Current Environment: Production

Medical Services

Specialties

Programs & Services

Languages

  • Dutch
  • English
  • Spanish

Education

Undergraduate School

Utrecht University

2010, Utrecht, Netherlands

Medical School

Utrecht University

2014, Utrecht, Netherlands

Graduate School

Utrecht University (in collaboration with The Rockefeller University)

2018, Utrecht, Netherlands

Internship

Boston Combined Residency Program (BCRP)

2019, Boston, MA

Residency

Boston Combined Residency Program (BCRP)

2021, Boston, MA

Fellowship

Allergy/Immunology

Boston Children's Hospital

2024, Boston, MA

Certifications

  • American Board of Allergy & Immunology (General)
  • American Board of Pediatrics (General)

Professional History

David Hoytema van Konijnenburg completed his MD, PhD at Utrecht University, with PhD research in Immunology completed in the Van Wijk lab in Utrecht and in the Mucida lab at The Rockefeller University in New York, NY. His research focused on intestinal T cells in gut homeostasis, inflammation and infection using a combination of techniques including live imaging. Next, Dr. Hoytema completed pediatrics residency at Boston Childrens Hospital and Harvard Medical School / Boston Medical Center and Boston University (Boston Combined Residency Program in Pediatrics) concurrent with research in the Kirchhausen lab and Zon lab at Harvard Medical School, where he studied the function of tissue-resident immune cells in the skin and tumors. After pediatrics residency, Dr. Hoytema completed Allergy and Immunology fellowship at Boston Children's Hospital and Harvard Medical School.

Dr. Hoytema is a current Allergy and Immunology Attending Physician at Boston Children's Hospital and Instructor at Harvard Medical School, working in Nigrovic lab and Zanoni lab on tissue-resident immune cells in the lung. Clinically, Dr. Hoytema is especially passionate about providing care for patients with immune dysregulation syndromes or immunodeficiency, with a focus on immunogenetics and research-based clinical care for patients with rare diseases of the immune system. Dr. Hoytema has won several awards for his research and clinical work. He is a member of the MIDAS program for immune dysregulation, the Immunogenetics program and the program for Interstitial Lung Diseases. Dr. Hoytema is Board Certified in Pediatrics and Allergy/Immunology.

Publications

  1. Clinical manifestations, disease penetrance, and treatment in individuals with SOCS1 insufficiency: a registry-based and population-based study. Lancet Rheumatol. 2025 Feb 27. View Abstract

  2. Monoallelic expression can govern penetrance of inborn errors of immunity. Nature. 2025 Jan; 637(8048):1186-1197. View Abstract

  3. Regional specialization within the mammalian respiratory immune system. Trends Immunol. 2024 Nov; 45(11):871-891. View Abstract

  4. Compartment-driven imprinting of intestinal CD4 T cells in inflammatory bowel disease and homeostasis. Clin Exp Immunol. 2023 12 13; 214(3):235-248. View Abstract

  5. Rethinking Immunological Risk: A Retrospective Cohort Study of Severe SARS-Cov-2 Infections in Individuals With Congenital Immunodeficiencies. J Allergy Clin Immunol Pract. 2023 11; 11(11):3391-3399.e3. View Abstract

  6. Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges. J Exp Med. 2019 04 01; 216(4):786-806. View Abstract

  7. The elusive case of human intraepithelial T cells in gut homeostasis and inflammation. Nat Rev Gastroenterol Hepatol. 2018 10; 15(10):637-649. View Abstract

  8. PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation. J Clin Invest. 2018 10 01; 128(10):4669-4681. View Abstract

  9. Intestinal Epithelial and Intraepithelial T Cell Crosstalk Mediates a Dynamic Response to Infection. Cell. 2017 Nov 02; 171(4):783-794.e13. View Abstract

  10. Intraepithelial lymphocytes. Curr Biol. 2017 Aug 07; 27(15):R737-R739. View Abstract

  11. Tissue adaptation of regulatory and intraepithelial CD4? T cells controls gut inflammation. Science. 2016 Jun 24; 352(6293):1581-6. View Abstract

  12. Transcription factor T-bet regulates intraepithelial lymphocyte functional maturation. Immunity. 2014 Aug 21; 41(2):244-56. View Abstract

  13. The role of prolonged viral gastrointestinal infections in the development of immunodeficiency-related enteropathy. Clin Rev Allergy Immunol. 2012 Feb; 42(1):79-91. View Abstract

  14. Airway and interstitial lung disease are distinct entities in paediatric common variable immunodeficiency. Clin Exp Immunol. 2011 Aug; 165(2):235-42. View Abstract

  15. A CT scan score for the assessment of lung disease in children with common variable immunodeficiency disorders. Chest. 2010 Aug; 138(2):371-9. View Abstract

I believe in providing each patient with the best possible diagnosis and treatment options based on a scientific approach to their problem. I aim to provide families with the knowledge and understanding they need to make the best decision for their child's care. I am especially passionate about finding creative, "out-of-the-box" solutions for patients with rare disorders or challenging problems.

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