English | Education
Undergraduate School
Harvard College
1983, Cambridge, MA
Medical School
Harvard Medical School
1991, Boston, MA
Internship
Massachusetts General Hospital
1992, Boston, MA
Residency
Massachusetts General Hospital
1997, Boston, MA
Fellowship
Boston Children's Hospital
1999, Boston, MA
Fellowship
Massachusetts General Hospital
1999, Boston, MA
English | Publications
Enhancing Drug Development for Paediatric Pulmonary Hypertension-An Integrative Perspective. Pulm Circ. 2025 Jul; 15(3):e70126. View Enhancing Drug Development for Paediatric Pulmonary Hypertension-An Integrative Perspective. Abstract
Procedural Variation May Contribute to 6-Minute Walk Distance Variability in Real-World Pediatric Pulmonary Arterial Hypertension Study. AAPS J. 2025 Jun 27; 27(5):114. View Procedural Variation May Contribute to 6-Minute Walk Distance Variability in Real-World Pediatric Pulmonary Arterial Hypertension Study. Abstract
Anxiety and Depression Screening of Youth in Pediatric Pulmonary Hypertension Clinic: A Multi-Center, Cross-Sectional Study. Pulm Circ. 2025 Apr; 15(2):e70117. View Anxiety and Depression Screening of Youth in Pediatric Pulmonary Hypertension Clinic: A Multi-Center, Cross-Sectional Study. Abstract
Interventional Strategies for Children with Progressive Pulmonary Hypertension Despite Optimal Therapy: An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2025 Feb; 211(2):157-173. View Interventional Strategies for Children with Progressive Pulmonary Hypertension Despite Optimal Therapy: An Official American Thoracic Society Clinical Practice Guideline. Abstract
SOX17-Associated Pulmonary Hypertension in Children: A Distinct Developmental and Clinical Syndrome. J Pediatr. 2025 Mar; 278:114422. View SOX17-Associated Pulmonary Hypertension in Children: A Distinct Developmental and Clinical Syndrome. Abstract
Actigraphy Study Endpoints to Reduce Sample Size and Facilitate Drug Development for Pediatric Pulmonary Arterial Hypertension. J Pediatr. 2025 Feb; 277:114383. View Actigraphy Study Endpoints to Reduce Sample Size and Facilitate Drug Development for Pediatric Pulmonary Arterial Hypertension. Abstract
An interdisciplinary consensus approach to pulmonary hypertension in developmental lung disease. Eur Respir J. 2024 Sep; 64(3). View An interdisciplinary consensus approach to pulmonary hypertension in developmental lung disease. Abstract
Correlation of Transthoracic Echocardiographic Estimates of Right Ventricular Pressure with Right Ventricular Pressure Measurements on Cardiac Catheterization in Children with Pulmonary Hypertension. J Cardiothorac Vasc Anesth. 2024 Dec; 38(12):3101-3108. View Correlation of Transthoracic Echocardiographic Estimates of Right Ventricular Pressure with Right Ventricular Pressure Measurements on Cardiac Catheterization in Children with Pulmonary Hypertension. Abstract
Disparities in Healthcare Utilization: An Analysis of Disease Specific and Patient Level Factors in a Congenital Diaphragmatic Hernia Clinic. J Pediatr Surg. 2024 Oct; 59(10):161569. View Disparities in Healthcare Utilization: An Analysis of Disease Specific and Patient Level Factors in a Congenital Diaphragmatic Hernia Clinic. Abstract
Exercise-Induced Pulmonary Hypertension in Long-Term Survivors of Congenital Diaphragmatic Hernia. J Pediatr. 2024 Aug; 271:114034. View Exercise-Induced Pulmonary Hypertension in Long-Term Survivors of Congenital Diaphragmatic Hernia. Abstract
Childhood Pulmonary Embolism: Characterizing a Critical and Challenging Diagnosis. JACC Adv. 2024 Apr; 3(4):100896. View Childhood Pulmonary Embolism: Characterizing a Critical and Challenging Diagnosis. Abstract
Actigraphy methodology in the Kids Mod PAH trial: Physical activity as a functional endpoint in pediatric clinical trials. Pulm Circ. 2024 Jan; 14(1):e12339. View Actigraphy methodology in the Kids Mod PAH trial: Physical activity as a functional endpoint in pediatric clinical trials. Abstract
Kids Mod PAH trial: A multicenter trial comparing mono- versus duo-therapy for initial treatment of pediatric pulmonary hypertension. Pulm Circ. 2023 Oct; 13(4):e12305. View Kids Mod PAH trial: A multicenter trial comparing mono- versus duo-therapy for initial treatment of pediatric pulmonary hypertension. Abstract
Measurement of Physical Activity by Actigraphy in Infants and Young Children with Pulmonary Arterial Hypertension. J Pediatr. 2023 11; 262:113639. View Measurement of Physical Activity by Actigraphy in Infants and Young Children with Pulmonary Arterial Hypertension. Abstract
Transcatheter Ductus Arteriosus Stenting for Acute Pediatric Pulmonary Arterial Hypertension is Associated with Improved Right Ventricular Echocardiography Strain. Pediatr Cardiol. 2024 Oct; 45(7):1573-1580. View Transcatheter Ductus Arteriosus Stenting for Acute Pediatric Pulmonary Arterial Hypertension is Associated with Improved Right Ventricular Echocardiography Strain. Abstract
Long-Term Functional Outcomes at 1-Year After Hospital Discharge in Critically Ill Neonates With Congenital Diaphragmatic Hernia. Pediatr Crit Care Med. 2023 08 01; 24(8):e372-e381. View Long-Term Functional Outcomes at 1-Year After Hospital Discharge in Critically Ill Neonates With Congenital Diaphragmatic Hernia. Abstract
Exercise Pathophysiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Postacute Sequelae of SARS-CoV-2: More in Common Than Not? Chest. 2023 09; 164(3):717-726. View Exercise Pathophysiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Postacute Sequelae of SARS-CoV-2: More in Common Than Not? Abstract
Pulmonary Hypertension in Infants and Children with Vein of Galen Malformation and Association with Clinical Outcomes. J Pediatr. 2023 07; 258:113404. View Pulmonary Hypertension in Infants and Children with Vein of Galen Malformation and Association with Clinical Outcomes. Abstract
Molecular Function and Contribution of TBX4 in Development and Disease. Am J Respir Crit Care Med. 2023 04 01; 207(7):855-864. View Molecular Function and Contribution of TBX4 in Development and Disease. Abstract
An intronic variant in TBX4 in a single family with variable and severe pulmonary manifestations. NPJ Genom Med. 2023 Mar 06; 8(1):7. View An intronic variant in TBX4 in a single family with variable and severe pulmonary manifestations. Abstract
JACC:Advances. Metabolomics in Single Ventricle Heart Disease: Glimpsing the Pathobiology of Stage 2 Palliation. 2023; 2(1). View JACC:Advances Abstract
Metabolomics in Single Ventricle Heart Disease: Glimpsing the Pathobiology of Stage 2 Palliation. JACC Adv. 2023 Jan; 2(1):100170. View Metabolomics in Single Ventricle Heart Disease: Glimpsing the Pathobiology of Stage 2 Palliation. Abstract
Understanding Genotype-Phenotype Correlations in Patients with TBX4 Mutations: New Views Inside and Outside the Box. Am J Respir Crit Care Med. 2022 12 15; 206(12):1448-1449. View Understanding Genotype-Phenotype Correlations in Patients with TBX4 Mutations: New Views Inside and Outside the Box. Abstract
Of Registries and Disease Classification: Unmasking the Challenges of Pediatric Pulmonary Hypertension. Am J Respir Crit Care Med. 2022 09 15; 206(6):664-665. View Of Registries and Disease Classification: Unmasking the Challenges of Pediatric Pulmonary Hypertension. Abstract
Pulmonary Hypertension in Children with Down Syndrome: Results from the Pediatric Pulmonary Hypertension Network Registry. J Pediatr. 2023 01; 252:131-140.e3. View Pulmonary Hypertension in Children with Down Syndrome: Results from the Pediatric Pulmonary Hypertension Network Registry. Abstract
Factors determining change in treatment for ambulatory children with pulmonary arterial hypertension: Implications for monitoring. Pulm Circ. 2022 Jul; 12(3):e12121. View Factors determining change in treatment for ambulatory children with pulmonary arterial hypertension: Implications for monitoring. Abstract
Outcomes for Children With Pulmonary Hypertension Undergoing Tracheostomy Placement: A Multi-Institutional Analysis. Pediatr Crit Care Med. 2022 09 01; 23(9):717-726. View Outcomes for Children With Pulmonary Hypertension Undergoing Tracheostomy Placement: A Multi-Institutional Analysis. Abstract
Cardiac Catheterization and Hemodynamics in a Multicenter Cohort of Children with Pulmonary Hypertension. Ann Am Thorac Soc. 2022 06; 19(6):1000-1012. View Cardiac Catheterization and Hemodynamics in a Multicenter Cohort of Children with Pulmonary Hypertension. Abstract
Case 2-2022: An Adolescent Male in Cardiac Arrest 3 Days After Liver Transplantation for End-Stage Liver Disease. Pediatr Crit Care Med. 2022 09 01; 23(9):e440-e450. View Case 2-2022: An Adolescent Male in Cardiac Arrest 3 Days After Liver Transplantation for End-Stage Liver Disease. Abstract
Diagnosis and management of pulmonary hypertension in infants with bronchopulmonary dysplasia. Semin Fetal Neonatal Med. 2022 08; 27(4):101351. View Diagnosis and management of pulmonary hypertension in infants with bronchopulmonary dysplasia. Abstract
Supraventricular Tachycardia in Infants With Congenital Diaphragmatic Hernia: Prevalence, Associations, and Outcomes. Pediatr Crit Care Med. 2022 07 01; 23(7):e329-e337. View Supraventricular Tachycardia in Infants With Congenital Diaphragmatic Hernia: Prevalence, Associations, and Outcomes. Abstract
Recovery of right ventricular function after bilateral lung transplantation for pediatric pulmonary hypertension. Pediatr Transplant. 2022 06; 26(4):e14236. View Recovery of right ventricular function after bilateral lung transplantation for pediatric pulmonary hypertension. Abstract
Serial cardiac biomarker assessment in adults with congenital heart disease hospitalized for decompensated heart failure?. Int J Cardiol Congenit Heart Dis. 2022 Mar; 7. View Serial cardiac biomarker assessment in adults with congenital heart disease hospitalized for decompensated heart failure?. Abstract
Characterisation of paediatric pulmonary hypertensive vascular disease from the PPHNet Registry. Eur Respir J. 2022 01; 59(1). View Characterisation of paediatric pulmonary hypertensive vascular disease from the PPHNet Registry. Abstract
High altitude simulation testing in patients with congenital diaphragmatic hernia. J Pediatr Surg. 2022 Feb; 57(2):195-198. View High altitude simulation testing in patients with congenital diaphragmatic hernia. Abstract
Biomarkers of Pulmonary Hypertension Are Altered in Children with Down Syndrome and Pulmonary Hypertension. J Pediatr. 2022 02; 241:68-76.e3. View Biomarkers of Pulmonary Hypertension Are Altered in Children with Down Syndrome and Pulmonary Hypertension. Abstract
Isolation and Culturing Primary Chaolangiocytes from Mouse Liver. Bio Protoc. 2021 Oct 20; 11(20):e4192. View Isolation and Culturing Primary Chaolangiocytes from Mouse Liver. Abstract
A homozygous stop-gain variant in ARHGAP42 is associated with childhood interstitial lung disease, systemic hypertension, and immunological findings. PLoS Genet. 2021 07; 17(7):e1009639. View A homozygous stop-gain variant in ARHGAP42 is associated with childhood interstitial lung disease, systemic hypertension, and immunological findings. Abstract
Lower oxygen saturation targets in preterm infants are not associated with increased rates of pulmonary hypertension. J Neonatal Perinatal Med. 2021; 14(4):519-526. View Lower oxygen saturation targets in preterm infants are not associated with increased rates of pulmonary hypertension. Abstract
Prostanoids in pediatric pulmonary hypertension: clinical response, time-to-effect, and dose-response. Pulm Circ. 2020 Oct-Dec; 10(4):2045894020944858. View Prostanoids in pediatric pulmonary hypertension: clinical response, time-to-effect, and dose-response. Abstract
Long-Term Fate of the Truncal Valve. J Am Heart Assoc. 2020 11 17; 9(22):e019104. View Long-Term Fate of the Truncal Valve. Abstract
Prenatal duct closure leading to severe pulmonary hypertension in a preterm neonate-a case report. Cardiovasc Diagn Ther. 2020 Oct; 10(5):1691-1695. View Prenatal duct closure leading to severe pulmonary hypertension in a preterm neonate-a case report. Abstract
Pharmacokinetics of Oral Treprostinil in Children With Pulmonary Arterial Hypertension. J Cardiovasc Pharmacol. 2020 07; 76(1):94-100. View Pharmacokinetics of Oral Treprostinil in Children With Pulmonary Arterial Hypertension. Abstract
Adverse drug event rates in pediatric pulmonary hypertension: a comparison of real-world data sources. J Am Med Inform Assoc. 2020 02 01; 27(2):294-300. View Adverse drug event rates in pediatric pulmonary hypertension: a comparison of real-world data sources. Abstract
Longitudinal Analysis of Ventilation Perfusion Mismatch in Congenital Diaphragmatic Hernia Survivors. J Pediatr. 2020 04; 219:160-166.e2. View Longitudinal Analysis of Ventilation Perfusion Mismatch in Congenital Diaphragmatic Hernia Survivors. Abstract
Phenotype characterisation of TBX4 mutation and deletion carriers with neonatal and paediatric pulmonary hypertension. Eur Respir J. 2019 08; 54(2). View Phenotype characterisation of TBX4 mutation and deletion carriers with neonatal and paediatric pulmonary hypertension. Abstract
Standardized outcomes in reproductive cardiovascular care: The STORCC initiative. Am Heart J. 2019 11; 217:112-120. View Standardized outcomes in reproductive cardiovascular care: The STORCC initiative. Abstract
Improving Safety of Intravenous Prostacyclin Administration to Pediatric Patients With Pulmonary Hypertension. Crit Care Nurse. 2019 Aug; 39(4):e1-e7. View Improving Safety of Intravenous Prostacyclin Administration to Pediatric Patients With Pulmonary Hypertension. Abstract
Oral treprostinil in transition or as add-on therapy in pediatric pulmonary arterial hypertension. Pulm Circ. 2019 Jul-Sep; 9(3):2045894019856471. View Oral treprostinil in transition or as add-on therapy in pediatric pulmonary arterial hypertension. Abstract
Racial and Ethnic Differences in Pediatric Pulmonary Hypertension: An Analysis of the Pediatric Pulmonary Hypertension Network Registry. J Pediatr. 2019 08; 211:63-71.e6. View Racial and Ethnic Differences in Pediatric Pulmonary Hypertension: An Analysis of the Pediatric Pulmonary Hypertension Network Registry. Abstract
Feature extraction for phenotyping from semantic and knowledge resources. J Biomed Inform. 2019 03; 91:103122. View Feature extraction for phenotyping from semantic and knowledge resources. Abstract
Pulmonary Artery Banding in Post-tricuspid Congenital Cardiac Shunting Defects with High Pulmonary Vascular Resistance. Pediatr Cardiol. 2019 Apr; 40(4):719-725. View Pulmonary Artery Banding in Post-tricuspid Congenital Cardiac Shunting Defects with High Pulmonary Vascular Resistance. Abstract
The Left Ventricle in Congenital Diaphragmatic Hernia: Implications for the Management of Pulmonary Hypertension. J Pediatr. 2018 06; 197:17-22. View The Left Ventricle in Congenital Diaphragmatic Hernia: Implications for the Management of Pulmonary Hypertension. Abstract
Evaluation and Management of Pulmonary Hypertension in Children with Bronchopulmonary Dysplasia. J Pediatr. 2017 09; 188:24-34.e1. View Evaluation and Management of Pulmonary Hypertension in Children with Bronchopulmonary Dysplasia. Abstract
A Computable Phenotype Improves Cohort Ascertainment in a Pediatric Pulmonary Hypertension Registry. J Pediatr. 2017 09; 188:224-231.e5. View A Computable Phenotype Improves Cohort Ascertainment in a Pediatric Pulmonary Hypertension Registry. Abstract
Learning a Comorbidity-Driven Taxonomy of Pediatric Pulmonary Hypertension. Circ Res. 2017 Aug 04; 121(4):341-353. View Learning a Comorbidity-Driven Taxonomy of Pediatric Pulmonary Hypertension. Abstract
Recommendations for the Use of Inhaled Nitric Oxide Therapy in Premature Newborns with Severe Pulmonary Hypertension. J Pediatr. 2016 Mar; 170:312-4. View Recommendations for the Use of Inhaled Nitric Oxide Therapy in Premature Newborns with Severe Pulmonary Hypertension. Abstract
Pediatric Pulmonary Hypertension: Guidelines From the American Heart Association and American Thoracic Society. Circulation. 2015 Nov 24; 132(21):2037-99. View Pediatric Pulmonary Hypertension: Guidelines From the American Heart Association and American Thoracic Society. Abstract
Lung Pathology in Pediatric Pulmonary Vein Stenosis. Pediatr Dev Pathol. 2016 May-Jun; 19(3):219-29. View Lung Pathology in Pediatric Pulmonary Vein Stenosis. Abstract
Central venous line complications with chronic ambulatory infusion of prostacyclin analogues in pediatric patients with pulmonary arterial hypertension. Pulm Circ. 2015 Jun; 5(2):322-326. View Central venous line complications with chronic ambulatory infusion of prostacyclin analogues in pediatric patients with pulmonary arterial hypertension. Abstract
Chromosome microarray testing for patients with congenital heart defects reveals novel disease causing loci and high diagnostic yield. BMC Genomics. 2014 Dec 17; 15:1127. View Chromosome microarray testing for patients with congenital heart defects reveals novel disease causing loci and high diagnostic yield. Abstract
Response. Chest. 2014 Jun; 145(6):1439. View Response. Abstract
Quality of life and parental adjustment in pediatric pulmonary hypertension. Chest. 2014 Feb; 145(2):237-244. View Quality of life and parental adjustment in pediatric pulmonary hypertension. Abstract
Pulmonary hypertension associated with scurvy and vitamin deficiencies in an autistic child. Pediatrics. 2013 Dec; 132(6):e1699-703. View Pulmonary hypertension associated with scurvy and vitamin deficiencies in an autistic child. Abstract
Right heart failure: toward a common language. J Heart Lung Transplant. 2014 Feb; 33(2):123-6. View Right heart failure: toward a common language. Abstract
Effect of inhaled iloprost on the exercise function of Fontan patients: a demonstration of concept. Int J Cardiol. 2013 Oct 03; 168(3):2435-40. View Effect of inhaled iloprost on the exercise function of Fontan patients: a demonstration of concept. Abstract
Transcatheter Potts shunt creation in patients with severe pulmonary arterial hypertension: initial clinical experience. J Heart Lung Transplant. 2013 Apr; 32(4):381-7. View Transcatheter Potts shunt creation in patients with severe pulmonary arterial hypertension: initial clinical experience. Abstract
Obstruction of the superior vena cava after neonatal extracorporeal membrane oxygenation: association with chylothorax and outcome of transcatheter treatment. Pediatr Crit Care Med. 2013 Jan; 14(1):37-43. View Obstruction of the superior vena cava after neonatal extracorporeal membrane oxygenation: association with chylothorax and outcome of transcatheter treatment. Abstract
Implications of the U.S. Food and Drug Administration warning against the use of sildenafil for the treatment of pediatric pulmonary hypertension. Am J Respir Crit Care Med. 2013 Mar 15; 187(6):572-5. View Implications of the U.S. Food and Drug Administration warning against the use of sildenafil for the treatment of pediatric pulmonary hypertension. Abstract
Bilateral lung transplant for hereditary hemorrhagic telangiectasia in a pediatric patient. Pediatr Transplant. 2012 Dec; 16(8):E364-7. View Bilateral lung transplant for hereditary hemorrhagic telangiectasia in a pediatric patient. Abstract
Treatment of segmental pulmonary artery hypertension in adults with congenital heart disease. Int J Cardiol. 2013 Mar 20; 164(1):106-10. View Treatment of segmental pulmonary artery hypertension in adults with congenital heart disease. Abstract
Pulmonary arterial hypertension: what the large pulmonary arteries tell us. Pediatr Cardiol. 2011 Aug; 32(6):759-65. View Pulmonary arterial hypertension: what the large pulmonary arteries tell us. Abstract
Pulmonary arterial hypertension in infants with chronic lung disease: will we ever understand it? J Pediatr. 2010 Aug; 157(2):186-90. View Pulmonary arterial hypertension in infants with chronic lung disease: will we ever understand it? Abstract
Diagnostic strategies for acute presentation of pulmonary hypertension in children: particular focus on use of echocardiography, cardiac catheterization, magnetic resonance imaging, chest computed tomography, and lung biopsy. Pediatr Crit Care Med. 2010 Mar; 11(2 Suppl):S23-6. View Diagnostic strategies for acute presentation of pulmonary hypertension in children: particular focus on use of echocardiography, cardiac catheterization, magnetic resonance imaging, chest computed tomography, and lung biopsy. Abstract
Lung abscess in adults with tetralogy of fallot and pulmonary atresia. Cardiol Young. 2010 Feb; 20(1):91-3. View Lung abscess in adults with tetralogy of fallot and pulmonary atresia. Abstract
Clinical features of pulmonary arterial hypertension in young people with an ALK1 mutation and hereditary haemorrhagic telangiectasia. Arch Dis Child. 2009 Jul; 94(7):506-11. View Clinical features of pulmonary arterial hypertension in young people with an ALK1 mutation and hereditary haemorrhagic telangiectasia. Abstract
The incidence and implications of anti-heparin-platelet factor 4 antibody formation in a pediatric cardiac surgical population. Anesth Analg. 2008 Aug; 107(2):371-8. View The incidence and implications of anti-heparin-platelet factor 4 antibody formation in a pediatric cardiac surgical population. Abstract
Pulmonary artery hypertension in formerly premature infants with bronchopulmonary dysplasia: clinical features and outcomes in the surfactant era. Pediatrics. 2007 Dec; 120(6):1260-9. View Pulmonary artery hypertension in formerly premature infants with bronchopulmonary dysplasia: clinical features and outcomes in the surfactant era. Abstract
Cardiovascular malformations in Fryns syndrome: is there a pathogenic role for neural crest cells? Am J Med Genet A. 2005 Dec 15; 139(3):186-93. View Cardiovascular malformations in Fryns syndrome: is there a pathogenic role for neural crest cells? Abstract
Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy. N Engl J Med. 2000 Dec 07; 343(23):1688-96. View Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy. Abstract
Alpha-tropomyosin mutually exclusive exon selection: competition between branchpoint/polypyrimidine tracts determines default exon choice. Genes Dev. 1991 Apr; 5(4):642-55. View Alpha-tropomyosin mutually exclusive exon selection: competition between branchpoint/polypyrimidine tracts determines default exon choice. Abstract
Carcinogenic effects of monofunctional and bifunctional furocoumarins. Natl Cancer Inst Monogr. 1984 Dec; 66:205-10. View Carcinogenic effects of monofunctional and bifunctional furocoumarins. Abstract