Current Environment: Production

Physicians | Education

Medical School

Kansas University Medical School

1967, Kansas City, MO

Internship

Boston Children's Hospital

1968, Boton, MA

Residency

Boston Children's Hospital

1969, Boston, MA

Fellowship

Boston Children's Hospital

1973, Boston, MA

Physicians | Publications

  1. Application Factors Associated With Clinical Performance During Pediatric Internship. Acad Pediatr. 2020 Sep - Oct; 20(7):1007-1012. View Application Factors Associated With Clinical Performance During Pediatric Internship. Abstract

  2. Exome sequencing results in successful diagnosis and treatment of a severe congenital anemia. Cold Spring Harb Mol Case Stud. 2016 Jul; 2(4):a000885. View Exome sequencing results in successful diagnosis and treatment of a severe congenital anemia. Abstract

  3. Anatomy of the red cell membrane skeleton: unanswered questions. Blood. 2016 Jan 14; 127(2):187-99. View Anatomy of the red cell membrane skeleton: unanswered questions. Abstract

  4. Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S. Am J Physiol Cell Physiol. 2011 Dec; 301(6):C1325-43. View Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S. Abstract

  5. Training program in cancer and blood diseases: Pediatric Hematology/Oncology Fellowship Program, Children's Hospital Boston/Dana-Farber Cancer Institute. Am J Hematol. 2010 Oct; 85(10):793-4. View Training program in cancer and blood diseases: Pediatric Hematology/Oncology Fellowship Program, Children's Hospital Boston/Dana-Farber Cancer Institute. Abstract

  6. The carboxyterminal EF domain of erythroid alpha-spectrin is necessary for optimal spectrin-actin binding. Blood. 2010 Oct 07; 116(14):2600-7. View The carboxyterminal EF domain of erythroid alpha-spectrin is necessary for optimal spectrin-actin binding. Abstract

  7. Targeted deletion of betaIII spectrin impairs synaptogenesis and generates ataxic and seizure phenotypes. Proc Natl Acad Sci U S A. 2010 Mar 30; 107(13):6022-7. View Targeted deletion of betaIII spectrin impairs synaptogenesis and generates ataxic and seizure phenotypes. Abstract

  8. Analysis of novel sph (spherocytosis) alleles in mice reveals allele-specific loss of band 3 and adducin in alpha-spectrin-deficient red cells. Blood. 2010 Mar 04; 115(9):1804-14. View Analysis of novel sph (spherocytosis) alleles in mice reveals allele-specific loss of band 3 and adducin in alpha-spectrin-deficient red cells. Abstract

  9. Protein 4.2 binds to the carboxyl-terminal EF-hands of erythroid alpha-spectrin in a calcium- and calmodulin-dependent manner. J Biol Chem. 2010 Feb 12; 285(7):4757-70. View Protein 4.2 binds to the carboxyl-terminal EF-hands of erythroid alpha-spectrin in a calcium- and calmodulin-dependent manner. Abstract

  10. A uniform third-year application and offer date for pediatric fellow applicants: pro and con. J Pediatr. 2006 Nov; 149(5):587-588. View A uniform third-year application and offer date for pediatric fellow applicants: pro and con. Abstract

  11. Identification and functional characterization of protein 4.1R and actin-binding sites in erythrocyte beta spectrin: regulation of the interactions by phosphatidylinositol-4,5-bisphosphate. Biochemistry. 2005 Aug 09; 44(31):10681-8. View Identification and functional characterization of protein 4.1R and actin-binding sites in erythrocyte beta spectrin: regulation of the interactions by phosphatidylinositol-4,5-bisphosphate. Abstract

  12. Hereditary spherocytosis--defects in proteins that connect the membrane skeleton to the lipid bilayer. Semin Hematol. 2004 Apr; 41(2):118-41. View Hereditary spherocytosis--defects in proteins that connect the membrane skeleton to the lipid bilayer. Abstract

  13. A functional magnetic resonance imaging study of local/global processing with stimulus presentation in the peripheral visual hemifields. Neuroscience. 2004; 124(1):113-20. View A functional magnetic resonance imaging study of local/global processing with stimulus presentation in the peripheral visual hemifields. Abstract

  14. Identification of quantitative trait loci that modify the severity of hereditary spherocytosis in wan, a new mouse model of band-3 deficiency. Blood. 2004 Apr 15; 103(8):3233-40. View Identification of quantitative trait loci that modify the severity of hereditary spherocytosis in wan, a new mouse model of band-3 deficiency. Abstract

  15. Simultaneous (AC)n microsatellite polymorphism analysis and single-stranded conformation polymorphism screening is an efficient strategy for detecting ankyrin-1 mutations in dominant hereditary spherocytosis. Br J Haematol. 2003 Aug; 122(4):669-77. View Simultaneous (AC)n microsatellite polymorphism analysis and single-stranded conformation polymorphism screening is an efficient strategy for detecting ankyrin-1 mutations in dominant hereditary spherocytosis. Abstract

  16. Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency. Nat Genet. 2003 May; 34(1):59-64. View Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency. Abstract

  17. A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix. J Biol Chem. 2001 Jun 29; 276(26):23974-85. View A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix. Abstract

  18. The human ankyrin-1 gene is selectively transcribed in erythroid cell lines despite the presence of a housekeeping-like promoter. Blood. 2000 Aug 01; 96(3):1136-43. View The human ankyrin-1 gene is selectively transcribed in erythroid cell lines despite the presence of a housekeeping-like promoter. Abstract

  19. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature. 2000 Feb 17; 403(6771):776-81. View Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Abstract

  20. Immunolocalization of AE2 anion exchanger in rat and mouse epididymis. Biol Reprod. 1999 Oct; 61(4):973-80. View Immunolocalization of AE2 anion exchanger in rat and mouse epididymis. Abstract

  21. Dependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS. J Neurosci. 1999 Sep 01; 19(17):7516-28. View Dependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS. Abstract

  22. The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons. Brain Res Mol Brain Res. 1999 Jun 08; 69(2):273-80. View The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons. Abstract

  23. Mild spherocytosis and altered red cell ion transport in protein 4. 2-null mice. J Clin Invest. 1999 Jun; 103(11):1527-37. View Mild spherocytosis and altered red cell ion transport in protein 4. 2-null mice. Abstract

  24. Red blood cell membrane disorders. Br J Haematol. 1999 Jan; 104(1):2-13. View Red blood cell membrane disorders. Abstract

  25. Notch1 inhibits neurite outgrowth in postmitotic primary neurons. Neuroscience. 1999; 93(2):433-9. View Notch1 inhibits neurite outgrowth in postmitotic primary neurons. Abstract

  26. Regulation of band 3 rotational mobility by ankyrin in intact human red cells. Biochemistry. 1998 Dec 22; 37(51):17828-35. View Regulation of band 3 rotational mobility by ankyrin in intact human red cells. Abstract

  27. A widely expressed betaIII spectrin associated with Golgi and cytoplasmic vesicles. Proc Natl Acad Sci U S A. 1998 Nov 24; 95(24):14158-63. View A widely expressed betaIII spectrin associated with Golgi and cytoplasmic vesicles. Abstract

  28. Distribution of epithelial ankyrin (Ank3) spliceoforms in renal proximal and distal tubules. Am J Physiol. 1998 01; 274(1):F129-38. View Distribution of epithelial ankyrin (Ank3) spliceoforms in renal proximal and distal tubules. Abstract

  29. Structure and organization of the human ankyrin-1 gene. Basis for complexity of pre-mRNA processing. J Biol Chem. 1997 Aug 01; 272(31):19220-8. View Structure and organization of the human ankyrin-1 gene. Basis for complexity of pre-mRNA processing. Abstract

  30. Isoforms of ankyrin-3 that lack the NH2-terminal repeats associate with mouse macrophage lysosomes. J Cell Biol. 1997 Mar 10; 136(5):1059-70. View Isoforms of ankyrin-3 that lack the NH2-terminal repeats associate with mouse macrophage lysosomes. Abstract

  31. Anion exchanger 1 (band 3) is required to prevent erythrocyte membrane surface loss but not to form the membrane skeleton. Cell. 1996 Sep 20; 86(6):917-27. View Anion exchanger 1 (band 3) is required to prevent erythrocyte membrane surface loss but not to form the membrane skeleton. Abstract

  32. Isolated beta-globin chains reproduce, in normal red cell membranes, the defective binding of spectrin to alpha-thalassaemic membranes. Br J Haematol. 1996 Aug; 94(2):273-8. View Isolated beta-globin chains reproduce, in normal red cell membranes, the defective binding of spectrin to alpha-thalassaemic membranes. Abstract

  33. Ankyrin-1 mutations are a major cause of dominant and recessive hereditary spherocytosis. Nat Genet. 1996 Jun; 13(2):214-8. View Ankyrin-1 mutations are a major cause of dominant and recessive hereditary spherocytosis. Abstract

  34. Constitutively active human Notch1 binds to the transcription factor CBF1 and stimulates transcription through a promoter containing a CBF1-responsive element. Proc Natl Acad Sci U S A. 1996 May 28; 93(11):5663-7. View Constitutively active human Notch1 binds to the transcription factor CBF1 and stimulates transcription through a promoter containing a CBF1-responsive element. Abstract

  35. A nonsense mutation in the erythrocyte band 3 gene associated with decreased mRNA accumulation in a kindred with dominant hereditary spherocytosis. J Clin Invest. 1996 Jan 15; 97(2):373-80. View A nonsense mutation in the erythrocyte band 3 gene associated with decreased mRNA accumulation in a kindred with dominant hereditary spherocytosis. Abstract

  36. Differential expression of Na(+)-K(+)-ATPase, ankyrin, fodrin, and E-cadherin along the kidney nephron. Am J Physiol. 1995 Dec; 269(6 Pt 1):C1417-32. View Differential expression of Na(+)-K(+)-ATPase, ankyrin, fodrin, and E-cadherin along the kidney nephron. Abstract

  37. Increased cation permeability in mutant mouse red blood cells with defective membrane skeletons. Blood. 1995 Dec 01; 86(11):4307-14. View Increased cation permeability in mutant mouse red blood cells with defective membrane skeletons. Abstract

  38. Characterization of the binary interaction between human erythrocyte protein 4.1 and actin. Eur J Biochem. 1995 Aug 01; 231(3):644-50. View Characterization of the binary interaction between human erythrocyte protein 4.1 and actin. Abstract

  39. Ank3 (epithelial ankyrin), a widely distributed new member of the ankyrin gene family and the major ankyrin in kidney, is expressed in alternatively spliced forms, including forms that lack the repeat domain. J Cell Biol. 1995 Jul; 130(2):313-30. View Ank3 (epithelial ankyrin), a widely distributed new member of the ankyrin gene family and the major ankyrin in kidney, is expressed in alternatively spliced forms, including forms that lack the repeat domain. Abstract

  40. Chromosomal location of the murine anion exchanger genes encoding AE2 and AE3. Mamm Genome. 1994 Dec; 5(12):827-9. View Chromosomal location of the murine anion exchanger genes encoding AE2 and AE3. Abstract

  41. Combined spectrin and ankyrin deficiency is common in autosomal dominant hereditary spherocytosis. Blood. 1993 Nov 15; 82(10):2953-60. View Combined spectrin and ankyrin deficiency is common in autosomal dominant hereditary spherocytosis. Abstract

  42. A highly conserved region of human erythrocyte ankyrin contains the capacity to bind spectrin. J Biol Chem. 1993 Nov 15; 268(32):24421-6. View A highly conserved region of human erythrocyte ankyrin contains the capacity to bind spectrin. Abstract

  43. Beta spectrin kissimmee: a spectrin variant associated with autosomal dominant hereditary spherocytosis and defective binding to protein 4.1. J Clin Invest. 1993 Aug; 92(2):612-6. View Beta spectrin kissimmee: a spectrin variant associated with autosomal dominant hereditary spherocytosis and defective binding to protein 4.1. Abstract

  44. Complex patterns of sequence variation and multiple 5' and 3' ends are found among transcripts of the erythroid ankyrin gene. J Biol Chem. 1993 May 05; 268(13):9533-40. View Complex patterns of sequence variation and multiple 5' and 3' ends are found among transcripts of the erythroid ankyrin gene. Abstract

  45. Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2. Nature. 1993 Apr 22; 362(6422):768-70. View Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2. Abstract

  46. Ankyrins: structure and function in normal cells and hereditary spherocytes. Semin Hematol. 1993 Apr; 30(2):85-118. View Ankyrins: structure and function in normal cells and hereditary spherocytes. Abstract

  47. The murine pallid mutation is a platelet storage pool disease associated with the protein 4.2 (pallidin) gene. Nat Genet. 1992 Sep; 2(1):80-3. View The murine pallid mutation is a platelet storage pool disease associated with the protein 4.2 (pallidin) gene. Abstract

  48. Expression, purification, and characterization of the functional dimeric cytoplasmic domain of human erythrocyte band 3 in Escherichia coli. Protein Sci. 1992 Sep; 1(9):1206-14. View Expression, purification, and characterization of the functional dimeric cytoplasmic domain of human erythrocyte band 3 in Escherichia coli. Abstract

  49. Changing patterns in cytoskeletal mRNA expression and protein synthesis during murine erythropoiesis in vivo. Proc Natl Acad Sci U S A. 1992 Jul 01; 89(13):5749-53. View Changing patterns in cytoskeletal mRNA expression and protein synthesis during murine erythropoiesis in vivo. Abstract

  50. Murine erythrocyte ankyrin cDNA: highly conserved regions of the regulatory domain. Mamm Genome. 1992; 3(5):281-5. View Murine erythrocyte ankyrin cDNA: highly conserved regions of the regulatory domain. Abstract

  51. Large numbers of alternatively spliced isoforms of the regulatory region of human erythrocyte ankyrin. Trans Assoc Am Physicians. 1992; 105:268-77. View Large numbers of alternatively spliced isoforms of the regulatory region of human erythrocyte ankyrin. Abstract

  52. Purkinje cell degeneration associated with erythroid ankyrin deficiency in nb/nb mice. J Cell Biol. 1991 Sep; 114(6):1233-41. View Purkinje cell degeneration associated with erythroid ankyrin deficiency in nb/nb mice. Abstract

  53. Isolation and chromosomal localization of a novel nonerythroid ankyrin gene. Genomics. 1991 Aug; 10(4):858-66. View Isolation and chromosomal localization of a novel nonerythroid ankyrin gene. Abstract

  54. Radiolabel-transfer cross-linking demonstrates that protein 4.1 binds to the N-terminal region of beta spectrin and to actin in binary interactions. Eur J Biochem. 1990 Nov 13; 193(3):827-36. View Radiolabel-transfer cross-linking demonstrates that protein 4.1 binds to the N-terminal region of beta spectrin and to actin in binary interactions. Abstract

  55. Linkage of dominant hereditary spherocytosis to the gene for the erythrocyte membrane-skeleton protein ankyrin. N Engl J Med. 1990 Oct 11; 323(15):1046-50. View Linkage of dominant hereditary spherocytosis to the gene for the erythrocyte membrane-skeleton protein ankyrin. Abstract

  56. Hereditary spherocytosis associated with deletion of human erythrocyte ankyrin gene on chromosome 8. Nature. 1990 Jun 21; 345(6277):736-9. View Hereditary spherocytosis associated with deletion of human erythrocyte ankyrin gene on chromosome 8. Abstract

  57. Ankyrin and the hemolytic anemia mutation, nb, map to mouse chromosome 8: presence of the nb allele is associated with a truncated erythrocyte ankyrin. Proc Natl Acad Sci U S A. 1990 Apr; 87(8):3117-21. View Ankyrin and the hemolytic anemia mutation, nb, map to mouse chromosome 8: presence of the nb allele is associated with a truncated erythrocyte ankyrin. Abstract

  58. Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins. Nature. 1990 Mar 01; 344(6261):36-42. View Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins. Abstract

  59. Demonstration of the deletion of a copy of the ankyrin gene in a patient with hereditary spherocytosis by in situ hybridization. Trans Assoc Am Physicians. 1990; 103:242-8. View Demonstration of the deletion of a copy of the ankyrin gene in a patient with hereditary spherocytosis by in situ hybridization. Abstract

  60. Cloning and characterization of band 3, the human erythrocyte anion-exchange protein (AE1). Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9089-93. View Cloning and characterization of band 3, the human erythrocyte anion-exchange protein (AE1). Abstract

  61. Hereditary disorders of the red cell membrane skeleton. Trends Genet. 1989 Jul; 5(7):222-7. View Hereditary disorders of the red cell membrane skeleton. Abstract

  62. Mapping the ankyrin-binding site of the human erythrocyte anion exchanger. J Biol Chem. 1989 Jun 05; 264(16):9665-72. View Mapping the ankyrin-binding site of the human erythrocyte anion exchanger. Abstract

  63. Differing erythrocyte membrane skeletal protein defects in alpha and beta thalassemia. J Clin Invest. 1989 Feb; 83(2):404-10. View Differing erythrocyte membrane skeletal protein defects in alpha and beta thalassemia. Abstract

  64. Hemoglobin Brockton [beta 138 (H16) Ala----Pro]: an unstable variant near the C-terminus of the beta-subunits with normal oxygen-binding properties. Biochemistry. 1988 Oct 04; 27(20):7614-9. View Hemoglobin Brockton [beta 138 (H16) Ala----Pro]: an unstable variant near the C-terminus of the beta-subunits with normal oxygen-binding properties. Abstract

  65. Abnormal oxidant sensitivity and beta-chain structure of spectrin in hereditary spherocytosis associated with defective spectrin-protein 4.1 binding. J Clin Invest. 1987 Aug; 80(2):557-65. View Abnormal oxidant sensitivity and beta-chain structure of spectrin in hereditary spherocytosis associated with defective spectrin-protein 4.1 binding. Abstract

  66. Molecular defect in the membrane skeleton of blood bank-stored red cells. Abnormal spectrin-protein 4.1-actin complex formation. J Clin Invest. 1986 Dec; 78(6):1681-6. View Molecular defect in the membrane skeleton of blood bank-stored red cells. Abnormal spectrin-protein 4.1-actin complex formation. Abstract

  67. Cation depletion by the sodium pump in red cells with pathologic cation leaks. Sickle cells and xerocytes. J Clin Invest. 1986 Dec; 78(6):1487-96. View Cation depletion by the sodium pump in red cells with pathologic cation leaks. Sickle cells and xerocytes. Abstract

  68. The effect of mild diamide oxidation on the structure and function of human erythrocyte spectrin. J Biol Chem. 1986 Apr 05; 261(10):4620-8. View The effect of mild diamide oxidation on the structure and function of human erythrocyte spectrin. Abstract

  69. An examination of the soluble oligomeric complexes extracted from the red cell membrane and their relation to the membrane cytoskeleton. Eur J Cell Biol. 1985 Mar; 36(2):299-306. View An examination of the soluble oligomeric complexes extracted from the red cell membrane and their relation to the membrane cytoskeleton. Abstract

  70. Hereditary spherocytosis and related disorders. Clin Haematol. 1985 Feb; 14(1):15-43. View Hereditary spherocytosis and related disorders. Abstract

  71. The effect of oxidation on the structure and function of human erythrocyte spectrin. Prog Clin Biol Res. 1985; 195:185-93. View The effect of oxidation on the structure and function of human erythrocyte spectrin. Abstract

  72. Molecular defect in the sickle erythrocyte skeleton. Abnormal spectrin binding to sickle inside-our vesicles. J Clin Invest. 1985 Jan; 75(1):266-71. View Molecular defect in the sickle erythrocyte skeleton. Abnormal spectrin binding to sickle inside-our vesicles. Abstract

  73. Platelet membrane glycoprotein IIIa contains target antigens that bind anti-platelet antibodies in immune thrombocytopenias. J Clin Invest. 1984 Nov; 74(5):1701-7. View Platelet membrane glycoprotein IIIa contains target antigens that bind anti-platelet antibodies in immune thrombocytopenias. Abstract

  74. The erythrocyte membrane skeleton: pathophysiology. Hosp Pract (Off Ed). 1984 Nov; 19(11):89-95, 99, 103 passim. View The erythrocyte membrane skeleton: pathophysiology. Abstract

  75. The erythrocyte membrane skeleton: biochemistry. Hosp Pract (Off Ed). 1984 Oct; 19(10):77-83. View The erythrocyte membrane skeleton: biochemistry. Abstract

  76. Analysis of the ternary interaction of the red cell membrane skeletal proteins spectrin, actin, and 4.1. Biochemistry. 1984 Sep 11; 23(19):4416-20. View Analysis of the ternary interaction of the red cell membrane skeletal proteins spectrin, actin, and 4.1. Abstract

  77. An analogue of the erythroid membrane skeletal protein 4.1 in nonerythroid cells. J Cell Biol. 1984 Sep; 99(3):886-93. View An analogue of the erythroid membrane skeletal protein 4.1 in nonerythroid cells. Abstract

  78. A phenomenological difference between membrane skeletal protein complexes isolated from normal and hereditary spherocytosis erythrocytes. Br J Haematol. 1983 Nov; 55(3):455-63. View A phenomenological difference between membrane skeletal protein complexes isolated from normal and hereditary spherocytosis erythrocytes. Abstract

  79. High yield purification of protein 4.1 from human erythrocyte membranes. Anal Biochem. 1983 Jul 01; 132(1):195-201. View High yield purification of protein 4.1 from human erythrocyte membranes. Abstract

  80. Red cell membrane skeletal defects in hereditary and acquired hemolytic anemias. Semin Hematol. 1983 Jul; 20(3):189-224. View Red cell membrane skeletal defects in hereditary and acquired hemolytic anemias. Abstract

  81. Hemolytic anemia in the mouse. Report of a new mutation and clarification of its genetics. J Hered. 1983 Mar-Apr; 74(2):88-92. View Hemolytic anemia in the mouse. Report of a new mutation and clarification of its genetics. Abstract

  82. A genetic defect in the binding of protein 4.1 to spectrin in a kindred with hereditary spherocytosis. N Engl J Med. 1982 Nov 25; 307(22):1367-74. View A genetic defect in the binding of protein 4.1 to spectrin in a kindred with hereditary spherocytosis. Abstract

  83. A technique to detect reduced mechanical stability of red cell membranes: relevance to elliptocytic disorders. Blood. 1982 Apr; 59(4):768-74. View A technique to detect reduced mechanical stability of red cell membranes: relevance to elliptocytic disorders. Abstract

  84. Exercise-induced hemolysis in xerocytosis. Erythrocyte dehydration and shear sensitivity. J Clin Invest. 1981 Sep; 68(3):631-8. View Exercise-induced hemolysis in xerocytosis. Erythrocyte dehydration and shear sensitivity. Abstract

  85. Elliptical erythrocyte membrane skeletons and heat-sensitive spectrin in hereditary elliptocytosis. Proc Natl Acad Sci U S A. 1981 Mar; 78(3):1911-5. View Elliptical erythrocyte membrane skeletons and heat-sensitive spectrin in hereditary elliptocytosis. Abstract

  86. Hemolytic anemias due to abnormalities in red cell spectrin: a brief review. Prog Clin Biol Res. 1981; 45:159-68. View Hemolytic anemias due to abnormalities in red cell spectrin: a brief review. Abstract

  87. Structural characterization of the phosphorylation sites of human erythrocyte spectrin. J Biol Chem. 1980 Dec 10; 255(23):11512-20. View Structural characterization of the phosphorylation sites of human erythrocyte spectrin. Abstract

  88. Comparison of the phosphorylation of human erythrocyte spectrin in the intact red cell and in various cell-free systems. J Biol Chem. 1980 Dec 10; 255(23):11521-5. View Comparison of the phosphorylation of human erythrocyte spectrin in the intact red cell and in various cell-free systems. Abstract

  89. Inherited disorders of the red cell membrane skeleton. Pediatr Clin North Am. 1980 May; 27(2):463-86. View Inherited disorders of the red cell membrane skeleton. Abstract

  90. Dissecting the red cell membrane skeleton. Nature. 1979 Oct 11; 281(5731):426-9. View Dissecting the red cell membrane skeleton. Abstract

  91. Spectrin-actin membrane skeleton of normal and abnormal red blood cells. Semin Hematol. 1979 Jan; 16(1):21-51. View Spectrin-actin membrane skeleton of normal and abnormal red blood cells. Abstract

  92. Hemolytic anemias associated with deficient or dysfunctional spectrin. Prog Clin Biol Res. 1979; 30:463-9. View Hemolytic anemias associated with deficient or dysfunctional spectrin. Abstract

  93. Energy reserve and cation composition of irreversibly sickled cells in vivo. Br J Haematol. 1978 Dec; 40(4):527-32. View Energy reserve and cation composition of irreversibly sickled cells in vivo. Abstract

  94. Membrane protein phosphorylation of intact normal and hereditary spherocytic erythrocytes. J Biol Chem. 1978 May 10; 253(9):3336-42. View Membrane protein phosphorylation of intact normal and hereditary spherocytic erythrocytes. Abstract

  95. Diminished spectrin extraction from ATP-depleted human erythrocytes. Evidence relating spectrin to changes in erythrocyte shape and deformability. J Clin Invest. 1978 Mar; 61(3):815-27. View Diminished spectrin extraction from ATP-depleted human erythrocytes. Evidence relating spectrin to changes in erythrocyte shape and deformability. Abstract

  96. Isolation and partial characterization of a high molecular weight red cell membrane protein complex normally removed by the spleen. Blood. 1977 Oct; 50(4):625-41. View Isolation and partial characterization of a high molecular weight red cell membrane protein complex normally removed by the spleen. Abstract

  97. Evidence that spectrin is a determinant of shape and deformability in the human erythrocyte. Prog Clin Biol Res. 1977; 17:481-91. View Evidence that spectrin is a determinant of shape and deformability in the human erythrocyte. Abstract

  98. Irreversible deformation of the spectrin-actin lattice in irreversibly sickled cells. J Clin Invest. 1976 Oct; 58(4):955-63. View Irreversible deformation of the spectrin-actin lattice in irreversibly sickled cells. Abstract

  99. Human plasma high density lipoprotein. Interaction of the cyanogen bromide fragments from apolipoprotein glutamine II (A-II) with phosphatidylcholine. J Biol Chem. 1973 Dec 25; 248(24):8449-56. View Human plasma high density lipoprotein. Interaction of the cyanogen bromide fragments from apolipoprotein glutamine II (A-II) with phosphatidylcholine. Abstract

  100. Isolation and characterization of apoLp-Gln-II (apoA-II), a plasma high density apolipoprotein containing two identical polypeptide chains. J Biol Chem. 1972 Dec 10; 247(23):7510-8. View Isolation and characterization of apoLp-Gln-II (apoA-II), a plasma high density apolipoprotein containing two identical polypeptide chains. Abstract

  101. Isolation and characterization of the tryptic and cyanogen bromide peptides of apoLp-Gln-II (apoA-II), plasma high density apolipoprotein. J Biol Chem. 1972 Dec 10; 247(23):7519-27. View Isolation and characterization of the tryptic and cyanogen bromide peptides of apoLp-Gln-II (apoA-II), plasma high density apolipoprotein. Abstract

  102. Identification of the lipid-binding cyanogen bromide fragment from the cystine-containing high density apolipoprotein, APOLP-GLN-II. Biochem Biophys Res Commun. 1972 Oct 06; 49(1):23-9. View Identification of the lipid-binding cyanogen bromide fragment from the cystine-containing high density apolipoprotein, APOLP-GLN-II. Abstract

  103. Studies on the protein defect in Tangier disease. Isolation and characterization of an abnormal high density lipoprotein. J Clin Invest. 1972 Oct; 51(10):2505-19. View Studies on the protein defect in Tangier disease. Isolation and characterization of an abnormal high density lipoprotein. Abstract

  104. Further characterization of the polymorphic forms of a human high density apolipoprotein, apoLP-Gln-I (apoA-I). Biochim Biophys Acta. 1972 Sep 29; 278(2):266-70. View Further characterization of the polymorphic forms of a human high density apolipoprotein, apoLP-Gln-I (apoA-I). Abstract

  105. Amino acid sequence of human apoLp-Gln-II (apoA-II), an apolipoprotein isolated from the high-density lipoprotein complex. Proc Natl Acad Sci U S A. 1972 May; 69(5):1304-8. View Amino acid sequence of human apoLp-Gln-II (apoA-II), an apolipoprotein isolated from the high-density lipoprotein complex. Abstract

  106. Degradation of membrane phospholipids and thiols in peroxide hemolysis: studies in vitamin E deficiency. Blood. 1968 Oct; 32(4):549-68. View Degradation of membrane phospholipids and thiols in peroxide hemolysis: studies in vitamin E deficiency. Abstract

Physicians | Education

Medical School

New Jersey Medical School

2009, Newark, NJ

Internship

Surgery

Westchester Medical Center, New York Medical College

2010, Valhalla, NY

Residency

Pediatric Anesthesia

St. Elizabeth’s Medical Center, Tuft’s University Medical School

2014, Boston, MA

Fellowship

Pediatric Anesthesia

Boston Children’s Hospital

2015, Boston, MA

Physicians | Publications

Physicians | Education

Undergraduate School

Dartmouth College

2000, Hanover, NH

Medical School

Washington University School of Medicine

2004, St. Louis, MO

Internship

Pediatrics

St. Louis Children's Hospital

2005, St. Louis, MO

Residency

Pediatrics

St. Louis Children's Hospital

2008, St. Louis, MO

Fellowship

Neonatal-Perinatal Fellowship Training Program

Harvard Medical School

2011, Boston, MA

Physicians | Publications

Physicians | Education

Undergraduate School

Massachusetts College of Pharmacy and Health Sciences

2011, Boston, MA

Medical School

University of Massachusetts Medical School

2015, Boston, MA

Residency

Internal Medicine/Pediatrics

Massachusetts General Hospital

2019, Boston, MA

Fellowship

Sports Medicine

Boston Children’s Hospital

2020, Boston, MA

Fellowship

Musculoskeletal-Sports Ultrasound

Boston Children's Hospital

2021, Boston, MA

Physicians | Publications

Physicians | Education

Undergraduate School

Harvard College

2006, Cambridge, MA

Medical School

Harvard Medical School

2010, Boston, MA

Residency

Boston Combined Residency Program (BCRP)

2015, Boston, MA

Graduate School

Harvard Graduate School of Education

2017, Cambridge, MA

Fellowship

Stroke and Cerebrovascular Disorders

Boston Children's Hospital

2017, Boston, MA

Fellowship

Medical Education

Boston Children's Hospital

2017, Boston, MA

Physicians | Publications

Physicians | Education

Graduate School

Washington University of St. Louis

St. Louis, MO

Medical School

Washington University of St. Louis

St. Louis, MO

Internship

Boston Children's Hospital

Boston, MA

Residency

Boston Children's Hospital

Boston, MA

Fellowship

Boston Children's Hospital

Boston, MA

Physicians | Publications

Physicians | Education

Undergraduate School

Yale University

1984, New Haven, CT

Medical School

McGill University

1988, Montreal, Quebec, Canada

Internship

Tufts-New England Medical Center

1989, Boston, MA

Residency

Tufts-New England Medical Center

1991, Boston, MA

Graduate School

University of Massachusetts at Amherst

2010, Amherst, MA

Physicians | Publications

Physicians | Education

Undergraduate School

Taipei Medical University

1987, Taipei, Taiwan

Graduate School

MS, Orthodontic Program

University of Michigan

Ann Arbor, MI

Medical School

Northwestern University Dental School

1991, Chicago, IL

Physicians | Publications

Physicians | Education

Medical School

Medical College of Pennsylvania

1975, Philadelphia, PA

Internship

Boston Children's Hospital

1976, Boston, MA

Residency

Boston Children's Hospital

1978, Boston, MA

Fellowship

Boston Children's Hospital

1979, Boston, MA

Physicians | Publications

Physicians | Education

Graduate School

Mount Sinai School of Medicine

1998, New York, NY

Medical School

Mount Sinai School of Medicine

2000, New York, NY

Internship

Internal Medicine

NYU Downtown Hospital

2001, New York, NY

Residency

Anesthesiology

Mount Sinai Medical Center

2005, New York, NY

Fellowship

Pediatric Anesthesia

Boston Children's Hospital

2006, Boston, MA

Physicians | Publications

Talk to Lesley

If this is a medical emergency, please dial 9-1-1. This application should not be used in an emergency. This chat is being transmitted via a secure connection.

Hi! My name is Lesley. I am a virtual agent programmed to help you. If you would like to speak to a live agent, please call 617-355-6000.

I am unable to answer specific questions regarding your child's case, including appointments and conditions/diagnosis. Please contact your physician's office.

Quick links:

- MyChildrens Portal
- Global Services
- Find a Doctor
- Find a Location
- Programs and Services