Current Environment: Production

Medical Services

Programs & Services

Languages

  • English

Education

Medical School

Stanford University School of Medicine

1980, Stanford, CA

Internship

Boston Children's Hospital

1981, Boston, MA

Residency

Boston Children's Hospital

1983, Boston, MA

Residency

Anesthesia

Massachusetts General Hospital

1985, Boston, MA

Fellowship

Pediatric Anesthesia

Boston Children's Hospital

1985, Boston, MA

Certifications

  • American Board of Anesthesiology (Hospice and Palliative Medicine)
  • American Board of Anesthesiology (Pain Medicine)
  • American Board of Anesthesiology (Pediatric Anesthesiology)
  • American Board of Pediatrics (General)

Media

Caregiver Profile

Meet Dr. Charles Berde

Publications

  1. Neurodevelopment at 10 months and 2-3 years old after early and prolonged anaesthesia in infancy: General Anaesthesia & Brain Activity study (GABA) secondary analysis. BJA Open. 2025 Jun; 14:100383. View Abstract

  2. Pediatric erythromelalgia from multidisciplinary perspectives: a scoping review. Pediatr Res. 2025 Jan 16. View Abstract

  3. Improving Pain Management after Tonsillectomy. Anesthesiology. 2024 Sep 01; 141(3):425-427. View Abstract

  4. Development and validation of a home quantitative sensory testing tool-kit to assess changes in sensory and pain processing: a study in healthy young adults. Pain. 2025 Jan 01; 166(1):52-66. View Abstract

  5. Neurodevelopment of children exposed to prolonged anesthesia in infancy: GABA study interim analysis of resting-state brain networks at 2, 4, and 10-months old. Neuroimage Clin. 2024; 42:103614. View Abstract

  6. Rescue designs in analgesic trials from 0 to 2 years of age: scoping review. Pediatr Res. 2024 Apr; 95(5):1237-1245. View Abstract

  7. Clinical Characterization of Pediatric Erythromelalgia: A Single-Center Case Series. Children (Basel). 2023 Jul 26; 10(8). View Abstract

  8. Late-presenting dural leak following spine fusion in the pediatric population. Spine Deform. 2023 Nov; 11(6):1371-1380. View Abstract

  9. A framework for individualized splice-switching oligonucleotide therapy. Nature. 2023 Jul; 619(7971):828-836. View Abstract

  10. Electroencephalographic delta and alpha oscillations reveal phase-amplitude coupling in paediatric patients undergoing sevoflurane-based general anaesthesia. Br J Anaesth. 2023 05; 130(5):595-602. View Abstract

  11. Anesthesia and epidural analgesia for "heroic" cancer surgery. Paediatr Anaesth. 2023 03; 33(3):182-184. View Abstract

  12. Tactile sensitivity and motor coordination in infancy: Effect of age, prior surgery, anaesthesia & critical illness. PLoS One. 2022; 17(12):e0279705. View Abstract

  13. Ultrasound-guided spinal anesthesia in infants: a narrative review. Reg Anesth Pain Med. 2023 12; 48(12):608-614. View Abstract

  14. Mendelian Disorders in an Interstitial Cystitis/Bladder Pain Syndrome Cohort. Adv Genet (Hoboken). 2023 Mar; 4(1):2200013. View Abstract

  15. Emerging functional connectivity patterns during sevoflurane anaesthesia in the developing human brain. Br J Anaesth. 2023 02; 130(2):e381-e390. View Abstract

  16. Nusinersen for Patients With Spinal Muscular Atrophy: 1415 Doses via an Interdisciplinary Institutional Approach. Pediatr Neurol. 2022 07; 132:33-40. View Abstract

  17. Ultrasound-guided "saline myelogram": Confirmation of intrathecal drug delivery despite "dry tap" in infants for spinal anesthesia and spinal therapeutics. Paediatr Anaesth. 2022 07; 32(7):883-884. View Abstract

  18. Transforaminal lumbar puncture for spinal anesthesia or novel drug administration: a technique combining C-arm fluoroscopy and ultrasound. Reg Anesth Pain Med. 2022 06; 47(6):380-383. View Abstract

  19. Modified Sensory Testing in Non-verbal Patients Receiving Novel Intrathecal Therapies for Neurological Disorders. Front Neurol. 2022; 13:664710. View Abstract

  20. Standardizing Opioid Prescribing in a Pediatric Hospital: A Quality Improvement Effort. Hosp Pediatr. 2022 02 01; 12(2):164-173. View Abstract

  21. Mendelian etiologies identified with whole exome sequencing in cerebral palsy. Ann Clin Transl Neurol. 2022 02; 9(2):193-205. View Abstract

  22. Initial Adjustment to the COVID-19 Pandemic and the Associated Shutdown in Children and Adolescents With Chronic Pain and Their Families. Front Pain Res (Lausanne). 2021; 2:713430. View Abstract

  23. Racial and Ethnic Disparities in Pain Management of Children With Limb Fractures or Suspected Appendicitis: A Retrospective Cross-Sectional Study. Front Pediatr. 2021; 9:652854. View Abstract

  24. The Effectiveness of Cancer Pain Management in a Tertiary Hospital Outpatient Pain Clinic in Thailand: A Prospective Observational Study. Pain Res Manag. 2021; 2021:5599023. View Abstract

  25. Trends in Gabapentin and Pregabalin Prescribing in a Tertiary Pediatric Medical Center. Hosp Pediatr. 2021 08; 11(8):909-914. View Abstract

  26. Intrathecal catheter and port placement for nusinersen infusion in children with spinal muscular atrophy and spinal fusion. Pediatr Radiol. 2021 12; 51(13):2588-2595. View Abstract

  27. Explicit and implicit bias based on race, ethnicity, and weight among pediatric emergency physicians. Acad Emerg Med. 2021 09; 28(9):1073-1076. View Abstract

  28. Nonpharmacological Interventions for Pediatric Migraine: A Network Meta-analysis. Pediatrics. 2021 04; 147(4). View Abstract

  29. Association of Genetic Variants With Migraine Subclassified by Clinical Symptoms in Adult Females. Front Neurol. 2020; 11:617472. View Abstract

  30. Epidural catheter placement in children with baclofen pumps. Paediatr Anaesth. 2021 02; 31(2):178-185. View Abstract

  31. Case Studies Using the Electroencephalogram to Monitor Anesthesia-Induced Brain States in Children. Anesth Analg. 2020 10; 131(4):1043-1056. View Abstract

  32. Neurophysiological Assessment of Prolonged Recovery From Neuromuscular Blockade in the Neonatal Intensive Care Unit. Front Pediatr. 2020; 8:580. View Abstract

  33. Genome-wide association analysis of opioid use disorder: A novel approach using clinical data. Drug Alcohol Depend. 2020 12 01; 217:108276. View Abstract

  34. Case Studies Using the Electroencephalogram to Monitor Anesthesia-Induced Brain States in Children. Anesth Analg. 2020 Aug 17. View Abstract

  35. Effect of lumbar medial branch blocks on extension-related axial chronic low back pain in a pediatric population: a retrospective chart review and prospective follow-up. Reg Anesth Pain Med. 2020 12; 45(12):1019-1020. View Abstract

  36. Efficacy, Safety, and Acceptability of Pharmacologic Treatments for Pediatric Migraine Prophylaxis: A Systematic Review and Network Meta-analysis. JAMA Pediatr. 2020 04 01; 174(4):341-349. View Abstract

  37. Off-label use of prescription analgesics among hospitalized children in the United States. Pharmacoepidemiol Drug Saf. 2020 04; 29(4):474-481. View Abstract

  38. d-Oscillation Correlates of Anesthesia-induced Unconsciousness in Large-scale Brain Networks of Human Infants. Anesthesiology. 2019 12; 131(6):1239-1253. View Abstract

  39. Developing a pediatric pain data repository. JAMIA Open. 2020 Apr; 3(1):31-36. View Abstract

  40. Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease. N Engl J Med. 2019 10 24; 381(17):1644-1652. View Abstract

  41. Electroencephalographic features of discontinuous activity in anesthetized infants and children. PLoS One. 2019; 14(10):e0223324. View Abstract

  42. Morphine compared to placebo for procedural pain in preterm infants: safety, efficacy and equipoise. J Perinatol. 2019 10; 39(10):1428-1431. View Abstract

  43. The effect of suprainguinal fascia iliaca block on the recovery of patients after arthroscopic hip surgery. Paediatr Anaesth. 2019 08; 29(8):829-834. View Abstract

  44. The Society for Pediatric Anesthesia recommendations for the use of opioids in children during the perioperative period. Paediatr Anaesth. 2019 06; 29(6):547-571. View Abstract

  45. Neural Correlates of Anesthesia in Newborn Mice and Humans. Front Neural Circuits. 2019; 13:38. View Abstract

  46. Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial. Lancet. 2019 02 16; 393(10172):664-677. View Abstract

  47. Patient- and Nurse-Controlled Analgesia: 22-Year Experience in a Pediatric Hospital. Hosp Pediatr. 2019 02; 9(2):129-133. View Abstract

  48. An open label pilot study of a dexmedetomidine-remifentanil-caudal anesthetic for infant lower abdominal/lower extremity surgery: The T REX pilot study. Paediatr Anaesth. 2019 01; 29(1):59-67. View Abstract

  49. Maximum Recommended Dosage of Ropivacaine and Bupivacaine for Pediatric Regional Anesthesia. Reg Anesth Pain Med. 2018 11; 43(8):895-896. View Abstract

  50. Effects of Childhood Life Events on Adjustment Problems in Adolescence: A Longitudinal Study. J Dev Behav Pediatr. 2018 Oct/Nov; 39(8):629-641. View Abstract

  51. Neuropathic pain drives anxiety behavior in mice, results consistent with anxiety levels in diabetic neuropathy patients. Pain Rep. 2018 May; 3(3):e651. View Abstract

  52. Electroencephalographic markers of brain development during sevoflurane anaesthesia in children up to 3 years old. Br J Anaesth. 2018 Jun; 120(6):1274-1286. View Abstract

  53. Clinical trial designs and models for analgesic medications for acute pain in neonates, infants, toddlers, children, and adolescents: ACTTION recommendations. Pain. 2018 02; 159(2):193-205. View Abstract

  54. Clinical signs and electroencephalographic patterns of emergence from sevoflurane anaesthesia in children: An observational study. Eur J Anaesthesiol. 2018 01; 35(1):49-59. View Abstract

  55. Children With Chronic Pain: Response Trajectories After Intensive Pain Rehabilitation Treatment. J Pain. 2018 02; 19(2):207-218. View Abstract

  56. Continuous Regional Anesthesia and Inpatient Rehabilitation for Pediatric Complex Regional Pain Syndrome. Reg Anesth Pain Med. 2017 Jul/Aug; 42(4):527-534. View Abstract

  57. Electroencephalographic discontinuity during sevoflurane anesthesia in infants and children. Paediatr Anaesth. 2017 Mar; 27(3):251-262. View Abstract

  58. Image-guided intrathecal baclofen pump catheter implantation: a technical note and case series. J Neurosurg Spine. 2017 May; 26(5):621-627. View Abstract

  59. Measurement of neosaxitoxin in human plasma using liquid-chromatography tandem mass spectrometry: Proof of concept for a pharmacokinetic application. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Nov 15; 1036-1037:42-49. View Abstract

  60. Biomedical science: Protection for anaesthetized mice. Nature. 2016 08 04; 536(7614):36-7. View Abstract

  61. Lidocaine Infusions and Other Options for Opioid-Resistant Pain Due to Pediatric Advanced Cancer. Pediatr Blood Cancer. 2016 07; 63(7):1141-3. View Abstract

  62. Bundled analgesia interventions for day-stay surgery. Paediatr Anaesth. 2016 Feb; 26(2):120-1. View Abstract

  63. Fear and Reward Circuit Alterations in Pediatric CRPS. Front Hum Neurosci. 2015; 9:703. View Abstract

  64. Epidural Steroid Injections for Radiculopathy and/or Back Pain in Children and Adolescents: A Retrospective Cohort Study With a Prospective Follow-Up. Reg Anesth Pain Med. 2016 Jan-Feb; 41(1):86-92. View Abstract

  65. Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial. Lancet. 2016 Jan 16; 387(10015):239-50. View Abstract

  66. Electroencephalography during general anaesthesia differs between term-born and premature-born children. Clin Neurophysiol. 2016 Feb; 127(2):1216-1222. View Abstract

  67. A Phase 1, Dose-escalation, Double-blind, Block-randomized, Controlled Trial of Safety and Efficacy of Neosaxitoxin Alone and in Combination with 0.2% Bupivacaine, with and without Epinephrine, for Cutaneous Anesthesia. Anesthesiology. 2015 Oct; 123(4):873-85. View Abstract

  68. Neosaxitoxin in Rat Sciatic Block: Improved Therapeutic Index Using Combinations with Bupivacaine, with and without Epinephrine. Anesthesiology. 2015 Oct; 123(4):886-98. View Abstract

  69. Age-dependent electroencephalogram (EEG) patterns during sevoflurane general anesthesia in infants. Elife. 2015 Jun 23; 4:e06513. View Abstract

  70. Transient Alterations of Cutaneous Sensory Nerve Function by Noninvasive Cryolipolysis. J Invest Dermatol. 2015 Nov; 135(11):2623-2631. View Abstract

  71. Developing better local anesthetics. Anesth Analg. 2015 Apr; 120(4):718-20. View Abstract

  72. Endogenous cholinergic neurotransmission contributes to behavioral sensitization to morphine. PLoS One. 2015; 10(2):e0117601. View Abstract

  73. Immediate rescue designs in pediatric analgesic trials: a systematic review and meta-analysis. Anesthesiology. 2015 Jan; 122(1):150-171. View Abstract

  74. Pain hypersensitivity in juvenile idiopathic arthritis: a quantitative sensory testing study. Pediatr Rheumatol Online J. 2014; 12:39. View Abstract

  75. Intrinsic brain networks normalize with treatment in pediatric complex regional pain syndrome. Neuroimage Clin. 2014; 6:347-69. View Abstract

  76. The responsive amygdala: treatment-induced alterations in functional connectivity in pediatric complex regional pain syndrome. Pain. 2014 Sep; 155(9):1727-1742. View Abstract

  77. Paravertebral block for analgesia after pediatric thoracic surgery. Reg Anesth Pain Med. 2014 May-Jun; 39(3):179-80. View Abstract

  78. Documented electronic medical record-based pain intensity scores at a tertiary pediatric medical center: a cohort analysis. J Pain Symptom Manage. 2014 Nov; 48(5):924-33. View Abstract

  79. A single institution's effort to translate codeine knowledge into specific clinical practice. J Pain Symptom Manage. 2014 Jul; 48(1):119-26. View Abstract

  80. Regional anesthesia approaches to pain management in pediatric palliative care: a review of current knowledge. J Pain Symptom Manage. 2013 Dec; 46(6):859-73. View Abstract

  81. A case of cerebrospinal fluid leak in an infant after spinal anesthesia. J Clin Anesth. 2013 May; 25(3):217-9. View Abstract

  82. Transient and persistent pain induced connectivity alterations in pediatric complex regional pain syndrome. PLoS One. 2013; 8(3):e57205. View Abstract

  83. Children and adolescents with complex regional pain syndrome: more psychologically distressed than other children in pain? Pain Res Manag. 2013 Mar-Apr; 18(2):87-93. View Abstract

  84. Pediatric regional anesthesia: drawing inferences on safety from prospective registries and case reports. Anesth Analg. 2012 Dec; 115(6):1259-62. View Abstract

  85. A day-hospital approach to treatment of pediatric complex regional pain syndrome: initial functional outcomes. Clin J Pain. 2012 Nov-Dec; 28(9):766-74. View Abstract

  86. Periaqueductal gray neuroplasticity following chronic morphine varies with age: role of oxidative stress. Neuroscience. 2012 Dec 13; 226:165-77. View Abstract

  87. Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas. Brain Res. 2012 May 31; 1457:1-12. View Abstract

  88. Respiratory, neuromuscular, and cardiovascular effects of neosaxitoxin in isoflurane-anesthetized sheep. Reg Anesth Pain Med. 2012 Mar-Apr; 37(2):152-8. View Abstract

  89. Response to "A new definition of neuropathic pain". Pain. 2012 Apr; 153(4):934-935. View Abstract

  90. Pediatric analgesic clinical trial designs, measures, and extrapolation: report of an FDA scientific workshop. Pediatrics. 2012 Feb; 129(2):354-64. View Abstract

  91. Sympathetic nerve blocks, pragmatic trials, and responder analysis. Anesthesiology. 2012 Jan; 116(1):12-4. View Abstract

  92. Tetrodotoxin-bupivacaine-epinephrine combinations for prolonged local anesthesia. Mar Drugs. 2011 Dec; 9(12):2717-2728. View Abstract

  93. Spinal anesthesia in infant rats: development of a model and assessment of neurologic outcomes. Anesthesiology. 2011 Jun; 114(6):1325-35. View Abstract

  94. Comparison of neosaxitoxin versus bupivacaine via port infiltration for postoperative analgesia following laparoscopic cholecystectomy: a randomized, double-blind trial. Reg Anesth Pain Med. 2011 Mar-Apr; 36(2):103-9. View Abstract

  95. The Fear of Pain Questionnaire (FOPQ): assessment of pain-related fear among children and adolescents with chronic pain. J Pain. 2011 Jun; 12(6):677-86. View Abstract

  96. Fatigue in children with cancer at the end of life. J Pain Symptom Manage. 2010 Oct; 40(4):483-94. View Abstract

  97. Blood sampling and other needle procedures - the Achilles heel of newborn intensive care. Pain. 2009 Dec 15; 147(1-3):15-6. View Abstract

  98. Pain measurement and Beecher's challenge: 50 years later. Anesthesiology. 2009 Sep; 111(3):473-4. View Abstract

  99. Lumbar sympathetic blockade in children with complex regional pain syndromes: a double blind placebo-controlled crossover trial. Anesthesiology. 2009 Aug; 111(2):372-80. View Abstract

  100. Challenges of functional imaging research of pain in children. Mol Pain. 2009 Jun 16; 5:30. View Abstract

  101. In vivo lipid diffusion coefficient measurements in rat bone marrow. Magn Reson Imaging. 2009 Jul; 27(6):859-64. View Abstract

  102. fMRI reveals distinct CNS processing during symptomatic and recovered complex regional pain syndrome in children. Brain. 2008 Jul; 131(Pt 7):1854-79. View Abstract

  103. Opioid side effects--mechanism-based therapy. N Engl J Med. 2008 May 29; 358(22):2400-2. View Abstract

  104. Easing of suffering in children with cancer at the end of life: is care changing? J Clin Oncol. 2008 Apr 01; 26(10):1717-23. View Abstract

  105. Postoperative pain and other sequelae of dental rehabilitations performed on children under general anesthesia. Pediatr Dent. 2008 Mar-Apr; 30(2):111-21. View Abstract

  106. Stable plasma concentrations of unbound ropivacaine during postoperative epidural infusion for 24-72 hours in children. Eur J Anaesthesiol. 2008 May; 25(5):410-7. View Abstract

  107. Pharmacologic management of painful bladder syndrome/interstitial cystitis: a systematic review. Arch Intern Med. 2007 Oct 08; 167(18):1922-9. View Abstract

  108. Nerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen-activated protein kinase in spinal microglia in the rat spared nerve injury model. Anesthesiology. 2007 Aug; 107(2):312-21. View Abstract

  109. Cutaneous sensory abnormalities in children and adolescents with complex regional pain syndromes. Pain. 2007 Sep; 131(1-2):153-61. View Abstract

  110. Effects of bupivacaine and tetrodotoxin on carrageenan-induced hind paw inflammation in rats (Part 1): hyperalgesia, edema, and systemic cytokines. Anesthesiology. 2006 Jul; 105(1):128-38. View Abstract

  111. Effects of bupivacaine and tetrodotoxin on carrageenan-induced hind paw inflammation in rats (Part 2): cytokines and p38 mitogen-activated protein kinases in dorsal root ganglia and spinal cord. Anesthesiology. 2006 Jul; 105(1):139-45. View Abstract

  112. Factors associated with fatigue in children with cancer at the end of life. J Clin Oncol. 2006 Jun 20; 24(18_suppl):8574. View Abstract

  113. Complex regional pain syndromes in children and adolescents: regional and systemic signs and symptoms and hemodynamic response to tilt table testing. Clin J Pain. 2006 May; 22(4):399-406. View Abstract

  114. Summary proceedings from the neonatal pain-control group. Pediatrics. 2006 Mar; 117(3 Pt 2):S9-S22. View Abstract

  115. Use of complementary and alternative medicine in pediatric pain management service: a survey. Pain Med. 2005 Nov-Dec; 6(6):452-8. View Abstract

  116. Biexponential parameterization of diffusion and T2 relaxation decay curves in a rat muscle edema model: decay curve components and water compartments. Magn Reson Med. 2005 Sep; 54(3):524-31. View Abstract

  117. Pain management for the hospitalized pediatric patient. Pediatr Clin North Am. 2005 Aug; 52(4):995-1027, vii-viii. View Abstract

  118. Analgesia and anesthesia for neonates: study design and ethical issues. Clin Ther. 2005 Jun; 27(6):814-43. View Abstract

  119. Anesthesia and analgesia during and after surgery in neonates. Clin Ther. 2005 Jun; 27(6):900-21. View Abstract

  120. Caudal analgesia and anesthesia techniques in children. Curr Opin Anaesthesiol. 2005 Jun; 18(3):283-8. View Abstract

  121. Complex regional pain syndromes in children and adolescents. Anesthesiology. 2005 Feb; 102(2):252-5. View Abstract

  122. A randomized controlled trial to evaluate S-Caine patch for reducing pain associated with vascular access in children. Anesthesiology. 2005 Feb; 102(2):403-8. View Abstract

  123. Epinephrine prevents muscle blood flow increases after perineural injection of tetrodotoxin. Anesthesiology. 2004 Dec; 101(6):1428-34. View Abstract

  124. Self-mutilation in young children following brachial plexus birth injury. Pain. 2004 Jul; 110(1-2):123-9. View Abstract

  125. Local anesthetics in infants and children: an update. Paediatr Anaesth. 2004 May; 14(5):387-93. View Abstract

  126. The use of herbs and complementary and alternative medicine in pediatric preoperative patients. J Clin Anesth. 2004 Feb; 16(1):4-6. View Abstract

  127. Effects of repeated injection of local anesthetic on sciatic nerve blocks response. J Huazhong Univ Sci Technolog Med Sci. 2004; 24(5):497-9. View Abstract

  128. Development of neuropathic pain in the rat spared nerve injury model is not prevented by a peripheral nerve block. Anesthesiology. 2003 Dec; 99(6):1402-8. View Abstract

  129. Prolonged duration local anesthesia from tetrodotoxin-enhanced local anesthetic microspheres. Pain. 2003 Jul; 104(1-2):415-21. View Abstract

  130. Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle. J Neurophysiol. 2003 Oct; 90(4):2098-105. View Abstract

  131. Opioids: more to learn, improvements to be made. Anesthesiology. 2003 Jun; 98(6):1309-12. View Abstract

  132. Pain, anxiety, distress, and suffering: interrelated, but not interchangeable. J Pediatr. 2003 Apr; 142(4):361-3. View Abstract

  133. Activation of peripheral excitatory amino acid receptors decreases the duration of local anesthesia. Anesthesiology. 2003 Feb; 98(2):521-9. View Abstract

  134. Analgesics for the treatment of pain in children. N Engl J Med. 2002 Oct 03; 347(14):1094-103. View Abstract

  135. The effects of lidocaine and adrenergic agonists on rat sciatic nerve and skeletal muscle blood flow in vivo. Anesth Analg. 2002 Oct; 95(4):1080-6, table of contents. View Abstract

  136. Diagnosis and management of MNGIE syndrome in children: case report and review of the literature. J Pediatr Gastroenterol Nutr. 2002 Sep; 35(3):377-83. View Abstract

  137. Physical therapy and cognitive-behavioral treatment for complex regional pain syndromes. J Pediatr. 2002 Jul; 141(1):135-40. View Abstract

  138. Prolonged sensory and motor deficit following short-term lumbar epidural analgesia in a patient with mixed connective tissue disease. J Pain Symptom Manage. 2002 Feb; 23(2):89-92. View Abstract

  139. Glutamate-induced sensitization of rat masseter muscle fibers. Neuroscience. 2002; 109(2):389-99. View Abstract

  140. Quantitative assessment of cutaneous thermal and vibration sensation and thermal pain detection thresholds in healthy children and adolescents. Muscle Nerve. 2001 Oct; 24(10):1339-45. View Abstract

  141. The pharmacokinetics of epidural ropivacaine in infants and young children. Anesth Analg. 2001 Oct; 93(4):893-7. View Abstract

  142. Evidence that spinal segmental nitric oxide mediates tachyphylaxis to peripheral local anesthetic nerve block. Acta Anaesthesiol Scand. 2001 Sep; 45(8):945-53. View Abstract

  143. Osmotic effects on the T2 relaxation decay of in vivo muscle. Magn Reson Med. 2001 Sep; 46(3):592-9. View Abstract

  144. High concentrations of adrenergic antagonists prolong sciatic nerve blockade by tetrodotoxin. Acta Anaesthesiol Scand. 2001 Aug; 45(7):899-905. View Abstract

  145. Effects of adrenergic agonists and antagonists on tetrodotoxin-induced nerve block. Reg Anesth Pain Med. 2001 May-Jun; 26(3):239-45. View Abstract

  146. Developmental pharmacology across species: promise and problems. Anesth Analg. 2000 Jul; 91(1):1-5. View Abstract

  147. Reports of pain by children undergoing rapid palatal expansion. Pediatr Dent. 2000 May-Jun; 22(3):221-6. View Abstract

  148. On pins and needles? Pediatric pain patients' experience with acupuncture. Pediatrics. 2000 Apr; 105(4 Pt 2):941-7. View Abstract

  149. The local anesthetic properties and toxicity of saxitonin homologues for rat sciatic nerve block in vivo. Reg Anesth Pain Med. 2000 Jan-Feb; 25(1):52-9. View Abstract

  150. Survey of acupuncturists: practice characteristics and pediatric care. West J Med. 1999 Sep; 171(3):153-7. View Abstract

  151. Acupressure-acupuncture antiemetic prophylaxis in children undergoing tonsillectomy. Anesthesiology. 1999 May; 90(5):1311-6. View Abstract

  152. Prolonged local myometrial blockade prevents preterm labor after fetal surgery in a leporine model. J Pediatr Surg. 1999 Apr; 34(4):540-2. View Abstract

  153. Vanilloid receptor agonists potentiate the in vivo local anesthetic activity of percutaneously injected site 1 sodium channel blockers. Anesthesiology. 1999 Feb; 90(2):524-34. View Abstract

  154. Sciatic nerve blockade in infant, adolescent, and adult rats: a comparison of ropivacaine with bupivacaine. Anesthesiology. 1998 Nov; 89(5):1199-208; discussion 10A. View Abstract

  155. Prolonged intercostal nerve blockade in sheep using controlled-release of bupivacaine and dexamethasone from polymer microspheres. Anesthesiology. 1998 Oct; 89(4):969-79. View Abstract

  156. A re-examination of tetrodotoxin for prolonged duration local anesthesia. Anesthesiology. 1998 Jul; 89(1):119-31. View Abstract

  157. End-of-life care in cystic fibrosis. Pediatrics. 1997 Aug; 100(2 Pt 1):205-9. View Abstract

  158. Neurologic evaluation of infant and adult rats before and after sciatic nerve blockade. Anesthesiology. 1997 Apr; 86(4):957-65. View Abstract

  159. "Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid". 1997.

  160. "Biodegradable polymer matrices for sustained delivery of local anesthetic agents". 1997.

  161. NG-nitro-L-arginine methyl ester (L-NAME) prevents tachyphylaxis to local anesthetics in a dose-dependent manner. Anesth Analg. 1996 Dec; 83(6):1251-5. View Abstract

  162. Regional anesthesia in children: what have we learned? Anesth Analg. 1996 Nov; 83(5):897-900. View Abstract

  163. Halothane and cardiac autonomic control in infants: assessment with quantitative respiratory sinus arrhythmia. Pediatr Res. 1996 Nov; 40(5):710-7. View Abstract

  164. Glucocorticoids prolong rat sciatic nerve blockade in vivo from bupivacaine microspheres. Anesthesiology. 1996 Nov; 85(5):1157-66. View Abstract

  165. Patient-controlled analgesia for mucositis pain in children: a three-period crossover study comparing morphine and hydromorphone. J Pediatr. 1996 Nov; 129(5):722-8. View Abstract

  166. Chronic pain in cystic fibrosis. Pediatrics. 1996 Oct; 98(4 Pt 1):741-7. View Abstract

  167. Safety of intravenous ketorolac therapy in children and cost savings with a unit dosing system. J Pediatr. 1996 Aug; 129(2):292-6. View Abstract

  168. The management of opioid and benzodiazepine dependence in infants, children, and adolescents. Pediatrics. 1996 Jul; 98(1):135-40. View Abstract

  169. Prolonged regional nerve blockade. Injectable biodegradable bupivacaine/polyester microspheres. Anesthesiology. 1996 Jun; 84(6):1401-10. View Abstract

  170. Regional anesthesia for pain associated with terminal pediatric malignancy. Pain. 1996 Apr; 65(1):63-69. View Abstract

  171. Massive opioid resistance in an infant with a localized metastasis to the midbrain periaqueductal gray. Pain. 1995 Nov; 63(2):271-275. View Abstract

  172. Intravenous amitriptyline in pediatrics. J Pain Symptom Manage. 1995 Aug; 10(6):471-5. View Abstract

  173. Pediatric oncology procedures: to sleep or perchance to dream? Pain. 1995 Jul; 62(1):1-2. View Abstract

  174. Control of severe pain in children with terminal malignancy. J Pediatr. 1995 Apr; 126(4):653-7. View Abstract

  175. A double-blind evaluation of ketorolac tromethamine versus acetaminophen in pediatric tonsillectomy: analgesia and bleeding. Anesth Analg. 1995 Feb; 80(2):226-9. View Abstract

  176. The risk of infection from epidural analgesia in children: a review of 1620 cases. Anesth Analg. 1995 Feb; 80(2):234-8. View Abstract

  177. Infants tolerate spinal anesthesia with minimal overall autonomic changes: analysis of heart rate variability in former premature infants undergoing hernia repair. Anesth Analg. 1995 Jan; 80(1):20-7. View Abstract

  178. L-nitroso-arginine methyl ester prevents tachyphylaxis to sciatic nerve blockade in a dose-dependent manner. Anesthesiology. 1995; 83:A808.

  179. Epidural analgesia accelerates recovery following major pediatric urologic reconstructive surgery. Society for Pediatric Anesthesia/American Academy of Pediatrics. 1995.

  180. Anesthesia and perioperative care in cystic fibrosis. Anesth. Analg. 1995.

  181. Thermal hyperalgesia accelerates and MK-801 prevents the development of tachyphylaxis to rat sciatic nerve blockade. Anesthesiology. 1994 Nov; 81(5):1284-93. View Abstract

  182. Epidural analgesia in children. Can J Anaesth. 1994 Jul; 41(7):555-60. View Abstract

  183. A double blind evaluation of ketorolac tromethamine versus acetaminophen in the pediatric tonsillectomy patient, effects on analgesia and bleeding. American Academy of Pediatrics, Section on Anesthesiology. 1994.

  184. Dextroamphetamine or methylphenidate as adjuvants to opioid analgesia for adolescents with cancer. J Pain Symptom Manage. 1994 Feb; 9(2):122-5. View Abstract

  185. Management of tracheobronchial and esophageal foreign bodies in children: a survey study. J Clin Anesth. 1994 Jan-Feb; 6(1):28-32. View Abstract

  186. Tachyphylaxis to sciatic blockade persists in spinalized rats. Anesthesiology. 1994; 81:A964.

  187. Neuropathic pain in children. Abstracts of the 3rd International Pediatric Pain Symposium. 1994.

  188. Cephalad advancement of epidural catheters: radiographic correlation. Anesthesiology. 1994; 81:A1345.

  189. Evaluation of epinephrine epidural test dose in children receiving isoflurane anesthesia. Anesthesiology. 1994; 81:A1344.

  190. Absolute volume predicts duration of sciatic blockade better than volume/kilogram in infant and adult rats. Anesthesiology. 1994; 81:A1375.

  191. The dose-response of epidural hydromorphone in children. Anesthesiology. 1994; 81:A1346.

  192. Epinephrine prolongs sciatic nerve block in infant but not adult rats. Anesthesiology. 1994; 81:A1356.

  193. The safety in pediatric regional analgesia study group: a multicenter study of safety and risk factors in pediatric regional analgesia. Anesthesiology. 1994; 81:A1386.

  194. Optimal pain relief in infants and children. BMJ. 1993 Oct 02; 307(6908):815-6. View Abstract

  195. Sustained local anesthetic release from bioerodible polymer matrices: a potential method for prolonged regional anesthesia. Pharm Res. 1993 Oct; 10(10):1527-32. View Abstract

  196. Chronic exposure to lidocaine does not alter flux through sodium channels in cultured neuronal cells. Reg Anesth. 1993 Sep-Oct; 18(5):283-9. View Abstract

  197. Prolonged regional nerve blockade by controlled release of local anesthetic from a biodegradable polymer matrix. Anesthesiology. 1993 Aug; 79(2):340-6. View Abstract

  198. Performance of pediatric resuscitation bags assessed with an infant lung simulator. Anesth Analg. 1993 Aug; 77(2):261-4. View Abstract

  199. Venous air embolism during identification of the epidural space in children. Anesth Analg. 1993 May; 76(5):925-7. View Abstract

  200. Toxicity of local anesthetics in infants and children. J Pediatr. 1993 May; 122(5 Pt 2):S14-20. View Abstract

  201. Continuous caudal anesthesia for inguinal hernia repair in former preterm infants. J Clin Anesth. 1993 Mar-Apr; 5(2):129-33. View Abstract

  202. Pain, euthanasia, and anesthesiologists. Anesthesiology. 1993 Feb; 78(2):353-60. View Abstract

  203. Pain management in pediatrics. West J Med. 1993 Feb; 158(2):178-9. View Abstract

  204. Intravenous isoproterenol as a marker for epidural test-dosing in children. Anesth Analg. 1993 Jan; 76(1):178-81. View Abstract

  205. Comparison of injection and sustained release bupivicaine sciatic nerve blockade between adult and weaning rats. Anesthesiology. 1993; 79(3A):A908.

  206. Comparison of sciatic nerve blockade between infant and adult rats. Anesthesiology. 1993; 79(3A):A1137.

  207. Barbiturates in the care of the terminally ill. N Engl J Med. 1992 Dec 03; 327(23):1678-82. View Abstract

  208. Convulsions associated with pediatric regional anesthesia. Anesth Analg. 1992 Aug; 75(2):164-6. View Abstract

  209. Reflex sympathetic dystrophy in children. Clinical characteristics and follow-up of seventy patients. J Bone Joint Surg Am. 1992 Jul; 74(6):910-9. View Abstract

  210. High sensitivity quantification of RNA from gels and autoradiograms with affordable optical scanning. Biotechniques. 1992 Jun; 12(6):902-6, 908-11. View Abstract

  211. Pediatric regional anesthesia equipment. Int Anesthesiol Clin. 1992; 30(3):163-76. View Abstract

  212. Laser Doppler measurements of skin blood flow before, during, and after lumbar sympathetic blockade in children and young adults with reflex sympathetic dystrophy syndrome. J Clin Monit. 1992 Jan; 8(1):16-9. View Abstract

  213. The risk of infection from pediatric epidural analgesia is low. Anesthesiology. 1992; 77:A1158.

  214. Patient-controlled analgesia in children and adolescents: safety and outcome amoung 1,589 patients. Anesthesiology. 1992; 77:A1187.

  215. Performance of pediatric resuscitation bags assessed with an infant lung simulator. Anesthesiology. 1992; 77:A509.

  216. Midazolam for conscious sedation during pediatric oncology procedures: safety and recovery parameters. Pediatrics. 1991 Dec; 88(6):1172-9. View Abstract

  217. Continuous subarachnoid analgesia in two adolescents with severe scoliosis and impaired pulmonary function. Reg Anesth. 1991 Nov-Dec; 16(6):333-6. View Abstract

  218. Comparison of morphine and methadone for prevention of postoperative pain in 3- to 7-year-old children. J Pediatr. 1991 Jul; 119(1 Pt 1):136-41. View Abstract

  219. Patient-controlled analgesia in children and adolescents: a randomized, prospective comparison with intramuscular administration of morphine for postoperative analgesia. J Pediatr. 1991 Mar; 118(3):460-6. View Abstract

  220. Efficacy of adrenaline, lignocaine-adrenaline and isoprenaline as a test dose in halothane-anaesthetized lambs. Eur J Anaesthesiol. 1991 Mar; 8(2):123-8. View Abstract

  221. Memories of pain in three- to seven-year-old children. Journal of Pain and Symptom Management. 1991; 6:174.

  222. Methylphenidate or dextraamphetamine as adjuvants in opioid analgesia. Journal of Pain and Symptom Management. 1991; 6:162.

  223. Implementation of a PCA program. Journal of Pain and Symptom Management. 1991; 6:187.

  224. Recognition and treatment of pain in pediatric patients with AIDS. Journal of Pain and Symptom Management. 1991; 6:162.

  225. Porlonged sciatic nerve blockade using sustained release of bupivicaine from a biodegradable polymer matrix. Anesthesiology. 1991; 75:A765.

  226. Experience with 852 epidural infusions in a children's hospital. Journal of Pain and Symptom Management. 1991; 6:164.

  227. Continuous caudal anesthesia with 2-chloroprocaine for premature infants undergoing inguinal hernia repair. Anesthesiology. 1991; 75:A693.

  228. Reflex sympathetic dystrophy in children and adolescents: follow-up of 70 patients adn development of a treatment algorithm. Anesthesiology. 1991; 75:A916.

  229. Children's pain and family functioning: a comparative analysis. J. Pain and Symptom Management. 1991; 6:146.

  230. Discordance between self-report and behavioral pain measures in children aged 3-7 years after surgery. J Pain Symptom Manage. 1990 Dec; 5(6):350-6. View Abstract

  231. Celiac plexus blockade for a 3-year-old boy with hepatoblastoma and refractory pain. Pediatrics. 1990 Nov; 86(5):779-81. View Abstract

  232. American Academy of Pediatrics Report of the Subcommittee on Disease-Related Pain in Childhood Cancer. Pediatrics. 1990 Nov; 86(5 Pt 2):818-25. View Abstract

  233. Subarachnoid bupivacaine analgesia for seven months for a patient with a spinal cord tumor. Anesthesiology. 1990 Jun; 72(6):1094-6. View Abstract

  234. Continuous epidural bupivacaine-fentanyl infusions in children following ureteral reimplantation. Anesthesiology. 1990; 73:A775.

  235. Hypotension, flushing and bronchospasm in myelodysplasia patients undergoing surgery. Section on Anesthesiology, American Academy of Pediatrics. 1990; Spring.

  236. Patient-controlled analgesia in children and adolescents: a randomized comparison with intramuscular morphine. Anesthesiology. 1990; 73:A1102.

  237. Isoproterenol for test dosing in pediatric regional blockade. Anesthesiology. 1990; 73:A1127.

  238. Sustained release of dibucaine from a biodegradable polymer matrix: a potential method for prolonged neural blockade. Anesthesiology. 1990; 73:A776.

  239. Regional analgesia in the management of chronic pain in childhood. J Pain Symptom Manage. 1989 Dec; 4(4):232-7. View Abstract

  240. Meningococcal purpura fulminans: treatment of vascular insufficiency in a 2-yr-old child with lumbar epidural sympathetic blockade. Anesthesiology. 1989 Sep; 71(3):463-4. View Abstract

  241. Pharmacologic management of pain in children and adolescents. Pediatr Clin North Am. 1989 Aug; 36(4):855-71. View Abstract

  242. Pediatric postoperative pain management. Pediatr Clin North Am. 1989 Aug; 36(4):921-40. View Abstract

  243. Sufentanil, morphine, met-enkephalin, and kappa-agonist (U-50,488H) inhibit substance P release from primary sensory neurons: a model for presynaptic spinal opioid actions. Anesthesiology. 1989 Apr; 70(4):672-7. View Abstract

  244. Caudal epidural morphine analgesia for an infant with advanced neuroblastoma: report of a case. Pain. 1989 Feb; 36(2):219-223. View Abstract

  245. Pediatric pain clinics: recommendations for their development. Pediatrician. 1989; 16(1-2):94-102. View Abstract

  246. Regional analgesia on pediatric medical and surgical wards. Intensive Care Med. 1989; 15 Suppl 1:S40-3. View Abstract

  247. Postoperative lordoscoliosis causing extrinsic compression of the right main stem bronchus and respiratory insufficiency. A case report. Spine (Phila Pa 1976). 1989 Jan; 14(1):110-4. View Abstract

  248. Epidural test dosing in halothane-anesthesized lambs. Anesthesiology. 1989; 72:A1022.

  249. Spinal vs. general anesthesia in infants undergoing hernia repair. Section on Anesthesiology, American Academy of Pediatrics. 1989.

  250. Stellate ganglion blockade in children and adolescents. Anesthesiology. 1989; 71:A1023.

  251. Reflex sympathetic dystrophy in children and adolescents. Society for Behavioral Medicine. 1989.

  252. Pediatric pain management. Hosp Pract (Off Ed). 1988 May 30; 23(5A):83-4, 89, 93-4 passim. View Abstract

  253. Radiological case of the month. Bronchial compression and ventilatory dysfunction in scoliosis. Am J Dis Child. 1988 May; 142(5):545-6. View Abstract

  254. A technique for continuous lumbar sympathetic blockade for severe reflex sympathetic dystrophy in children and adolescents. Anesth Analg. 1988; 67:S4.

  255. A comparison of methadone and morphine for postoperative analgesia in children and adolescents. Anesthesiology. 1988; 69:A768.

  256. Initial experience with a multidiscplinary pediatric pain treatment service. Pain. 1987; Supplement 4:S99.

  257. Pharmacokinetics of methadone in children and adolescents in the perioperative period. Anesthesiology. 1987; 67:A519.

  258. Regional anesthetic approaches to post-operative pain in children and adolescents. Intensive Care Med. 1987; 13:460.

  259. Opioids inhibit substance P release from cultured dorsal root ganglia: a model for spinal narcotic action. Anesthesiology. 1987; 67:A388.

  260. Effects of free fatty acids on release of superoxide and on change of shape by human neutrophils. Reversibility by albumin. J Biol Chem. 1984 Jun 25; 259(12):7870-7. View Abstract

  261. Zoonotic filariasis with lymphedema in an immunodeficient infant. N Engl J Med. 1984 May 10; 310(19):1243-5. View Abstract

  262. Bilirubin binding in the plasma of newborns: critical evaluation of a fluorescence quenching method and comparison to the peroxidase method. Pediatr Res. 1984 Apr; 18(4):349-54. View Abstract

  263. Some functional effects of physical changes in the membranes of white cells. Kroc Found Ser. 1984; 16:111-27. View Abstract

  264. The excitable membrane of phagocytic leukocytes. Prog Clin Biol Res. 1984; 164:347-54. View Abstract

  265. Pregnancy in women with pseudoxanthoma elasticum. Obstet Gynecol Surv. 1983 Jun; 38(6):339-44. View Abstract

  266. Gel to liquid-crystalline phase transitions of aqueous dispersions of polyunsaturated mixed-acid phosphatidylcholines. Biochemistry. 1983 Mar 15; 22(6):1466-73. View Abstract

  267. Cytochalasin E diminishes the lag phase in the release of superoxide by human neutrophils. Biochem Biophys Res Commun. 1982 May 14; 106(1):170-4. View Abstract

  268. Phase transitions of dispersions of polyunsaturated mixed acid phosphatidyl cholines: calorimetric measurements and a statistical-mechanical description. Mackinac Conference on Artificial Surfactant Proceedings. 1982.

  269. Monitoring intravenous fat emulsions in neonates with the fatty acid/serum albumin molar ratio. JPEN J Parenter Enteral Nutr. 1981 Nov-Dec; 5(6):517-8. View Abstract

  270. A theory of the effects of head-group structure and chain unsaturation on the chain melting transition of phospholipid dispersions. Biochemistry. 1980 Sep 02; 19(18):4279-93. View Abstract

  271. Use of the conjugated polyene fatty acid, parinaric acid, in assaying fatty acids in serum or plasma. Clin Chem. 1980 Jul; 26(8):1173-7. View Abstract

  272. Human alpha-fetoprotein. Fluorescence studies on binding and proximity relationships for fatty acids and bilirubin. J Biol Chem. 1979 Dec 25; 254(24):12609-14. View Abstract

  273. Human serum albumin. Spectroscopic studies of binding and proximity relationships for fatty acids and bilirubin. J Biol Chem. 1979 Jan 25; 254(2):391-400. View Abstract

  274. Binding of bilirubin and fatty acids in the sera of neonates. Clin Res. 1979; 27:134A.

  275. Two coupled oscillators: simulations of the circadian pacemaker in mammalian activity rhythms. J Theor Biol. 1978 Feb 06; 70(3):297-313. View Abstract

  276. A free fatty acid binding index for serum. Pediatr Res. 1978; 12:502.

  277. Activation of purified 3-hydroxy-3-methylglutaryl-CoA reductase by phospholipids. Biochim Biophys Acta. 1977 Jul 20; 488(1):112-20. View Abstract

  278. A population-family planning resource center: a community educational service. Fam Plann Resume. 1977; 1(1):142-3. View Abstract

  279. Nonmonotonic transients and some mathematical models of circadian rhythms. J Theor Biol. 1976 Feb; 56(2):435-41. View Abstract
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