Glomuvenous Malformation | Symptoms & Causes

What are the symptoms of glomuvenous malformation?

Glomuvenous malformations typically appear on the skin, most commonly on fingers and toes. In some cases, they can involve the mucous membranes, such as the inside of the mouth or extend into fat and muscles.

At first, a glomuvenous malformation looks like a raised pink or blue patch that feels bumpy to the touch. Over time, they tend to thicken and become more bluish in color, resembling a raised bruise.

These malformations vary in size and may develop at any age. GVMs can be painful with or without touch. Pain may be caused by:

  • getting bumped or hit
  • direct pressure
  • extreme temperature changes (because they are associated with an abnormal growth of cells that regulate body heat)

Sclerotherapy, surgery and medications are treatment options that relieve and reduce pain.

What causes a glomuvenous malformation?

Glomuvenous malformations are frequently hereditary. Researchers have identified mutations in the glomulin gene in the majority of GVM cases. If a child has a hereditary form, it means at least one parent carries the mutated gene.

While GVMs may run in families, they can present differently from one person to the next. Some family members may have less prominent lesions, while another may have multiple or extensive malformations.