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PPOC Alliance | Education

Undergraduate School

University of New Hampshire

1991, Durham, NH

Graduate School

Dartmouth Medical School

1997, Hanover, NH

Medical School

Dartmouth Medical School

1999, Lebanon, NH

Residency

Dartmouth Hitchcock Medical Center

2000, Lebanon, NH

Residency

Dartmouth Hitchcock Medical Center

2002, Lebanon, NH

PPOC Alliance | Education

Undergraduate School

College of the Holy Cross

1996, Worcester, MA

Medical School

Mayo Medical School

2001, Rochester, MN

Internship

Massachusetts General Hospital for Children

2002, Boston, MA

Residency

Massachusetts General Hospital for Children

2005, Boston, MA

PPOC Alliance | Education

Undergraduate School

Brown University

1979, Providence, RI

Medical School

Harvard Medical School

1984, Boston, MA

Internship

Boston Children's Hospital

1985, Boston, MA

Residency

Boston Children's Hospital

1987, Boston, MA

Fellowship

Boston Children's Hospital

1988, Boston, MA

PPOC Alliance | Publications

  1. MixOmics Integration of Biological Datasets Identifies Highly Correlated Variables of COVID-19 Severity. Int J Mol Sci. 2025 May 15; 26(10). View MixOmics Integration of Biological Datasets Identifies Highly Correlated Variables of COVID-19 Severity. Abstract

  2. Structure and function relationships of mucociliary clearance in human and rat airways. Nat Commun. 2025 Mar 12; 16(1):2446. View Structure and function relationships of mucociliary clearance in human and rat airways. Abstract

  3. Culture conditions differentially regulate the inflammatory niche and cellular phenotype of tracheobronchial basal stem cells. Am J Physiol Lung Cell Mol Physiol. 2025 Apr 01; 328(4):L538-L553. View Culture conditions differentially regulate the inflammatory niche and cellular phenotype of tracheobronchial basal stem cells. Abstract

  4. Structure and Function Relationships of Mucociliary Clearance in Human and Rat Airways. bioRxiv. 2025 Feb 20. View Structure and Function Relationships of Mucociliary Clearance in Human and Rat Airways. Abstract

  5. Targeting fibroblast-endothelial cell interactions in LAM pathogenesis using 3D spheroid models and spatial transcriptomics. JCI Insight. 2025 Feb 04; 10(6). View Targeting fibroblast-endothelial cell interactions in LAM pathogenesis using 3D spheroid models and spatial transcriptomics. Abstract

  6. Engineered hydrogel biomaterials facilitate lung progenitor cell differentiation from induced pluripotent stem cells. Am J Physiol Lung Cell Mol Physiol. 2025 Mar 01; 328(3):L379-L388. View Engineered hydrogel biomaterials facilitate lung progenitor cell differentiation from induced pluripotent stem cells. Abstract

  7. Protocol for the Generation and 3D Culture of Fluorescently Labeled Multicellular Spheroids. Methods Mol Biol. 2025 Jan 17. View Protocol for the Generation and 3D Culture of Fluorescently Labeled Multicellular Spheroids. Abstract

  8. CFTR mutation is associated with bone differentiation abnormalities in cystic fibrosis. J Cyst Fibros. 2025 Jan 11. View CFTR mutation is associated with bone differentiation abnormalities in cystic fibrosis. Abstract

  9. Targeting Fibroblast-Endothelial Interactions in LAM Pathogenesis: 3D Spheroid and Spatial Transcriptomic Insights for Therapeutic Innovation. bioRxiv. 2024 Sep 06. View Targeting Fibroblast-Endothelial Interactions in LAM Pathogenesis: 3D Spheroid and Spatial Transcriptomic Insights for Therapeutic Innovation. Abstract

  10. Culture Conditions Differentially Regulate the Inflammatory Niche and Cellular Phenotype of Tracheo-Bronchial Basal Stem Cells. bioRxiv. 2024 Sep 05. View Culture Conditions Differentially Regulate the Inflammatory Niche and Cellular Phenotype of Tracheo-Bronchial Basal Stem Cells. Abstract

  11. Stem cells, cell therapies, and bioengineering in lung biology and diseases 2023. Am J Physiol Lung Cell Mol Physiol. 2024 Sep 01; 327(3):L327-L340. View Stem cells, cell therapies, and bioengineering in lung biology and diseases 2023. Abstract

  12. STRUCTURE-FUNCTION RELATIONSHIPS OF MUCOCILIARY CLEARANCE IN HUMAN AIRWAYS. Res Sq. 2024 Apr 25. View STRUCTURE-FUNCTION RELATIONSHIPS OF MUCOCILIARY CLEARANCE IN HUMAN AIRWAYS. Abstract

  13. RBL2 represses the transcriptional activity of Multicilin to inhibit multiciliogenesis. Cell Death Dis. 2024 01 22; 15(1):81. View RBL2 represses the transcriptional activity of Multicilin to inhibit multiciliogenesis. Abstract

  14. Proteomic profiling identifies biomarkers of COVID-19 severity. Heliyon. 2024 Jan 15; 10(1):e23320. View Proteomic profiling identifies biomarkers of COVID-19 severity. Abstract

  15. Alveolar type I cells can give rise to KRAS-induced lung adenocarcinoma. Cell Rep. 2023 12 26; 42(12):113286. View Alveolar type I cells can give rise to KRAS-induced lung adenocarcinoma. Abstract

  16. RBL2 represses the transcriptional activity of Multicilin to inhibit multiciliogenesis. bioRxiv. 2023 Aug 04. View RBL2 represses the transcriptional activity of Multicilin to inhibit multiciliogenesis. Abstract

  17. Breathing on chip: Dynamic flow and stretch accelerate mucociliary maturation of airway epithelium in vitro. Mater Today Bio. 2023 Aug; 21:100713. View Breathing on chip: Dynamic flow and stretch accelerate mucociliary maturation of airway epithelium in vitro. Abstract

  18. Neutrophilic inflammation promotes SARS-CoV-2 infectivity and augments the inflammatory responses in airway epithelial cells. Front Immunol. 2023; 14:1112870. View Neutrophilic inflammation promotes SARS-CoV-2 infectivity and augments the inflammatory responses in airway epithelial cells. Abstract

  19. Basic Science Perspective on Engineering and Modeling the Large Airways. Adv Exp Med Biol. 2023; 1413:73-106. View Basic Science Perspective on Engineering and Modeling the Large Airways. Abstract

  20. Stem cells, cell therapies, and bioengineering in lung biology and disease 2021. Am J Physiol Lung Cell Mol Physiol. 2022 09 01; 323(3):L341-L354. View Stem cells, cell therapies, and bioengineering in lung biology and disease 2021. Abstract

  21. Development of human alveolar epithelial cell models to study distal lung biology and disease. iScience. 2022 Feb 18; 25(2):103780. View Development of human alveolar epithelial cell models to study distal lung biology and disease. Abstract

  22. National Heart, Lung, and Blood Institute and Building Respiratory Epithelium and Tissue for Health (BREATH) Consortium Workshop Report: Moving Forward in Lung Regeneration. Am J Respir Cell Mol Biol. 2021 07; 65(1):22-29. View National Heart, Lung, and Blood Institute and Building Respiratory Epithelium and Tissue for Health (BREATH) Consortium Workshop Report: Moving Forward in Lung Regeneration. Abstract

  23. The One-Stop Gyrification Station - Challenges and New Technologies. Prog Neurobiol. 2021 09; 204:102111. View The One-Stop Gyrification Station - Challenges and New Technologies. Abstract

  24. Implications for Extracellular Matrix Interactions With Human Lung Basal Stem Cells in Lung Development, Disease, and Airway Modeling. Front Pharmacol. 2021; 12:645858. View Implications for Extracellular Matrix Interactions With Human Lung Basal Stem Cells in Lung Development, Disease, and Airway Modeling. Abstract

  25. Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition. Nat Med. 2021 05; 27(5):806-814. View Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition. Abstract

  26. Engineering Tissue-Informed Biomaterials to Advance Pulmonary Regenerative Medicine. Front Med (Lausanne). 2021; 8:647834. View Engineering Tissue-Informed Biomaterials to Advance Pulmonary Regenerative Medicine. Abstract

  27. Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Disease 2019. ERJ Open Res. 2020 Oct; 6(4). View Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Disease 2019. Abstract

  28. Stem cells and lung regeneration. Am J Physiol Cell Physiol. 2020 10 01; 319(4):C675-C693. View Stem cells and lung regeneration. Abstract

  29. Protocol for Differentiation of Human iPSCs into Pulmonary Neuroendocrine Cells. STAR Protoc. 2020 09 18; 1(2):100068. View Protocol for Differentiation of Human iPSCs into Pulmonary Neuroendocrine Cells. Abstract

  30. The D614G mutation in the SARS-CoV2 Spike protein increases infectivity in an ACE2 receptor dependent manner. bioRxiv. 2020 Jul 22. View The D614G mutation in the SARS-CoV2 Spike protein increases infectivity in an ACE2 receptor dependent manner. Abstract

  31. Technological advances in study of lung regenerative medicine:perspective from the 2019 Vermont lung stem cell conference. Cytotherapy. 2020 10; 22(10):519-520. View Technological advances in study of lung regenerative medicine:perspective from the 2019 Vermont lung stem cell conference. Abstract

  32. Correcting CFTR: New Gene Editing Strategies for Rescuing CFTR Function Ex Vivo. Cell Stem Cell. 2020 04 02; 26(4):476-478. View Correcting CFTR: New Gene Editing Strategies for Rescuing CFTR Function Ex Vivo. Abstract

  33. Derivation of induced pluripotent stem cells from ferret somatic cells. Am J Physiol Lung Cell Mol Physiol. 2020 04 01; 318(4):L671-L683. View Derivation of induced pluripotent stem cells from ferret somatic cells. Abstract

  34. Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases 2017. An Official American Thoracic Society Workshop Report. Am J Respir Cell Mol Biol. 2019 10; 61(4):429-439. View Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases 2017. An Official American Thoracic Society Workshop Report. Abstract

PPOC Alliance | Education

Undergraduate School

6 Year Medical Program

Boston University

Boston, MA

Medical School

Boston University School of Medicine

1991, Boston, MA

Residency

Pediatrics

Boston City Hospital

1994, Boston, MA

PPOC Alliance | Education

Undergraduate School

Cornell University

1987, Ithaca, NY

Medical School

Upstate Medical Center

1991, Syracuse, NY

Residency

Tufts Medical Center - Boston Floating Hospital for Children

1994, Boston, MA

PPOC Alliance | Education

Medical School

New York Medical College

Valhalla, NY

Residency

Pediatrics

University of California at Los Angeles

Los Angeles, CA

PPOC Alliance | Education

Graduate School

Facultad de Medicina

1985, Buenos Aires, Argentina

Medical School

Facultad de Medicina

1986, Buenos Aires, Argentina

Internship

Facultad de Medicina

1987, Buenos Aires, Argentina

Internship

Buenos Aires Children's Hospital

1992, Buenos Aires, Argentina

Residency

Albany Medical Center

1996, Albany, NY

PPOC Alliance | Education

Undergraduate School

Union College

1997, Schenectady, NY

Medical School

Albany Medical School

2000, Albany, NY

Internship

Children's Hospital at Albany Medical Center

2001, Albany, NY

Residency

Children's Hospital at Albany Medical Center

2003, Albany, NY

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