My goal is to provide expertise, love and support to patients and their families in real time, and also to look for ways to make the care we provide better in the future.



Undergraduate Degree

  • University of Virginia , 1998 , Charlottesville , VA

Medical School

  • University of Virginia , 2002 , Charlottesville , VA


  • Cincinnati Children's Hospital Medical Center , 2003 , Cincinnati , OH


Chief Resident, Pediatrics
  • Cincinnati Children's Hospital Medical Center , 2006 , Cincinnati , OH


Clinical Fellow, Anesthesia
  • Boston Children's Hospital , 2010 , Boston , MA

Philosophy of Care

Caring for critically ill patients and their families is a tremendous privilege and responsibility. A responsibility because there is nothing more precious to a human being than their child, and a privilege because I consider it an honor to walk along side families during such trying times.  The ICU can be an imposing place to be, with many caregivers to get to know and a sick child.  My goal is to provide expertise, love and support to patients and their families in real time, and also to look for ways to make the care we provide better in the future.


Dr. Kheir joined the staff of the Boston Children’s Hospital Heart Center in 2010.  He is a staff physician in the cardiac intensive care unit, where he cares for critically ill patients with congenital heart disease.  He is also the co-founder of the Translational Research Lab within the Heart Center, a group focused upon the development of new diagnostic and treatment tools related to oxygen deprivation, a common problem in patients with severe heart disease.  For example, he and his group are developing tools to deliver oxygen directly to the bloodstream for use in extreme emergencies.  Among his other interests are new ways to determine whether patients are receiving sufficient oxygen delivery following their operations, particularly in infants with hypoplastic left heart syndrome. 


  • American Board of Pediatrics, General Pediatrics
  • American Board of Pediatrics, Critical Care Medicine


Publications powered by Harvard Catalyst Profiles

  1. Hagel JA, Sperotto F, Laussen PC, Salvin JW, Bachu A, Kheir JN. Shock Index, Coronary Perfusion Pressure, and Rate Pressure Product As Predictors of Adverse Outcome After Pediatric Cardiac Surgery. Pediatr Crit Care Med. 2020 Oct 02. View abstract
  2. Cordova EG, Levy P, Kheir JN, Orbach DB, Barnewolt C, Estroff JA. Vein of Galen Malformation. Neoreviews. 2020 Oct; 21(10):e678-e686. View abstract
  3. Gagnon MH, Kussman BD, Zhou L, DiNardo JA, Kheir JN. Sensitivity of a Next-Generation NIRS Device to Detect Low Mixed Venous Oxyhemoglobin Saturations in the Single Ventricle Population. Anesth Analg. 2020 09; 131(3):e138-e141. View abstract
  4. Nguyen T, Peng Y, Seekell RP, Kheir JN, Polizzotti BD. Hyperbaric polymer microcapsules for tunable oxygen delivery. J Control Release. 2020 Nov 10; 327:420-428. View abstract
  5. Assaad IE, Hood-Pishchany MI, Kheir J, Mistry K, Dixit A, Halyabar O, Mah DY, Meyer-Macaulay C, Cheng H. WITHDRAWN: Complete Heart Block, Severe Ventricular Dysfunction and Myocardial Inflammation in a Child with COVID-19 Infection. JACC Case Rep. 2020 May 27. View abstract
  6. El-Assaad I, Hood-Pishchany MI, Kheir J, Mistry K, Dixit A, Halyabar O, Mah DY, Meyer-Macaulay C, Cheng H. Complete Heart Block, Severe Ventricular Dysfunction, and Myocardial Inflammation in a Child With COVID-19 Infection. JACC Case Rep. 2020 Jul 15; 2(9):1351-1355. View abstract
  7. Mille FK, Badheka A, Yu P, Zhang X, Friedman DF, Kheir J, van den Bosch S, Cabrera AG, Lasa JJ, Katcoff H, Hu P, Borasino S, Hock K, Huskey J, Weller J, Kothari H, Blinder J. Red Blood Cell Transfusion After Stage I Palliation Is Associated With Worse Clinical Outcomes. J Am Heart Assoc. 2020 May 18; 9(10):e015304. View abstract
  8. Dionne A, Kheir JN, Gauvreau K, Triedman JK, Abrams DJ, Alexander ME, DeWitt ES, Mah DY, Walsh EP, Bezzerides VJ. Value of provocative electrophysiology testing in the management of pediatric patients after congenital heart surgery. Pacing Clin Electrophysiol. 2020 Apr 24. View abstract
  9. Sinha AM, van den Bosch SJ, Pozerski K, Zhou L, Kheir JN. Development of a Respiratory Support Score as a Visualization Tool in Intensive Care. Respir Care. 2020 Sep; 65(9):1268-1275. View abstract
  10. Thatte N, Zhou L, Kheir JN. Impact of the superior cavopulmonary anastomosis on cerebral oxygenation. Cardiol Young. 2020 Apr; 30(4):585-587. View abstract
  11. Dionne A, Kheir JN, Sleeper LA, Esch JJ, Breitbart RE. Value of Troponin Testing for Detection of Heart Disease in Previously Healthy Children. J Am Heart Assoc. 2020 02 18; 9(4):e012897. View abstract
  12. Weixler VHM, Zurakowski D, Kheir J, Guariento A, Kaza AK, Baird CW, Del Nido PJ, Emani SM. Fontan with lateral tunnel is associated with improved survival compared with extracardiac conduit. J Thorac Cardiovasc Surg. 2020 04; 159(4):1480-1491.e2. View abstract
  13. Cole AR, Raza A, Ahmed H, Polizzotti BD, Padera RF, Andrews N, Kheir JN. Safety of inhaled hydrogen gas in healthy mice. Med Gas Res. 2019 Jul-Sep; 9(3):133-138. View abstract
  14. Cole AR, Perry DA, Raza A, Nedder AP, Pollack E, Regan WL, van den Bosch SJ, Polizzotti BD, Yang E, Davila D, Afacan O, Warfield SK, Ou Y, Sefton B, Everett AD, Neil JJ, Lidov HGW, Mayer JE, Kheir JN. Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory Arrest in Swine. JACC Basic Transl Sci. 2019 Apr; 4(2):176-187. View abstract
  15. Kheir JN, DiNardo JA. Reply to Li, J "The Fick principle remains accurate to calculate cardiac output under hyperoxia". Acta Anaesthesiol Scand. 2019 07; 63(6):828. View abstract
  16. Mackin C, DeWitt ES, Black KJ, Tang X, Polizzotti BD, van den Bosch SJ, Alexander ME, Kheir JN. Intravenous Amiodarone and Sotalol Impair Contractility and Cardiac Output, but Procainamide Does Not: A Langendorff Study. J Cardiovasc Pharmacol Ther. 2019 05; 24(3):288-297. View abstract
  17. Peng Y, Li Q, Seekell RR, Kheir JN, Porter TM, Polizzotti BD. Tunable Nonlinear Acoustic Reporters Using Micro- and Nanosized Air Bubbles with Porous Polymeric Hard Shells. ACS Appl Mater Interfaces. 2019 Jan 09; 11(1):7-12. View abstract
  18. Peng Y, Kheir JN, Polizzotti BD. Injectable Oxygen: Interfacing Materials Chemistry with Resuscitative Science. Chemistry. 2018 Dec 17; 24(71):18820-18829. View abstract
  19. Mills KI, van den Bosch SJ, Gauvreau K, Allan CK, Thiagarajan RR, Hoganson DM, Baird CW, Nathan M, DiNardo JA, Kheir JN. Physiologic effects of delayed sternal closure following stage 1 palliation. Cardiol Young. 2018 Dec; 28(12):1393-1403. View abstract
  20. Perry DA, Thomson LM, Pigula FA, Polizzotti BD, DiNardo JA, Nedder A, Gauvreau K, Kheir JN. Changes in tissue oxygen tension, venous saturation, and Fick-based assessments of cardiac output during hyperoxia. Acta Anaesthesiol Scand. 2019 01; 63(1):93-100. View abstract
  21. Seekell RP, Peng Y, Lock AT, Kheir JN, Polizzotti BD. Tunable Polymer Microcapsules for Controlled Release of Therapeutic Gases. Langmuir. 2018 08 07; 34(31):9175-9183. View abstract
  22. Nachman E, Clemensen P, Santos K, Cole AR, Polizzotti BD, Hofmann G, Leeman KT, van den Bosch SJ, Kheir JN. A Device for the Quantification of Oxygen Consumption and Caloric Expenditure in the Neonatal Range. Anesth Analg. 2018 07; 127(1):95-104. View abstract
  23. Hoganson DM, Cigarroa CL, van den Bosch SJ, Sleeper LA, Callahan R, Friedman KG, Baird CW, Quinonez LG, Kaza AK, Emani SE, Kheir JN. Impact of a Composite Valved RV-PA Graft After Stage 1 Palliation. Ann Thorac Surg. 2018 11; 106(5):1452-1459. View abstract
  24. Nair AG, Oladunjoye OO, Trenor CC, LaRonde M, van den Bosch SJ, Sleeper LA, VanderPluym C, Emani SM, Kheir JN. An anticoagulation protocol for use after congenital cardiac surgery. J Thorac Cardiovasc Surg. 2018 07; 156(1):343-352.e4. View abstract
  25. Oladunjoye OO, Sleeper LA, Nair AG, Trenor CC, VanderPluym C, Kheir JN, Emani SM. Partial thromboplastin time is more predictive of bleeding than anti-Xa levels in heparinized pediatric patients after cardiac surgery. J Thorac Cardiovasc Surg. 2018 07; 156(1):332-340.e1. View abstract
  26. Kheir JN, Polizzotti BD, DiNardo JA. Use of Oxyhemoglobin Saturation or Oxygen Tension-an Unsolved Question-Reply. JAMA Pediatr. 2018 04 01; 172(4):390-391. View abstract
  27. Peng Y, Seekell RP, Cole AR, Lamothe JR, Lock AT, van den Bosch S, Tang X, Kheir JN, Polizzotti BD. Interfacial Nanoprecipitation toward Stable and Responsive Microbubbles and Their Use as a Resuscitative Fluid. Angew Chem Int Ed Engl. 2018 01 26; 57(5):1271-1276. View abstract
  28. Cigarroa CL, van den Bosch SJ, Tang X, Gauvreau K, Baird CW, DiNardo JA, Kheir JN. Measurement of Dead Space Fraction Upon ICU Admission Predicts Length of Stay and Clinical Outcomes Following Bidirectional Cavopulmonary Anastomosis. Pediatr Crit Care Med. 2018 01; 19(1):23-31. View abstract
  29. Ahmed H, Tang X, Polizzotti B, Gauvreau K, Kellogg M, DiNardo J, Kheir J. Use of Oxyhemoglobin Saturation, Rather Than Oxygen Tension, as a Marker of Oxygenation in Cyanotic Patients. JAMA Pediatr. 2017 10 01; 171(10):1012-1014. View abstract
  30. Perry DA, Salvin JW, Romfh P, Chen P, Krishnamurthy K, Thomson LM, Polizzotti BD, McGowan FX, Vakhshoori D, Kheir JN. Responsive monitoring of mitochondrial redox states in heart muscle predicts impending cardiac arrest. Sci Transl Med. 2017 Sep 20; 9(408). View abstract
  31. Black KJ, Lock AT, Thomson LM, Cole AR, Tang X, Polizzotti BD, Kheir JN. Hemodynamic Effects of Lipid-Based Oxygen Microbubbles via Rapid Intravenous Injection in Rodents. Pharm Res. 2017 Oct; 34(10):2156-2162. View abstract
  32. Rescoe E, Tang X, Perry DA, Sleeper LA, DiNardo JA, Kussman BD, Kheir JN. Cerebral near-infrared spectroscopy insensitively detects low cerebral venous oxygen saturations after stage 1 palliation. J Thorac Cardiovasc Surg. 2017 09; 154(3):1056-1062. View abstract
  33. Smallwood CD, Kheir JN, Walsh BK, Mehta NM. Accuracy of Oxygen Consumption and Carbon Dioxide Elimination Measurements in 2 Breath-by-Breath Devices. Respir Care. 2017 Apr; 62(4):475-480. View abstract
  34. Kheir JN, Polizzotti BD. Reply to Span et al.: Rational design of oxygen microparticles for radiation therapy. Proc Natl Acad Sci U S A. 2016 12 13; 113(50):E8010. View abstract
  35. Mills K, French C, Baird C, Santos K, Tang X, Kheir J, Mehta N. 450: SUBOPTIMAL PROTEIN INTAKE MAY PROLONG CICU LENGTH OF STAY AND WORSEN NUTRITIONAL STATUS IN CHILDREN. Crit Care Med. 2016 Dec; 44(12 Suppl 1):189. View abstract
  36. French C, Mills K, Baird C, Santos K, Tang X, Kheir J, Mehta N. 462: BEDSIDE VCO2 AS A GUIDE TO INDIVIDUALIZED ENERGY PRESCRIPTION IN VENTILATED CHILDREN IN THE CICU. Crit Care Med. 2016 Dec; 44(12 Suppl 1):192. View abstract
  37. Sinha A, Tang X, Kheir J. 191: QUANTIFYING ICU SUPPORT IN THE CONTEXT OF DISEASE-MATCHED PATIENTS OVER TIME USING PERCENTILE CURVES. Crit Care Med. 2016 Dec; 44(12 Suppl 1):125. View abstract
  38. Mills KI, Kaza AK, Walsh BK, Bond HC, Ford M, Wypij D, Thiagarajan RR, Almodovar MC, Quinonez LG, Baird CW, Emani SE, Pigula FA, DiNardo JA, Kheir JN. Phosphodiesterase Inhibitor-Based Vasodilation Improves Oxygen Delivery and Clinical Outcomes Following Stage 1 Palliation. J Am Heart Assoc. 2016 11 02; 5(11). View abstract
  39. Seekell RP, Lock AT, Peng Y, Cole AR, Perry DA, Kheir JN, Polizzotti BD. Oxygen delivery using engineered microparticles. Proc Natl Acad Sci U S A. 2016 11 01; 113(44):12380-12385. View abstract
  40. DeWitt ES, Black KJ, Kheir JN. Rodent Working Heart Model for the Study of Myocardial Performance and Oxygen Consumption. J Vis Exp. 2016 08 16; (114). View abstract
  41. DeWitt ES, Black KJ, Thiagarajan RR, DiNardo JA, Colan SD, McGowan FX, Kheir JN. Effects of commonly used inotropes on myocardial function and oxygen consumption under constant ventricular loading conditions. J Appl Physiol (1985). 2016 07 01; 121(1):7-14. View abstract
  42. Templin JS, Wylie MC, Kim JD, Kurgansky KE, Gorski G, Kheir J, Zurakowski D, Corfas G, Berde C. Neosaxitoxin in Rat Sciatic Block: Improved Therapeutic Index Using Combinations with Bupivacaine, with and without Epinephrine. Anesthesiology. 2015 Oct; 123(4):886-98. View abstract
  43. Walsh BK, Davis MD, Hunt JF, Kheir JN, Smallwood CD, Arnold JH. The effects of lung recruitment maneuvers on exhaled breath condensate pH. J Breath Res. 2015 Sep 03; 9(3):036009. View abstract
  44. Thomson LM, Polizzotti BD, McGowan FX, Kheir JN. Manufacture of concentrated, lipid-based oxygen microbubble emulsions by high shear homogenization and serial concentration. J Vis Exp. 2014 May 26; (87). View abstract
  45. Polizzotti BD, Thomson LM, O'Connell DW, McGowan FX, Kheir JN. Optimization and characterization of stable lipid-based, oxygen-filled microbubbles by mixture design. . 2014 Aug; 102(6):1148-56. View abstract
  46. Kheir JN, Polizzotti BD, Thomson LM, O'Connell DW, Black KJ, Lee RW, Wilking JN, Graham AC, Bell DC, McGowan FX. Bulk manufacture of concentrated oxygen gas-filled microparticles for intravenous oxygen delivery. Adv Healthc Mater. 2013 Aug; 2(8):1131-41. View abstract
  47. Kheir JN, Walsh BK, Smallwood CD, Rettig JS, Thompson JE, Gómez-Laberge C, Wolf GK, Arnold JH. Comparison of 2 lung recruitment strategies in children with acute lung injury. Respir Care. 2013 Aug; 58(8):1280-90. View abstract
  48. Wolf GK, Gómez-Laberge C, Kheir JN, Zurakowski D, Walsh BK, Adler A, Arnold JH. Reversal of dependent lung collapse predicts response to lung recruitment in children with early acute lung injury. Pediatr Crit Care Med. 2012 Sep; 13(5):509-15. View abstract
  49. Kheir JN, Scharp LA, Borden MA, Swanson EJ, Loxley A, Reese JH, Black KJ, Velazquez LA, Thomson LM, Walsh BK, Mullen KE, Graham DA, Lawlor MW, Brugnara C, Bell DC, McGowan FX. Oxygen gas-filled microparticles provide intravenous oxygen delivery. Sci Transl Med. 2012 Jun 27; 4(140):140ra88. View abstract
  50. Wylie MC, Johnson VM, Carpino E, Mullen K, Hauser K, Nedder A, Kheir JN, Rodriguez-Navarro AJ, Zurakowski D, Berde CB. Respiratory, neuromuscular, and cardiovascular effects of neosaxitoxin in isoflurane-anesthetized sheep. Reg Anesth Pain Med. 2012 Mar-Apr; 37(2):152-8. View abstract
  51. Swanson EJ, Mohan V, Kheir J, Borden MA. Phospholipid-stabilized microbubble foam for injectable oxygen delivery. Langmuir. 2010 Oct 19; 26(20):15726-9. View abstract
  52. Kheir JN, Lawlor MW, Ahn ES, Lehmann L, Riviello JJ, Silvera VM, McManus M, Folkerth RD. Neuropathology of a fatal case of posterior reversible encephalopathy syndrome. Pediatr Dev Pathol. 2010 Sep-Oct; 13(5):397-403. View abstract
  53. Brilli RJ, Gibson R, Luria JW, Wheeler TA, Shaw J, Linam M, Kheir J, McLain P, Lingsch T, Hall-Haering A, McBride M. Implementation of a medical emergency team in a large pediatric teaching hospital prevents respiratory and cardiopulmonary arrests outside the intensive care unit. Pediatr Crit Care Med. 2007 May; 8(3):236-46; quiz 247. View abstract