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Physicians | Education

Undergraduate School

University of Toronto

Toronto, Ontario, Canada

Undergraduate School

McGill University

Montreal, Quebec, Canada

Medical School

McGill University

Montreal, Quebec, Canada

Residency

Pediatrics

Schneider Children's Hospita

New Hyde Park, NY

Fellowship

Pediatrics

Hospital for Sick Children

Toronto, Ontario, Canada

Physicians | Publications

  1. PR1P, a VEGF-stabilizing peptide, reduces injury and inflammation in acute lung injury and ulcerative colitis animal models. Front Immunol. 2023; 14:1168676. View PR1P, a VEGF-stabilizing peptide, reduces injury and inflammation in acute lung injury and ulcerative colitis animal models. Abstract

  2. The Prominin-1-Derived Peptide Improves Cardiac Function Following Ischemia. Int J Mol Sci. 2021 May 13; 22(10). View The Prominin-1-Derived Peptide Improves Cardiac Function Following Ischemia. Abstract

  3. Molecular mapping of transmembrane mechanotransduction through the ß1 integrin-CD98hc-TRPV4 axis. J Cell Sci. 2020 11 02; 133(20). View Molecular mapping of transmembrane mechanotransduction through the ß1 integrin-CD98hc-TRPV4 axis. Abstract

  4. PR1P Stabilizes VEGF and Upregulates Its Signaling to Reduce Elastase-induced Murine Emphysema. Am J Respir Cell Mol Biol. 2020 10; 63(4):452-463. View PR1P Stabilizes VEGF and Upregulates Its Signaling to Reduce Elastase-induced Murine Emphysema. Abstract

  5. AAV-mediated gene therapy targeting TRPV4 mechanotransduction for inhibition of pulmonary vascular leakage. APL Bioeng. 2019 Dec; 3(4):046103. View AAV-mediated gene therapy targeting TRPV4 mechanotransduction for inhibition of pulmonary vascular leakage. Abstract

  6. Pregnancy and parental leave among obstetrics and gynecology residents: results of a nationwide survey of program directors. Am J Obstet Gynecol. 2018 08; 219(2):199.e1-199.e8. View Pregnancy and parental leave among obstetrics and gynecology residents: results of a nationwide survey of program directors. Abstract

  7. A novel strategy to enhance angiogenesis in vivo using the small VEGF-binding peptide PR1P. Angiogenesis. 2017 Aug; 20(3):399-408. View A novel strategy to enhance angiogenesis in vivo using the small VEGF-binding peptide PR1P. Abstract

  8. Prevention of ventilator-induced lung edema by inhalation of nanoparticles releasing ruthenium red. Am J Respir Cell Mol Biol. 2014 Jun; 50(6):1107-17. View Prevention of ventilator-induced lung edema by inhalation of nanoparticles releasing ruthenium red. Abstract

  9. Strain-induced differentiation of fetal type II epithelial cells is mediated via the integrin a6ß1-ADAM17/tumor necrosis factor-a-converting enzyme (TACE) signaling pathway. J Biol Chem. 2013 Aug 30; 288(35):25646-25657. View Strain-induced differentiation of fetal type II epithelial cells is mediated via the integrin a6ß1-ADAM17/tumor necrosis factor-a-converting enzyme (TACE) signaling pathway. Abstract

  10. A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice. Sci Transl Med. 2012 Nov 07; 4(159):159ra147. View A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice. Abstract

  11. Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels. Science. 2012 Aug 10; 337(6095):738-42. View Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels. Abstract

  12. Rapamycin suppresses self-renewal and vasculogenic potential of stem cells isolated from infantile hemangioma. J Invest Dermatol. 2011 Dec; 131(12):2467-76. View Rapamycin suppresses self-renewal and vasculogenic potential of stem cells isolated from infantile hemangioma. Abstract

  13. Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta1 integrins. Integr Biol (Camb). 2010 Sep; 2(9):435-42. View Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta1 integrins. Abstract

  14. Reconstituting organ-level lung functions on a chip. Science. 2010 Jun 25; 328(5986):1662-8. View Reconstituting organ-level lung functions on a chip. Abstract

  15. Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface β1 integrins. . Integrative Biology (In Review). 2010.

  16. Inhaled prophylactic nanotherapy for lung protection from Ventilator induced Lung Injury and Acute Respiratory Distress Syndrome (ARDS). 2010.

  17. High-throughput Screen Identifies Rapamycin as a Drug to Suppress Self-Renewal and Vasculogenesis in Infantile Hemangioma. Journal of Cell Investigation (In Review). 2010.

  18. TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. Circ Res. 2009 May 08; 104(9):1123-30. View TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. Abstract

  19. Wheeze detection in the pediatric intensive care unit: comparison among physician, nurses, respiratory therapists, and a computerized respiratory sound monitor. Respir Care. 2008 Oct; 53(10):1304-9. View Wheeze detection in the pediatric intensive care unit: comparison among physician, nurses, respiratory therapists, and a computerized respiratory sound monitor. Abstract

  20. Rheological behavior of living cells is timescale-dependent. Biophys J. 2007 Oct 15; 93(8):L39-41. View Rheological behavior of living cells is timescale-dependent. Abstract

  21. Tools to study cell mechanics and mechanotransduction. Methods Cell Biol. 2007; 83:443-72. View Tools to study cell mechanics and mechanotransduction. Abstract

  22. Integrin-dependent force transmission to mechanosensitive ion channels. In: Hammill O, editors. Mechanosensitive Ion Channels. 2007; 59-85.

  23. Tools to study cell mechanotransduction. In: Wang Y, Discher D., editors. Methods in Cell Biology. 2007; 441-472.

  24. Alpha-actinin-4 is required for normal podocyte adhesion. J Biol Chem. 2007 Jan 05; 282(1):467-77. View Alpha-actinin-4 is required for normal podocyte adhesion. Abstract

  25. Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels. J Cell Sci. 2006 Feb 01; 119(Pt 3):508-18. View Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels. Abstract

  26. Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain. J Cell Biol. 2005 Dec 19; 171(6):1073-84. View Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain. Abstract

  27. Novel dynamic rheological behavior of individual focal adhesions measured within single cells using electromagnetic pulling cytometry. Acta Biomater. 2005 May; 1(3):295-303. View Novel dynamic rheological behavior of individual focal adhesions measured within single cells using electromagnetic pulling cytometry. Abstract

  28. Mechanical properties of individual focal adhesions probed with a magnetic microneedle. Biochem Biophys Res Commun. 2004 Jan 16; 313(3):758-64. View Mechanical properties of individual focal adhesions probed with a magnetic microneedle. Abstract

  29. SGMD: the Soybean Genomics and Microarray Database. Nucleic Acids Res. 2004 Jan 01; 32(Database issue):D398-400. View SGMD: the Soybean Genomics and Microarray Database. Abstract

  30. Electromagnetic needles with submicron pole tip radii for nanomanipulation of biomolecules and living cells. Applied Physics Letters. 2004; 85:2968-2970..

  31. Management of oxygenation in pediatric acute hypoxemic respiratory failure. Pediatr Pulmonol. 2001 Dec; 32(6):459-70. View Management of oxygenation in pediatric acute hypoxemic respiratory failure. Abstract

  32. Role of the actin cytoskeleton in insulin action. Microsc Res Tech. 1999 Oct 15; 47(2):79-92. View Role of the actin cytoskeleton in insulin action. Abstract

  33. Nucleotide sequence of 10 kilobases of rat tyrosine aminotransferase gene 5' flanking region. Nucleic Acids Res. 1989 Nov 11; 17(21):8877-8. View Nucleotide sequence of 10 kilobases of rat tyrosine aminotransferase gene 5' flanking region. Abstract

Physicians | Education

Internship

Waltham Weston Hospital & Medical Center

1988, Waltham, MA

Residency

The University Hospital

1991, Boston, MA

Fellowship

Boston Children's Hospital

1992, Boston, MA

Physicians | Publications

Physicians | Education

Medical School

University of Florida School of Medicine

2010, Gainesville, FL

Residency

Boston Combined Residency Program (BCRP)

2013, Boston, MA

Fellowship

Pediatric Emergency Medicine

Boston Children's Hospital

2015, Boston, MA

Physicians | Publications

Physicians | Education

Medical School

Medical Institute of Kishinev

1979, Kishinev, USSR

Internship

Children's Hospital of Kishinev

1980, Kishinev, USSR

Residency

Child Neurology/Pediatrics

New England Medical Centerv

2000, Boston, MA

Fellowship

Pediatrics

New England Medical Center

2000, Boston, MA

Physicians | Publications

Physicians | Education

Undergraduate School

Temple University

2004, Philadelphia, PA

Graduate School

Perelman School of Medicine at University of Pennsylvania

2012, Philadelphia, PA

Medical School

Perelman School of Medicine at University of Pennsylvania

2013, Philadelphia, PA

Internship

Boston Combined Residency Program (BCRP)

2014, Boston, MA

Residency

Boston Combined Residency Program (BCRP)

2016, Boston, MA

Fellowship

Nephrology

Boston Children's Hospital

2020, Boston, MA

Physicians | Publications

Physicians | Education

Graduate School

MPH

Harvard University School of Public Health

Boston, MA

Medical School

Tuft's University School of Medicine

, Boston, MA

Internship

Tuft's University School of Medicine

Boston, MA

Residency

Tuft's University School of Medicine

Boston, MA

Fellowship

St. Margaret's Hospital/Boston Perinatal Center

Dorchester, MA

Physicians | Education

Medical School

University of Rochester

1995, Rochester, NY

Internship

Brigham & Women's Hospital

1996, Boston, MA

Residency

Clinical Pathology

Brigham & Women's Hospital

1998, Boston, MA

Physicians | Publications

Physicians | Publications

Physicians | Education

Undergraduate School

Virginia Tech

2008, Blacksburg, VA

Medical School

Virginia College of Osteopathic Medicine

2014, Blacksburg, VA

Residency

Norton Children's Hospital

2017, Louisville, KY

Fellowship

Riley Hospital for Children

2020, Indianapolis, IN

Graduate School

Indiana University

2020, Indianapolis, IN

Physicians | Publications

Physicians | Education

Undergraduate School

Johns Hopkins University

1974, Baltimore, MD

Graduate School

PhD, Neuroanatomy

Johns Hopkins University

1982, Baltimore, MD

Medical School

Johns Hopkins University School of Medicine

1982, Baltimore, MD

Internship

Pediatrics

Massachusetts General Hospital

1983, Boston, MA

Residency

Pediatric Neurology

Massachusetts General Hospital

1987, Boston, MA

Fellowship

National Hospital

1988, London, England

Fellowship

Brigham & Women's Hospital/Boston Children's Hospital

1991, Boston, MA

Physicians | Publications

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