyocytes by regulating an atrial-specific enhancer network. Nat Cardiovasc Res. 2023 Oct; 2(10):881-898. View Abstract

  35. Spatiotemporal cell junction assembly in human iPSC-CM models of arrhythmogenic cardiomyopathy. Stem Cell Reports. 2023 09 12; 18(9):1811-1826. View Abstract

  36. A shared role of the myocardin-family transcriptional coactivators in cardiomyocyte maturation. Sci China Life Sci. 2023 12; 66(12):2939-2942. View Abstract

  37. Fibre-infused gel scaffolds guide cardiomyocyte alignment in 3D-printed ventricles. Nat Mater. 2023 08; 22(8):1039-1046. View Abstract

  38. Editing the trajectory of hypertrophic cardiomyopathy. J Cardiovasc Aging. 2023 Jul; 3(3). View Abstract

  39. Genetic modifiers modulate phenotypic expression of tafazzin deficiency in a mouse model of Barth syndrome. Hum Mol Genet. 2023 06 05; 32(12):2055-2067. View Abstract

  40. Molecule in mothers' milk nurses pups' heart cells to maturity. Nature. 2023 Jun; 618(7964):242-243. View Abstract

  41. Tbx5 maintains atrial identity by regulating an atrial enhancer network. bioRxiv. 2023 Apr 22. View Abstract

  42. Dynamic changes in P300 enhancers and enhancer-promoter contacts control mouse cardiomyocyte maturation. Dev Cell. 2023 05 22; 58(10):898-914.e7. View Abstract

  43. Ryanodine receptor 2 (RYR2) dysfunction activates the unfolded protein response and perturbs cardiomyocyte maturation. Cardiovasc Res. 2023 03 17; 119(1):221-235. View Abstract

  44. Future Directions and Resource Needs for National Heart, Lung, and Blood Institute (NHLBI) Gene Therapy Research: A Report of an NHLBI Workshop. Hum Gene Ther. 2023 02; 34(3-4):83-89. View Abstract

  45. In Vivo Dissection of Chamber-Selective Enhancers Reveals Estrogen-Related Receptor as a Regulator of Ventricular Cardiomyocyte Identity. Circulation. 2023 03 14; 147(11):881-896. View Abstract

  46. RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function. Circ Res. 2022 12 02; 131(12):980-1000. View Abstract

  47. Addendum: A tissue-engineered scale model of the heart ventricle. Nat Biomed Eng. 2022 Nov; 6(11):1318. View Abstract

  48. GATA4 Regulates Developing Endocardium Through Interaction With ETS1. Circ Res. 2022 11 11; 131(11):e152-e168. View Abstract

  49. Intrinsic myocardial defects underlie an Rbfox-deficient zebrafish model of hypoplastic left heart syndrome. Nat Commun. 2022 10 05; 13(1):5877. View Abstract

  50. Yap1 modulates cardiomyocyte hypertrophy via impaired mitochondrial biogenesis in response to chronic mechanical stress overload. Theranostics. 2022; 12(16):7009-7031. View Abstract

  51. Depletion of VGLL4 Causes Perinatal Lethality without Affecting Myocardial Development. Cells. 2022 09 10; 11(18). View Abstract

  52. ACTN2 Mutant Causes Proteopathy in Human iPSC-Derived Cardiomyocytes. Cells. 2022 09 02; 11(17). View Abstract

  53. Population Prevalence of Premature Truncating Variants in Plakophilin-2 and Association With Arrhythmogenic Right Ventricular Cardiomyopathy: A UK Biobank Analysis. Circ Genom Precis Med. 2022 06; 15(3):e003507. View Abstract

  54. A new murine model of Barth syndrome neutropenia links TAFAZZIN deficiency to increased ER stress-induced apoptosis. Blood Adv. 2022 04 26; 6(8):2557-2577. View Abstract

  55. CMYA5 establishes cardiac dyad architecture and positioning. Nat Commun. 2022 04 21; 13(1):2185. View Abstract

  56. CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene programs in the developing heart. Genes Dev. 2022 04 01; 36(7-8):468-482. View Abstract

  57. Cardiac ISL1-Interacting Protein, a Cardioprotective Factor, Inhibits the Transition From Cardiac Hypertrophy to Heart Failure. Front Cardiovasc Med. 2022; 9:857049. View Abstract

  58. Efficient In Vivo Homology-Directed Repair Within Cardiomyocytes. Circulation. 2022 03 08; 145(10):787-789. View Abstract

  59. Current and future treatment approaches for Barth syndrome. J Inherit Metab Dis. 2022 01; 45(1):17-28. View Abstract

  60. Author Correction: Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation. Nat Commun. 2021 Aug 19; 12(1):5105. View Abstract

  61. Experimental models of Barth syndrome. J Inherit Metab Dis. 2022 01; 45(1):72-81. View Abstract

  62. Cardiac CIP protein regulates dystrophic cardiomyopathy. Mol Ther. 2022 02 02; 30(2):898-914. View Abstract

  63. Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation. Nat Commun. 2021 07 21; 12(1):4442. View Abstract

  64. Loss of Tsc1 in cerebellar Purkinje cells induces transcriptional and translation changes in FMRP target transcripts. Elife. 2021 07 14; 10. View Abstract

  65. YAP/TEAD1 Complex Is a Default Repressor of Cardiac Toll-Like Receptor Genes. Int J Mol Sci. 2021 Jun 22; 22(13). View Abstract

  66. Calcific aortic valve disease: turning therapeutic discovery up a notch. Nat Rev Cardiol. 2021 05; 18(5):309-310. View Abstract

  67. Increased Reactive Oxygen Species-Mediated Ca2+/Calmodulin-Dependent Protein Kinase II Activation Contributes to Calcium Handling Abnormalities and Impaired Contraction in Barth Syndrome. Circulation. 2021 05 11; 143(19):1894-1911. View Abstract

  68. Two sides of the same coin: new insights into mechanisms of ventricular fibrillation. Cardiovasc Res. 2021 03 21; 117(4):983-984. View Abstract

  69. LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis. Circulation. 2021 05 18; 143(20):2007-2022. View Abstract

  70. TEAD1 protects against necroptosis in postmitotic cardiomyocytes through regulation of nuclear DNA-encoded mitochondrial genes. Cell Death Differ. 2021 07; 28(7):2045-2059. View Abstract

  71. Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling. Proc Natl Acad Sci U S A. 2021 01 12; 118(2). View Abstract

  72. AAV Gene Transfer to the Heart. Methods Mol Biol. 2021; 2158:269-280. View Abstract

  73. Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease. Dev Cell. 2021 02 08; 56(3):292-309.e9. View Abstract

  74. Intercalated disc protein Xinß is required for Hippo-YAP signaling in the heart. Nat Commun. 2020 09 16; 11(1):4666. View Abstract

  75. MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII. J Clin Invest. 2020 09 01; 130(9):4663-4678. View Abstract

  76. Enhancer dependence of cell-type-specific gene expression increases with developmental age. Proc Natl Acad Sci U S A. 2020 09 01; 117(35):21450-21458. View Abstract

  77. LARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis. Cell Rep. 2020 Aug 18; 32(7):108058. View Abstract

  78. L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis. Cell Rep. 2020 07 28; 32(4):107974. View Abstract

  79. Regulation of myonuclear positioning and muscle function by the skeletal muscle-specific CIP protein. Proc Natl Acad Sci U S A. 2020 08 11; 117(32):19254-19265. View Abstract

  80. Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA. Sci Adv. 2020 07; 6(30):eaba7606. View Abstract

  81. Gene therapy for inherited arrhythmias. Cardiovasc Res. 2020 07 15; 116(9):1635-1650. View Abstract

  82. The architecture and function of cardiac dyads. Biophys Rev. 2020 Aug; 12(4):1007-1017. View Abstract

  83. Genetic and Epigenetic Control of Heart Development. Cold Spring Harb Perspect Biol. 2020 07 01; 12(7). View Abstract

  84. Cardiomyocyte Maturation: New Phase in Development. Circ Res. 2020 04 10; 126(8):1086-1106. View Abstract

  85. AAV Gene Therapy Prevents and Reverses Heart Failure in a Murine Knockout Model of Barth Syndrome. Circ Res. 2020 04 10; 126(8):1024-1039. View Abstract

  86. Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta. Elife. 2020 02 24; 9. View Abstract

  87. Two faces of bivalent domain regulate VEGFA responsiveness and angiogenesis. Cell Death Dis. 2020 01 30; 11(1):75. View Abstract

  88. aYAP modRNA reduces cardiac inflammation and hypertrophy in a murine ischemia-reperfusion model. Life Sci Alliance. 2020 01; 3(1). View Abstract

  89. Investigation of Streptococcus agalactiae using pcsB-based LAMP in milk, tilapia and vaginal swabs in Haikou, China. J Appl Microbiol. 2020 Mar; 128(3):784-793. View Abstract

  90. A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers. Nat Commun. 2019 10 28; 10(1):4907. View Abstract

  91. Immunoglobulin G galactosylation levels are decreased in systemic sclerosis patients and differ according to disease subclassification. Scand J Rheumatol. 2020 Mar; 49(2):146-153. View Abstract

  92. Molecular mechanisms of arrhythmogenic cardiomyopathy. Nat Rev Cardiol. 2019 09; 16(9):519-537. View Abstract

  93. Insights Into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia From Engineered Human Heart Tissue. Circulation. 2019 07 30; 140(5):390-404. View Abstract

  94. Gene Therapy for Catecholaminergic Polymorphic Ventricular Tachycardia by Inhibition of Ca2+/Calmodulin-Dependent Kinase II. Circulation. 2019 07 30; 140(5):405-419. View Abstract

  95. Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction. Nat Commun. 2019 04 17; 10(1):1802. View Abstract

  96. Three species of Aeromonas (A. dhakensis, A. hydrophila and A. jandaei) isolated from freshwater crocodiles (Crocodylus siamensis) with pneumonia and septicemia. Lett Appl Microbiol. 2019 Mar; 68(3):212-218. View Abstract

  97. A dynamic and integrated epigenetic program at distal regions orchestrates transcriptional responses to VEGFA. Genome Res. 2019 02; 29(2):193-207. View Abstract

  98. Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure. Circ Res. 2019 01 04; 124(1):161-169. View Abstract

  99. Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association. Circulation. 2018 11 20; 138(21):e653-e711. View Abstract

  100. Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor. Nat Commun. 2018 09 21; 9(1):3837. View Abstract

  101. Effectiveness of mHealth Interventions in Improving Medication Adherence Among People with Hypertension: a Systematic Review. Curr Hypertens Rep. 2018 08 07; 20(10):86. View Abstract

  102. A tissue-engineered scale model of the heart ventricle. Nat Biomed Eng. 2018 12; 2(12):930-941. View Abstract

  103. Exercising engineered heart muscle to maturity. Nat Rev Cardiol. 2018 07; 15(7):383-384. View Abstract

  104. Genetic Mosaics for Greater Precision in Cardiovascular Research. Circ Res. 2018 06 22; 123(1):27-29. View Abstract

  105. Enhancing the precision of genetic lineage tracing using dual recombinases. Nat Med. 2017 Dec; 23(12):1488-1498. View Abstract

  106. Mitochondrial Cardiomyopathy Caused by Elevated Reactive Oxygen Species and Impaired Cardiomyocyte Proliferation. Circ Res. 2018 01 05; 122(1):74-87. View Abstract

  107. CASAAV: A CRISPR-Based Platform for Rapid Dissection of Gene Function In Vivo. Curr Protoc Mol Biol. 2017 10 02; 120:31.11.1-31.11.14. View Abstract

  108. VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis. Nat Commun. 2017 08 29; 8(1):383. View Abstract

  109. Identification of a hybrid myocardial zone in the mammalian heart after birth. Nat Commun. 2017 07 20; 8(1):87. View Abstract

  110. Host non-inflammatory neutrophils mediate the engraftment of bioengineered vascular networks. Nat Biomed Eng. 2017; 1. View Abstract

  111. The complex genetics of hypoplastic left heart syndrome. Nat Genet. 2017 Jul; 49(7):1152-1159. View Abstract

  112. Divergent Requirements for EZH1 in Heart Development Versus Regeneration. Circ Res. 2017 Jul 07; 121(2):106-112. View Abstract

  113. Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos. J Exp Med. 2017 06 05; 214(6):1753-1767. View Abstract

  114. Depletion of polycomb repressive complex 2 core component EED impairs fetal hematopoiesis. Cell Death Dis. 2017 04 13; 8(4):e2744. View Abstract

  115. [Long-term outcomes after cataract surgery in infants with congenital cataract]. Zhonghua Yan Ke Za Zhi. 2017 Apr 11; 53(4):266-273. View Abstract

  116. EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent. Elife. 2017 04 10; 6. View Abstract

  117. Analysis of Cardiac Myocyte Maturation Using CASAAV, a Platform for Rapid Dissection of Cardiac Myocyte Gene Function In Vivo. Circ Res. 2017 Jun 09; 120(12):1874-1888. View Abstract

  118. Cardiac Regeneration: Lessons From Development. Circ Res. 2017 Mar 17; 120(6):941-959. View Abstract

  119. Mapping cell type-specific transcriptional enhancers using high affinity, lineage-specific Ep300 bioChIP-seq. Elife. 2017 01 25; 6. View Abstract

  120. Preparation of rAAV9 to Overexpress or Knockdown Genes in Mouse Hearts. J Vis Exp. 2016 12 17; (118). View Abstract

  121. Efficient, footprint-free human iPSC genome editing by consolidation of Cas9/CRISPR and piggyBac technologies. Nat Protoc. 2017 Jan; 12(1):88-103. View Abstract

  122. Modeling Inherited Arrhythmia Disorders Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circ J. 2016 Dec 22; 81(1):12-21. View Abstract

  123. Single-Cell Resolution of Temporal Gene Expression during Heart Development. Dev Cell. 2016 11 21; 39(4):480-490. View Abstract

  124. Insulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury. Circulation. 2017 Jan 03; 135(1):59-72. View Abstract

  125. Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy. Cardiovasc Res. 2016 Nov 01; 112(2):543-554. View Abstract

  126. Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth. Dev Cell. 2016 11 21; 39(4):466-479. View Abstract

  127. Comprehensive analysis of promoter-proximal RNA polymerase II pausing across mammalian cell types. Genome Biol. 2016 06 03; 17(1):120. View Abstract

  128. Epicardium is required for cardiac seeding by yolk sac macrophages, precursors of resident macrophages of the adult heart. Dev Biol. 2016 05 15; 413(2):153-159. View Abstract

  129. GATA4 regulates Fgf16 to promote heart repair after injury. Development. 2016 Mar 15; 143(6):936-49. View Abstract

  130. Recounting Cardiac Cellular Composition. Circ Res. 2016 Feb 05; 118(3):368-70. View Abstract

  131. Contribution of Fetal, but Not Adult, Pulmonary Mesothelium to Mesenchymal Lineages in Lung Homeostasis and Fibrosis. Am J Respir Cell Mol Biol. 2016 Feb; 54(2):222-30. View Abstract

  132. Failed cooperative, but not competitive, interaction between large-scale brain networks impairs working memory in schizophrenia. Psychol Med. 2016 Apr; 46(6):1211-24. View Abstract

  133. Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. J Clin Invest. 2015 Nov 02; 125(11):4122-34. View Abstract

  134. SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth. Sci Signal. 2015 Sep 22; 8(395):ra94. View Abstract

  135. Regional differences in WT-1 and Tcf21 expression during ventricular development: implications for myocardial compaction. PLoS One. 2015; 10(9):e0136025. View Abstract

  136. Nuclear receptor RORa regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10401-6. View Abstract

  137. Trbp regulates heart function through microRNA-mediated Sox6 repression. Nat Genet. 2015 Jul; 47(7):776-83. View Abstract

  138. Novel Roles of GATA4/6 in the Postnatal Heart Identified through Temporally Controlled, Cardiomyocyte-Specific Gene Inactivation by Adeno-Associated Virus Delivery of Cre Recombinase. PLoS One. 2015; 10(5):e0128105. View Abstract

  139. Cellular origin and developmental program of coronary angiogenesis. Circ Res. 2015 Jan 30; 116(3):515-30. View Abstract

  140. Releasing YAP from an a-catenin trap increases cardiomyocyte proliferation. Circ Res. 2015 Jan 02; 116(1):9-11. View Abstract

  141. Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells. Nat Commun. 2014 Nov 26; 5:5507. View Abstract

  142. Introduction to the special issue on heart regeneration and rejuvenation. Stem Cell Res. 2014 Nov; 13(3 Pt B):521-2. View Abstract

  143. Insights into the genetic structure of congenital heart disease from human and murine studies on monogenic disorders. Cold Spring Harb Perspect Med. 2014 Oct 01; 4(10). View Abstract

  144. Epicardium-to-fat transition in injured heart. Cell Res. 2014 Nov; 24(11):1367-9. View Abstract

  145. Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease. Nat Commun. 2014 Sep 24; 5:4907. View Abstract

  146. Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival. Circ Res. 2015 Jan 02; 116(1):35-45. View Abstract

  147. Optimization of genome engineering approaches with the CRISPR/Cas9 system. PLoS One. 2014; 9(8):e105779. View Abstract

  148. Ultrasound-guided transthoracic intramyocardial injection in mice. J Vis Exp. 2014 Aug 05; (90):e51566. View Abstract

  149. Vessel formation. De novo formation of a distinct coronary vascular population in neonatal heart. Science. 2014 Jul 04; 345(6192):90-4. View Abstract

  150. Strategies for cardiac regeneration and repair. Sci Transl Med. 2014 Jun 04; 6(239):239rv1. View Abstract

  151. GATA4 represses an ileal program of gene expression in the proximal small intestine by inhibiting the acetylation of histone H3, lysine 27. Biochim Biophys Acta. 2014 Nov; 1839(11):1273-82. View Abstract

  152. Notching up vascular regeneration. Cell Res. 2014 Jul; 24(7):777-8. View Abstract

  153. Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model. Circ Res. 2014 Jul 18; 115(3):354-63. View Abstract

  154. Yap1 is required for endothelial to mesenchymal transition of the atrioventricular cushion. J Biol Chem. 2014 Jul 04; 289(27):18681-92. View Abstract

  155. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nat Med. 2014 Jun; 20(6):616-23. View Abstract

  156. Harnessing Hippo in the heart: Hippo/Yap signaling and applications to heart regeneration and rejuvenation. Stem Cell Res. 2014 Nov; 13(3 Pt B):571-81. View Abstract

  157. Hippo activation in arrhythmogenic cardiomyopathy. Circ Res. 2014 Jan 31; 114(3):402-5. View Abstract

  158. Peritruncal coronary endothelial cells contribute to proximal coronary artery stems and their aortic orifices in the mouse heart. PLoS One. 2013; 8(11):e80857. View Abstract

  159. WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland. Dev Cell. 2013 Oct 14; 27(1):5-18. View Abstract

  160. Developing insights into cardiac regeneration. Development. 2013 Oct; 140(19):3933-7. View Abstract

  161. Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nat Biotechnol. 2013 Oct; 31(10):898-907. View Abstract

  162. Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification. Proc Natl Acad Sci U S A. 2013 Sep 17; 110(38):15395-400. View Abstract

  163. HCN4 charges up the first heart field. Circ Res. 2013 Aug 02; 113(4):350-1. View Abstract

  164. The mysterious origins of coronary vessels. Cell Res. 2013 Sep; 23(9):1063-4. View Abstract

  165. Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization. Circulation. 2013 Jul 09; 128(2):101-14. View Abstract

  166. A dynamic H3K27ac signature identifies VEGFA-stimulated endothelial enhancers and requires EP300 activity. Genome Res. 2013 Jun; 23(6):917-27. View Abstract

  167. A simple method for deriving functional MSCs and applied for osteogenesis in 3D scaffolds. Sci Rep. 2013; 3:2243. View Abstract

  168. GATA factors promote ER integrity and ß-cell survival and contribute to type 1 diabetes risk. Mol Endocrinol. 2014 Jan; 28(1):28-39. View Abstract

  169. Genetic Cre-loxP assessment of epicardial cell fate using Wt1-driven Cre alleles. Circ Res. 2012 Nov 09; 111(11):e276-80. View Abstract

  170. Myocardial regeneration: expanding the repertoire of thymosin ß4 in the ischemic heart. Ann N Y Acad Sci. 2012 Oct; 1269:92-101. View Abstract

  171. Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14035-40. View Abstract

  172. Mature cardiomyocytes recall their progenitor experience via polycomb repressive complex 2. Circ Res. 2012 Jul 06; 111(2):162-4. View Abstract

  173. Endostatin lowers blood pressure via nitric oxide and prevents hypertension associated with VEGF inhibition. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11306-11. View Abstract

  174. Endocardial and epicardial epithelial to mesenchymal transitions in heart development and disease. Circ Res. 2012 Jun 08; 110(12):1628-45. View Abstract

  175. Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo. PLoS Genet. 2012; 8(5):e1002690. View Abstract

  176. Equal modulation of endothelial cell function by four distinct tissue-specific mesenchymal stem cells. Angiogenesis. 2012 Sep; 15(3):443-55. View Abstract

  177. Cardiac expression of ms1/STARS, a novel gene involved in cardiac development and disease, is regulated by GATA4. Mol Cell Biol. 2012 May; 32(10):1830-43. View Abstract

  178. CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy. Circ Res. 2012 Mar 16; 110(6):818-30. View Abstract

  179. YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2394-9. View Abstract

  180. Transcription factor GATA4 is activated but not required for insulin-like growth factor 1 (IGF1)-induced cardiac hypertrophy. J Biol Chem. 2012 Mar 23; 287(13):9827-9834. View Abstract

  181. PRC2 directly methylates GATA4 and represses its transcriptional activity. Genes Dev. 2012 Jan 01; 26(1):37-42. View Abstract

  182. Isolation and characterization of embryonic and adult epicardium and epicardium-derived cells. Methods Mol Biol. 2012; 843:155-68. View Abstract

  183. Regulation of GATA4 transcriptional activity in cardiovascular development and disease. Curr Top Dev Biol. 2012; 100:143-69. View Abstract

  184. Polycomb repressive complex 2 regulates normal development of the mouse heart. Circ Res. 2012 Feb 03; 110(3):406-15. View Abstract

  185. Adult cardiac-resident MSC-like stem cells with a proepicardial origin. Cell Stem Cell. 2011 Dec 02; 9(6):527-40. View Abstract

  186. Epicardial epithelial-to-mesenchymal transition in injured heart. J Cell Mol Med. 2011 Dec; 15(12):2781-3. View Abstract

  187. Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes. J Mol Cell Cardiol. 2012 Jan; 52(1):43-7. View Abstract

  188. miR-155 inhibits expression of the MEF2A protein to repress skeletal muscle differentiation. J Biol Chem. 2011 Oct 14; 286(41):35339-35346. View Abstract

  189. Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A. 2011 Jul 26; 108(30):12331-6. View Abstract

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I am committed to providing the highest quality care for pediatric patients with heart disease, and to advance their diagnosis and treatment through research and innovation.

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