EDUCATION

Undergraduate Degree

  • Washington University , 2000 , St. Louis , MO

Graduate Degree

  • Johns Hopkins University School of Medicine , 2007 , Baltimore , MD

Medical School

  • Johns Hopkins University School of Medicine , 2007 , Baltimore , MD

Residency

  • Boston Combined Residency Program (BCRP) , 2010 , Boston , MA

Fellowship

  • Boston Children's Hospital , 2013 , Boston , MA

CERTIFICATIONS

  • American Board of Pediatrics, General Pediatrics
  • American Board of Pediatrics, Pediatric Gastroenterology

PUBLICATIONS

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  1. Interleukin-6 produced by enteric neurons regulates the number and phenotype of microbe-responsive regulatory T cells in the gut. Immunity. 2021 03 09; 54(3):499-513.e5. View abstract
  2. The Villin1 Gene Promoter Drives Cre Recombinase Expression in Extraintestinal Tissues. Cell Mol Gastroenterol Hepatol. 2020; 10(4):864-867.e5. View abstract
  3. Cerebral dopamine neurotrophic factor is essential for enteric neuronal development, maintenance, and regulation of gastrointestinal transit. J Comp Neurol. 2020 10; 528(14):2420-2444. View abstract
  4. An increasingly complex view of intestinal motility. Nat Rev Gastroenterol Hepatol. 2020 02; 17(2):72-73. View abstract
  5. Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense. Cell. 2020 01 09; 180(1):33-49.e22. View abstract
  6. Cerebral dopamine neurotrophic factor-deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice. Neurobiol Dis. 2020 02; 134:104696. View abstract
  7. Exploring the Potential of RET Kinase Inhibition for Irritable Bowel Syndrome: A Preclinical Investigation in Rodent Models of Colonic Hypersensitivity. J Pharmacol Exp Ther. 2019 02; 368(2):299-307. View abstract
  8. Advances in Enteric Neurobiology: The "Brain" in the Gut in Health and Disease. J Neurosci. 2018 10 31; 38(44):9346-9354. View abstract
  9. Enteric nervous system development: what could possibly go wrong? Nat Rev Neurosci. 2018 09; 19(9):552-565. View abstract
  10. Enteric Glia Regulate Gastrointestinal Motility but Are Not Required for Maintenance of the Epithelium in Mice. Gastroenterology. 2017 10; 153(4):1068-1081.e7. View abstract
  11. Neurogastroenterology: The dynamic cycle of life in the enteric nervous system. Nat Rev Gastroenterol Hepatol. 2017 08; 14(8):453-454. View abstract
  12. The bowel and beyond: the enteric nervous system in neurological disorders. Nat Rev Gastroenterol Hepatol. 2016 09; 13(9):517-28. View abstract
  13. Enteric glia express proteolipid protein 1 and are a transcriptionally unique population of glia in the mammalian nervous system. Glia. 2015 Nov; 63(11):2040-2057. View abstract
  14. Bugs, guts, and glia: how microbiota influence enteric gliogenesis and migration. Neuron. 2015 Jan 21; 85(2):229-30. View abstract
  15. Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential. Cell. 2015 Jan 15; 160(1-2):269-84. View abstract
  16. GDE2 regulates subtype-specific motor neuron generation through inhibition of Notch signaling. Neuron. 2011 Sep 22; 71(6):1058-70. View abstract
  17. The antioxidant enzyme Prdx1 controls neuronal differentiation by thiol-redox-dependent activation of GDE2. Cell. 2009 Sep 18; 138(6):1209-21. View abstract
  18. Transmembrane protein GDE2 induces motor neuron differentiation in vivo. Science. 2005 Sep 30; 309(5744):2212-5. View abstract
  19. Molecular mechanisms of RNAi: implications for development and disease. Birth Defects Res C Embryo Today. 2005 Mar; 75(1):28-42. View abstract
  20. In vivo comparative study of RNAi methodologies by in ovo electroporation in the chick embryo. Dev Dyn. 2004 Nov; 231(3):592-600. View abstract