Lara Wahlster

ANKRD26-related Thrombocytopenia 2 with a Baseline Increase in Blasts: Implications for Clinical Surveillance. Blood. 2025 May 07. View ANKRD26-related Thrombocytopenia 2 with a Baseline Increase in Blasts: Implications for Clinical Surveillance. Abstract

Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes. Science. 2025 04 04; 388(6742):52-59. View Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes. Abstract

Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation. bioRxiv. 2025 Mar 26. View Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation. Abstract

CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias. bioRxiv. 2024 Dec 30. View CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias. Abstract

Regulated GATA1 expression as a universal gene therapy for Diamond-Blackfan anemia. Cell Stem Cell. 2025 Jan 02; 32(1):38-52.e6. View Regulated GATA1 expression as a universal gene therapy for Diamond-Blackfan anemia. Abstract

Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes. bioRxiv. 2024 Sep 09. View Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes. Abstract

A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children. Cell Genom. 2024 Apr 10; 4(4):100526. View A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children. Abstract

Editorial: Advances in predisposition to bone marrow failure and hematopoietic neoplasms. Front Oncol. 2024; 14:1377974. View Editorial: Advances in predisposition to bone marrow failure and hematopoietic neoplasms. Abstract

Deciphering cell states and genealogies of human haematopoiesis. Nature. 2024 Mar; 627(8003):389-398. View Deciphering cell states and genealogies of human haematopoiesis. Abstract

High-content screening identifies a small molecule that restores AP-4-dependent protein trafficking in neuronal models of AP-4-associated hereditary spastic paraplegia. Nat Commun. 2024 Jan 17; 15(1):584. View High-content screening identifies a small molecule that restores AP-4-dependent protein trafficking in neuronal models of AP-4-associated hereditary spastic paraplegia. Abstract

High-Content Small Molecule Screen Identifies a Novel Compound That Restores AP-4-Dependent Protein Trafficking in Neuronal Models of AP-4-Associated Hereditary Spastic Paraplegia. Res Sq. 2023 Jun 12. View High-Content Small Molecule Screen Identifies a Novel Compound That Restores AP-4-Dependent Protein Trafficking in Neuronal Models of AP-4-Associated Hereditary Spastic Paraplegia. Abstract

Massively parallel base editing to map variant effects in human hematopoiesis. Cell. 2023 05 25; 186(11):2456-2474.e24. View Massively parallel base editing to map variant effects in human hematopoiesis. Abstract

A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia. Nat Immunol. 2023 01; 24(1):69-83. View A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia. Abstract

Familial thrombocytopenia due to a complex structural variant resulting in a WAC-ANKRD26 fusion transcript. J Exp Med. 2021 06 07; 218(6). View Familial thrombocytopenia due to a complex structural variant resulting in a WAC-ANKRD26 fusion transcript. Abstract

I SPI1 something needed for B cells. J Exp Med. 2021 07 05; 218(7). View I SPI1 something needed for B cells. Abstract

COVID-19 presenting with autoimmune hemolytic anemia in the setting of underlying immune dysregulation. Pediatr Blood Cancer. 2020 09; 67(9):e28382. View COVID-19 presenting with autoimmune hemolytic anemia in the setting of underlying immune dysregulation. Abstract

A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development. Cell Stem Cell. 2018 04 05; 22(4):575-588.e7. View A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development. Abstract

Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors. Sci Transl Med. 2017 02 08; 9(376). View Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors. Abstract

Using tuberous sclerosis complex to understand the impact of MTORC1 signaling on mitochondrial dynamics and mitophagy in neurons. Autophagy. 2017 Apr 03; 13(4):754-756. View Using tuberous sclerosis complex to understand the impact of MTORC1 signaling on mitochondrial dynamics and mitophagy in neurons. Abstract

Impaired Mitochondrial Dynamics And Mitophagy In Neuronal Models Of Tuberous Sclerosis Complex. Cell Rep. 2016 11 15; 17(8):2162. View Impaired Mitochondrial Dynamics And Mitophagy In Neuronal Models Of Tuberous Sclerosis Complex. Abstract

Impaired Mitochondrial Dynamics and Mitophagy in Neuronal Models of Tuberous Sclerosis Complex. Cell Rep. 2016 10 18; 17(4):1053-1070. View Impaired Mitochondrial Dynamics and Mitophagy in Neuronal Models of Tuberous Sclerosis Complex. Abstract

Progress towards generation of human haematopoietic stem cells. Nat Cell Biol. 2016 Nov; 18(11):1111-1117. View Progress towards generation of human haematopoietic stem cells. Abstract

Reduction of TMEM97 increases NPC1 protein levels and restores cholesterol trafficking in Niemann-pick type C1 disease cells. Hum Mol Genet. 2016 08 15; 25(16):3588-3599. View Reduction of TMEM97 increases NPC1 protein levels and restores cholesterol trafficking in Niemann-pick type C1 disease cells. Abstract

Congenital disorders of autophagy: an emerging novel class of inborn errors of neuro-metabolism. Brain. 2016 Feb; 139(Pt 2):317-37. View Congenital disorders of autophagy: an emerging novel class of inborn errors of neuro-metabolism. Abstract

Parkinson's disease: A disorder of axonal mitophagy? Mov Disord. 2014 Nov; 29(13):1582. View Parkinson's disease: A disorder of axonal mitophagy? Abstract

International electives in the final year of German medical school education--a student's perspective. GMS Z Med Ausbild. 2014; 31(3):Doc26. View International electives in the final year of German medical school education--a student's perspective. Abstract

Modeling Parkinson's disease in a dish--a story of yeast and men. Mov Disord. 2014 Jan; 29(1):34. View Modeling Parkinson's disease in a dish--a story of yeast and men. Abstract

Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathies. Acta Neuropathol Commun. 2013 Dec 05; 1:79. View Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathies. Abstract

Emerging role of autophagy in pediatric neurodegenerative and neurometabolic diseases. Pediatr Res. 2014 Jan; 75(1-2):217-26. View Emerging role of autophagy in pediatric neurodegenerative and neurometabolic diseases. Abstract

Restoring impaired protein metabolism in Parkinson's disease--TFEB-mediated autophagy as a novel therapeutic target. Mov Disord. 2013 Sep; 28(10):1346. View Restoring impaired protein metabolism in Parkinson's disease--TFEB-mediated autophagy as a novel therapeutic target. Abstract

Proteotoxicity and cardiac dysfunction. N Engl J Med. 2013 05 02; 368(18):1754. View Proteotoxicity and cardiac dysfunction. Abstract

Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer's disease. Acta Neuropathol. 2013 Feb; 125(2):187-99. View Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer's disease. Abstract

Familial Mediterranean fever in Germany: clinical presentation and amyloidosis risk. Scand J Rheumatol. 2013; 42(1):52-8. View Familial Mediterranean fever in Germany: clinical presentation and amyloidosis risk. Abstract

Protein degradation pathways in Parkinson's disease: curse or blessing. Acta Neuropathol. 2012 Aug; 124(2):153-72. View Protein degradation pathways in Parkinson's disease: curse or blessing. Abstract

Molecular chaperones in Parkinson's disease--present and future. J Parkinsons Dis. 2011; 1(4):299-320. View Molecular chaperones in Parkinson's disease--present and future. Abstract

Clinical manifestations and longterm followup of a patient with CINCA/NOMID syndrome. J Rheumatol. 2010 Oct; 37(10):2196-7. View Clinical manifestations and longterm followup of a patient with CINCA/NOMID syndrome. Abstract