Current Environment: Production

Medical Services

Specialties

Programs & Services

Languages

  • English

Education

Undergraduate School

Trinity College

1990, Hartford, CT

Graduate School

University of Connecticut School of Medicine

1997, Farmington, CT

Medical School

University of Connecticut School of Medicine

1997, Farmington, CT

Internship

Pediatrics

Yale-New Haven Hospital

New Haven, CT

Residency

Pediatrics

Yale-New Haven Hospital

2000, New Haven, CT

Fellowship

Pediatric Endocrinology

Boston Children's Hospital

2003, Boston, MA

Certifications

  • American Board of Pediatrics (Endocrinology)

Publications

  1. Human mesofluidic intestinal model for studying transport of drug carriers and bacteria through a live mucosal barrier. Lab Chip. 2025 May 20. View Abstract

  2. Hippo Signaling Is Essential for the Maintenance of Zona Glomerulosa Cell Fate in the Murine Adrenal Cortex. Endocrinology. 2025 Apr 22; 166(6). View Abstract

  3. The transcription factor HHEX maintains glucocorticoid levels and protects adrenals from androgen-induced lipid depletion. Res Sq. 2025 Apr 15. View Abstract

  4. Clonal memory of colitis accumulates and promotes tumor growth. Res Sq. 2025 Mar 27. View Abstract

  5. Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma. Cancer Commun (Lond). 2025 Mar 04. View Abstract

  6. Clonal memory of colitis accumulates and promotes tumor growth. bioRxiv. 2025 Feb 17. View Abstract

  7. RELMß sets the threshold for microbiome-dependent oral tolerance. Nature. 2025 Feb; 638(8051):760-768. View Abstract

  8. Cataloguing the postnatal small intestinal transcriptome during the first postnatal month. bioRxiv. 2024 Dec 27. View Abstract

  9. Human Mesofluidic Intestinal Model for Studying Transport of Drug Carriers and Bacteria Through a Live Mucosal Barrier. bioRxiv. 2024 Sep 22. View Abstract

  10. Response to Letter to the Editor From Hoekstra: "Adrenal Abcg1 Controls Cholesterol Flux and Steroidogenesis". Endocrinology. 2024 Aug 27; 165(10). View Abstract

  11. Non-canonical Wnt signaling triggered by WNT2B drives adrenal aldosterone production. bioRxiv. 2024 Aug 24. View Abstract

  12. Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma. bioRxiv. 2024 Aug 22. View Abstract

  13. Gut tumors in flies alter the taste valence of an anti-tumorigenic bitter compound. Curr Biol. 2024 Aug 05; 34(15):3591. View Abstract

  14. Pathogenic variants in KMT2C result in a neurodevelopmental disorder distinct from Kleefstra and Kabuki syndromes. Am J Hum Genet. 2024 Aug 08; 111(8):1626-1642. View Abstract

  15. Gut tumors in flies alter the taste valence of an anti-tumorigenic bitter compound. Curr Biol. 2024 Jun 17; 34(12):2623-2632.e5. View Abstract

  16. Faecalibacterium prausnitzii A2-165 metabolizes host- and media-derived chemicals and induces transcriptional changes in colonic epithelium in GuMI human gut microphysiological system. Microbiome Res Rep. 2024; 3(3):30. View Abstract

  17. WNT2B Deficiency Causes Enhanced Susceptibility to Colitis Due to Increased Inflammatory Cytokine Production. Cell Mol Gastroenterol Hepatol. 2024; 18(2):101349. View Abstract

  18. An immune-competent human gut microphysiological system enables inflammation-modulation by Faecalibacterium prausnitzii. NPJ Biofilms Microbiomes. 2024 Mar 29; 10(1):31. View Abstract

  19. Zona Glomerulosa-Derived Klotho Modulates Aldosterone Synthase Expression in Young Female Mice. Endocrinology. 2024 Mar 29; 165(5). View Abstract

  20. Adrenal Abcg1 Controls Cholesterol Flux and Steroidogenesis. Endocrinology. 2024 Jan 16; 165(3). View Abstract

  21. Extracellular carriers control lipid-dependent secretion, delivery, and activity of WNT morphogens. Dev Cell. 2024 01 22; 59(2):244-261.e6. View Abstract

  22. Direct therapeutic effect of sulfadoxine-pyrimethamine on nutritional deficiency-induced enteric dysfunction in a human Intestine Chip. EBioMedicine. 2024 Jan; 99:104921. View Abstract

  23. RET Signaling Persists in the Adult Intestine and Stimulates Motility by Limiting PYY Release From Enteroendocrine Cells. Gastroenterology. 2024 03; 166(3):437-449. View Abstract

  24. Generation of glucocorticoid-producing cells derived from human pluripotent stem cells. Cell Rep Methods. 2023 11 20; 3(11):100627. View Abstract

  25. Inflammation-induced adrenal dysfunction. Nat Rev Endocrinol. 2023 11; 19(11):622-623. View Abstract

  26. An immune-competent human gut microphysiological system enables inflammation-modulation of Faecalibacterium prausnitzii. Res Sq. 2023 Oct 12. View Abstract

  27. Calcineurin regulates aldosterone production via dephosphorylation of NFATC4. JCI Insight. 2023 07 24; 8(14). View Abstract

  28. ß-Catenin-Driven Differentiation Is a Tissue-Specific Epigenetic Vulnerability in Adrenal Cancer. Cancer Res. 2023 07 05; 83(13):2123-2141. View Abstract

  29. Stomach-derived human insulin-secreting organoids restore glucose homeostasis. Nat Cell Biol. 2023 05; 25(5):778-786. View Abstract

  30. WNT2B Deficiency Causes Increased Susceptibility to Colitis in Mice and Impairs Intestinal Epithelial Development in Humans. bioRxiv. 2023 Apr 22. View Abstract

  31. Stiffness Restricts the Stemness of the Intestinal Stem Cells and Skews Their Differentiation Toward Goblet Cells. Gastroenterology. 2023 06; 164(7):1137-1151.e15. View Abstract

  32. Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice. Nat Commun. 2022 12 21; 13(1):7858. View Abstract

  33. Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants. Nat Commun. 2022 11 09; 13(1):6786. View Abstract

  34. Intrinsic Adrenal TWIK-Related Acid-Sensitive TASK Channel Dysfunction Produces Spontaneous Calcium Oscillations Sufficient to Drive AngII (Angiotensin II)-Unresponsive Hyperaldosteronism. Hypertension. 2022 11; 79(11):2552-2564. View Abstract

  35. Mislocalization of protein kinase A drives pathology in Cushing's syndrome. Cell Rep. 2022 07 12; 40(2):111073. View Abstract

  36. Nutritional deficiency in an intestine-on-a-chip recapitulates injury hallmarks associated with environmental enteric dysfunction. Nat Biomed Eng. 2022 11; 6(11):1236-1247. View Abstract

  37. Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain. J Vis Exp. 2022 05 20; (183). View Abstract

  38. Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn's disease. Gut. 2023 05; 72(5):870-881. View Abstract

  39. Establishment of physiologically relevant oxygen gradients in microfluidic organ chips. Lab Chip. 2022 04 12; 22(8):1584-1593. View Abstract

  40. A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine. Nat Commun. 2022 03 21; 13(1):1503. View Abstract

  41. Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors. Cell. 2022 03 31; 185(7):1157-1171.e22. View Abstract

  42. Telomerase Reverse Transcriptase Expression Marks a Population of Rare Adipose Tissue Stem Cells. Stem Cells. 2022 03 03; 40(1):102-111. View Abstract

  43. Robust differentiation of human enteroendocrine cells from intestinal stem cells. Nat Commun. 2022 01 11; 13(1):261. View Abstract

  44. Triple-Decker Sandwich Cultures of Intestinal Organoids for Long-Term Live Imaging, Uniform Perturbation, and Statistical Sampling. Curr Protoc. 2022 Jan; 2(1):e330. View Abstract

  45. Innervated adrenomedullary microphysiological system to model nicotine and opioid exposure. Organs Chip. 2021 Nov; 3. View Abstract

  46. Coculture of primary human colon monolayer with human gut bacteria. Nat Protoc. 2021 08; 16(8):3874-3900. View Abstract

  47. Rosette morphology in zona glomerulosa formation and function. Mol Cell Endocrinol. 2021 06 15; 530:111287. View Abstract

  48. Telomerase expression marks transitional growth-associated skeletal progenitor/stem cells. Stem Cells. 2021 03; 39(3):296-305. View Abstract

  49. Yersinia pseudotuberculosis YopE prevents uptake by M cells and instigates M cell extrusion in human ileal enteroid-derived monolayers. Gut Microbes. 2021 Jan-Dec; 13(1):1988390. View Abstract

  50. False-positive very long-chain fatty acids in a case of autoimmune adrenal insufficiency. J Pediatr Endocrinol Metab. 2021 Apr 27; 34(4):517-520. View Abstract

  51. Organoid culture system for patient-derived lung metastatic osteosarcoma. Med Oncol. 2020 Oct 20; 37(11):105. View Abstract

  52. Primary human colonic mucosal barrier crosstalk with super oxygen-sensitive Faecalibacterium prausnitzii in continuous culture. Med. 2021 01 15; 2(1):74-98.e9. View Abstract

  53. Cholinergic Activation of Primary Human Derived Intestinal Epithelium Does Not Ameliorate TNF-a Induced Injury. Cell Mol Bioeng. 2020 Oct; 13(5):487-505. View Abstract

  54. Wnt/ß-catenin activation cooperates with loss of p53 to cause adrenocortical carcinoma in mice. Oncogene. 2020 07; 39(30):5282-5291. View Abstract

  55. Rapid Prototyping of Multilayer Microphysiological Systems. ACS Biomater Sci Eng. 2021 07 12; 7(7):2949-2963. View Abstract

  56. Fully synthetic matrices for in vitro culture of primary human intestinal enteroids and endometrial organoids. Biomaterials. 2020 09; 254:120125. View Abstract

  57. Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation. Cell Rep. 2020 04 21; 31(3):107524. View Abstract

  58. Angiotensin II induces coordinated calcium bursts in aldosterone-producing adrenal rosettes. Nat Commun. 2020 04 03; 11(1):1679. View Abstract

  59. ß-Catenin and FGFR2 regulate postnatal rosette-based adrenocortical morphogenesis. Nat Commun. 2020 04 03; 11(1):1680. View Abstract

  60. Intestinal enteroids recapitulate the effects of short-chain fatty acids on the intestinal epithelium. PLoS One. 2020; 15(4):e0230231. View Abstract

  61. Chemogenetic activation of adrenocortical Gq signaling causes hyperaldosteronism and disrupts functional zonation. J Clin Invest. 2020 01 02; 130(1):83-93. View Abstract

  62. Human Colon-on-a-Chip Enables Continuous In Vitro Analysis of Colon Mucus Layer Accumulation and Physiology. Cell Mol Gastroenterol Hepatol. 2020; 9(3):507-526. View Abstract

  63. Sex Differences in Adrenal Bmal1 Deletion-Induced Augmentation of Glucocorticoid Responses to Stress and ACTH in Mice. Endocrinology. 2019 10 01; 160(10):2215-2229. View Abstract

  64. Author Correction: A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip. Nat Biomed Eng. 2019 Jul; 3(7):583. View Abstract

  65. Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells. Nat Microbiol. 2019 10; 4(10):1760-1769. View Abstract

  66. A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip. Nat Biomed Eng. 2019 07; 3(7):520-531. View Abstract

  67. Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites. Microbiome. 2019 03 20; 7(1):43. View Abstract

  68. Adrenal Tissue-Specific Deletion of TASK Channels Causes Aldosterone-Driven Angiotensin II-Independent Hypertension. Hypertension. 2019 02; 73(2):407-414. View Abstract

  69. A ZNRF3-dependent Wnt/ß-catenin signaling gradient is required for adrenal homeostasis. Genes Dev. 2019 02 01; 33(3-4):209-220. View Abstract

  70. The Adrenal Clock Prevents Aberrant Light-Induced Alterations in Circadian Glucocorticoid Rhythms. Endocrinology. 2018 12 01; 159(12):3950-3964. View Abstract

  71. Telomerase Reverse Transcriptase Expression in Mouse Endometrium During Reepithelialization and Regeneration in a Menses-Like Model. Stem Cells Dev. 2019 01 01; 28(1):1-12. View Abstract

  72. Early Identification of Primary Hypothyroidism in Neonates Exposed to Intralymphatic Iodinated Contrast: A Case Series. J Clin Endocrinol Metab. 2018 10 01; 103(10):3585-3588. View Abstract

  73. High-dimensional immune phenotyping and transcriptional analyses reveal robust recovery of viable human immune and epithelial cells from frozen gastrointestinal tissue. Mucosal Immunol. 2018 11; 11(6):1684-1693. View Abstract

  74. Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations. Am J Hum Genet. 2018 07 05; 103(1):131-137. View Abstract

  75. Adrenocortical development: Lessons from mouse models. Ann Endocrinol (Paris). 2018 Jun; 79(3):95-97. View Abstract

  76. The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile. PLoS Biol. 2018 03; 16(3):e2002417. View Abstract

  77. Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells. Arterioscler Thromb Vasc Biol. 2018 06; 38(6):1283-1296. View Abstract

  78. Move Over Caco-2 Cells: Human-Induced Organoids Meet Gut-on-a-Chip. Cell Mol Gastroenterol Hepatol. 2018; 5(4):634-635. View Abstract

  79. Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids. Sci Rep. 2018 02 13; 8(1):2871. View Abstract

  80. PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal. JCI Insight. 2018 01 25; 3(2). View Abstract

  81. JAK/STAT-1 Signaling Is Required for Reserve Intestinal Stem Cell Activation during Intestinal Regeneration Following Acute Inflammation. Stem Cell Reports. 2018 01 09; 10(1):17-26. View Abstract

  82. Bone Marrow Stem Cells Do Not Contribute to Endometrial Cell Lineages in Chimeric Mouse Models. Stem Cells. 2018 01; 36(1):91-102. View Abstract

  83. Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity. Cell Stem Cell. 2017 07 06; 21(1):78-90.e6. View Abstract

  84. A case report of methadone-associated hypoglycemia in an 11-month-old male. Clin Toxicol (Phila). 2018 01; 56(1):74-76. View Abstract

  85. The Circadian Clock Gene BMAL1 Coordinates Intestinal Regeneration. Cell Mol Gastroenterol Hepatol. 2017 Jul; 4(1):95-114. View Abstract

  86. CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types. Genome Biol. 2016 09 29; 17(1):201. View Abstract

  87. Frizzled proteins are colonic epithelial receptors for C. difficile toxin B. Nature. 2016 Oct 20; 538(7625):350-355. View Abstract

  88. Regulation of zonation and homeostasis in the adrenal cortex. Mol Cell Endocrinol. 2017 02 05; 441:146-155. View Abstract

  89. An enduring role for quiescent stem cells. Dev Dyn. 2016 07; 245(7):718-26. View Abstract

  90. Role of voltage-gated calcium channels in the regulation of aldosterone production from zona glomerulosa cells of the adrenal cortex. J Physiol. 2016 10 15; 594(20):5851-5860. View Abstract

  91. Reprogrammed Stomach Tissue as a Renewable Source of Functional ß Cells for Blood Glucose Regulation. Cell Stem Cell. 2016 Mar 03; 18(3):410-21. View Abstract

  92. Factors regulating quiescent stem cells: insights from the intestine and other self-renewing tissues. J Physiol. 2016 09 01; 594(17):4805-13. View Abstract

  93. The mouse endometrium contains epithelial, endothelial and leucocyte populations expressing the stem cell marker telomerase reverse transcriptase. Mol Hum Reprod. 2016 Apr; 22(4):272-84. View Abstract

  94. Dormant Intestinal Stem Cells Are Regulated by PTEN and Nutritional Status. Cell Rep. 2015 Dec 22; 13(11):2403-2411. View Abstract

  95. Distinct Processes and Transcriptional Targets Underlie CDX2 Requirements in Intestinal Stem Cells and Differentiated Villus Cells. Stem Cell Reports. 2015 Nov 10; 5(5):673-681. View Abstract

  96. Circulating IGF-I and IGFBP3 Levels Control Human Colonic Stem Cell Function and Are Disrupted in Diabetic Enteropathy. Cell Stem Cell. 2015 10 01; 17(4):486-498. View Abstract

  97. Oncogenic K-Ras promotes proliferation in quiescent intestinal stem cells. Stem Cell Res. 2015 Jul; 15(1):165-71. View Abstract

  98. Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism. Atherosclerosis. 2014 Oct; 236(2):312-20. View Abstract

  99. Optimised protocols for the identification of the murine cardiac side population. Stem Cell Rev Rep. 2013 Oct; 9(5):731-9. View Abstract

  100. Adrenocortical zonation results from lineage conversion of differentiated zona glomerulosa cells. Dev Cell. 2013 Sep 30; 26(6):666-673. View Abstract

  101. Telomerase expression in the mammalian heart. FASEB J. 2012 Dec; 26(12):4832-40. View Abstract

  102. International workshop: radiation effects on mutation in somatic and germline stem cells. Int J Radiat Biol. 2012 Jun; 88(6):501-6. View Abstract

  103. Tales from the crypt: the expanding role of slow cycling intestinal stem cells. Cell Stem Cell. 2012 Jan 06; 10(1):2-4. View Abstract

  104. Characterization and fate of telomerase-expressing epithelia during kidney repair. J Am Soc Nephrol. 2011 Dec; 22(12):2256-65. View Abstract

  105. Slowly cycling versus rapidly cycling intestinal stem cells: distinct roles or redundancy. Cell Cycle. 2011 Mar 01; 10(5):723-4. View Abstract

  106. Guidelines for the Development of Comprehensive Care Centers for Congenital Adrenal Hyperplasia: Guidance from the CARES Foundation Initiative. Int J Pediatr Endocrinol. 2010; 2010:275213. View Abstract

  107. Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):179-84. View Abstract

  108. Regulation of gene expression in the intestinal epithelium. Prog Mol Biol Transl Sci. 2010; 96:207-29. View Abstract

  109. Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells. Proc Natl Acad Sci U S A. 2008 Jul 29; 105(30):10420-5. View Abstract

  110. Small intestinal stem cell markers. J Anat. 2008 Jul; 213(1):52-8. View Abstract

  111. Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell. 2008 Mar 06; 2(3):230-40. View Abstract

  112. Corticotropin-releasing hormone deficiency increases allergen-induced airway inflammation in a mouse model of asthma. J Allergy Clin Immunol. 2004 Oct; 114(4):747-54. View Abstract

  113. COL1A1 transgene expression in stably transfected osteoblastic cells. Relative contributions of first intron, 3'-flanking sequences, and sequences derived from the body of the human COL1A1 minigene. J Biol Chem. 1997 Dec 12; 272(50):31241-50. View Abstract

  114. Role of the first intron in the regulation of the COL 1A1 gene. Matrix Biol. 1996 Jul; 15(2):62-3; author reply 70. View Abstract

  115. Novel use for BAL 31 nuclease-generated nested deletions: sequencing from the inside out. Biotechniques. 1995 Apr; 18(4):614-7. View Abstract

  116. Inhibition of collagen synthesis by prostaglandins in the immortalized rat osteoblastic cell line Py1a: structure-activity relations and signal transduction mechanisms. J Bone Miner Res. 1994 Dec; 9(12):1935-43. View Abstract

  117. Regulation of the alpha 1(I) collagen promoter in vascular smooth muscle cells. Comparison with other alpha 1(I) collagen-producing cells in transgenic animals and cultured cells. J Biol Chem. 1994 Feb 18; 269(7):4903-9. View Abstract
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