Current Environment: Production

Medical Services

Specialties

Programs & Services

Languages

  • English

Education

Undergraduate School

Princeton University

1998, Princeton, NJ

Medical School

Jefferson Medical College, Thomas Jefferson University

1998, Philadelphia, PA

Internship

Surgery

University of Washington

1999, Seattle, WA

Residency

Surgery

University of Washington

2000, Seattle, WA

Residency

Urology

University of Washington

2003, Seattle, WA

Residency

Chief Urology Resident

University of Washington

2004, Seattle, WA

Fellowship

Pediatric Urology

Boston Children's Hospital

2007, Boston, MA

Certifications

  • American Board of Urology (Pediatric Urology)

Professional History

Richard S. Lee, MD is the Vice Chair, Research, Director of Pediatric Urologic Oncology, Director of Pediatric Urologic Transplantation, and the Co-Director of the Bladder Exstrophy Program. He is a board-certified pediatric urologist specializing in complex genitourinary reconstruction, including bladder exstrophy and other complex pelvic malformations, pediatric urologic oncology, pediatric renal transplantation and reconstruction, and robotic surgery. Dr. Lee received his undergraduate degree in Chemical Engineering at Princeton University and his medical degree at Jefferson Medical College. He completed his 6-year Urologic Surgery residency at the University of Washington and then trained in a 3-year pediatric urology fellowship at Boston Children’s Hospital, Harvard Medical School.

Dr. Lee has multiple research interests each with a strong focus on preservation of kidney function. His laboratory focuses on identifying urinary biomarkers of kidney injury, kidney obstruction and infection. He has received numerous research grants for his work and has been continuously federally funded by the National Institutes of Health (NIH) since 2007.

Media

Caregiver Profile

Meet Dr. Richard Lee

Publications

  1. Multiomics analysis unveils an inosine-sensitive DNA damage response in neurogenic bladder after spinal cord injury. JCI Insight. 2025 May 08. View Abstract

  2. Long-Term Urinary and Sexual Outcomes in Pediatric Genitourinary Rhabdomyosarcoma Survivors: A Qualitative Study. J Urol. 2025 Apr; 213(4):494-503. View Abstract

  3. Integrated omics analysis unveils a DNA damage response to neurogenic injury. bioRxiv. 2023 Dec 10. View Abstract

  4. Ureteropelvic Junction Obstruction/Hydronephrosis. Urol Clin North Am. 2023 Aug; 50(3):361-369. View Abstract

  5. Long-term Urological Outcomes in Pelvic Genitourinary Rhabdomyosarcoma: A 48-Year Single-center Experience. J Urol. 2023 06; 209(6):1202-1209. View Abstract

  6. Prenatal Diagnosis of Bladder Exstrophy and OEIS over 20 Years. Urology. 2023 02; 172:174-177. View Abstract

  7. Copy Number Variation Analysis Facilitates Identification of Genetic Causation in Patients with Congenital Anomalies of the Kidney and Urinary Tract. Eur Urol Open Sci. 2022 Oct; 44:106-112. View Abstract

  8. Association between urinary biomarkers MMP-7/TIMP-2 and reduced renal function in children with ureteropelvic junction obstruction. PLoS One. 2022; 17(7):e0270018. View Abstract

  9. Primary and secondary vaginal reconstruction with autologous buccal mucosa and intravaginal wound vacuum therapy. J Pediatr Surg. 2022 Aug; 57(8):1687-1693. View Abstract

  10. Malignancy Yield of Testis Pathology in Older Boys and Adolescents with Cryptorchidism. J Urol. 2022 Mar; 207(3):694-700. View Abstract

  11. The Urinary Proteomic Profile Implicates Key Regulators for Urologic Chronic Pelvic Pain Syndrome (UCPPS): A MAPP Research Network Study. Mol Cell Proteomics. 2022 01; 21(1):100176. View Abstract

  12. Proteomic Discovery of Noninvasive Biomarkers Associated With Sport-Related Concussions. Neurology. 2022 01 11; 98(2):e186-e198. View Abstract

  13. Urinary Tract Infections in Children with Vesicoureteral Reflux Are Accompanied by Alterations in Urinary Microbiota and Metabolome Profiles. Eur Urol. 2022 02; 81(2):151-154. View Abstract

  14. Uromodulin Isolation and Its N-Glycosylation Analysis by NanoLC-MS/MS. J Proteome Res. 2021 05 07; 20(5):2662-2672. View Abstract

  15. Characterizing Patients with Recurrent Urinary Tract Infections in Vesicoureteral Reflux: A Pilot Study of the Urinary Proteome. Mol Cell Proteomics. 2020 Mar; 19(3):456-466. View Abstract

  16. Modeling dynamic radial contrast enhanced MRI with linear time invariant systems for motion correction in quantitative assessment of kidney function. Med Image Anal. 2021 01; 67:101880. View Abstract

  17. An in-depth Comparison of the Pediatric and Adult Urinary N-glycomes. Mol Cell Proteomics. 2020 11; 19(11):1767-1776. View Abstract

  18. Correction to: Prospective pediatric study comparing glomerular filtration rate estimates based on motion-robust dynamic contrast-enhanced magnetic resonance imaging and serum creatinine (eGFR) to 99mTc DTPA. Pediatr Radiol. 2020 May; 50(5):755-756. View Abstract

  19. Accuracy of Ultrasound in Identifying Renal Scarring as Compared to DMSA Scan. Urology. 2020 04; 138:134-137. View Abstract

  20. Prospective pediatric study comparing glomerular filtration rate estimates based on motion-robust dynamic contrast-enhanced magnetic resonance imaging and serum creatinine (eGFR) to 99mTc DTPA. Pediatr Radiol. 2020 05; 50(5):698-705. View Abstract

  21. Characterizing Patients with Recurrent Urinary Tract Infections in Vesicoureteral Reflux: A Pilot Study of the Urinary Proteome. Mol Cell Proteomics. 2020 03; 19(3):456-466. View Abstract

  22. Feed and wrap magnetic resonance urography provides anatomic and functional imaging in infants without anesthesia. J Pediatr Urol. 2020 Feb; 16(1):116-120. View Abstract

  23. CAKUT and Autonomic Dysfunction Caused by Acetylcholine Receptor Mutations. Am J Hum Genet. 2019 12 05; 105(6):1286-1293. View Abstract

  24. Renal outcomes of neonates with early presentation of posterior urethral valves: a 10-year single center experience. J Perinatol. 2020 01; 40(1):112-117. View Abstract

  25. Interobserver and Intra-Observer Reliability of the Urinary Tract Dilation Classification System in Neonates: A Multicenter Study. J Urol. 2019 06; 201(6):1186-1192. View Abstract

  26. Whole-Exome Sequencing Identifies Causative Mutations in Families with Congenital Anomalies of the Kidney and Urinary Tract. J Am Soc Nephrol. 2018 09; 29(9):2348-2361. View Abstract

  27. Collaborating with our adult colleagues: A case series of robotic surgery for suspicious and cancerous lesions in children and young adults performed in a free-standing children's hospital. J Pediatr Urol. 2018 04; 14(2):182.e1-182.e8. View Abstract

  28. Has the robot caught up? National trends in utilization, perioperative outcomes, and cost for open, laparoscopic, and robotic pediatric pyeloplasty in the United States from 2003 to 2015. J Pediatr Urol. 2018 08; 14(4):336.e1-336.e8. View Abstract

  29. Identification of novel non-invasive biomarkers of urinary chronic pelvic pain syndrome: findings from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. BJU Int. 2017 07; 120(1):130-142. View Abstract

  30. Urinary NGAL deficiency in recurrent urinary tract infections. Pediatr Nephrol. 2017 06; 32(6):1077-1080. View Abstract

  31. Biomarkers for Wilms Tumor: A Brave New World. J Urol. 2016 11; 196(5):1337-1338. View Abstract

  32. Urinary Proteomics Yield Pathological Insights for Ureteropelvic Junction Obstruction. Mol Cell Proteomics. 2016 08; 15(8):2607-15. View Abstract

  33. Universal Solid-Phase Reversible Sample-Prep for Concurrent Proteome and N-Glycome Characterization. J Proteome Res. 2016 Mar 04; 15(3):891-9. View Abstract

  34. Targeted sequencing of 96 renal developmental microRNAs in 1213 individuals from 980 families with congenital anomalies of the kidney and urinary tract. Nephrol Dial Transplant. 2016 08; 31(8):1280-3. View Abstract

  35. Yolk Sac Tumor of the Testis in Infants and Children: A Clinicopathologic Analysis of 33 Cases. Am J Surg Pathol. 2015 Aug; 39(8):1121-31. View Abstract

  36. Mutations in TBX18 Cause Dominant Urinary Tract Malformations via Transcriptional Dysregulation of Ureter Development. Am J Hum Genet. 2015 Aug 06; 97(2):291-301. View Abstract

  37. Dual modifications strategy to quantify neutral and sialylated N-glycans simultaneously by MALDI-MS. Anal Chem. 2014 Jul 01; 86(13):6277-84. View Abstract

  38. Can we do better? J Urol. 2014 Apr; 191(4):893-4. View Abstract

  39. Multi-planar dynamic contrast-enhanced ultrasound assessment of blood flow in a rabbit model of testicular torsion. Ultrasound Med Biol. 2014 Feb; 40(2):361-70. View Abstract

  40. The GlycoFilter: a simple and comprehensive sample preparation platform for proteomics, N-glycomics and glycosylation site assignment. Mol Cell Proteomics. 2013 Oct; 12(10):2981-91. View Abstract

  41. An in-depth comparison of the male pediatric and adult urinary proteomes. Biochim Biophys Acta. 2014 May; 1844(5):1044-50. View Abstract

  42. SweetSEQer, simple de novo filtering and annotation of glycoconjugate mass spectra. Mol Cell Proteomics. 2013 Jun; 12(6):1735-40. View Abstract

  43. A classifier based on accurate mass measurements to aid large scale, unbiased glycoproteomics. Mol Cell Proteomics. 2013 Apr; 12(4):1017-25. View Abstract

  44. PNGase F catalyzes de-N-glycosylation in a domestic microwave. Anal Biochem. 2012 Aug 01; 427(1):33-5. View Abstract

  45. Economic and radiation costs of initial imaging approaches after a child's first febrile urinary tract infection. Clin Pediatr (Phila). 2012 Jan; 51(1):23-30. View Abstract

  46. Costs and consequences of universal sibling screening for vesicoureteral reflux: decision analysis. Pediatrics. 2010 Nov; 126(5):865-71. View Abstract

  47. One-step sample concentration, purification, and albumin depletion method for urinary proteomics. J Proteome Res. 2010 Nov 05; 9(11):6082-9. View Abstract

  48. The predictive value of the first postnatal ultrasound in children with antenatal hydronephrosis. J Pediatr Urol. 2011 Apr; 7(2):128-36. View Abstract

  49. Sonourethrogram to manage adolescent anterior urethral stricture. J Urol. 2010 Oct; 184(4 Suppl):1699-702. View Abstract

  50. Radiation dose and screening for vesicoureteral reflux. AJR Am J Roentgenol. 2010 Feb; 194(2):W243. View Abstract

  51. Robot-assisted laparoscopic nephrectomy and contralateral ureteral reimplantation in children. J Endourol. 2010 Jan; 24(1):123-8. View Abstract

  52. Biofeedback training for lower urinary tract symptoms: factors affecting efficacy. J Urol. 2009 Oct; 182(4 Suppl):2050-5. View Abstract

  53. Ultrasound versus computerized tomography for evaluating urolithiasis. J Urol. 2009 Oct; 182(4 Suppl):1829-34. View Abstract

  54. Nomograms for predicting annual resolution rate of primary vesicoureteral reflux: results from 2,462 children. J Urol. 2009 Oct; 182(4):1535-41. View Abstract

  55. Proteomics and opportunities for clinical translation in urological disease. J Urol. 2009 Sep; 182(3):835-43. View Abstract

  56. Biomarkers for pediatric urological disease. Curr Opin Urol. 2009 Jul; 19(4):397-401. View Abstract

  57. Perinatal Urology. Pediatric Nephrology Ellis Avner and William Harmon, editors. 2009.

  58. Pediatric Laparoscopic Nephrectomy / Partial Nephrectomy. Glenn’s Urologic Surgery Sam Graham and Thomas Keane, editors . 2009.

  59. Robot assisted laparoscopic partial nephrectomy: a viable and safe option in children. J Urol. 2009 Feb; 181(2):823-8; discussion 828-9. View Abstract

  60. Optimizing sample handling for urinary proteomics. J Proteome Res. 2008 Sep; 7(9):4022-30. View Abstract

  61. Does the Deflux procedure reduce the incidence of urinary tract infections in children with vesicoureteral reflux? Nat Clin Pract Urol. 2008 Apr; 5(4):182-3. View Abstract

  62. Temporal variations of the postnatal rat urinary proteome as a reflection of systemic maturation. Proteomics. 2008 Mar; 8(5):1097-112. View Abstract

  63. Robot-assisted laparoscopic ileal bladder augmentation: defining techniques and potential pitfalls. J Endourol. 2008 Feb; 22(2):355-60. View Abstract

  64. Obstruction of the Urinary Tract, including Hydronephrosis. Hansen AR, Puder M, editors. Manual of Neonatal Surgical Intensive Care. 2008.

  65. Laparoscopic reoperative pediatric pyeloplasty with robotic assistance. J Endourol. 2007 Oct; 21(10):1137-40. View Abstract

  66. Early results of robot assisted laparoscopic lithotomy in adolescents. J Urol. 2007 Jun; 177(6):2306-9; discussion 2309-10. View Abstract

  67. Ureteral complications in renal transplantation: a comparison of the Lich-Gregoir versus the Taguchi technique. Transplant Proc. 2007 Jun; 39(5):1461-4. View Abstract

  68. Determining the optimal method of extracting proteins from urine for proteomic biomarker discovery. American Society of Mass Spectrometry. 2007.

  69. Health A to Z: Male Infertility. 2007.

  70. Health A to Z: Phimosis and Paraphimosis. 2007.

  71. Health A to Z: Priapism. 2007.

  72. Ask the Expert: Cystoscopy. 2007.

  73. Can a complete primary repair approach be applied to cloacal exstrophy? J Urol. 2006 Dec; 176(6 Pt 1):2643-8. View Abstract

  74. Global methods for protein glycosylation analysis by mass spectrometry. Biochim Biophys Acta. 2006 Dec; 1764(12):1870-80. View Abstract

  75. Applying the ALARA concept to the evaluation of vesicoureteric reflux. Pediatr Radiol. 2006 Sep; 36 Suppl 2:185-91. View Abstract

  76. Antenatal hydronephrosis as a predictor of postnatal outcome: a meta-analysis. Pediatrics. 2006 Aug; 118(2):586-93. View Abstract

  77. Robotic surgery for ureteropelvic junction obstruction. Curr Opin Urol. 2006 Jul; 16(4):291-4. View Abstract

  78. Health A to Z: Peyronies Disease. 2006.

  79. Ask the Expert: Radiation treatment and the bladder. 2006.

  80. A proteomics platform based on spectrum alignment for de novo sequencing by LTQ FT MS. American Society of Mass Spectrometry. 2006.

  81. The SeqR – a software tool for the analysis of high accuracy mass spectral data. American Society of Mass Spectrometry,. 2006.

  82. Health A to Z: Impotence. 2006.

  83. Health A to Z: Retrograde Ejaculation. 2006.

  84. Pediatric robot assisted laparoscopic dismembered pyeloplasty: comparison with a cohort of open surgery. J Urol. 2006 Feb; 175(2):683-7; discussion 687. View Abstract

  85. Pediatric retroperitoneal laparoscopic partial nephrectomy: comparison with an age matched cohort of open surgery. J Urol. 2005 Aug; 174(2):708-11; discussion 712. View Abstract

  86. Indirect recognition of MHC class I allopeptides accelerates lung allograft rejection in miniature swine. Am J Transplant. 2005 Jul; 5(7):1626-34. View Abstract

  87. Health A to Z: Epididymitis and Orchitis. 2005.

  88. Commentary on: Timing of Follow-up Voiding Cystourethrogram in Children with Primary Vesicoureteral Reflux: Development and Application of a Clinical Algorithm. American Journal of Urology Review. 2005; 3(11):481-3.

  89. Symptomatic refluxing distal ureteral stumps after nephroureterectomy and heminephroureterectomy. What should we do? J Urol. 2005 Jan; 173(1):204-6; discussion 206. View Abstract

  90. Molecular cloning and characterization of canine ICOS. Genomics. 2004 Oct; 84(4):730-6. View Abstract

  91. Hematopoietic stem cell transplantation does not restore dystrophin expression in Duchenne muscular dystrophy dogs. Blood. 2004 Dec 15; 104(13):4311-8. View Abstract

  92. Intracorporeal laparoscopic appendicovesicostomy: a case report of a novel approach. J Urol. 2004 May; 171(5):1899. View Abstract

  93. Vasoepididymostomy. Graham SD, editor. Glenn's Urology Surgery. 2004; 455-461.

  94. Traumatic renal artery pseudoaneurysm: diagnosis and management techniques. J Trauma. 2003 Nov; 55(5):972-8. View Abstract

  95. FTY720 does not abrogate acute graft-versus-host disease in the dog leukocyte antigen-nonidentical unrelated canine model. Transplantation. 2003 Oct 27; 76(8):1155-8. View Abstract

  96. Induction of tolerance to heart transplants by simultaneous cotransplantation of donor kidneys may depend on a radiation-sensitive renal-cell population. Transplantation. 2003 Aug 27; 76(4):625-31. View Abstract

  97. Postgrafting immunosuppression with sirolimus and cyclosporine facilitates stable mixed hematopoietic chimerism in dogs given sublethal total body irradiation before marrow transplantation from DLA-identical littermates. Biol Blood Marrow Transplant. 2003 Aug; 9(8):489-95. View Abstract

  98. Intermediate outcomes of dual renal allografts: the University of Washington experience. J Urol. 2003 Mar; 169(3):855-8. View Abstract

  99. Intermediate outcomes of dual renal allografts. Transplant Proc. 2003 Mar; 35(2):854-5. View Abstract

  100. Survival of small bowel transplants in canine mixed hematopoietic chimeras: preliminary results. Transplant Proc. 2002 Dec; 34(8):3366-7. View Abstract

  101. Percutaneous central dual-lumen catheter for apheresis in the canine. J Invest Surg. 2002 Nov-Dec; 15(6):337-41. View Abstract

  102. A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes. Genome Res. 2002 Apr; 12(4):543-54. View Abstract

  103. Treatment outcomes in localized prostate cancer: a patient-oriented approach. Semin Urol Oncol. 2002 Feb; 20(1):63-73. View Abstract

  104. Salvage anterior C1-C2 screw fixation and arthrodesis through the lateral approach in a patient with a symptomatic pseudoarthrosis. Am J Orthop (Belle Mead NJ). 1997 May; 26(5):349-53. View Abstract

  105. Cervical Orthoses: A biomechanical and functional review. Jefferson Orthopaedic J. 1995; 24:29-36.

  106. An Examination of the Application of a Proton Exchange Membrane Fuel Cell for Cogeneration in a Hospital. 1994.
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