Summary
The goal of the Fontan Imaging Biomarkers (FIB) study is to identify the associations of blood and urine biomarkers to imaging parameters of ventricular mechanics.
Conditions
Single-ventricle, Congenital Heart Disease
Recruitment Status
Completed
Detailed Description
This study has the following research questions: What is the reproducibility of ventricular systolic function measurements (including ventricular strain) in Fontan patients using echocardiography (Echo) and cardiac magnetic resonance imaging (CMR)? What is the reproducibility of ventricular diastolic function measurements (including tissue Doppler and strain rate) in Fontan patients using Echo and CMR? Is there a correlation between ventricular function measurements and circulating biomarkers (including galectin-3 levels, NT-proBNP, ST2, and MELD-XI score)?
Eligibility Criteria
Inclusion Criteria:
All patients with Fontan circulation undergoing clinically indicated CMR at Boston Children's Hospital will be considered for the study
Exclusion Criteria:
Inadequate imaging quality to perform proposed analysis
Patients <15 kg will be excluded to simplify compliance with BCH minimal risk research blood draw volume guidelines (minimal risk is defined as < 5% total blood volume)
Gender
All
Min Age
3 Years
Max Age
N/A
Download Date
November 5, 2021
Principal Investigator
Rahul Rathod
Primary Contact Information
For more information on this trial, visit clinicaltrials.gov.
Contact
For more information and to contact the study team: