What is Li-Fraumeni syndrome?
Li-Fraumeni syndrome (LFS) is a hereditary condition that is often associated with a pathogenic or likely pathogenic variant (mutation) in the TP53 gene (TP53 positive genetic test result or TP53+ result). People with LFS have greatly increased risks of various cancers over their lifetimes. Some people have a TP53+ result identified in their genetic testing, but their personal and family cancer histories do not look like typical LFS. Traditionally, people with TP53+ results were thought to have a diagnosis of LFS, however, more recent evidence has shown that not all people with TP53+ results have LFS.
How we care for Li-Fraumeni syndrome
The high cancer risks seen with LFS and often with other TP53+ results make it important for children, adolescents, and adults to be cared for by medical providers who are experts in LFS and TP53+ results. Dana-Farber's Li-Fraumeni Syndrome and TP53 Center is the first comprehensive multi-disciplinary center in the world that specializes in coordinating the care of people with LFS and TP53+ results, as well as provides psychological and social support for patients and their families.
Learn more about Li-Fraumeni syndrome and our TP53 Center on the Dana-Farber Cancer Institute website.