Current Environment: Production

1 Boston Children's Hospital | Education

Undergraduate School

University of Michigan

Ann Arbor, MI

Medical School

Stanford University School of Medicine

1974, Stanford, CA

Internship

Internal Medicine

Brigham and Women's Hospital

1975, Boston, MA

Residency

Internal Medicine

Brigham and Women's Hospital

1976, Boston, MA

Fellowship

Adult Endocrinology

Massachusetts General Hospital

Boston, MA

1 Boston Children's Hospital | Publications

  1. Harmonizing TUNEL with multiplexed iterative immunofluorescence enriches spatial contextualization of cell death. Cell Rep Methods. 2025 May 19; 5(5):101047. View Harmonizing TUNEL with multiplexed iterative immunofluorescence enriches spatial contextualization of cell death. Abstract

  2. Absent, but not glucocorticoid-modulated, corticotropin-releasing hormone (Crh) regulates anxiety-like behaviors in mice. bioRxiv. 2024 Oct 03. View Absent, but not glucocorticoid-modulated, corticotropin-releasing hormone (Crh) regulates anxiety-like behaviors in mice. Abstract

  3. Severe Hypernatremia in an Adolescent With Anorexia Nervosa. Clin Pediatr (Phila). 2021 12; 60(14):586-590. View Severe Hypernatremia in an Adolescent With Anorexia Nervosa. Abstract

  4. Ultrasonographic Tissue Perfusion in Peri-implant Health and Disease. J Dent Res. 2022 03; 101(3):278-285. View Ultrasonographic Tissue Perfusion in Peri-implant Health and Disease. Abstract

  5. A Resident-Led Virtual Journal Club to Educate Pediatric Residents About Coronavirus Disease 2019. Acad Pediatr. 2021 May-Jun; 21(4):759-761. View A Resident-Led Virtual Journal Club to Educate Pediatric Residents About Coronavirus Disease 2019. Abstract

  6. The Changing Face of Adrenoleukodystrophy. Endocr Rev. 2020 08 01; 41(4). View The Changing Face of Adrenoleukodystrophy. Abstract

  7. Correction: The Genomics Research and Innovation Network: creating an interoperable, federated, genomics learning system. Genet Med. 2020 Feb; 22(2):449. View Correction: The Genomics Research and Innovation Network: creating an interoperable, federated, genomics learning system. Abstract

  8. The Genomics Research and Innovation Network: creating an interoperable, federated, genomics learning system. Genet Med. 2020 02; 22(2):371-380. View The Genomics Research and Innovation Network: creating an interoperable, federated, genomics learning system. Abstract

  9. A novel missense mutation in TFAP2B associated with Char syndrome and central diabetes insipidus. Am J Med Genet A. 2019 07; 179(7):1299-1303. View A novel missense mutation in TFAP2B associated with Char syndrome and central diabetes insipidus. Abstract

  10. Glycogen storage disease presenting as Cushing syndrome. JIMD Rep. 2019 May; 47(1):17-22. View Glycogen storage disease presenting as Cushing syndrome. Abstract

  11. Hyperadrenocorticism of calorie restriction contributes to its anti-inflammatory action in mice. Aging Cell. 2019 06; 18(3):e12944. View Hyperadrenocorticism of calorie restriction contributes to its anti-inflammatory action in mice. Abstract

  12. Abnormal Glycerol Metabolism in a Child with Global Developmental Delay, Adrenal Insufficiency, and Intellectual Disability. Clin Chem. 2018 12; 64(12):1785-1787. View Abnormal Glycerol Metabolism in a Child with Global Developmental Delay, Adrenal Insufficiency, and Intellectual Disability. Abstract

  13. Behavioural dysfunctions of 10-year-old children born extremely preterm associated with corticotropin-releasing hormone expression in the placenta. Acta Paediatr. 2018 11; 107(11):1932-1936. View Behavioural dysfunctions of 10-year-old children born extremely preterm associated with corticotropin-releasing hormone expression in the placenta. Abstract

  14. A New Model for Adrenarche: Inhibition of 3ß-Hydroxysteroid Dehydrogenase Type 2 by Intra-Adrenal Cortisol. Horm Res Paediatr. 2018; 89(5):311-319. View A New Model for Adrenarche: Inhibition of 3ß-Hydroxysteroid Dehydrogenase Type 2 by Intra-Adrenal Cortisol. Abstract

  15. Racial differences in neonatal hypoglycemia among very early preterm births. J Perinatol. 2018 03; 38(3):258-263. View Racial differences in neonatal hypoglycemia among very early preterm births. Abstract

  16. Loss of hypothalamic corticotropin-releasing hormone markedly reduces anxiety behaviors in mice. Mol Psychiatry. 2017 05; 22(5):733-744. View Loss of hypothalamic corticotropin-releasing hormone markedly reduces anxiety behaviors in mice. Abstract

  17. Maternal first trimester serum levels of free-beta human chorionic gonadotrophin and male genital anomalies. Hum Reprod. 2016 08; 31(8):1895-903. View Maternal first trimester serum levels of free-beta human chorionic gonadotrophin and male genital anomalies. Abstract

  18. Brain disorders associated with corticotropin-releasing hormone expression in the placenta among children born before the 28th week of gestation. Acta Paediatr. 2016 Jan; 105(1):e7-11. View Brain disorders associated with corticotropin-releasing hormone expression in the placenta among children born before the 28th week of gestation. Abstract

  19. Endocrinology research-reflecting on the past decade and looking to the next. Nat Rev Endocrinol. 2015 Nov; 11(11):672-80. View Endocrinology research-reflecting on the past decade and looking to the next. Abstract

  20. Regulation of human 3ß-hydroxysteroid dehydrogenase type 2 by adrenal corticosteroids and product-feedback by androstenedione in human adrenarche. J Pharmacol Exp Ther. 2015 Jan; 352(1):67-76. View Regulation of human 3ß-hydroxysteroid dehydrogenase type 2 by adrenal corticosteroids and product-feedback by androstenedione in human adrenarche. Abstract

  21. An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. Genome Biol. 2014 Mar 25; 15(3):R53. View An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. Abstract

  22. Adrenocortical zonation results from lineage conversion of differentiated zona glomerulosa cells. Dev Cell. 2013 Sep 30; 26(6):666-673. View Adrenocortical zonation results from lineage conversion of differentiated zona glomerulosa cells. Abstract

  23. Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity. Science. 2013 Jul 19; 341(6143):275-8. View Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity. Abstract

  24. Epinephrine deficiency results in intact glucose counter-regulation, severe hepatic steatosis and possible defective autophagy in fasting mice. Int J Biochem Cell Biol. 2012 Jun; 44(6):905-13. View Epinephrine deficiency results in intact glucose counter-regulation, severe hepatic steatosis and possible defective autophagy in fasting mice. Abstract

  25. Fetal-placental inflammation, but not adrenal activation, is associated with extreme preterm delivery. Am J Obstet Gynecol. 2012 Mar; 206(3):236.e1-8. View Fetal-placental inflammation, but not adrenal activation, is associated with extreme preterm delivery. Abstract

  26. Cortisol stimulates secretion of dehydroepiandrosterone in human adrenocortical cells through inhibition of 3betaHSD2. J Clin Endocrinol Metab. 2011 Jan; 96(1):E31-9. View Cortisol stimulates secretion of dehydroepiandrosterone in human adrenocortical cells through inhibition of 3betaHSD2. Abstract

  27. Nocturnal Dexamethasone versus Hydrocortisone for the Treatment of Children with Congenital Adrenal Hyperplasia. Int J Pediatr Endocrinol. 2010; 2010. View Nocturnal Dexamethasone versus Hydrocortisone for the Treatment of Children with Congenital Adrenal Hyperplasia. Abstract

  28. Effect of epinephrine deficiency on cold tolerance and on brown adipose tissue. Mol Cell Endocrinol. 2010 Oct 26; 328(1-2):34-9. View Effect of epinephrine deficiency on cold tolerance and on brown adipose tissue. Abstract

  29. Monitoring of therapy in congenital adrenal hyperplasia. Clin Chem. 2010 Aug; 56(8):1245-51. View Monitoring of therapy in congenital adrenal hyperplasia. Abstract

  30. Glucocorticoid treatment--effect on adrenal medullary catecholamine production. Shock. 2010 Feb; 33(2):213-7. View Glucocorticoid treatment--effect on adrenal medullary catecholamine production. Abstract

  31. Permanent Neonatal Diabetes in a Patient with a KCNJ11/Q52R Mutation Accompanied by Intermittent Hypoglycemia and Liver Failure. Int J Pediatr Endocrinol. 2009; 2009:453240. View Permanent Neonatal Diabetes in a Patient with a KCNJ11/Q52R Mutation Accompanied by Intermittent Hypoglycemia and Liver Failure. Abstract

  32. Mass spectrometry in the clinical laboratory: how have we done, and where do we need to be? Clin Chem. 2009 Jun; 55(6):1236-9. View Mass spectrometry in the clinical laboratory: how have we done, and where do we need to be? Abstract

  33. Maternal levels of corticotropin-releasing hormone during pregnancy in relation to adiponectin and leptin in early childhood. J Clin Endocrinol Metab. 2009 Apr; 94(4):1409-15. View Maternal levels of corticotropin-releasing hormone during pregnancy in relation to adiponectin and leptin in early childhood. Abstract

  34. Long-term effects of dietary glycemic index on adiposity, energy metabolism, and physical activity in mice. Am J Physiol Endocrinol Metab. 2008 Nov; 295(5):E1126-31. View Long-term effects of dietary glycemic index on adiposity, energy metabolism, and physical activity in mice. Abstract

  35. Genetic diagnosis of primary immune deficiencies. Immunol Allergy Clin North Am. 2008 May; 28(2):387-412, x. View Genetic diagnosis of primary immune deficiencies. Abstract

  36. Elevated midpregnancy corticotropin-releasing hormone is associated with prenatal, but not postpartum, maternal depression. J Clin Endocrinol Metab. 2008 May; 93(5):1946-51. View Elevated midpregnancy corticotropin-releasing hormone is associated with prenatal, but not postpartum, maternal depression. Abstract

  37. Pomc knockout mice have secondary hyperaldosteronism despite an absence of adrenocorticotropin. Endocrinology. 2008 Feb; 149(2):681-6. View Pomc knockout mice have secondary hyperaldosteronism despite an absence of adrenocorticotropin. Abstract

  38. Diabetes insipidus: clinical and basic aspects. Pediatr Endocrinol Rev. 2006 Dec; 4 Suppl 1:60-5. View Diabetes insipidus: clinical and basic aspects. Abstract

  39. Maternal corticotropin-releasing hormone levels during pregnancy and offspring adiposity. Obesity (Silver Spring). 2006 Sep; 14(9):1647-53. View Maternal corticotropin-releasing hormone levels during pregnancy and offspring adiposity. Abstract

  40. Measuring corticotropin-releasing hormone in pregnant women - comparing blood collection protocols for epidemiological studies. Paediatr Perinat Epidemiol. 2006 Jan; 20(1):67-71. View Measuring corticotropin-releasing hormone in pregnant women - comparing blood collection protocols for epidemiological studies. Abstract

  41. Recombinant human growth hormone treatment for dilated cardiomyopathy in children. Pediatrics. 2004 Oct; 114(4):e452-8. View Recombinant human growth hormone treatment for dilated cardiomyopathy in children. Abstract

  42. Corticotropin-releasing hormone deficiency increases allergen-induced airway inflammation in a mouse model of asthma. J Allergy Clin Immunol. 2004 Oct; 114(4):747-54. View Corticotropin-releasing hormone deficiency increases allergen-induced airway inflammation in a mouse model of asthma. Abstract

  43. Perioperative management of diabetes insipidus in children. J Neurosurg Anesthesiol. 2004 Jul; 16(3):220-5. View Perioperative management of diabetes insipidus in children. Abstract

  44. Catecholamine synthesizing enzymes and their modulation by immobilization stress in knockout mice. Ann N Y Acad Sci. 2004 Jun; 1018:458-65. View Catecholamine synthesizing enzymes and their modulation by immobilization stress in knockout mice. Abstract

  45. Urocortin III, a brain neuropeptide of the corticotropin-releasing hormone family: modulation by stress and attenuation of some anxiety-like behaviours. J Neuroendocrinol. 2004 May; 16(5):411-22. View Urocortin III, a brain neuropeptide of the corticotropin-releasing hormone family: modulation by stress and attenuation of some anxiety-like behaviours. Abstract

  46. Maternal activating mutation of the calcium-sensing receptor: implications for calcium metabolism in the neonate. J Pediatr Endocrinol Metab. 2004 Apr; 17(4):673-7. View Maternal activating mutation of the calcium-sensing receptor: implications for calcium metabolism in the neonate. Abstract

  47. Impaired leptin expression and abnormal response to fasting in corticotropin-releasing hormone-deficient mice. Endocrinology. 2004 Jul; 145(7):3174-81. View Impaired leptin expression and abnormal response to fasting in corticotropin-releasing hormone-deficient mice. Abstract

  48. Perioperative management of diabetes insipidus in children [corrected]. J Neurosurg Anesthesiol. 2004 Jan; 16(1):14-9. View Perioperative management of diabetes insipidus in children [corrected]. Abstract

  49. Dissecting adrenal and behavioral responses to stress by targeted gene inactivation in mice. Stress. 2003 Jun; 6(2):121-5. View Dissecting adrenal and behavioral responses to stress by targeted gene inactivation in mice. Abstract

  50. Lessons from CRH knockout mice. Neuropeptides. 2002 Apr-Jun; 36(2-3):96-102. View Lessons from CRH knockout mice. Abstract

  51. Neural substrates of anorexia nervosa: a behavioral challenge study with positron emission tomography. J Pediatr. 2001 Jul; 139(1):51-7. View Neural substrates of anorexia nervosa: a behavioral challenge study with positron emission tomography. Abstract

  52. Maternal experiences of racism and violence as predictors of preterm birth: rationale and study design. Paediatr Perinat Epidemiol. 2001 Jul; 15 Suppl 2:124-35. View Maternal experiences of racism and violence as predictors of preterm birth: rationale and study design. Abstract

  53. The physiology of corticotropin-releasing hormone deficiency in mice. Peptides. 2001 May; 22(5):725-31. View The physiology of corticotropin-releasing hormone deficiency in mice. Abstract

  54. Repressor element silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) can act as an enhancer as well as a repressor of corticotropin-releasing hormone gene transcription. J Biol Chem. 2001 Apr 27; 276(17):13917-23. View Repressor element silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) can act as an enhancer as well as a repressor of corticotropin-releasing hormone gene transcription. Abstract

  55. Exogenous growth hormone: a new therapy for dilated cardiomyopathy. Prog Pediatr Cardiol. 2000 Nov 04; 12(1):125-132. View Exogenous growth hormone: a new therapy for dilated cardiomyopathy. Abstract

  56. Pituitary-adrenal axis regulation in CRH-deficient mice. Endocr Res. 2000 Nov; 26(4):1057-66. View Pituitary-adrenal axis regulation in CRH-deficient mice. Abstract

  57. Asthma, steroids, and growth. N Engl J Med. 2000 Oct 12; 343(15):1113-4. View Asthma, steroids, and growth. Abstract

  58. Endocrinologic and psychological effects of short-term dexamethasone in anorexia nervosa. Eat Weight Disord. 2000 Sep; 5(3):175-82. View Endocrinologic and psychological effects of short-term dexamethasone in anorexia nervosa. Abstract

  59. Effects of various mutations in the neurophysin/glycopeptide portion of the vasopressin gene on vasopressin expression in vitro. Tohoku J Exp Med. 2000 Aug; 191(4):187-202. View Effects of various mutations in the neurophysin/glycopeptide portion of the vasopressin gene on vasopressin expression in vitro. Abstract

  60. Circadian rise in maternal glucocorticoid prevents pulmonary dysplasia in fetal mice with adrenal insufficiency. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7336-41. View Circadian rise in maternal glucocorticoid prevents pulmonary dysplasia in fetal mice with adrenal insufficiency. Abstract

  61. Corticotropin-releasing hormone links pituitary adrenocorticotropin gene expression and release during adrenal insufficiency. J Clin Invest. 2000 May; 105(9):1269-77. View Corticotropin-releasing hormone links pituitary adrenocorticotropin gene expression and release during adrenal insufficiency. Abstract

  62. Impaired basal and restraint-induced epinephrine secretion in corticotropin-releasing hormone-deficient mice. Endocrinology. 2000 Mar; 141(3):1142-50. View Impaired basal and restraint-induced epinephrine secretion in corticotropin-releasing hormone-deficient mice. Abstract

  63. Neuroanatomy of human appetitive function: A positron emission tomography investigation. Int J Eat Disord. 2000 Mar; 27(2):163-71. View Neuroanatomy of human appetitive function: A positron emission tomography investigation. Abstract

  64. Impaired Basal and Restraint-Induced Epinephrine Secretion in Corticotropin-Releasing Hormone- Deficient Mice. Endocrinology. 2000 Mar 01; 141(3):1142-1150. View Impaired Basal and Restraint-Induced Epinephrine Secretion in Corticotropin-Releasing Hormone- Deficient Mice. Abstract

  65. CRH deficiency impairs but does not block pituitary-adrenal responses to diverse stressors. Neuroendocrinology. 2000 Feb; 71(2):79-87. View CRH deficiency impairs but does not block pituitary-adrenal responses to diverse stressors. Abstract

  66. Urocortin expression in the Edinger-Westphal nucleus is up-regulated by stress and corticotropin-releasing hormone deficiency. Endocrinology. 2000 Jan; 141(1):256-63. View Urocortin expression in the Edinger-Westphal nucleus is up-regulated by stress and corticotropin-releasing hormone deficiency. Abstract

  67. Urocortin Expression in the Edinger-Westphal Nucleus Is Up-Regulated by Stress and Corticotropin-Releasing Hormone Deficiency1. Endocrinology. 2000 Jan 01; 141(1):256-263. View Urocortin Expression in the Edinger-Westphal Nucleus Is Up-Regulated by Stress and Corticotropin-Releasing Hormone Deficiency1. Abstract

  68. Corticotropin-releasing hormone stimulates angiogenesis and epithelial tumor growth in the skin. J Invest Dermatol. 1999 Nov; 113(5):838-42. View Corticotropin-releasing hormone stimulates angiogenesis and epithelial tumor growth in the skin. Abstract

  69. Virilising 21-hydroxylase deficiency: timing of newborn screening and confirmatory tests can be crucial. J Pediatr Endocrinol Metab. 1999 Nov-Dec; 12(6):895-901. View Virilising 21-hydroxylase deficiency: timing of newborn screening and confirmatory tests can be crucial. Abstract

  70. CRH-deficient mice have a normal anorectic response to chronic stress. Regul Pept. 1999 Oct 22; 84(1-3):69-74. View CRH-deficient mice have a normal anorectic response to chronic stress. Abstract

  71. Stress-induced behaviors require the corticotropin-releasing hormone (CRH) receptor, but not CRH. Proc Natl Acad Sci U S A. 1999 Jul 06; 96(14):8283-8. View Stress-induced behaviors require the corticotropin-releasing hormone (CRH) receptor, but not CRH. Abstract

  72. Pediatric reference intervals for serum thyroxine, triiodothyronine, thyrotropin, and free thyroxine. Clin Chem. 1999 Jul; 45(7):1087-91. View Pediatric reference intervals for serum thyroxine, triiodothyronine, thyrotropin, and free thyroxine. Abstract

  73. Corticotropin-releasing hormone deficiency unmasks the proinflammatory effect of epinephrine. Proc Natl Acad Sci U S A. 1999 Jun 08; 96(12):7093-7. View Corticotropin-releasing hormone deficiency unmasks the proinflammatory effect of epinephrine. Abstract

  74. Inducible binding of cyclic adenosine 3',5'-monophosphate (cAMP)-responsive element binding protein (CREB) to a cAMP-responsive promoter in vivo. Mol Endocrinol. 1999 May; 13(5):659-69. View Inducible binding of cyclic adenosine 3',5'-monophosphate (cAMP)-responsive element binding protein (CREB) to a cAMP-responsive promoter in vivo. Abstract

  75. Animal models of CRH deficiency. Front Neuroendocrinol. 1999 Apr; 20(2):122-45. View Animal models of CRH deficiency. Abstract

  76. Normal suppression of the reproductive axis following stress in corticotropin-releasing hormone-deficient mice. Endocrinology. 1999 Apr; 140(4):1702-8. View Normal suppression of the reproductive axis following stress in corticotropin-releasing hormone-deficient mice. Abstract

  77. High glycemic index foods, overeating, and obesity. Pediatrics. 1999 Mar; 103(3):E26. View High glycemic index foods, overeating, and obesity. Abstract

  78. Regulation of hepatic glycogen in the insulin-like growth factor II-deficient mouse. Endocrinology. 1999 Mar; 140(3):1442-8. View Regulation of hepatic glycogen in the insulin-like growth factor II-deficient mouse. Abstract

  79. Proliferation and differentiation defects during lung development in corticotropin-releasing hormone-deficient mice. Am J Respir Cell Mol Biol. 1999 Feb; 20(2):181-8. View Proliferation and differentiation defects during lung development in corticotropin-releasing hormone-deficient mice. Abstract

  80. A central theory of preterm and term labor: putative role for corticotropin-releasing hormone. Am J Obstet Gynecol. 1999 Jan; 180(1 Pt 3):S232-41. View A central theory of preterm and term labor: putative role for corticotropin-releasing hormone. Abstract

  81. Placental corticotropin-releasing hormone: function and regulation. Am J Obstet Gynecol. 1999 Jan; 180(1 Pt 3):S242-6. View Placental corticotropin-releasing hormone: function and regulation. Abstract

  82. Two novel mutations of the vasopressin gene associated with familial diabetes insipidus and identification of an asymptomatic carrier infant. J Clin Endocrinol Metab. 1998 Nov; 83(11):3958-64. View Two novel mutations of the vasopressin gene associated with familial diabetes insipidus and identification of an asymptomatic carrier infant. Abstract

  83. Glucocorticoid deficiency delays stratum corneum maturation in the fetal mouse. J Invest Dermatol. 1998 Sep; 111(3):440-4. View Glucocorticoid deficiency delays stratum corneum maturation in the fetal mouse. Abstract

  84. Vasopressin messenger ribonucleic acid regulation via the protein kinase A pathway. Endocrinology. 1998 Jun; 139(6):2831-7. View Vasopressin messenger ribonucleic acid regulation via the protein kinase A pathway. Abstract

  85. Four cases of mucosal neuroma syndrome: multiple endocrine neoplasm 2B or not 2B? J Clin Endocrinol Metab. 1998 Jan; 83(1):17-20. View Four cases of mucosal neuroma syndrome: multiple endocrine neoplasm 2B or not 2B? Abstract

  86. Gene transfer into hepatocytes mediated by helper virus-free HSV/AAV hybrid vectors. Mol Med. 1997 Dec; 3(12):813-25. View Gene transfer into hepatocytes mediated by helper virus-free HSV/AAV hybrid vectors. Abstract

  87. Positive and negative regulation of the rat vasopressin gene promoter. Endocrinology. 1997 Dec; 138(12):5266-74. View Positive and negative regulation of the rat vasopressin gene promoter. Abstract

  88. Sodium balance modulates thirst in normal man. Endocr Res. 1997 Nov; 23(4):377-92. View Sodium balance modulates thirst in normal man. Abstract

  89. Impaired diurnal adrenal rhythmicity restored by constant infusion of corticotropin-releasing hormone in corticotropin-releasing hormone-deficient mice. J Clin Invest. 1997 Jun 15; 99(12):2923-9. View Impaired diurnal adrenal rhythmicity restored by constant infusion of corticotropin-releasing hormone in corticotropin-releasing hormone-deficient mice. Abstract

  90. Protein malnutrition increases plasma adrenocorticotropin and anterior pituitary proopiomelanocortin messenger ribonucleic acid in the rat. Endocrinology. 1997 Mar; 138(3):1048-57. View Protein malnutrition increases plasma adrenocorticotropin and anterior pituitary proopiomelanocortin messenger ribonucleic acid in the rat. Abstract

  91. CRH and the immune system. J Neuroimmunol. 1997 Feb; 72(2):131-6. View CRH and the immune system. Abstract

  92. Chronic central nervous system exposure to interleukin-1 beta causes catabolism in the rat. Am J Physiol. 1996 Nov; 271(5 Pt 2):R1142-8. View Chronic central nervous system exposure to interleukin-1 beta causes catabolism in the rat. Abstract

  93. Cortisol blockade of progesterone: a possible molecular mechanism involved in the initiation of human labor. Nat Med. 1996 May; 2(5):556-60. View Cortisol blockade of progesterone: a possible molecular mechanism involved in the initiation of human labor. Abstract

  94. Transcription of the human corticotropin-releasing hormone gene in NPLC cells is correlated with Z-DNA formation. Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8):3664-8. View Transcription of the human corticotropin-releasing hormone gene in NPLC cells is correlated with Z-DNA formation. Abstract

  95. Knockout mice. N Engl J Med. 1996 Apr 04; 334(14):904-7. View Knockout mice. Abstract

  96. Production of corticotropin-releasing hormone-deficient mice by targeted mutation in embryonic stem cells. Ann N Y Acad Sci. 1996 Mar 22; 780:49-59. View Production of corticotropin-releasing hormone-deficient mice by targeted mutation in embryonic stem cells. Abstract

  97. Molecular and transgenic studies of the corticotropin-releasing hormone gene. Ann N Y Acad Sci. 1995 Dec 29; 771:293-300. View Molecular and transgenic studies of the corticotropin-releasing hormone gene. Abstract

  98. Regulation of placental corticotropin-releasing hormone by steroids. Possible implications in labor initiation. Ann N Y Acad Sci. 1995 Dec 29; 771:551-5. View Regulation of placental corticotropin-releasing hormone by steroids. Possible implications in labor initiation. Abstract

  99. Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. Nature. 1995 Feb 02; 373(6513):427-32. View Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. Abstract

  100. Expression of the mouse corticotropin-releasing hormone gene in vivo and targeted inactivation in embryonic stem cells. J Clin Invest. 1994 May; 93(5):2066-72. View Expression of the mouse corticotropin-releasing hormone gene in vivo and targeted inactivation in embryonic stem cells. Abstract

  101. Regulation of the ectopically expressed human glycoprotein alpha-subunit gene in the human hepatoma cell line NPLC. Endocrinology. 1994 Feb; 134(2):582-7. View Regulation of the ectopically expressed human glycoprotein alpha-subunit gene in the human hepatoma cell line NPLC. Abstract

  102. Corticotrophin releasing hormone levels in human plasma and amniotic fluid during gestation. Clin Endocrinol (Oxf). 1994 Feb; 40(2):257-62. View Corticotrophin releasing hormone levels in human plasma and amniotic fluid during gestation. Abstract

  103. Effects of hydroxyurea and cyclic adenosine monophosphate/protein kinase A inhibitors on the expression of the human chorionic gonadotropin alpha subunit and c-myc genes in choriocarcinoma. J Endocrinol Invest. 1993 Dec; 16(11):849-56. View Effects of hydroxyurea and cyclic adenosine monophosphate/protein kinase A inhibitors on the expression of the human chorionic gonadotropin alpha subunit and c-myc genes in choriocarcinoma. Abstract

  104. Contribution of vasopressin to blood pressure regulation during hypovolemic hypotension in humans. J Appl Physiol (1985). 1993 Nov; 75(5):1984-8. View Contribution of vasopressin to blood pressure regulation during hypovolemic hypotension in humans. Abstract

  105. Transgenic mouse models of vasopressin expression. Hypertension. 1993 Oct; 22(4):640-5. View Transgenic mouse models of vasopressin expression. Abstract

  106. Tissue-specific expression and osmotic regulation of a rat vasopressin gene in transgenic mice. Ann N Y Acad Sci. 1993 Jul 22; 689:530-3. View Tissue-specific expression and osmotic regulation of a rat vasopressin gene in transgenic mice. Abstract

  107. Expression of the rat arginine vasopressin gene in transgenic mice. Mol Endocrinol. 1993 May; 7(5):659-67. View Expression of the rat arginine vasopressin gene in transgenic mice. Abstract

  108. Differential regulation of choriocarcinoma gene expression by DNA synthesis inhibitors. Endocr J. 1993 Apr; 40(2):263-8. View Differential regulation of choriocarcinoma gene expression by DNA synthesis inhibitors. Abstract

  109. Second messenger regulation of mRNA for corticotropin-releasing factor. Ciba Found Symp. 1993; 172:30-43; discussion 43-58. View Second messenger regulation of mRNA for corticotropin-releasing factor. Abstract

  110. Regulated expression of vasopressin gene by cAMP and phorbol ester in primary rat fetal hypothalamic cultures. Mol Cell Endocrinol. 1992 Jul; 86(1-2):29-36. View Regulated expression of vasopressin gene by cAMP and phorbol ester in primary rat fetal hypothalamic cultures. Abstract

  111. Effects of glucocorticoid on corticotropin-releasing hormone gene regulation by second messenger pathways in NPLC and AtT-20 cells. Endocrinology. 1992 Apr; 130(4):2237-44. View Effects of glucocorticoid on corticotropin-releasing hormone gene regulation by second messenger pathways in NPLC and AtT-20 cells. Abstract

  112. Protein kinase-C activation increases the quantity and poly(A) tail length of corticotropin-releasing hormone messenger RNA in NPLC cells. Mol Endocrinol. 1992 Mar; 6(3):476-84. View Protein kinase-C activation increases the quantity and poly(A) tail length of corticotropin-releasing hormone messenger RNA in NPLC cells. Abstract

  113. The effect of insulin-induced hypoglycemia on gene expression in the hypothalamic-pituitary-adrenal axis of the rat. Endocrinology. 1992 Feb; 130(2):920-5. View The effect of insulin-induced hypoglycemia on gene expression in the hypothalamic-pituitary-adrenal axis of the rat. Abstract

  114. Regulation of gene expression in choriocarcinoma by methotrexate and hydroxyurea. Endocrinology. 1991 Feb; 128(2):972-8. View Regulation of gene expression in choriocarcinoma by methotrexate and hydroxyurea. Abstract

  115. Both cyclooxygenase-dependent and cyclooxygenase-independent pathways mediate the neuroendocrine response in humans. Surgery. 1990 Aug; 108(2):254-9; discussion 259-61. View Both cyclooxygenase-dependent and cyclooxygenase-independent pathways mediate the neuroendocrine response in humans. Abstract

  116. Second messengers involved in the regulation of corticotropin-releasing hormone mRNA and peptide in cultured rat fetal hypothalamic primary cultures. Endocrinology. 1990 Jun; 126(6):3016-21. View Second messengers involved in the regulation of corticotropin-releasing hormone mRNA and peptide in cultured rat fetal hypothalamic primary cultures. Abstract

  117. Regulated expression of the human corticotropin releasing hormone gene by cyclic AMP. Mol Cell Endocrinol. 1990 Apr 17; 70(2):165-74. View Regulated expression of the human corticotropin releasing hormone gene by cyclic AMP. Abstract

  118. Differential regulation of corticotropin-releasing hormone mRNA in rat brain. Am J Physiol. 1990 Apr; 258(4 Pt 1):E686-92. View Differential regulation of corticotropin-releasing hormone mRNA in rat brain. Abstract

  119. The testicular effects of tumor necrosis factor. Ann Surg. 1990 Apr; 211(4):470-5. View The testicular effects of tumor necrosis factor. Abstract

  120. Developmental expression of corticotropin releasing hormone messenger RNA and peptide in rat hypothalamus. Peptides. 1989 Nov-Dec; 10(6):1165-9. View Developmental expression of corticotropin releasing hormone messenger RNA and peptide in rat hypothalamus. Abstract

  121. Vasopressin-mediated forearm vasodilation in normal humans. Evidence for a vascular vasopressin V2 receptor. J Clin Invest. 1989 Aug; 84(2):418-26. View Vasopressin-mediated forearm vasodilation in normal humans. Evidence for a vascular vasopressin V2 receptor. Abstract

  122. Increases in plasma digitalis-like factor activity during insulin-induced hypoglycemia. Neuroendocrinology. 1989 Jun; 49(6):586-91. View Increases in plasma digitalis-like factor activity during insulin-induced hypoglycemia. Abstract

  123. Species-specific placental corticotropin releasing hormone messenger RNA and peptide expression. Mol Cell Endocrinol. 1989 Apr; 62(2):337-41. View Species-specific placental corticotropin releasing hormone messenger RNA and peptide expression. Abstract

  124. Preprocorticotropin releasing hormone: cDNA sequence and in vitro processing. Mol Cell Endocrinol. 1989 Feb; 61(2):175-80. View Preprocorticotropin releasing hormone: cDNA sequence and in vitro processing. Abstract

  125. Vasopressin mRNA in the suprachiasmatic nuclei: daily regulation of polyadenylate tail length. Science. 1988 Jul 15; 241(4863):342-4. View Vasopressin mRNA in the suprachiasmatic nuclei: daily regulation of polyadenylate tail length. Abstract

  126. Characterization and gestational regulation of corticotropin-releasing hormone messenger RNA in human placenta. J Clin Invest. 1988 Jul; 82(1):287-92. View Characterization and gestational regulation of corticotropin-releasing hormone messenger RNA in human placenta. Abstract

  127. Glucocorticoid stimulates expression of corticotropin-releasing hormone gene in human placenta. Proc Natl Acad Sci U S A. 1988 Jul; 85(14):5244-8. View Glucocorticoid stimulates expression of corticotropin-releasing hormone gene in human placenta. Abstract

  128. The vasopressin mRNA poly(A) tract is unusually long and increases during stimulation of vasopressin gene expression in vivo. Mol Cell Biol. 1988 Jun; 8(6):2267-74. View The vasopressin mRNA poly(A) tract is unusually long and increases during stimulation of vasopressin gene expression in vivo. Abstract

  129. A chemically synthesized radiolabeled signal peptide: design, preparation, and biological evaluation of an iodinated analog of preproparathyroid hormone. Mol Endocrinol. 1988 May; 2(5):452-8. View A chemically synthesized radiolabeled signal peptide: design, preparation, and biological evaluation of an iodinated analog of preproparathyroid hormone. Abstract

  130. Expression and dexamethasone regulation of the human corticotropin-releasing hormone gene in a mouse anterior pituitary cell line. J Biol Chem. 1988 Apr 25; 263(12):5846-52. View Expression and dexamethasone regulation of the human corticotropin-releasing hormone gene in a mouse anterior pituitary cell line. Abstract

  131. Human corticotropin releasing hormone gene is located on the long arm of chromosome 8. Cytogenet Cell Genet. 1988; 47(3):113-6. View Human corticotropin releasing hormone gene is located on the long arm of chromosome 8. Abstract

  132. Relationship of cardiac chamber volume to baroreflex activity in normal humans. J Clin Endocrinol Metab. 1987 Sep; 65(3):475-81. View Relationship of cardiac chamber volume to baroreflex activity in normal humans. Abstract

  133. Influence of infused hypertonic saline on the response to insulin-induced hypoglycemia in man. J Clin Endocrinol Metab. 1987 Jul; 65(1):116-21. View Influence of infused hypertonic saline on the response to insulin-induced hypoglycemia in man. Abstract

  134. Defective regulation of vasopressin gene expression in Brattleboro rats. Am J Physiol. 1987 May; 252(5 Pt 1):E637-42. View Defective regulation of vasopressin gene expression in Brattleboro rats. Abstract

  135. Vasopressin gene is expressed at low levels in the hypothalamus of the Brattleboro rat. Proc Natl Acad Sci U S A. 1984 Sep; 81(17):5296-9. View Vasopressin gene is expressed at low levels in the hypothalamus of the Brattleboro rat. Abstract

  136. Vasopressin and oxytocin mRNA regulation in the rat assessed by hybridization with synthetic oligonucleotides. J Biol Chem. 1983 Dec 10; 258(23):14061-4. View Vasopressin and oxytocin mRNA regulation in the rat assessed by hybridization with synthetic oligonucleotides. Abstract

  137. Cellular and cell-free processing of parathyroid secretory proteins. J Biol Chem. 1982 Apr 10; 257(7):3581-8. View Cellular and cell-free processing of parathyroid secretory proteins. Abstract

  138. Synthetic pre-proparathyroid hormone leader sequence inhibits cell-free processing of placental, parathyroid, and pituitary prehormones. J Biol Chem. 1980 Dec 10; 255(23):11478-83. View Synthetic pre-proparathyroid hormone leader sequence inhibits cell-free processing of placental, parathyroid, and pituitary prehormones. Abstract

  139. Cloning and nucleotide sequence of DNA coding for bovine preproparathyroid hormone. Proc Natl Acad Sci U S A. 1979 Oct; 76(10):4981-5. View Cloning and nucleotide sequence of DNA coding for bovine preproparathyroid hormone. Abstract

  140. Identification and cell-free translation of mRNA coding for a precursor of parathyroid secretory protein. J Biol Chem. 1979 Aug 10; 254(15):7449-55. View Identification and cell-free translation of mRNA coding for a precursor of parathyroid secretory protein. Abstract

  141. Letter: "Smudge" ECG. N Engl J Med. 1975 01 02; 292(1):50. View Letter: "Smudge" ECG. Abstract

1 Boston Children's Hospital | Education

Undergraduate School

Princeton University

Princeton, NJ

Medical School

Columbia University, College of Physicians and Surgeons

New York, NY

Internship

Massachusetts General Hospital

Boston, MA

Residency

Surgery

Massachusetts General Hospital

Boston, MA

Residency

Plastic Surgery

Johns Hopkins Hospital

Baltimore, MD

Fellowship

Research in Medicine

Developmental Biology Laboratory, Massachusetts General Hospital

Boston, MA

1 Boston Children's Hospital | Publications

1 Boston Children's Hospital | Education

Medical School

David Geffen School of Medicine at UCLA

2008, Los Angeles, CA

Internship

Pediatrics

Lucile Packard Children’s Hospital at Stanford University

2009, Palo Alto, CA

Residency

Pediatrics

Lucile Packard Children’s Hospital at Stanford University

2011, Palo Alto, CA

Fellowship

Clinical Ethics

MacLean Center for Clinical Medical Ethics, University of Chicago

2012, Chicago, IL

Fellowship

Pediatric Hematology/Oncology

Boston Children’s Hospital/Dana-Farber Cancer Institute

2015, Boston, MA

Fellowship

Health Services Research

Harvard Medical School

2016, Boston, MA

Graduate School

MPH

Harvard T.H. Chan School of Public Health

2016, Boston, MA

1 Boston Children's Hospital | Publications

1 Boston Children's Hospital | Education

Undergraduate School

Haverford College

1991, Haverford, PA

Graduate School

Duke University School of Medicine

Durham, NC

Graduate School

MPH

Harvard School of Public Health

Boston, MA

Medical School

Duke University School of Medicine

1996, Durham, NC

Internship

Pediatrics

Boston Combined Residency Program (BCRP)

1997, Boston, MA

Residency

Pediatrics

Boston Combined Residency Program (BCRP)

1999, Boston, MA

Fellowship

Combined Fellowship in Adolescent and Division of General Pediatrics

Boston Children's Hospital

2002, Boston, MA

1 Boston Children's Hospital | Publications

1 Boston Children's Hospital | Education

Medical School

Istanbul University, Cerrahpasa Medical School

2005, Istanbul, Turkey

Internship

Boston Children's Hospital

2011, Boston, MA

Residency

Boston Children's Hospital

2013, Boston, MA

Fellowship

Boston Children's Hospital

2016, Boston, MA

1 Boston Children's Hospital | Publications

1 Boston Children's Hospital | Education

Undergraduate School

Dartmouth College

1995, Hanover, NH

Medical School

Tufts University School of Medicine

1999, Boston, MA

Internship

Dartmouth Hitchcock Medical Center

2001, Lebanon, NH

Residency

Tufts-New England Medical Center/Floating Hospital for Children

2004, Boston, MA

Fellowship

Tufts-New England Medical Center/Floating Hospital for Children

2005, Boston, MA

1 Boston Children's Hospital | Publications

1 Boston Children's Hospital | Education

Medical School

Tufts University School of Medicine

Boston, MA

Residency

Pediatrics/Psychiatry/Child and Adolescent Psychiatry

Hasbro/Bradley, Brown University

Providence, RI

1 Boston Children's Hospital | Publications

1 Boston Children's Hospital | Education

Undergraduate School

Princeton University

1984, Princeton, NJ

Medical School

Harvard Medical School

1988, Boston, MA

Internship

Pediatrics

Boston Children's Hospital

1989, Boston, MA

Residency

Pediatrics

Boston Children's Hospital

1991, Boston, MA

1 Boston Children's Hospital | Publications

1 Boston Children's Hospital | Education

Undergraduate School

Massachusetts Institute of Technology

2008, Cambridge, MA

Medical School

Harvard Medical School

2013, Boston, MA

Internship

Boston Combined Residency Program (BCRP)

2014, Boston, MA

Residency

Boston Combined Residency Program (BCRP)

2016, Boston, MA

Fellowship

Nephrology

Boston Children's Hospital

2020, Boston, MA

1 Boston Children's Hospital | Publications

1 Boston Children's Hospital | Education

Undergraduate School

University of Toronto

Toronto, Ontario, Canada

Undergraduate School

McGill University

Montreal, Quebec, Canada

Medical School

McGill University

Montreal, Quebec, Canada

Residency

Pediatrics

Schneider Children's Hospita

New Hyde Park, NY

Fellowship

Pediatrics

Hospital for Sick Children

Toronto, Ontario, Canada

1 Boston Children's Hospital | Publications

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