Max Horlbeck

Multiscale footprints reveal the organization of cis-regulatory elements. Nature. 2025 Feb; 638(8051):779-786. View Multiscale footprints reveal the organization of cis-regulatory elements. Abstract

Novel Phenotypes and Genotype-Phenotype Correlations in a Large Clinical Cohort of Patients With Kleefstra Syndrome. Clin Genet. 2025 Jun; 107(6):636-645. View Novel Phenotypes and Genotype-Phenotype Correlations in a Large Clinical Cohort of Patients With Kleefstra Syndrome. Abstract

FET fusion oncoproteins disrupt physiologic DNA repair networks in cancer. bioRxiv. 2024 Nov 21. View FET fusion oncoproteins disrupt physiologic DNA repair networks in cancer. Abstract

CRISPRi screens identify the lncRNA, LOUP, as a multifunctional locus regulating macrophage differentiation and inflammatory signaling. Proc Natl Acad Sci U S A. 2024 May 28; 121(22):e2322524121. View CRISPRi screens identify the lncRNA, LOUP, as a multifunctional locus regulating macrophage differentiation and inflammatory signaling. Abstract

FET fusion oncoproteins disrupt physiologic DNA repair networks and induce ATR synthetic lethality in cancer. Res Sq. 2023 May 29. View FET fusion oncoproteins disrupt physiologic DNA repair networks and induce ATR synthetic lethality in cancer. Abstract

Single-cell multi-scale footprinting reveals the modular organization of DNA regulatory elements. bioRxiv. 2023 Mar 29. View Single-cell multi-scale footprinting reveals the modular organization of DNA regulatory elements. Abstract

GATOR2-dependent mTORC1 activity is a therapeutic vulnerability in FOXO1 fusion-positive rhabdomyosarcoma. JCI Insight. 2022 12 08; 7(23). View GATOR2-dependent mTORC1 activity is a therapeutic vulnerability in FOXO1 fusion-positive rhabdomyosarcoma. Abstract

Dual genome-wide coding and lncRNA screens in neural induction of induced pluripotent stem cells. Cell Genom. 2022 Nov 09; 2(11). View Dual genome-wide coding and lncRNA screens in neural induction of induced pluripotent stem cells. Abstract

Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells. Elife. 2021 05 26; 10. View Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells. Abstract

High-content imaging-based pooled CRISPR screens in mammalian cells. J Cell Biol. 2021 02 01; 220(2). View High-content imaging-based pooled CRISPR screens in mammalian cells. Abstract

Genome-Scale Perturbation of Long Noncoding RNA Expression Using CRISPR Interference. Methods Mol Biol. 2021; 2254:323-338. View Genome-Scale Perturbation of Long Noncoding RNA Expression Using CRISPR Interference. Abstract

Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent. Mol Cell. 2020 07 02; 79(1):191-198.e3. View Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent. Abstract

CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma. Genome Biol. 2020 03 31; 21(1):83. View CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma. Abstract

Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes. Nat Biotechnol. 2020 May; 38(5):573-576. View Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes. Abstract

Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs. Nat Biotechnol. 2020 Mar; 38(3):355-364. View Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs. Abstract

New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells. J Cell Biol. 2019 11 04; 218(11):3861-3879. View New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells. Abstract

Exploring genetic interaction manifolds constructed from rich single-cell phenotypes. Science. 2019 08 23; 365(6455):786-793. View Exploring genetic interaction manifolds constructed from rich single-cell phenotypes. Abstract

Cellular response to small molecules that selectively stall protein synthesis by the ribosome. PLoS Genet. 2019 03; 15(3):e1008057. View Cellular response to small molecules that selectively stall protein synthesis by the ribosome. Abstract

A high-throughput screen of real-time ATP levels in individual cells reveals mechanisms of energy failure. PLoS Biol. 2018 08; 16(8):e2004624. View A high-throughput screen of real-time ATP levels in individual cells reveals mechanisms of energy failure. Abstract

Mapping the Genetic Landscape of Human Cells. Cell. 2018 08 09; 174(4):953-967.e22. View Mapping the Genetic Landscape of Human Cells. Abstract

Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform. Hepatology. 2018 Aug; 68(2):663-676. View Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform. Abstract

Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates. Elife. 2018 05 10; 7. View Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates. Abstract

Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element. Cell. 2018 05 31; 173(6):1398-1412.e22. View Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element. Abstract

Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins. Elife. 2018 01 23; 7. View Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins. Abstract

Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent. Mol Cell. 2017 Oct 05; 68(1):210-223.e6. View Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent. Abstract

A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response. Cell. 2016 Dec 15; 167(7):1867-1882.e21. View A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response. Abstract

CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells. Science. 2017 01 06; 355(6320). View CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells. Abstract

Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation. Elife. 2016 Sep 23; 5. View Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation. Abstract

Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):E3892-900. View Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation. Abstract

Single-cell analysis of long non-coding RNAs in the developing human neocortex. Genome Biol. 2016 Apr 14; 17:67. View Single-cell analysis of long non-coding RNAs in the developing human neocortex. Abstract

Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification. Nat Chem Biol. 2016 May; 12(5):361-6. View Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification. Abstract

Nucleosomes impede Cas9 access to DNA in vivo and in vitro. Elife. 2016 03 17; 5. View Nucleosomes impede Cas9 access to DNA in vivo and in vitro. Abstract

CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs. Cell Stem Cell. 2016 Apr 07; 18(4):541-53. View CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs. Abstract

Next-generation libraries for robust RNA interference-based genome-wide screens. Proc Natl Acad Sci U S A. 2015 Jun 30; 112(26):E3384-91. View Next-generation libraries for robust RNA interference-based genome-wide screens. Abstract

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation. Cell. 2014 Oct 23; 159(3):647-61. View Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation. Abstract

A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. Cell. 2013 Feb 14; 152(4):909-22. View A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. Abstract

ER cargo properties specify a requirement for COPII coat rigidity mediated by Sec13p. Science. 2012 Mar 16; 335(6074):1359-62. View ER cargo properties specify a requirement for COPII coat rigidity mediated by Sec13p. Abstract

[Initial results following implantation of silastic wrist joint prostheses in patients with chronic polyarthritis with additional use of titanium grommets]. Handchir Mikrochir Plast Chir. 1989 Jan; 21(1):48-50. View [Initial results following implantation of silastic wrist joint prostheses in patients with chronic polyarthritis with additional use of titanium grommets]. Abstract