American Board of Pediatrics (General) | Education
Medical School
Medical University of Graz
Graz, Austria
Residency
Pediatrics
Boston Children's Hospital
Boston, MA
Fellowship
Pediatric Hematology/Oncology
Dana-Farber/Boston Children's Cancer and Blood Disorders Center
Boston, MA
American Board of Pediatrics (General) | Publications
Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor-ligand interactions. Nat Cancer. 2025 May 26. View Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor-ligand interactions. Abstract
Dissecting the immune landscape in pediatric high-grade glioma reveals cell state changes under therapeutic pressure. Cell Rep Med. 2025 May 20; 6(5):102095. View Dissecting the immune landscape in pediatric high-grade glioma reveals cell state changes under therapeutic pressure. Abstract
Effective targeting of PDGFRA-altered high-grade glioma with avapritinib. Cancer Cell. 2025 Apr 14; 43(4):740-756.e8. View Effective targeting of PDGFRA-altered high-grade glioma with avapritinib. Abstract
Correction: Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways. Cancer Discov. 2025 Mar 03; 15(3):657. View Correction: Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways. Abstract
Neuroimmune-competent human brain organoid model of diffuse midline glioma. Neuro Oncol. 2025 Feb 10; 27(2):369-382. View Neuroimmune-competent human brain organoid model of diffuse midline glioma. Abstract
Paediatric strategy forum for medicinal product development in diffuse midline gliomas in children and adolescents ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration. Eur J Cancer. 2025 Feb 25; 217:115230. View Paediatric strategy forum for medicinal product development in diffuse midline gliomas in children and adolescents ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration. Abstract
Multi-omics approaches reveal that diffuse midline gliomas present altered DNA replication and are susceptible to replication stress therapy. Genome Biol. 2024 Dec 20; 25(1):319. View Multi-omics approaches reveal that diffuse midline gliomas present altered DNA replication and are susceptible to replication stress therapy. Abstract
Applying single-cell and single-nucleus genomics to studies of cellular heterogeneity and cell fate transitions in the nervous system. Nat Neurosci. 2024 Dec; 27(12):2278-2291. View Applying single-cell and single-nucleus genomics to studies of cellular heterogeneity and cell fate transitions in the nervous system. Abstract
GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant. Cancer Cell. 2024 Aug 27. View GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant. Abstract
Diffuse midline glioma invasion and metastasis rely on cell-autonomous signaling. Neuro Oncol. 2024 03 04; 26(3):553-568. View Diffuse midline glioma invasion and metastasis rely on cell-autonomous signaling. Abstract
Clinically relevant molecular hallmarks of PFA ependymomas display intratumoral heterogeneity and correlate with tumor morphology. Acta Neuropathol. 2024 01 24; 147(1):23. View Clinically relevant molecular hallmarks of PFA ependymomas display intratumoral heterogeneity and correlate with tumor morphology. Abstract
An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma. Cell Rep. 2024 01 23; 43(1):113557. View An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma. Abstract
A road map for the treatment of pediatric diffuse midline glioma. Cancer Cell. 2024 01 08; 42(1):1-5. View A road map for the treatment of pediatric diffuse midline glioma. Abstract
Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways. Cancer Discov. 2023 11 01; 13(11):2370-2393. View Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways. Abstract
TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory. Cancer Cell. 2023 11 13; 41(11):1911-1926.e8. View TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory. Abstract
Mapping pediatric brain tumors to their origins in the developing cerebellum. Neuro Oncol. 2023 10 03; 25(10):1895-1909. View Mapping pediatric brain tumors to their origins in the developing cerebellum. Abstract
A comprehensive genomic study of 390 H3F3A-mutant pediatric and adult diffuse high-grade gliomas, CNS WHO grade 4. Acta Neuropathol. 2023 09; 146(3):515-525. View A comprehensive genomic study of 390 H3F3A-mutant pediatric and adult diffuse high-grade gliomas, CNS WHO grade 4. Abstract
Why haven't we solved intracranial pediatric ependymoma? Current questions and barriers to treatment advances. Neoplasia. 2023 05; 39:100895. View Why haven't we solved intracranial pediatric ependymoma? Current questions and barriers to treatment advances. Abstract
Characterizing the biology of primary brain tumors and their microenvironment via single-cell profiling methods. Neuro Oncol. 2023 02 14; 25(2):234-247. View Characterizing the biology of primary brain tumors and their microenvironment via single-cell profiling methods. Abstract
Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways. Acta Neuropathol Commun. 2023 02 09; 11(1):25. View Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways. Abstract
Neuronal-Activity Dependent Mechanisms of Small Cell Lung Cancer Progression. bioRxiv. 2023 Jan 20. View Neuronal-Activity Dependent Mechanisms of Small Cell Lung Cancer Progression. Abstract
Erratum to: Characterizing the biology of primary brain tumors and their microenvironment via single-cell profiling methods. Neuro Oncol. 2023 Jan 05; 25(1):211. View Erratum to: Characterizing the biology of primary brain tumors and their microenvironment via single-cell profiling methods. Abstract
Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma. Neuro Oncol. 2023 01 05; 25(1):54-67. View Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma. Abstract
Activation of Hedgehog signaling by the oncogenic RELA fusion reveals a primary cilia-dependent vulnerability in supratentorial ependymoma. Neuro Oncol. 2023 01 05; 25(1):185-198. View Activation of Hedgehog signaling by the oncogenic RELA fusion reveals a primary cilia-dependent vulnerability in supratentorial ependymoma. Abstract
The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location. Nat Genet. 2022 12; 54(12):1881-1894. View The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location. Abstract
BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma. Cancer Discov. 2022 12 02; 12(12):2880-2905. View BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma. Abstract
VRK1 as a synthetic lethal target in VRK2 promoter-methylated cancers of the nervous system. JCI Insight. 2022 10 10; 7(19). View VRK1 as a synthetic lethal target in VRK2 promoter-methylated cancers of the nervous system. Abstract
Immunotherapy approaches for the treatment of diffuse midline gliomas. Oncoimmunology. 2022; 11(1):2124058. View Immunotherapy approaches for the treatment of diffuse midline gliomas. Abstract
Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas. Neuro Oncol. 2022 09 01; 24(9):1438-1451. View Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas. Abstract
A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma. Cancer Cell. 2022 09 12; 40(9):957-972.e10. View A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma. Abstract
An affinity for brainstem microglia in pediatric high-grade gliomas of brainstem origin. Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac117. View An affinity for brainstem microglia in pediatric high-grade gliomas of brainstem origin. Abstract
Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas. Mol Cell. 2022 07 21; 82(14):2696-2713.e9. View Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas. Abstract
Bromodomain and Extra-Terminal Protein Inhibitors: Biologic Insights and Therapeutic Potential in Pediatric Brain Tumors. Pharmaceuticals (Basel). 2022 May 26; 15(6). View Bromodomain and Extra-Terminal Protein Inhibitors: Biologic Insights and Therapeutic Potential in Pediatric Brain Tumors. Abstract
GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas. Nature. 2022 03; 603(7903):934-941. View GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas. Abstract
Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas. Sci Transl Med. 2021 Oct 06; 13(614):eabc0497. View Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas. Abstract
Targeting fibroblast growth factor receptors to combat aggressive ependymoma. Acta Neuropathol. 2021 08; 142(2):339-360. View Targeting fibroblast growth factor receptors to combat aggressive ependymoma. Abstract
The imitation game: How glioblastoma outmaneuvers immune attack. Cell. 2021 04 29; 184(9):2278-2281. View The imitation game: How glioblastoma outmaneuvers immune attack. Abstract
Outcomes after first relapse of childhood intracranial ependymoma. Pediatr Blood Cancer. 2021 08; 68(8):e28930. View Outcomes after first relapse of childhood intracranial ependymoma. Abstract
Understanding the epigenetic landscape and cellular architecture of childhood brain tumors. Neurochem Int. 2021 03; 144:104940. View Understanding the epigenetic landscape and cellular architecture of childhood brain tumors. Abstract
Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis. Cell. 2020 12 10; 183(6):1617-1633.e22. View Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis. Abstract
Infiltrative gliomas of the thalamus in children: the role of surgery in the era of H3 K27M mutant midline gliomas. Acta Neurochir (Wien). 2021 07; 163(7):2025-2035. View Infiltrative gliomas of the thalamus in children: the role of surgery in the era of H3 K27M mutant midline gliomas. Abstract
Trametinib for the treatment of recurrent/progressive pediatric low-grade glioma. J Neurooncol. 2020 Sep; 149(2):253-262. View Trametinib for the treatment of recurrent/progressive pediatric low-grade glioma. Abstract
Into Thin Air: Hypoxia Drives Metabolic and Epigenomic Deregulation of Lethal Pediatric Ependymoma. Dev Cell. 2020 07 20; 54(2):134-136. View Into Thin Air: Hypoxia Drives Metabolic and Epigenomic Deregulation of Lethal Pediatric Ependymoma. Abstract
Molecular and clinicopathologic features of gliomas harboring NTRK fusions. Acta Neuropathol Commun. 2020 07 14; 8(1):107. View Molecular and clinicopathologic features of gliomas harboring NTRK fusions. Abstract
Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma. Cancer Cell. 2020 07 13; 38(1):44-59.e9. View Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma. Abstract
The growing role of epigenetics in childhood cancers. Curr Opin Pediatr. 2020 02; 32(1):67-75. View The growing role of epigenetics in childhood cancers. Abstract
Stalled developmental programs at the root of pediatric brain tumors. Nat Genet. 2019 12; 51(12):1702-1713. View Stalled developmental programs at the root of pediatric brain tumors. Abstract
Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG. Cancer Cell. 2019 11 11; 36(5):528-544.e10. View Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG. Abstract
Histone Variant and Cell Context Determine H3K27M Reprogramming of the Enhancer Landscape and Oncogenic State. Mol Cell. 2019 12 19; 76(6):965-980.e12. View Histone Variant and Cell Context Determine H3K27M Reprogramming of the Enhancer Landscape and Oncogenic State. Abstract
Increasing value of autopsies in patients with brain tumors in the molecular era. J Neurooncol. 2019 Nov; 145(2):349-355. View Increasing value of autopsies in patients with brain tumors in the molecular era. Abstract
Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements. Cell. 2019 09 19; 179(1):251-267.e24. View Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements. Abstract
Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells. Nat Commun. 2019 08 19; 10(1):3731. View Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells. Abstract
Resolving medulloblastoma cellular architecture by single-cell genomics. Nature. 2019 08; 572(7767):74-79. View Resolving medulloblastoma cellular architecture by single-cell genomics. Abstract
An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma. Cell. 2019 08 08; 178(4):835-849.e21. View An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma. Abstract
Developmental origins and emerging therapeutic opportunities for childhood cancer. Nat Med. 2019 03; 25(3):367-376. View Developmental origins and emerging therapeutic opportunities for childhood cancer. Abstract
Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma. Acta Neuropathol Commun. 2018 06 28; 6(1):51. View Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma. Abstract
Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq. Science. 2018 04 20; 360(6386):331-335. View Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq. Abstract
Gliomas in Children. Semin Neurol. 2018 02; 38(1):121-130. View Gliomas in Children. Abstract
Molecular pathogenesis and therapeutic implications in pediatric high-grade gliomas. Pharmacol Ther. 2018 02; 182:70-79. View Molecular pathogenesis and therapeutic implications in pediatric high-grade gliomas. Abstract
Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors. Neuro Oncol. 2017 Jul 01; 19(7):986-996. View Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors. Abstract
Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq. Science. 2017 03 31; 355(6332). View Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq. Abstract
Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma. Nature. 2016 11 10; 539(7628):309-313. View Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma. Abstract
Gliomas Genomics and Epigenomics: Arriving at the Start and Knowing It for the First Time. Annu Rev Pathol. 2016 05 23; 11:497-521. View Gliomas Genomics and Epigenomics: Arriving at the Start and Knowing It for the First Time. Abstract
A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies. J Vis Exp. 2015 Nov 07; (105):e53304. View A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies. Abstract
Of Brains and Blood: Developmental Origins of Glioma Diversity? Cancer Cell. 2015 Oct 12; 28(4):403-404. View Of Brains and Blood: Developmental Origins of Glioma Diversity? Abstract
How neuronal activity regulates glioma cell proliferation. Neuro Oncol. 2015 Dec; 17(12):1543-4. View How neuronal activity regulates glioma cell proliferation. Abstract
Metallothionein-I/II Promotes Axonal Regeneration in the Central Nervous System. J Biol Chem. 2015 Jun 26; 290(26):16343-56. View Metallothionein-I/II Promotes Axonal Regeneration in the Central Nervous System. Abstract
Soluble adenylyl cyclase is necessary and sufficient to overcome the block of axonal growth by myelin-associated factors. J Neurosci. 2014 Jul 09; 34(28):9281-9. View Soluble adenylyl cyclase is necessary and sufficient to overcome the block of axonal growth by myelin-associated factors. Abstract
PTEN inhibition enhances neurite outgrowth in human embryonic stem cell-derived neuronal progenitor cells. J Comp Neurol. 2014 Aug 15; 522(12):2741-55. View PTEN inhibition enhances neurite outgrowth in human embryonic stem cell-derived neuronal progenitor cells. Abstract
Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities. Nat Med. 2013 Nov; 19(11):1518-23. View Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities. Abstract
Secretory leukocyte protease inhibitor reverses inhibition by CNS myelin, promotes regeneration in the optic nerve, and suppresses expression of the transforming growth factor-ß signaling protein Smad2. J Neurosci. 2013 Mar 20; 33(12):5138-51. View Secretory leukocyte protease inhibitor reverses inhibition by CNS myelin, promotes regeneration in the optic nerve, and suppresses expression of the transforming growth factor-ß signaling protein Smad2. Abstract
Rolipram promotes functional recovery after contusive thoracic spinal cord injury in rats. Behav Brain Res. 2013 Apr 15; 243:66-73. View Rolipram promotes functional recovery after contusive thoracic spinal cord injury in rats. Abstract
A novel role for PTEN in the inhibition of neurite outgrowth by myelin-associated glycoprotein in cortical neurons. Mol Cell Neurosci. 2011 Jan; 46(1):235-44. View A novel role for PTEN in the inhibition of neurite outgrowth by myelin-associated glycoprotein in cortical neurons. Abstract
Feasibility and tolerability of bevacizumab in children with primary CNS tumors. Pediatr Blood Cancer. 2010 May; 54(5):681-6. View Feasibility and tolerability of bevacizumab in children with primary CNS tumors. Abstract
A large-scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone daidzeinas a clinically approved small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathway. J Neurosci. 2010 Jan 13; 30(2):739-48. View A large-scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone daidzeinas a clinically approved small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathway. Abstract
Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury. Neuron. 2009 Oct 29; 64(2):165-72. View Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury. Abstract
Live or let die: CCM2 provides the link. Neuron. 2009 Sep 10; 63(5):559-60. View Live or let die: CCM2 provides the link. Abstract
Increased synthesis of spermidine as a result of upregulation of arginase I promotes axonal regeneration in culture and in vivo. J Neurosci. 2009 Jul 29; 29(30):9545-52. View Increased synthesis of spermidine as a result of upregulation of arginase I promotes axonal regeneration in culture and in vivo. Abstract
Tumor stabilization under treatment with imatinib in progressive hypothalamic-chiasmatic glioma. Pediatr Blood Cancer. 2009 Apr; 52(4):476-80. View Tumor stabilization under treatment with imatinib in progressive hypothalamic-chiasmatic glioma. Abstract
Neurotrophin 3/TrkC-regulated proteins in the human medulloblastoma cell line DAOY. Electrophoresis. 2009 Feb; 30(3):540-9. View Neurotrophin 3/TrkC-regulated proteins in the human medulloblastoma cell line DAOY. Abstract
Pharmacokinetics and safety of intrathecal liposomal cytarabine in children aged <3 years. Clin Pharmacokinet. 2009; 48(4):265-71. View Pharmacokinetics and safety of intrathecal liposomal cytarabine in children aged <3 years. Abstract
PirB, a second receptor for the myelin inhibitors of axonal regeneration Nogo66, MAG, and OMgp: implications for regeneration in vivo. Neuron. 2008 Dec 10; 60(5):740-2. View PirB, a second receptor for the myelin inhibitors of axonal regeneration Nogo66, MAG, and OMgp: implications for regeneration in vivo. Abstract
Mitosis-dependent protein expression in neuroblastoma cell line N1E-115. J Proteome Res. 2008 Aug; 7(8):3412-22. View Mitosis-dependent protein expression in neuroblastoma cell line N1E-115. Abstract
Synthesis, chaperoning, and metabolism of proteins are regulated by NT-3/TrkC signaling in the medulloblastoma cell line DAOY. J Proteome Res. 2008 May; 7(5):1932-44. View Synthesis, chaperoning, and metabolism of proteins are regulated by NT-3/TrkC signaling in the medulloblastoma cell line DAOY. Abstract
BDNF activates CaMKIV and PKA in parallel to block MAG-mediated inhibition of neurite outgrowth. Mol Cell Neurosci. 2008 May; 38(1):110-6. View BDNF activates CaMKIV and PKA in parallel to block MAG-mediated inhibition of neurite outgrowth. Abstract
The role of cyclic AMP signaling in promoting axonal regeneration after spinal cord injury. Exp Neurol. 2008 Feb; 209(2):321-32. View The role of cyclic AMP signaling in promoting axonal regeneration after spinal cord injury. Abstract
The inhibition site on myelin-associated glycoprotein is within Ig-domain 5 and is distinct from the sialic acid binding site. J Neurosci. 2007 Aug 22; 27(34):9146-54. View The inhibition site on myelin-associated glycoprotein is within Ig-domain 5 and is distinct from the sialic acid binding site. Abstract
Therapeutic approaches to promoting axonal regeneration in the adult mammalian spinal cord. Int Rev Neurobiol. 2007; 77:57-105. View Therapeutic approaches to promoting axonal regeneration in the adult mammalian spinal cord. Abstract
Myelin-associated inhibitory signaling and strategies to overcome inhibition. J Cereb Blood Flow Metab. 2007 Jun; 27(6):1096-107. View Myelin-associated inhibitory signaling and strategies to overcome inhibition. Abstract
Recapitulate development to promote axonal regeneration: good or bad approach? Philos Trans R Soc Lond B Biol Sci. 2006 Sep 29; 361(1473):1565-74. View Recapitulate development to promote axonal regeneration: good or bad approach? Abstract
How inflammation promotes regeneration. Nat Neurosci. 2006 Jun; 9(6):715-7. View How inflammation promotes regeneration. Abstract
Nectin-like molecule 1 is a high abundance protein in cerebellar neurons. Amino Acids. 2006 Jun; 30(4):409-15. View Nectin-like molecule 1 is a high abundance protein in cerebellar neurons. Abstract
The cytokine interleukin-6 is sufficient but not necessary to mimic the peripheral conditioning lesion effect on axonal growth. J Neurosci. 2006 May 17; 26(20):5565-73. View The cytokine interleukin-6 is sufficient but not necessary to mimic the peripheral conditioning lesion effect on axonal growth. Abstract
The medulloblastoma cell line DAOY but not eleven other tumor cell lines expresses minichromosome maintenance protein 4. Cancer Lett. 2006 Jul 08; 238(1):76-84. View The medulloblastoma cell line DAOY but not eleven other tumor cell lines expresses minichromosome maintenance protein 4. Abstract
MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth. Neuron. 2005 Jun 16; 46(6):849-55. View MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth. Abstract
Overcoming inhibitors in myelin to promote axonal regeneration. J Neurol Sci. 2005 Jun 15; 233(1-2):43-7. View Overcoming inhibitors in myelin to promote axonal regeneration. Abstract
Activated CREB is sufficient to overcome inhibitors in myelin and promote spinal axon regeneration in vivo. Neuron. 2004 Nov 18; 44(4):609-21. View Activated CREB is sufficient to overcome inhibitors in myelin and promote spinal axon regeneration in vivo. Abstract
Expression of proteasomal proteins in ten different tumor cell lines. Amino Acids. 2004 Oct; 27(2):129-40. View Expression of proteasomal proteins in ten different tumor cell lines. Abstract
Combinatorial therapy with neurotrophins and cAMP promotes axonal regeneration beyond sites of spinal cord injury. J Neurosci. 2004 Jul 14; 24(28):6402-9. View Combinatorial therapy with neurotrophins and cAMP promotes axonal regeneration beyond sites of spinal cord injury. Abstract
The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recovery. Proc Natl Acad Sci U S A. 2004 Jun 08; 101(23):8786-90. View The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recovery. Abstract
cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury. Nat Med. 2004 Jun; 10(6):610-6. View cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury. Abstract
A role for cAMP in regeneration of the adult mammalian CNS. J Anat. 2004 Jan; 204(1):49-55. View A role for cAMP in regeneration of the adult mammalian CNS. Abstract
Neurotrophins elevate cAMP to reach a threshold required to overcome inhibition by MAG through extracellular signal-regulated kinase-dependent inhibition of phosphodiesterase. J Neurosci. 2003 Dec 17; 23(37):11770-7. View Neurotrophins elevate cAMP to reach a threshold required to overcome inhibition by MAG through extracellular signal-regulated kinase-dependent inhibition of phosphodiesterase. Abstract
Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS. Nat Rev Neurosci. 2003 Sep; 4(9):703-13. View Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS. Abstract
New roles for old proteins in adult CNS axonal regeneration. Curr Opin Neurobiol. 2003 Feb; 13(1):133-9. View New roles for old proteins in adult CNS axonal regeneration. Abstract
Arginase I and polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro. Neuron. 2002 Aug 15; 35(4):711-9. View Arginase I and polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro. Abstract
Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth. Neuron. 2002 Jul 18; 35(2):283-90. View Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth. Abstract
Spinal axon regeneration induced by elevation of cyclic AMP. Neuron. 2002 Jun 13; 34(6):895-903. View Spinal axon regeneration induced by elevation of cyclic AMP. Abstract
A role for cAMP in regeneration during development and after injury. Prog Brain Res. 2002; 137:381-7. View A role for cAMP in regeneration during development and after injury. Abstract