Multiple Endocrine Neoplasia | Symptoms & Causes

What are the symptoms of multiple endocrine neoplasia?

The symptoms of multiple endocrine neoplasia (MEN) may vary from child to child and depend on the type of the disease. Symptoms might mimic other, more common ailments. Sometimes your child may not experience symptoms but MEN type 1 or 2 may be suggested because of a family history.

Some symptoms of MEN1 may include:

  • elevated calcium levels
  • abdominal pain, vomiting and weight changes due to pancreatic islet cell tumors
  • headaches, visual disturbances and problems with fertility from pituitary gland tumors

Some symptoms of MEN2 might include:

  • elevated calcium levels
  • kidney stones from overactive parathyroid glands.
  • high blood pressure, headaches or sweating
  • lump or swelling in the neck
  • difficulty breathing or swallowing

Because many of these symptoms can also point to other conditions, it’s important to have your child evaluated by a qualified medical professional right away.

What causes MEN?

Both MEN1 and MEN2 are inherited disorders, meaning that they are usually the result of an abnormal gene that is passed down in families. Occasionally the conditions can arise from a new gene abnormality that develops for unknown reasons in a patient without a family history of these conditions. In general, MEN1 results from abnormalities in the MEN1 gene, while MEN2 can arise from abnormalities in the RET gene.