Current Environment: Production

Medical Services

Specialties

Programs & Services

Education

Medical School

Madras Medical College

1989, Madras, India

Internship

Government General Hospital, Madras Medical College

1989, Madra, India

Internship

Henry Ford Hospital

1996, Detriot, MI

Residency

Pediatrics

Henry Ford Hospital

2000, Detroit, MI

Residency

Child Neurology

Tufts New England Medical Center

2005, Boston, MA

Fellowship

Epilepsy and Neurophysiology

Boston Children's Hospital

2006, Boston, MA

Certifications

  • American Board of Clinical Neurophysiology
  • American Board of Psychiatry and Neurology (Child and Adolescent Neurology)
  • American Board of Psychiatry and Neurology (Epilepsy)

Professional History

Dr. Harini serves as an expert for the Department of Neurology for Boston Children's Hospital Precision Medicine Service. For more information about the Precision Medicine Service please visit bostonchildrens.org/precisionmed.

Publications

  1. Evaluating the effectiveness of medical therapy in infantile epileptic spasms syndrome due to surgically-remediable lesions. Epilepsia. 2025 May; 66(5):1433-1446. View Abstract

  2. Outcomes following resective and disconnective strategies in the treatment of epileptic spasms: a systematic review of the literature and individual patient data meta-analysis. Front Neurol. 2024; 15:1518554. View Abstract

  3. Infantile-Onset Epilepsies: Steering Towards New Horizons. Indian J Pediatr. 2025 Jan; 92(1):42-43. View Abstract

  4. A Multicenter Training and Interrater Reliability Study of the BASED Score for Infantile Epileptic Spasms Syndrome. J Clin Neurophysiol. 2024 Jul 11. View Abstract

  5. A Multicenter Training and Interrater Reliability Study of the BASED Score for Infantile Epileptic Spasms Syndrome. J Clin Neurophysiol. 2025 Mar 01; 42(3):230-234. View Abstract

  6. The spectrum of movement disorders in young children with ARX-related epilepsy-dyskinesia syndrome. Ann Clin Transl Neurol. 2024 Jun; 11(6):1643-1647. View Abstract

  7. Diagnostic Yield of CSF Testing in Infants for Disorders of Biogenic Amine Neurotransmitter Metabolism. Neurology. 2024 May; 102(9):e209300. View Abstract

  8. Timing the clinical onset of epileptic spasms in infantile epileptic spasms syndrome: A tertiary health center's experience. Epilepsia. 2024 Apr; 65(4):984-994. View Abstract

  9. Initial combination versus early sequential standard therapies for Infantile Epileptic Spasms Syndrome-Feedback from stakeholders. Epilepsia Open. 2024 Apr; 9(2):819-822. View Abstract

  10. Delays to care in infantile epileptic spasms syndrome: Racial and ethnic inequities. Epilepsia. 2024 Jan; 65(1):107-114. View Abstract

  11. Post-zygotic rescue of meiotic errors causes brain mosaicism and focal epilepsy. Nat Genet. 2023 Nov; 55(11):1920-1928. View Abstract

  12. Influence of extent and age at corpus callosotomy on seizure outcomes. A single center experience. Epilepsia Open. 2023 Dec; 8(4):1596-1601. View Abstract

  13. Epileptic spasms in CDKL5 deficiency disorder: Delayed treatment and poor response to first-line therapies. Epilepsia. 2023 07; 64(7):1821-1832. View Abstract

  14. Hospital readmissions in children with new-onset infantile epileptic spasms syndrome. Epilepsia Open. 2023 06; 8(2):444-455. View Abstract

  15. Clinical characteristics of children with infantile epileptic spasms syndrome from a tertiary-care hospital in Dhaka, Bangladesh. Heliyon. 2023 Mar; 9(3):e14323. View Abstract

  16. Temporal trends in the cost and use of first-line treatments for infantile epileptic spasms syndrome. Epilepsia. 2023 03; 64(3):630-640. View Abstract

  17. Association of Time to Clinical Remission With Sustained Resolution in Children With New-Onset Infantile Spasms. Neurology. 2022 11 29; 99(22):e2494-e2503. View Abstract

  18. Interictal Connectivity Revealed by Granger Analysis of Stereoelectroencephalography: Association With Ictal Onset Zone, Resection, and Outcome. Neurosurgery. 2022 10 01; 91(4):583-589. View Abstract

  19. Inequities in Therapy for Infantile Spasms: A Call to Action. Ann Neurol. 2022 07; 92(1):32-44. View Abstract

  20. Infantile spasms: Assessing the diagnostic yield of an institutional guideline and the impact of etiology on long-term treatment response. Epilepsia. 2022 05; 63(5):1164-1176. View Abstract

  21. Comparison of Cosyntropin, Vigabatrin, and Combination Therapy in New-Onset Infantile Spasms in a Prospective Randomized Trial. J Child Neurol. 2022 03; 37(3):186-193. View Abstract

  22. Confirmation of infantile spasms resolution by prolonged outpatient EEGs. Epilepsia Open. 2021 12; 6(4):714-719. View Abstract

  23. Comparative Effectiveness of Initial Treatment for Infantile Spasms in a Contemporary US Cohort. Neurology. 2021 Sep 20; 97(12):e1217-e1228. View Abstract

  24. Subclinical seizures detected on intracranial EEG: Patient characteristics and impact on surgical outcome in a single pediatric epilepsy surgery center. Epilepsy Behav. 2021 08; 121(Pt A):108040. View Abstract

  25. Hippocampal Involvement With Vigabatrin-Related MRI Signal Abnormalities in Patients With Infantile Spasms: A Novel Finding. J Child Neurol. 2021 06; 36(7):575-582. View Abstract

  26. Cost-effectiveness of adrenocorticotropic hormone versus oral steroids for infantile spasms. Epilepsia. 2021 02; 62(2):347-357. View Abstract

  27. Management of Infantile Spasms During the COVID-19 Pandemic. J Child Neurol. 2020 10; 35(12):828-834. View Abstract

  28. Crisis Standard of Care: Management of Infantile Spasms during COVID-19. Ann Neurol. 2020 08; 88(2):215-217. View Abstract

  29. Mortality in infantile spasms: A hospital-based study. Epilepsia. 2020 04; 61(4):702-713. View Abstract

  30. Recurrent SLC1A2 variants cause epilepsy via a dominant negative mechanism. Ann Neurol. 2019 06; 85(6):921-926. View Abstract

  31. Brain MRI abnormalities in patients with infantile spasms and Down syndrome. Epilepsy Behav. 2019 03; 92:57-60. View Abstract

  32. Detailed Magnetic Resonance Imaging (MRI) Analysis in Infantile Spasms. J Child Neurol. 2018 05; 33(6):405-412. View Abstract

  33. White matter spongiosis with vigabatrin therapy for infantile spasms. Epilepsia. 2018 04; 59(4):e40-e44. View Abstract

  34. Seizure clustering during presurgical electroencephalographic monitoring in children. Epilepsy Behav. 2018 03; 80:291-295. View Abstract

  35. Brain tumors and epileptic spasms: Natural history and outcomes. Epilepsy Behav. 2017 10; 75:25-28. View Abstract

  36. Patterns of Head Computed Tomography Abnormalities During Pediatric Extracorporeal Membrane Oxygenation and Association With Outcomes. Pediatr Neurol. 2017 Aug; 73:64-70. View Abstract

  37. Expanding the phenotypic spectrum of GABRG2 variants: a recurrent GABRG2 missense variant associated with a severe phenotype. J Neurogenet. 2017 Mar - Jun; 31(1-2):30-36. View Abstract

  38. A pediatric epilepsy diagnostic tool for use in resource-limited settings: A pilot study. Epilepsy Behav. 2016 06; 59:57-61. View Abstract

  39. Effectiveness of once-daily high-dose ACTH for infantile spasms. Epilepsy Behav. 2016 06; 59:4-8. View Abstract

  40. Utility of initial EEG in first complex febrile seizure. Epilepsy Behav. 2015 Nov; 52(Pt A):200-4. View Abstract

  41. Clinical and Neuroimaging Profile of Children with Lesions in the Corpus Callosum. J Neuroimaging. 2015 Sep-Oct; 25(5):824-31. View Abstract

  42. Safety and retention rate of rufinamide in 300 patients: a single pediatric epilepsy center experience. Epilepsia. 2014 Aug; 55(8):1235-44. View Abstract

  43. Localization of the epileptogenic foci in tuberous sclerosis complex: a pediatric case report. Front Hum Neurosci. 2014; 8:175. View Abstract

  44. Rasmussen's encephalitis presenting as focal cortical dysplasia. Epilepsy Behav Case Rep. 2014; 2:86-9. View Abstract

  45. Clobazam: effect on frequency of seizures and safety profile in different subgroups of children with epilepsy. Pediatr Neurol. 2014 Jul; 51(1):60-6. View Abstract

  46. Neurological maturation of late preterm infants at 34?wk assessed by amplitude integrated electroencephalogram. Pediatr Res. 2013 Dec; 74(6):705-11. View Abstract

  47. Continuous Spikes and Waves during Sleep: Electroclinical Presentation and Suggestions for Management. Epilepsy Res Treat. 2013; 2013:583531. View Abstract

  48. Electrode localization for planning surgical resection of the epileptogenic zone in pediatric epilepsy. Int J Comput Assist Radiol Surg. 2014 Jan; 9(1):91-105. View Abstract

  49. Predictors of seizure occurrence in children undergoing pre-surgical monitoring. Seizure. 2013 Oct; 22(8):640-6. View Abstract

  50. Teaching NeuroImages: mesial temporal sclerosis after a prolonged unprovoked seizure in an infant. Neurology. 2011 Nov 08; 77(19):e112-3. View Abstract

  51. Transient suppression of seizures by repetitive transcranial magnetic stimulation in a case of Rasmussen's encephalitis. Epilepsy Behav. 2008 Jul; 13(1):260-2. View Abstract
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