"My goal is to provide expertise, love and support to patients and their families in real time, and also to look for ways to make the care we provide better in the future."

EDUCATION

Undergraduate
  • University of Virginia , Charlottesville , VA
Medical Degree
  • University of Virginia , Charlottesville , VA

Internship

  • Cincinnati Children's Hospital Medical Center , Cincinnati , OH

Graduate Degree

Pediatric Chief Resident
  • Cincinnati Children's Hospital Medical Center , Cincinnati , OH

Fellowship

Clinical Fellow in Anesthesia
  • Boston Children's Hospital , Boston , MA

Caring for critically ill patients and their families is a tremendous privilege and responsibility.

A responsibility because there is nothing more precious to a human being than their child, and a privilege because I consider it an honor to walk along side families during such trying times.  The ICU can be an imposing place to be, with many caregivers to get to know and a sick child.  My goal is to provide expertise, love and support to patients and their families in real time, and also to look for ways to make the care we provide better in the future.

PROFESSIONAL HISTORY

Dr. Kheir joined the staff of the Boston Children’s Hospital Heart Center in 2010.  He is a staff physician in the cardiac intensive care unit, where he cares for critically ill patients with congenital heart disease.  He is also the co-founder of the Translational Research Lab within the Heart Center, a group focused upon the development of new diagnostic and treatment tools related to oxygen deprivation, a common problem in patients with severe heart disease.  For example, he and his group are developing tools to deliver oxygen directly to the bloodstream for use in extreme emergencies.  Among his other interests are new ways to determine whether patients are receiving sufficient oxygen delivery following their operations, particularly in infants with hypoplastic left heart syndrome. 

CERTIFICATIONS

  • Pediatric Advanced Life Support
  • Neonatal Resuscitation Program
  • Basic Life Support

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Kheir JN, Polizzotti BD, DiNardo JA. Use of Oxyhemoglobin Saturation or Oxygen Tension-an Unsolved Question-Reply. JAMA Pediatr. 2018 Apr 01; 172(4):390-391. View abstract
  2. Nachman E, Clemensen P, Santos K, Cole AR, Polizzotti BD, Hofmann G, Leeman KT, van den Bosch SJ, Kheir JN. A Device for the Quantification of Oxygen Consumption and Caloric Expenditure in the Neonatal Range. Anesth Analg. 2018 Mar 01. View abstract
  3. Peng Y, Seekell RP, Cole AR, Lamothe JR, Lock AT, van den Bosch S, Tang X, Kheir JN, Polizzotti BD. Interfacial Nanoprecipitation toward Stable and Responsive Microbubbles and Their Use as a Resuscitative Fluid. Angew Chem Int Ed Engl. 2018 Jan 26; 57(5):1271-1276. View abstract
  4. Cigarroa CL, van den Bosch SJ, Tang X, Gauvreau K, Baird CW, DiNardo JA, Kheir JN. Measurement of Dead Space Fraction Upon ICU Admission Predicts Length of Stay and Clinical Outcomes Following Bidirectional Cavopulmonary Anastomosis. Pediatr Crit Care Med. 2018 Jan; 19(1):23-31. View abstract
  5. Ahmed H, Tang X, Polizzotti B, Gauvreau K, Kellogg M, DiNardo J, Kheir J. Use of Oxyhemoglobin Saturation, Rather Than Oxygen Tension, as a Marker of Oxygenation in Cyanotic Patients. JAMA Pediatr. 2017 Oct 01; 171(10):1012-1014. View abstract
  6. Perry DA, Salvin JW, Romfh P, Chen P, Krishnamurthy K, Thomson LM, Polizzotti BD, McGowan FX, Vakhshoori D, Kheir JN. Responsive monitoring of mitochondrial redox states in heart muscle predicts impending cardiac arrest. Sci Transl Med. 2017 Sep 20; 9(408). View abstract
  7. Black KJ, Lock AT, Thomson LM, Cole AR, Tang X, Polizzotti BD, Kheir JN. Hemodynamic Effects of Lipid-Based Oxygen Microbubbles via Rapid Intravenous Injection in Rodents. Pharm Res. 2017 Oct; 34(10):2156-2162. View abstract
  8. Rescoe E, Tang X, Perry DA, Sleeper LA, DiNardo JA, Kussman BD, Kheir JN. Cerebral near-infrared spectroscopy insensitively detects low cerebral venous oxygen saturations after stage 1 palliation. J Thorac Cardiovasc Surg. 2017 Sep; 154(3):1056-1062. View abstract
  9. Smallwood CD, Kheir JN, Walsh BK, Mehta NM. Accuracy of Oxygen Consumption and Carbon Dioxide Elimination Measurements in 2 Breath-by-Breath Devices. Respir Care. 2017 Apr; 62(4):475-480. View abstract
  10. Kheir JN, Polizzotti BD. Reply to Span et al.: Rational design of oxygen microparticles for radiation therapy. Proc Natl Acad Sci U S A. 2016 12 13; 113(50):E8010. View abstract
  11. Mills K, French C, Baird C, Santos K, Tang X, Kheir J, Mehta N. 450: SUBOPTIMAL PROTEIN INTAKE MAY PROLONG CICU LENGTH OF STAY AND WORSEN NUTRITIONAL STATUS IN CHILDREN. Crit Care Med. 2016 Dec; 44(12 Suppl 1):189. View abstract
  12. French C, Mills K, Baird C, Santos K, Tang X, Kheir J, Mehta N. 462: BEDSIDE VCO2 AS A GUIDE TO INDIVIDUALIZED ENERGY PRESCRIPTION IN VENTILATED CHILDREN IN THE CICU. Crit Care Med. 2016 Dec; 44(12 Suppl 1):192. View abstract
  13. Sinha A, Tang X, Kheir J. 191: QUANTIFYING ICU SUPPORT IN THE CONTEXT OF DISEASE-MATCHED PATIENTS OVER TIME USING PERCENTILE CURVES. Crit Care Med. 2016 Dec; 44(12 Suppl 1):125. View abstract
  14. Mills KI, Kaza AK, Walsh BK, Bond HC, Ford M, Wypij D, Thiagarajan RR, Almodovar MC, Quinonez LG, Baird CW, Emani SE, Pigula FA, DiNardo JA, Kheir JN. Phosphodiesterase Inhibitor-Based Vasodilation Improves Oxygen Delivery and Clinical Outcomes Following Stage 1 Palliation. J Am Heart Assoc. 2016 Nov 02; 5(11). View abstract
  15. Seekell RP, Lock AT, Peng Y, Cole AR, Perry DA, Kheir JN, Polizzotti BD. Oxygen delivery using engineered microparticles. Proc Natl Acad Sci U S A. 2016 11 01; 113(44):12380-12385. View abstract
  16. DeWitt ES, Black KJ, Kheir JN. Rodent Working Heart Model for the Study of Myocardial Performance and Oxygen Consumption. J Vis Exp. 2016 08 16; (114). View abstract
  17. DeWitt ES, Black KJ, Thiagarajan RR, DiNardo JA, Colan SD, McGowan FX, Kheir JN. Effects of commonly used inotropes on myocardial function and oxygen consumption under constant ventricular loading conditions. J Appl Physiol (1985). 2016 Jul 01; 121(1):7-14. View abstract
  18. Templin JS, Wylie MC, Kim JD, Kurgansky KE, Gorski G, Kheir J, Zurakowski D, Corfas G, Berde C. Neosaxitoxin in Rat Sciatic Block: Improved Therapeutic Index Using Combinations with Bupivacaine, with and without Epinephrine. Anesthesiology. 2015 Oct; 123(4):886-98. View abstract
  19. Walsh BK, Davis MD, Hunt JF, Kheir JN, Smallwood CD, Arnold JH. The effects of lung recruitment maneuvers on exhaled breath condensate pH. J Breath Res. 2015 Sep 03; 9(3):036009. View abstract
  20. Thomson LM, Polizzotti BD, McGowan FX, Kheir JN. Manufacture of concentrated, lipid-based oxygen microbubble emulsions by high shear homogenization and serial concentration. J Vis Exp. 2014 May 26; (87). View abstract
  21. Polizzotti BD, Thomson LM, O'Connell DW, McGowan FX, Kheir JN. Optimization and characterization of stable lipid-based, oxygen-filled microbubbles by mixture design. J Biomed Mater Res B Appl Biomater. 2014 Aug; 102(6):1148-56. View abstract
  22. Kheir JN, Polizzotti BD, Thomson LM, O'Connell DW, Black KJ, Lee RW, Wilking JN, Graham AC, Bell DC, McGowan FX. Bulk manufacture of concentrated oxygen gas-filled microparticles for intravenous oxygen delivery. Adv Healthc Mater. 2013 Aug; 2(8):1131-41. View abstract
  23. Kheir JN, Walsh BK, Smallwood CD, Rettig JS, Thompson JE, Gómez-Laberge C, Wolf GK, Arnold JH. Comparison of 2 lung recruitment strategies in children with acute lung injury. Respir Care. 2013 Aug; 58(8):1280-90. View abstract
  24. Wolf GK, Gómez-Laberge C, Kheir JN, Zurakowski D, Walsh BK, Adler A, Arnold JH. Reversal of dependent lung collapse predicts response to lung recruitment in children with early acute lung injury. Pediatr Crit Care Med. 2012 Sep; 13(5):509-15. View abstract
  25. Kheir JN, Scharp LA, Borden MA, Swanson EJ, Loxley A, Reese JH, Black KJ, Velazquez LA, Thomson LM, Walsh BK, Mullen KE, Graham DA, Lawlor MW, Brugnara C, Bell DC, McGowan FX. Oxygen gas-filled microparticles provide intravenous oxygen delivery. Sci Transl Med. 2012 Jun 27; 4(140):140ra88. View abstract
  26. Wylie MC, Johnson VM, Carpino E, Mullen K, Hauser K, Nedder A, Kheir JN, Rodriguez-Navarro AJ, Zurakowski D, Berde CB. Respiratory, neuromuscular, and cardiovascular effects of neosaxitoxin in isoflurane-anesthetized sheep. Reg Anesth Pain Med. 2012 Mar-Apr; 37(2):152-8. View abstract
  27. Swanson EJ, Mohan V, Kheir J, Borden MA. Phospholipid-stabilized microbubble foam for injectable oxygen delivery. Langmuir. 2010 Oct 19; 26(20):15726-9. View abstract
  28. Kheir JN, Lawlor MW, Ahn ES, Lehmann L, Riviello JJ, Silvera VM, McManus M, Folkerth RD. Neuropathology of a fatal case of posterior reversible encephalopathy syndrome. Pediatr Dev Pathol. 2010 Sep-Oct; 13(5):397-403. View abstract
  29. Brilli RJ, Gibson R, Luria JW, Wheeler TA, Shaw J, Linam M, Kheir J, McLain P, Lingsch T, Hall-Haering A, McBride M. Implementation of a medical emergency team in a large pediatric teaching hospital prevents respiratory and cardiopulmonary arrests outside the intensive care unit. Pediatr Crit Care Med. 2007 May; 8(3):236-46; quiz 247. View abstract