Chronic Granulomatous Disease (CGD) | Diagnosis & Treatment

How is chronic granulomatous disease diagnosed?

Chronic granulomatous disease (CGD) is diagnosed through:

  • neutrophil function tests to determine how well these white blood cells are functioning
  • dihydrorhodamine reduction test
  • genetic testing to confirm the presence of a specific gene mutation that results in CGD

After all tests are completed, doctors will be able to outline the best treatment options.

Study of Gene Therapy linked to treat x-linked CGD

A new gene therapy clinical trial at Dana-Farber/Boston Children’s may help pave the way toward new treatment approaches for CGD.




Dr. Gutierrez examining test tubes in a gene therapy lab

How is CGD treated?

Treatment for chronic granulomatous disease (CGD) includes:

  • preventative (prophylactic) antibiotics and antifungals on a long-term basis
  • infection management with antibacterial or antifungal medications
  • gamma-interferon therapy to help boost the immune system to help fight infections
  • surgery to relieve obstruction from granulomas, drain abscesses or remove established infections

A new gene therapy clinical trial may help pave the way toward new treatment approaches for CGD.