Current Environment: Production

Medical Services

Specialties

Programs & Services

Languages

  • English
  • Japanese

Education

Graduate School

Keio University

1989, Tokyo, Japan

Medical School

Keio University School of Medicine

1993, Tokyo, Japan

Internship

Keio University

1995, Tokyo, Japan

Residency

Massachusetts General Hospital

1998, Boston, MA

Fellowship

Boston Children's Hospital

2000, Boston, MA

Certifications

  • American Board of Clinical Neurophysiology
  • American Board of Psychiatry and Neurology (Child and Adolescent Neurology)
  • American Board of Psychiatry and Neurology (Neurology)

Publications

  1. Epilepsy surgery in Sturge-Weber syndrome with unilateral or bilateral asymmetric brain involvement: Boston Children's Hospital experience. Epilepsia. 2025 Mar 24. View Abstract

  2. Variation in neuroimaging and outcomes in patients with Sturge Weber syndrome Type III. Brain Dev. 2024 Aug; 46(7):244-249. View Abstract

  3. Interictal Connectivity Revealed by Granger Analysis of Stereoelectroencephalography: Association With Ictal Onset Zone, Resection, and Outcome. Neurosurgery. 2022 10 01; 91(4):583-589. View Abstract

  4. Infantile Hemiconvulsion-Hemiplegia and Epilepsy (IHHE) in a boy with tuberous sclerosis complex. Epilepsy Behav Rep. 2021; 16:100473. View Abstract

  5. Mortality in infantile spasms: A hospital-based study. Epilepsia. 2020 04; 61(4):702-713. View Abstract

  6. Neuroimaging in Pediatric Epilepsy. Brain Sci. 2019 Aug 07; 9(8). View Abstract

  7. Yield of Emergent Neuroimaging in Patients With Sturge-Weber Syndrome Presenting With Acute Neurologic Symptoms. J Child Neurol. 2019 01; 34(1):17-21. View Abstract

  8. Transient regional cerebral hypoperfusion during a paroxysmal hemiplegic event in GLUT1 deficiency syndrome. Eur J Paediatr Neurol. 2018 May; 22(3):544-547. View Abstract

  9. Response to clobazam in continuous spike-wave during sleep. Dev Med Child Neurol. 2018 03; 60(3):283-289. View Abstract

  10. Systemic Manifestations in Pyridox(am)ine 5'-Phosphate Oxidase Deficiency. Pediatr Neurol. 2017 Nov; 76:47-53. View Abstract

  11. Genetics and genotype-phenotype correlations in early onset epileptic encephalopathy with burst suppression. Ann Neurol. 2017 Mar; 81(3):419-429. View Abstract

  12. Compound heterozygosity with PRRT2: Pushing the phenotypic envelope in genetic epilepsies. Epilepsy Behav Case Rep. 2019; 11:125-128. View Abstract

  13. Sturge-Weber Syndrome: Brain Magnetic Resonance Imaging and Neuropathology Findings. Pediatr Neurol. 2016 05; 58:25-30. View Abstract

  14. Utility of initial EEG in first complex febrile seizure. Epilepsy Behav. 2015 Nov; 52(Pt A):200-4. View Abstract

  15. Pediatric anti-Hu-associated encephalitis with clinical features of Rasmussen encephalitis. Neurol Neuroimmunol Neuroinflamm. 2015 Oct; 2(5):e150. View Abstract

  16. Clinical and Neuroimaging Profile of Children with Lesions in the Corpus Callosum. J Neuroimaging. 2015 Sep-Oct; 25(5):824-31. View Abstract

  17. Safety and retention rate of rufinamide in 300 patients: a single pediatric epilepsy center experience. Epilepsia. 2014 Aug; 55(8):1235-44. View Abstract

  18. Copy number variation plays an important role in clinical epilepsy. Ann Neurol. 2014 Jun; 75(6):943-58. View Abstract

  19. Surgery for intractable epilepsy due to unilateral brain disease: a retrospective study comparing hemispherectomy techniques. Pediatr Neurol. 2014 Sep; 51(3):336-43. View Abstract

  20. Clobazam: effect on frequency of seizures and safety profile in different subgroups of children with epilepsy. Pediatr Neurol. 2014 Jul; 51(1):60-6. View Abstract

  21. Long-term response to high-dose diazepam treatment in continuous spikes and waves during sleep. Pediatr Neurol. 2013 Sep; 49(3):163-170.e4. View Abstract

  22. Electrode localization for planning surgical resection of the epileptogenic zone in pediatric epilepsy. Int J Comput Assist Radiol Surg. 2014 Jan; 9(1):91-105. View Abstract

  23. Predictors of seizure occurrence in children undergoing pre-surgical monitoring. Seizure. 2013 Oct; 22(8):640-6. View Abstract

  24. Perfusion Imaging of Focal Cortical Dysplasia Using Arterial Spin Labeling: Correlation With Histopathological Vascular Density. J Child Neurol. 2013 Nov; 28(11):1474-1482. View Abstract

  25. Early thalamic lesions in patients with sleep-potentiated epileptiform activity. Neurology. 2012 Nov 27; 79(22):2218; author reply 2218-9. View Abstract

  26. Clinical staging and electroencephalographic evolution of continuous spikes and waves during sleep. Epilepsia. 2012 Jul; 53(7):1185-95. View Abstract

  27. Short-term response of sleep-potentiated spiking to high-dose diazepam in electric status epilepticus during sleep. Pediatr Neurol. 2012 May; 46(5):312-8. View Abstract

  28. Early thalamic lesions in patients with sleep-potentiated epileptiform activity. Neurology. 2012 May 29; 78(22):1721-7. View Abstract

  29. Patients with electrical status epilepticus in sleep share similar clinical features regardless of their focal or generalized sleep potentiation of epileptiform activity. J Child Neurol. 2013 Jan; 28(1):83-9. View Abstract

  30. Benign rolandic epileptiform discharges are associated with mood and behavior problems. Epilepsy Behav. 2011 Oct; 22(2):298-303. View Abstract

  31. Electroencephalography in clinical epilepsy research. Epilepsy Behav. 2011 Sep; 22(1):126-33. View Abstract

  32. Experience with lacosamide in a series of children with drug-resistant focal epilepsy. Pediatr Neurol. 2011 Jun; 44(6):414-9. View Abstract

  33. A novel mutation in the aristaless domain of the ARX gene leads to Ohtahara syndrome, global developmental delay, and ambiguous genitalia in males and neuropsychiatric disorders in females. Epilepsia. 2011 May; 52(5):984-92. View Abstract

  34. Rufinamide for the treatment of epileptic spasms. Epilepsy Behav. 2011 Feb; 20(2):344-8. View Abstract

  35. Experience with rufinamide in a pediatric population: a single center's experience. Pediatr Neurol. 2010 Sep; 43(3):155-8. View Abstract

  36. Exercise effects on methylation of ASC gene. Int J Sports Med. 2010 Sep; 31(9):671-5. View Abstract

  37. High-dose intravenous levetiracetam for acute seizure exacerbation in children with intractable epilepsy. Epilepsia. 2010 Jul; 51(7):1319-22. View Abstract

  38. Reversible uncal herniation in a neonate with a large MCA infarct. Brain Dev. 2009 Nov; 31(10):763-5. View Abstract

  39. Repetitive transcranial magnetic stimulation in the treatment of epilepsia partialis continua. Epilepsy Behav. 2009 Jan; 14(1):253-7. View Abstract

  40. Microdeletion/duplication at 15q13.2q13.3 among individuals with features of autism and other neuropsychiatric disorders. J Med Genet. 2009 Apr; 46(4):242-8. View Abstract

  41. Transient suppression of seizures by repetitive transcranial magnetic stimulation in a case of Rasmussen's encephalitis. Epilepsy Behav. 2008 Jul; 13(1):260-2. View Abstract

  42. Present status of surgical intervention for children with intractable seizures. Curr Neurol Neurosci Rep. 2008 Mar; 8(2):123-9. View Abstract

  43. Oxcarbazepine in children with nocturnal frontal-lobe epilepsy. Pediatr Neurol. 2007 Nov; 37(5):345-9. View Abstract

  44. Focal cortical malformations can show asymmetrically higher uptake on interictal fluorine-18 fluorodeoxyglucose positron emission tomography (PET). J Child Neurol. 2007 Feb; 22(2):232-7. View Abstract

  45. A distinct asymmetrical pattern of cortical malformation: large unilateral malformation of cortical development with contralateral periventricular nodular heterotopia in three pediatric cases. Epilepsia. 2005 Aug; 46(8):1317-21. View Abstract

  46. Focal status epilepticus as atypical presentation of pyridoxine-dependent epilepsy. J Child Neurol. 2005 Aug; 20(8):696-8. View Abstract

  47. Brain asymmetries in autism and developmental language disorder: a nested whole-brain analysis. Brain. 2005 Jan; 128(Pt 1):213-26. View Abstract

  48. Bilateral volume reduction of the superior temporal areas in Landau-Kleffner syndrome. Neurology. 2004 Oct 12; 63(7):1289-92. View Abstract

  49. FK506-associated limbic injury following umbilical cord blood transplantation. Bone Marrow Transplant. 2003 Sep; 32(5):523-5. View Abstract

  50. Reduced expression of actin-binding proteins, h-caldesmon and calponin h1, in the vascular smooth muscle inside melanoma lesions: an adverse prognostic factor for malignant melanoma. Br J Dermatol. 2003 May; 148(5):971-80. View Abstract

  51. MRI volumetric analysis in rasmussen encephalitis: a longitudinal study. Epilepsia. 2003 Feb; 44(2):247-51. View Abstract

  52. Abnormal asymmetry in language association cortex in autism. Ann Neurol. 2002 Nov; 52(5):588-96. View Abstract

  53. Concomitant treatment with topiramate and ketogenic diet in pediatric epilepsy. Epilepsia. 2002 Sep; 43(9):1072-5. View Abstract

  54. Infectious and inflammatory disorders of the circulatory system and stroke in childhood. Curr Opin Neurol. 2002 Apr; 15(2):159-64. View Abstract

  55. Diffusion-weighted images in neonatal cerebral hypoxic-ischemic injury. Pediatr Neurol. 2002 Apr; 26(4):274-81. View Abstract

  56. Diffusion-weighted imaging in moyamoya disease. J Child Neurol. 2001 Jul; 16(7):526-30. View Abstract

  57. Carbamyl phosphate synthetase 1 deficiency: a destructive encephalopathy. Pediatr Neurol. 2001 Mar; 24(3):193-9. View Abstract

  58. Topiramate and metabolic acidosis in pediatric epilepsy. Epilepsia. 2001 Mar; 42(3):387-92. View Abstract

  59. Diffusion-weighted imaging in neonatal cerebral infarction: clinical utility and follow-up. J Child Neurol. 2000 Sep; 15(9):592-602. View Abstract

  60. Fosphenytoin in infants. J Child Neurol. 1998 Nov; 13(11):537-40. View Abstract

  61. Petroclival meningioma presenting with pathological laughter. Neurology. 1998 Jun; 50(6):1918-9. View Abstract
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