Current Environment: Production

Jeffrey Bolton | Medical Services

Specialties

Programs & Services

Languages

  • English

Jeffrey Bolton | Education

Undergraduate School

Vanderbilt University

2002, Nashville, TN

Medical School

University of Louisville School of Medicine

2006, Louisville, KY

Internship

Children's Hospital of Philadelphia

2008, Philadelphia, PA

Residency

Boston Children's Hospital

2011, Boston, MA

Fellowship

Boston Children's Hospital

2012, Boston, MA

Jeffrey Bolton | Certifications

  • American Board of Psychiatry and Neurology (Child and Adolescent Neurology)
  • American Board of Psychiatry and Neurology (Clinical Physiology)

Jeffrey Bolton | Professional History

After completing residency in pediatric neurology at Boston Children’s hospital, I stayed on as a fellow in Epilepsy/Clinical Neurophysiology.  I joined the department as a staff physician in July 2012 and see patients in clinic in our Weymouth satellite.  I enjoy seeing patients with various neurologic disorders but have a special interest in patients with epilepsy.  In addition to working in the clinic, I also spend time supervising the epilepsy in-patient and neurology consult services.  During my training I became interested in epilepsy surgery and have been focusing my research work into looking at factors that influence the success of epilepsy surgery.

Jeffrey Bolton | Publications

  1. A multi-center comparison of surgical techniques for corpus Callosotomy in pediatric drug-resistant epilepsy. Epilepsia. 2024 Feb; 65(2):422-429. View A multi-center comparison of surgical techniques for corpus Callosotomy in pediatric drug-resistant epilepsy. Abstract

  2. Development of an online calculator for the prediction of seizure freedom following pediatric hemispherectomy using the Hemispherectomy Outcome Prediction Scale (HOPS). Epilepsia. 2024 Jan; 65(1):46-56. View Development of an online calculator for the prediction of seizure freedom following pediatric hemispherectomy using the Hemispherectomy Outcome Prediction Scale (HOPS). Abstract

  3. Added value of corpus callosotomy following vagus nerve stimulation in children with Lennox-Gastaut syndrome: A multicenter, multinational study. Epilepsia. 2023 Dec; 64(12):3205-3212. View Added value of corpus callosotomy following vagus nerve stimulation in children with Lennox-Gastaut syndrome: A multicenter, multinational study. Abstract

  4. Influence of extent and age at corpus callosotomy on seizure outcomes. A single center experience. Epilepsia Open. 2023 Dec; 8(4):1596-1601. View Influence of extent and age at corpus callosotomy on seizure outcomes. A single center experience. Abstract

  5. Spike propagation mapping reveals effective connectivity and predicts surgical outcome in epilepsy. Brain. 2023 09 01; 146(9):3898-3912. View Spike propagation mapping reveals effective connectivity and predicts surgical outcome in epilepsy. Abstract

  6. Functional connectivity discriminates epileptogenic states and predicts surgical outcome in children with drug resistant epilepsy. Sci Rep. 2023 06 14; 13(1):9622. View Functional connectivity discriminates epileptogenic states and predicts surgical outcome in children with drug resistant epilepsy. Abstract

  7. Comparison of fMRI language laterality with and without sedation in pediatric epilepsy. Neuroimage Clin. 2023; 38:103448. View Comparison of fMRI language laterality with and without sedation in pediatric epilepsy. Abstract

  8. Non-invasive mapping of epileptogenic networks predicts surgical outcome. Brain. 2023 05 02; 146(5):1916-1931. View Non-invasive mapping of epileptogenic networks predicts surgical outcome. Abstract

  9. Stereoelectroencephalography followed by combined electrode removal and MRI-guided laser interstitial thermal therapy or open resection: a single-center series in pediatric patients with medically refractory epilepsy. J Neurosurg Pediatr. 2023 03 01; 31(3):206-211. View Stereoelectroencephalography followed by combined electrode removal and MRI-guided laser interstitial thermal therapy or open resection: a single-center series in pediatric patients with medically refractory epilepsy. Abstract

  10. Interictal Connectivity Revealed by Granger Analysis of Stereoelectroencephalography: Association With Ictal Onset Zone, Resection, and Outcome. Neurosurgery. 2022 10 01; 91(4):583-589. View Interictal Connectivity Revealed by Granger Analysis of Stereoelectroencephalography: Association With Ictal Onset Zone, Resection, and Outcome. Abstract

  11. Discrepant expressive language lateralization in children and adolescents with epilepsy. Ann Clin Transl Neurol. 2022 09; 9(9):1459-1464. View Discrepant expressive language lateralization in children and adolescents with epilepsy. Abstract

  12. Mendelian etiologies identified with whole exome sequencing in cerebral palsy. Ann Clin Transl Neurol. 2022 02; 9(2):193-205. View Mendelian etiologies identified with whole exome sequencing in cerebral palsy. Abstract

  13. Surgical evaluation in children <3 years of age with drug-resistant epilepsy: Patient characteristics, diagnostic utilization, and potential for treatment delays. Epilepsia. 2022 01; 63(1):96-107. View Surgical evaluation in children <3 years of age with drug-resistant epilepsy: Patient characteristics, diagnostic utilization, and potential for treatment delays. Abstract

  14. A Standardized Electrode Nomenclature for Stereoelectroencephalography Applications. J Clin Neurophysiol. 2021 Nov 01; 38(6):509-515. View A Standardized Electrode Nomenclature for Stereoelectroencephalography Applications. Abstract

  15. Comparison of the real-world effectiveness of vertical versus lateral functional hemispherotomy techniques for pediatric drug-resistant epilepsy: A post hoc analysis of the HOPS study. Epilepsia. 2021 11; 62(11):2707-2718. View Comparison of the real-world effectiveness of vertical versus lateral functional hemispherotomy techniques for pediatric drug-resistant epilepsy: A post hoc analysis of the HOPS study. Abstract

  16. Subclinical seizures detected on intracranial EEG: Patient characteristics and impact on surgical outcome in a single pediatric epilepsy surgery center. Epilepsy Behav. 2021 08; 121(Pt A):108040. View Subclinical seizures detected on intracranial EEG: Patient characteristics and impact on surgical outcome in a single pediatric epilepsy surgery center. Abstract

  17. Presurgical accuracy of dipole clustering in MRI-negative pediatric patients with epilepsy: Validation against intracranial EEG and resection. Clin Neurophysiol. 2022 09; 141:126-138. View Presurgical accuracy of dipole clustering in MRI-negative pediatric patients with epilepsy: Validation against intracranial EEG and resection. Abstract

  18. Hemispherectomy Outcome Prediction Scale: Development and validation of a seizure freedom prediction tool. Epilepsia. 2021 05; 62(5):1064-1073. View Hemispherectomy Outcome Prediction Scale: Development and validation of a seizure freedom prediction tool. Abstract

  19. Patterns of anti-seizure medication (ASM) use in pediatric patients with surgically managed epilepsy: A retrospective review of data from Boston Children's Hospital. Epilepsy Res. 2020 02; 160:106257. View Patterns of anti-seizure medication (ASM) use in pediatric patients with surgically managed epilepsy: A retrospective review of data from Boston Children's Hospital. Abstract

  20. The Evolution of Subclinical Seizures in Children With Tuberous Sclerosis Complex. J Child Neurol. 2019 10; 34(12):770-777. View The Evolution of Subclinical Seizures in Children With Tuberous Sclerosis Complex. Abstract

  21. Non-invasive Seizure Localization with Ictal Single-Photon Emission Computed Tomography is Impacted by Preictal/Early Ictal Network Dynamics. IEEE Trans Biomed Eng. 2018 Nov 09. View Non-invasive Seizure Localization with Ictal Single-Photon Emission Computed Tomography is Impacted by Preictal/Early Ictal Network Dynamics. Abstract

  22. Surgical resection of ripple onset predicts outcome in pediatric epilepsy. Ann Neurol. 2018 09; 84(3):331-346. View Surgical resection of ripple onset predicts outcome in pediatric epilepsy. Abstract

  23. Seizure clustering during presurgical electroencephalographic monitoring in children. Epilepsy Behav. 2018 03; 80:291-295. View Seizure clustering during presurgical electroencephalographic monitoring in children. Abstract

  24. Pediatric epilepsy surgery. Curr Neurol Neurosci Rep. 2015 Jun; 15(6):31. View Pediatric epilepsy surgery. Abstract

  25. Safety and retention rate of rufinamide in 300 patients: a single pediatric epilepsy center experience. Epilepsia. 2014 Aug; 55(8):1235-44. View Safety and retention rate of rufinamide in 300 patients: a single pediatric epilepsy center experience. Abstract

  26. Clobazam: effect on frequency of seizures and safety profile in different subgroups of children with epilepsy. Pediatr Neurol. 2014 Jul; 51(1):60-6. View Clobazam: effect on frequency of seizures and safety profile in different subgroups of children with epilepsy. Abstract

  27. Juvenile myasthenia gravis: three case reports and a literature review. J Child Neurol. 2009 May; 24(5):584-90. View Juvenile myasthenia gravis: three case reports and a literature review. Abstract

  28. Trust and the healing encounter: an examination of an unorthodox healing performance. Theor Med Bioeth. 2000; 21(4):305-19. View Trust and the healing encounter: an examination of an unorthodox healing performance. Abstract

  29. Alternatively spliced isoforms of a Cis2-His2 zinc-finger domain. Developmental regulation and binding-site selection. Ann N Y Acad Sci. 1993 Jun 11; 684:218-9. View Alternatively spliced isoforms of a Cis2-His2 zinc-finger domain. Developmental regulation and binding-site selection. Abstract

  30. Sequence discrimination by alternatively spliced isoforms of a DNA binding zinc finger domain. Science. 1992 Sep 25; 257(5078):1951-5. View Sequence discrimination by alternatively spliced isoforms of a DNA binding zinc finger domain. Abstract

  31. Asymptomatic bronchogenic cysts: what is the best management? Ann Thorac Surg. 1992 Jun; 53(6):1134-7. View Asymptomatic bronchogenic cysts: what is the best management? Abstract

Entering medical school with a background in neuroscience, I was naturally drawn to neurology. After rotating in pediatrics and enjoying my time spent with this patient population, it made sense to pursue a career in pediatric neurology. I am thankful that I can do something I love and help families while doing so.

Spending most of my early years in the south, I think I bring a more laid-back, southern attitude to our department. Despite my roots, I love living in Boston and feel it’s a great place to raise my family of three energetic little boys. When not at work, I enjoy spending time outdoors with my family, playing sports, hiking, biking or whatever other adventure we may stumble upon.

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