Current Environment: Production

Medical Services

Programs & Services

Languages

  • English
  • Greek

Education

Medical School

Aristotelian University of Thessaloniki

1988, Thessaloniki, Greece

Residency

Pediatrics

Hospital for Infectious Diseases

1989, Thessaloniki, Greece

Internship

Beth Israel Deaconess Medical Center

1990, Boston, MA

Residency

Pediatrics

Beth Israel Medical Center

1992, New York, MA

Fellowship

Joint Program in Neonatology

Harvard Medical School

1996, Boston, MA

Certifications

  • American Board of Pediatrics (Neonatal-Perinatal Medicine)

Publications

  1. A narrative review of the clinical applications of renal NIRS and integration with cerebral NIRS in the NICU. J Perinatol. 2025 Apr 15. View Abstract

  2. Impact of persistent pulmonary hypertension on cerebral oxygenation in infants with neonatal encephalopathy. Pediatr Res. 2024 Nov 07. View Abstract

  3. Stress Granule Assembly in Pulmonary Arterial Hypertension. Cells. 2024 10 30; 13(21). View Abstract

  4. Adult and neonatal models of chemogenetic heart failure caused by oxidative stress. J Clin Invest. 2024 Mar 14; 134(9). View Abstract

  5. Maternal Obesity Modulates Cord Blood Concentrations of Proprotein Convertase Subtilisin/Kexin-type 9 Levels. J Endocr Soc. 2024 Feb 19; 8(4):bvae031. View Abstract

  6. Pericytes contribute to pulmonary vascular remodeling via HIF2a signaling. EMBO Rep. 2024 Feb; 25(2):616-645. View Abstract

  7. Single center experience with first-intention high-frequency jet vs. volume-targeted ventilation in extremely preterm neonates. Front Pediatr. 2023; 11:1326668. View Abstract

  8. Proceedings of the 15th International Newborn Brain Conference: Fetal and/or neonatal brain development, both normal and abnormal. J Neonatal Perinatal Med. 2024; 17(3):S285-S316. View Abstract

  9. Proceedings of the 15th International Newborn Brain Conference: Other forms of brain monitoring, such as NIRS, fMRI, biochemical, etc. J Neonatal Perinatal Med. 2024; 17(3):S393-S419. View Abstract

  10. Pneumoprotein CC16 in the Umbilical Cord Blood of Preterm Neonates. Am J Perinatol. 2024 05; 41(S 01):e3367-e3373. View Abstract

  11. Predictors of successful extubation from volume-targeted ventilation in extremely preterm neonates. J Perinatol. 2024 02; 44(2):250-256. View Abstract

  12. Pulmonary Hypertension in Infants and Children with Vein of Galen Malformation and Association with Clinical Outcomes. J Pediatr. 2023 07; 258:113404. View Abstract

  13. Proceedings of the 14th International Newborn Brain Conference: Other forms of brain monitoring, such as NIRS, fMRI, biochemical, etc. J Neonatal Perinatal Med. 2023; 16(s1):S63-S73. View Abstract

  14. Maternal diabetes and the role of neonatal reticulocyte hemoglobin content as a biomarker of iron status in the perinatal period. Front Endocrinol (Lausanne). 2022; 13:1011897. View Abstract

  15. Skeletal Muscle Dysfunction in Experimental Pulmonary Hypertension. Int J Mol Sci. 2022 Sep 18; 23(18). View Abstract

  16. Changes, Challenges, and Variations in Neonatal-Perinatal Medicine Fellowship: A View from the Program Directors. Am J Perinatol. 2024 05; 41(S 01):e163-e173. View Abstract

  17. Pleiotropic Effects of Pyruvate Kinase M2 in Right Ventricular Failure and Pulmonary Arterial Hypertension. JACC Basic Transl Sci. 2022 Apr; 7(4):404-405. View Abstract

  18. Mechanisms of pulmonary vascular dysfunction in pulmonary hypertension and implications for novel therapies. Am J Physiol Heart Circ Physiol. 2022 05 01; 322(5):H702-H724. View Abstract

  19. ETV2 regulates PARP-1 binding protein to induce ER stress-mediated death in tuberin-deficient cells. Life Sci Alliance. 2022 05; 5(5). View Abstract

  20. Metabolomic and transcriptomic signatures of chemogenetic heart failure. Am J Physiol Heart Circ Physiol. 2022 03 01; 322(3):H451-H465. View Abstract

  21. Proceedings of the 13th International Newborn Brain Conference: Neonatal Neurocritical Care, Seizures, and Continuous EEG monitoring. J Neonatal Perinatal Med. 2022; 15(2):467-485. View Abstract

  22. Acetazolamide Improves Right Ventricular Function and Metabolic Gene Dysregulation in Experimental Pulmonary Arterial Hypertension. Front Cardiovasc Med. 2021; 8:662870. View Abstract

  23. Off-label use of PAH-targeted medications approved for adults and their financial coverage by health insurances are vital for children with pulmonary hypertension. Eur J Clin Invest. 2021 Aug; 51(8):e13571. View Abstract

  24. Carbonic anhydrase inhibition improves pulmonary artery reactivity and nitric oxide-mediated relaxation in sugen-hypoxia model of pulmonary hypertension. Am J Physiol Regul Integr Comp Physiol. 2021 06 01; 320(6):R835-R850. View Abstract

  25. Adipokines and Metabolic Regulators in Human and Experimental Pulmonary Arterial Hypertension. Int J Mol Sci. 2021 Feb 01; 22(3). View Abstract

  26. Lower oxygen saturation targets in preterm infants are not associated with increased rates of pulmonary hypertension. J Neonatal Perinatal Med. 2021; 14(4):519-526. View Abstract

  27. Echocardiographic markers of pulmonary hemodynamics and right ventricular hypertrophy in rat models of pulmonary hypertension. Pulm Circ. 2020 Apr-Jun; 10(2):2045894020910976. View Abstract

  28. Association of circulating FGF-21 levels in the first week of life and postnatal growth in hospitalized preterm infants. Metabol Open. 2020 Mar; 5:100030. View Abstract

  29. Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation. Nat Genet. 2020 02; 52(2):138-145. View Abstract

  30. GLYCOSYLATED FIBRONECTIN AND INHIBIN ARE LOWER AND ANTI-MÜLLERIAN HORMONE IS HIGHER IN UMBILICAL CORD BLOOD WHEN MOTHERS HAVE PREECLAMPSIA. Endocr Pract. 2020 Mar; 26(3):318-327. View Abstract

  31. Carbonic Anhydrase Inhibition Ameliorates Inflammation and Experimental Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2019 10; 61(4):512-524. View Abstract

  32. Placental proteases PAPP-A and PAPP-A2, the binding proteins they cleave (IGFBP-4 and -5), and IGF-I and IGF-II: Levels in umbilical cord blood and associations with birth weight and length. Metabolism. 2019 11; 100:153959. View Abstract

  33. Early caloric deprivation in preterm infants affects Bayley-III scales performance at 18-24 months of corrected age. Res Dev Disabil. 2019 Aug; 91:103429. View Abstract

  34. Bronchopulmonary Dysplasia: An Update of Current Pharmacologic Therapies and New Approaches. Clin Med Insights Pediatr. 2018; 12:1179556518817322. View Abstract

  35. Macrophage FABP4 is required for neutrophil recruitment and bacterial clearance in Pseudomonas aeruginosa pneumonia. FASEB J. 2019 03; 33(3):3562-3574. View Abstract

  36. Adjuvant Effect of Bacille Calmette-Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn. Front Immunol. 2018; 9:29. View Abstract

  37. Is There More to Zika? Complex Cardiac Disease in a Case of Congenital Zika Syndrome. Neonatology. 2018; 113(2):177-182. View Abstract

  38. Impaired Pulmonary Arterial Vasoconstriction and Nitric Oxide-Mediated Relaxation Underlie Severe Pulmonary Hypertension in the Sugen-Hypoxia Rat Model. J Pharmacol Exp Ther. 2018 02; 364(2):258-274. View Abstract

  39. Cord Blood Adipocyte Fatty Acid-Binding Protein Levels Correlate With Gestational Age and Birth Weight in Neonates. J Clin Endocrinol Metab. 2017 05 01; 102(5):1606-1613. View Abstract

  40. Establishing Effective Mentoring Networks: Rationale and Strategies. MedEdPORTAL. 2017 Apr 18; 13:10571. View Abstract

  41. Vitamin D and bronchopulmonary dysplasia in preterm infants. J Perinatol. 2016 10; 36(10):878-82. View Abstract

  42. Sustaining careers of physician-scientists in neonatology and pediatric critical care medicine: formulating supportive departmental policies. Pediatr Res. 2016 11; 80(5):635-640. View Abstract

  43. Cord blood irisin levels are positively correlated with birth weight in newborn infants. Metabolism. 2015 Nov; 64(11):1507-14. View Abstract

  44. Hemopexin in severe inflammation and infection: mouse models and human diseases. Crit Care. 2015 Apr 15; 19:166. View Abstract

  45. Elk-3 is a KLF4-regulated gene that modulates the phagocytosis of bacteria by macrophages. J Leukoc Biol. 2015 Jan; 97(1):171-80. View Abstract

  46. Cord blood levels of osteopontin as a phenotype marker of gestational age and neonatal morbidities. Obesity (Silver Spring). 2014 May; 22(5):1317-24. View Abstract

  47. Vitamin D status among preterm and full-term infants at birth. Pediatr Res. 2014 Jan; 75(1-1):75-80. View Abstract

  48. Endothelial indoleamine 2,3-dioxygenase protects against development of pulmonary hypertension. Am J Respir Crit Care Med. 2013 Aug 15; 188(4):482-91. View Abstract

  49. An update on pharmacologic approaches to bronchopulmonary dysplasia. Semin Perinatol. 2013 Apr; 37(2):115-23. View Abstract

  50. Improved pulmonary vascular reactivity and decreased hypertrophic remodeling during nonhypercapnic acidosis in experimental pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2012 May 01; 302(9):L875-90. View Abstract

  51. Current pharmacologic approaches for prevention and treatment of bronchopulmonary dysplasia. Int J Pediatr. 2012; 2012:598606. View Abstract

  52. Heme oxygenase-1 does not mediate the effects of extracellular acidosis on vascular smooth muscle cell proliferation, migration, and susceptibility to apoptosis. J Vasc Res. 2011; 48(4):285-96. View Abstract

  53. Sex hormones and vascular protection in pulmonary arterial hypertension. J Cardiovasc Pharmacol. 2010 Nov; 56(5):471-4. View Abstract

  54. Impaired vasoconstriction and nitric oxide-mediated relaxation in pulmonary arteries of hypoxia- and monocrotaline-induced pulmonary hypertensive rats. J Pharmacol Exp Ther. 2010 Feb; 332(2):455-62. View Abstract

  55. Divergent cardiopulmonary actions of heme oxygenase enzymatic products in chronic hypoxia. PLoS One. 2009 Jun 19; 4(6):e5978. View Abstract

  56. Intrauterine closure of the ductus arteriosus: implications for the neonatologist. Am J Perinatol. 2009 Aug; 26(7):473-8. View Abstract

  57. The p38 mitogen-activated protein kinase pathway is involved in the regulation of heme oxygenase-1 by acidic extracellular pH in aortic smooth muscle cells. J Cell Biochem. 2008 Dec 01; 105(5):1298-306. View Abstract

  58. Gender differences in research grant applications and funding outcomes for medical school faculty. J Womens Health (Larchmt). 2008 Mar; 17(2):207-14. View Abstract

  59. Pharmacological strategies in the prevention and management of bronchopulmonary dysplasia. Semin Perinatol. 2006 Aug; 30(4):209-18. View Abstract

  60. Cerebral endothelial nitric oxide synthase expression is reduced after very-low-flow bypass. Ann Thorac Surg. 2006 Jun; 81(6):2202-6. View Abstract

  61. Mechanisms of heme oxygenase-1-mediated cardiac and pulmonary vascular protection in chronic hypoxia: roles of carbon monoxide and bilirubin. Chest. 2005 Dec; 128(6 Suppl):578S-579S. View Abstract

  62. Lung injury and bronchopulmonary dysplasia in newborn infants. J Intensive Care Med. 2005 Mar-Apr; 20(2):76-87. View Abstract

  63. Extracellular acidosis induces heme oxygenase-1 expression in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2005 Jun; 288(6):H2647-52. View Abstract

  64. Current concepts in intrauterine growth restriction. J Intensive Care Med. 2004 Nov-Dec; 19(6):307-19. View Abstract

  65. Primary ciliary dyskinesia as a cause of neonatal respiratory distress: implications for the neonatologist. J Perinatol. 2003 Dec; 23(8):684-7. View Abstract

  66. Leptin in relation to growth and developmental processes in the fetus. Semin Reprod Med. 2002 May; 20(2):123-30. View Abstract

  67. Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8798-803. View Abstract

  68. Cord blood leptin and insulin-like growth factor levels are independent predictors of fetal growth. J Clin Endocrinol Metab. 2001 Feb; 86(2):935-8. View Abstract

  69. Inhaled nitric oxide reduces the need for extracorporeal membrane oxygenation in infants with persistent pulmonary hypertension of the newborn. Crit Care Med. 2000 Nov; 28(11):3722-7. View Abstract

  70. Prevention of hypoxia-induced pulmonary hypertension by enhancement of endogenous heme oxygenase-1 in the rat. Circ Res. 2000 Jun 23; 86(12):1224-9. View Abstract

  71. Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice. J Clin Invest. 1999 Apr; 103(8):R23-9. View Abstract

  72. Inhaled nitric oxide does not affect adenosine 5'-diphosphate-dependent platelet activation in infants with persistent pulmonary hypertension of the newborn. Pediatrics. 1998 Dec; 102(6):1390-3. View Abstract

  73. Hypoxic responses of vascular cells. Chest. 1998 Jul; 114(1 Suppl):25S-28S. View Abstract

  74. Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5' enhancer. J Biol Chem. 1998 Jun 12; 273(24):15257-62. View Abstract

  75. Increased vascular endothelial growth factor production in the lungs of rats with hypoxia-induced pulmonary hypertension. Am J Respir Cell Mol Biol. 1998 Jun; 18(6):768-76. View Abstract

  76. Effect of inhaled nitric oxide on endothelin-1 and cyclic guanosine 5'-monophosphate plasma concentrations in newborn infants with persistent pulmonary hypertension. J Pediatr. 1997 Apr; 130(4):603-11. View Abstract

  77. Mechanisms by which oxygen regulates gene expression and cell-cell interaction in the vasculature. Kidney Int. 1997 Feb; 51(2):438-43. View Abstract

In the Boston Children’s Hospital (BCH) Neonatal Intensive Care Unit (NICU) our philosophy is to ensure that every patient receives the best care for the best possible outcomes. We consider our “patient” to be the baby and the family; we are constantly striving to serve the needs of both. This requires a team based approach with all members being essential.

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